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| 1 | Clinical management of inflammatory bowel disease in the organ recipient显示文摘There was estimated a higher incidence of de novo inflammatory bowel disease(IBD)after solid organ transplantation than in the general population.The onset of IBD in the organ transplant recipient population is an important clinical situation which is associated to higher morbidity and difficulty in the medical therapeutic management because of possible interaction between anti-reject therapy and IBD therapy.IBD course after liver transplantation(LT)is variable,but about one third of patients may worsen,needing an increase in medical therapy or a colectomy.Active IBD at the time of LT,discontinuation of 5-aminosalicylic acid or azathioprine at the time of LT and use of tacrolimusbased immunosuppression may be associated with an unfavorable outcome of IBD after LT.Anti-tumor necrosis factor alpha(TNFα)therapy for refractory IBD may be an effective and safe therapeutic option after LT.The little experience of the use of biological therapy in transplanted patients,with concomitant anti-rejection therapy,suggests there be a higher more careful surveillance regarding the risk of infectious diseases,autoimmune diseases,and neoplasms.An increased risk of colorectal cancer(CRC)is present also after LT in IBD patients with primary sclerosing cholangitis(PSC).Anannual program of endoscopic surveillance with serial biopsies for CRC is recommended.A prophylactic colectomy in selected IBD/PSC patients with CRC risk factors could be a good management strategy in the CRC prevention,but it is used infrequently in the majority of LT centers.About 30%of patients develop multiple IBD recurrence and 20%of patients require a colectomy after renal transplantation.Like in the liver transplantation,anti-TNFαtherapy could be an effective treatment in IBD patients with conventional refractory therapy after renal or heart transplantation.A large number of patients are needed to confirm the preliminary observations.Regarding the higher clinical complexity of this subgroup of IBD patients,a close multidisciplinary approach between an IBD dedicated gastroenterologist and surgeon and an organ transplantation specialist is necessary in order to have the best clinical management of IBD after transplantation. | Amedeo Indriolo Paolo Ravelli | 2014 | World Journal of Gastroenterology2014，20，13： | 4 |
| 2 | A Vacuolar Arsanite Transporter Necessary for ArsenicTolerance in the Arsenic Hyperaccumulating Fern Pteris vittata Is Missing in Flowering Plants显示文摘 | INDRIOLO E NAG N ELLIS D | 2010 | The Plant Cell2010，22，： | 1 |
| 3 | A novel arsenate reductase from the arsenic hyperaccumulating fern Pteris vittata显示文摘 | Ellis D R Gumaelius L Indriolo E | | 0，，04： | 1 |
| 4 | The ARC1 E3 ligase gene is frequently deleted in self-compatible Brassicaceae species and has a conserved role in Arabidopsis lyrata self-pollen rejection 显示文摘 | Indriolo E Tharmapalan P Wright S I | 2012 | Plant Cell2012，，11： | 1 |
| 5 | A novel arsenate reductase from the arsenic hyperaccumulating fern Pteris vittata 显示文摘 | Ellis D R Gumaelius L Indriolo E | 2006 | Plant Physiol2006，141，： | 1 |
| 6 | Localizing the biochemical transformations of arsenate in a hyperaccumulating fern显示文摘 | ELLIS D R GUMAEUUS L INDRIOLO E | 2006 | Environ Sci Technol2006，15，： | 1 |
| 7 | A vacuolar arsenite transporter necessary for arsenic tolerance in the arsenic hypemccumulating fern Pteris vittata is missing in flowering plants显示文摘 | Indriolo E Na G Ellis D | 2010 | Plant Cell2010，22，： | 1 |
| 8 | A conserved role for the ARC1 E3 ligase inbrassicaceae self-incompatibility 显示文摘 | Indriolo E Goring D R | 2014 | Frontiers in Plant Science2014，5，5： | 1 |
| 9 | Results of a Stepwise Approach to Extrahepatic Portal Vein Obstruction in Children显示文摘 | Daniele Alberti Mara Colusso Maurizio Cheli Paolo Ravelli Amedeo Indriolo Sergio Signorelli Stefano Fagiuoli Lorenzo D’Antiga | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，： | 1 |
| 10 | The ARC1 E3 ligase promotes two different self-pollen avoidance traits in Arab# dopsis 显示文摘 | Indriolo E Safavian D Goring D R | 2014 | The Plant Cell2014，26，4： | 1 |
| 11 | The ARC1 E3 ligase gene is frequently deleted in self-compatible Brassi- caceae species and has a conserved role in Arabidopsis lyrata self-pollen rejection 显示文摘 | Indriolo E Tharmapalan P Wright S I | 2012 | The Plant Cell2012，24，11： | 1 |
| 12 | Letter: infliximab therapy in inflammatory bowel disease patients after liver transplantation显示文摘 | A. Indriolo S. Fagiuoli L. Pasulo G. Fiorino S. Danese P. Ravelli | 2013 | Aliment Pharmacol Ther2013，，8： | 1 |
| 13 | P270 Infliximab in patients with ulcerative colitis and primary sclerosing cholangitis before and after liver transplatation显示文摘 | A. Indriolo S. Fagiuoli L. Pasulo A. Sonzogni M. Colledan G. Fiorino S. Danese P. Ravelli | 2012 | Journal of Crohn’s and Colitis2012，，： | 1 |
| 14 | A novel arsenate reductase from the arsenic hyperaccumulating fern Pteris vittata显示文摘 | Ellis D R Gumaelius L Indriolo E | 2006 | Plant Physiol2006，141，4： | 1 |
| 15 | Intestinal ischemic manifestations of SARS-CoV-2:Results from the ABDOCOVID multicentre study显示文摘BACKGROUND Intestinal ischemia has been described in case reports of patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)disease(coronavirus disease 19,COVID-19).AIM To define the clinical and histological,characteristics,as well as the outcome of ischemic gastrointestinal manifestations of SARS-CoV-2 infection.METHODS A structured retrospective collection was promoted among three tertiary referral centres during the first wave of the pandemic in northern Italy.Clinical,radiological,endoscopic and histological data of patients hospitalized for COVID-19 between March 1st and May 30th were reviewed.The diagnosis was established by consecutive analysis of all abdominal computed tomography(CT)scans performed.RESULTS Among 2929 patients,21(0.7%)showed gastrointestinal ischemic manifestations either as presenting symptom or during hospitalization.Abdominal CT showed bowel distention in 6 patients while signs of colitis/enteritis in 12.Three patients presented thrombosis of main abdominal veins.Endoscopy,when feasible,confirmed the diagnosis(6 patients).Surgical resection was necessary in 4/21 patients.Histological tissue examination showed distinctive features of endothelial inflammation in the small bowel and colon.Median hospital stay was 9 d with a mortality rate of 39%.CONCLUSION Gastrointestinal ischemia represents a rare manifestation of COVID-19.A high index of suspicion should lead to investigate this complication by CT scan,in the attempt to reduce its high mortality rate.Histology shows atypical feature of ischemia with important endotheliitis,probably linked to thrombotic microangiopathies. | Lorenzo Norsa Pietro Andrea Bonaffini Maja Caldato Cristiana Bonifacio Aurelio Sonzogni Amedeo Indriolo Clarissa Valle Federica Furfaro Alice Bonanomi Paolo NiccolòFranco Mauro Gori Veronica Smania Lucia Scaramella Laura Forzenigo Maurizio Vecchi Monica Solbiati Giorgio Costantino Silvio Danese Lorenzo D'Antiga Sandro Sironi Luca Elli | 2021 | World Journal of Gastroenterology2021，27，32： | 0 |
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