|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Division Algorithm and Implementations显示文摘 | Stuart Oberman Michael J.Flynn | | 0，，： | 1 |
| 2 | Ovarian cancer recurrence:is the definition of platinum resistance modified by PARPi and other intervening treatments?The evolving landscape in the management of platinum-resistant ovarian cancer显示文摘Definitions of platinum resistance have been questioned and changed over the last five years,even though no predictive biomarker of resistance exists.These have sculpted how we approach platinum retreatment and,consequently,how we devise new treatment strategies for those patients with tumour progression on platinum therapy.Platinum-non-eligible ovarian cancer is treated with single-agent non-platinum drugs.When bevacizumab can be added to chemotherapy,progression-free survival improves significantly.For patients with a BRCA mutation,PARP inhibitor monotherapy is an option compared to chemotherapy.There is currently no clearly identified role for immune-checkpoint inhibition in this patient population.This review describes some of the challenges in treating patients with platinum resistance and suggests refinements in the selection of patients most likely to benefit from targeting a DNA damage response,angiogenesis or immune modulation.It also describes novel agents of interest and possible mechanisms of the synergy of therapeutic combinations. | Michael J.Flynn Jonathan A.Ledermann | 2022 | Cancer Drug Resistance2022，5，2： | 1 |
| 3 | Interplays of liver fibrosis-associated microRNAs:Molecular mechanisms and implications in diagnosis and therapy显示文摘microRNAs(miRNAs)are a class of non-coding functional small RNA composed of 21e23 nucleotides,having multiple associations with liver fibrosis.Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis types.The former is capable of activating hepatic stellate cells(HSCs)by modulating pro-fibrotic signaling pathways,mainly including TGF-b/SMAD,WNT/b-catenin,and Hedgehog;the latter is responsible for maintenance of the quiescent phenotype of normal HSCs,phenotypic reversion of activated HSCs(aHSCs),inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene expression.Moreover,several miRNAs are involved in regulation of liver fibrosis via alternative mechanisms,such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of aHSCs.Thus,understanding the role of these miRNAs may provide new avenues for the development of novel interventions against hepatic fibrosis. | Hong Li Tingli Liu Yongchun Yang William C.Cho Robin J.Flynn Majid Fasihi Harandi Houhui Song Xuenong Luo Yadong Zheng | 2023 | Genes & Diseases2023，10，4： | 1 |
| 4 | Phase 2 study of bevacizumab plus erlotinib in patients with advanced hepatocellular cancer显示文摘 | Philip A.Philip Michelle R.Mahoney Kyle D.Holen Donald W.Northfelt Henry C.Pitot JoelPicus Patrick J.Flynn CharlesErlichman | 2012 | Cancer2012，，9： | 1 |
| 5 | 云南晚中新世苏门答腊兔(Nesolagus)分离时间的标定(英文)显示文摘报道了发现于云南昭通水塘坝的晚中新世兔类,它与时代较早的云南禄丰地点的长褶“翼兔”(“Alilepus”longisinuosus)属于同一个种,两者栖息的环境均为潮湿的沼泽地区。前臼齿的形态表明该种是现今生活在湿润地区条纹兔(即苏门答腊兔Nesolagus)的早期代表,因此将该种更名为长褶苏门答腊兔Nesolagus longisinuosus(Qiu&Han,1986)。Nesolagus化石记录在大约7 Ma的华南地区的证据与线粒体学研究推测Nesolagus的现生种类在晚中新世从兔科演化主线上分出来的结论一致。重建了苏门答腊兔演化历史的大致一幕,即其在8 Ma后出现,随即迅速地扩散到整个东南亚并最终到达现今的苏门答腊地区。 | Lawrence J.FLYNN 金昌柱 Jay KELLEY Nina G.JABLONSKI 吉学平 Denise F.SU 邓涛 李强 | 2019 | 古脊椎动物学报2019，57，3： | 1 |
| 6 | 谷歌力推新服务,邮件聊天两不误显示文摘搜索引擎界巨擘谷歌公司于本周二透露消息说,它将提供一项与流行程序Gmail相结合的即时通讯服务。这项最新的服务表明谷歌公司将目光对准了更加广阔的通信领域。 | Laurie J.Flynn 甘胜 | 2007 | 科技英语学习2007，，4： | 0 |
| 7 | MAMMIFRES DE SANSAN, coordinated by Stéphane Peigné and Sevket Sen, 2012. Mémoires du Muséum National d'Histoire naturelle, Publication Scientifi que 203, 709 pages, ISBN 978-2-85653-681-0.Mammifères de Sansan, key volume on a historical locality显示文摘The Muséum National d’Histoire naturelle,via the able hands of Stéphane Peignéand Sevket Sen,has produced a massive scientific work that compiles advanced studies on the diverse mammalian fossil assemblage of Sansan,Gers,southwestern France.Servais et al.(2012)called Sansan a'lagersttte',and so it is:a remarkable fossil site that assembles much of the biota of its past community in one place.Sansan is a site complex with | Dr.Lawrence J.FLYNN | 2014 | 古脊椎动物学报2014，52，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员