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| 1 | Glutamine transporters as pharmacological targets: From function to drug design显示文摘Among the different targets of administered drugs,there are membrane transporters that play also a role in drug delivery and disposition.Moreover,drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity.The improvement of the drug design process is subjected to the identification of those membrane transporters mostly relevant for drug absorption,delivery and side effect production.A peculiar group of proteins with great relevance to pharmacology is constituted by the membrane transporters responsible for managing glutamine traffic in different body districts.The interest around glutamine metabolism lies in its physio-pathological role;glutamine is considered a conditionally essential amino acid because highly proliferative cells have an increased request of glutamine that cannot be satisfied only by endogenous synthesis.Then,glutamine transporters provide cells with this special nutrient.Among the glutamine transporters,SLC1A5,SLC6A14,SLC6A19,SLC7A5,SLC7A8 and some members of SLC38 family are the best characterized,so far,in both physiological and pathological conditions.Few 3D structures have been solved by CryoEM;other structural data on these transporters have been obtained by computational analysis.Interactions with drugs have been described for several transporters of this group.For some of them,the studies are at an advanced stage,for others,the studies are still in nuce and novel biochemical findings open intriguing perspectives. | Mariafrancesca Scalise Lorena Pochini Michele Galluccio Lara Console Cesare Indiveri | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 5 |
| 2 | Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function显示文摘 | Piero Pingitore Carlo Pirazzi Rosellina M. Mancina Benedetta M. Motta Cesare Indiveri Arturo Pujia Tiziana Montalcini Kristina Hedfalk Stefano Romeo | 2013 | BBA - Molecular and Cell Biology of Lipids2013，，： | 2 |
| 3 | Impairment of CD8+ T suppressor cell function in patients with active systemic lupus erythematosus显示文摘 | Bacilieri S Indiveri F | 2001 | J Immunol2001，166，10： | 1 |
| 4 | Migration of Vdelta1and Vdelta2Tcells in response to CXCR3and CXCR4ligands in healthy donors and HIV-1infected patients:competition by HIV-1Tat显示文摘 | Poggi A Carosio R Fenoglio D Brenci S Murdaca G Setti M Indiveri F Scabini S Ferrero E Zocchi MR | 2004 | Blood2004，103，6： | 1 |
| 5 | Modeling and identification of openframe variable configuration unmanned underwater vehicles显示文摘 | Caccia M Indivery G Tiano A | 2000 | IEEE Journal of Oceanic Engineering2000，25，2： | 1 |
| 6 | Studying amino acid transport using liposomes显示文摘 | Indiveri C | 2010 | Methods Mol Biol2010，606，： | 1 |
| 7 | Swedish Wheeled Omnidirectional Mobile Robots: Ki- oematics Analysisand Control 显示文摘 | Indiveri G | 2009 | IEEE Transactions on Robotics2009，25，1： | 1 |
| 8 | Modeling and identification of open-frame variable configuration unmanned under-water vehicles 显示文摘 | Caccia M Indiveri G Veruggio G | 2000 | IEEE Journal of Oceanic Engineering2000，25，2： | 1 |
| 9 | Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway显示文摘 | Augello A Tasso R Negrini S M Amateis A Indiveri F Cancedda R | 2005 | Eur J Immunol2005，35，： | 1 |
| 10 | The null-space based behavioral control for mobile robots with velocity actuator saturations显示文摘 | Arriehiello F Chiaverini S Indiveri G | 2010 | Int J of Robotics Research2010，29，10： | 1 |
| 11 | Morphologies in Two-Dimensional Growth with Attractive I_ong-Range Interactions 显示文摘 | Indiveri G Scalas E Levi A C | 1999 | Physica1999，273，： | 1 |
| 12 | Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis显示文摘 | Daniela Fenoglio Florinda Battaglia Alessia Parodi Silvia Stringara Simone Negrini Nicoletta Panico Marta Rizzi Francesca Kalli Giuseppina Conteduca Massimo Ghio Raffaele De Palma Francesco Indiveri Gilberto Filaci | 2011 | Clinical Immunology2011，，3： | 1 |
| 13 | The mitochondrial carnitine/acylcarnitine carrier:function,structure and physiopathology显示文摘 | Indiveri C lacobazzi V Tonazzi A et aI | 2011 | Mol Aspects Med2011，52，46： | 1 |
| 14 | Membranetransporters for the special amino acid glutamine: structure/function relationships and relevance to human health显示文摘 | Pochini L Scalise M Galluccio M Indiveri C | 2014 | FrontChem2014，2，： | 1 |
| 15 | Modeling selective attention using a neuromorphic analog VLSI device 显示文摘 | Indiveri G | 2001 | Neural Computation2001，12，12： | 1 |
| 16 | Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis显示文摘 | Francesca Bernuzzi Daniela Fenoglio Florinda Battaglia Marco Fravega M. Eric Gershwin Francesco Indiveri Aftab A. Ansari Mauro Podda Pietro Invernizzi Gilberto Filaci | 2010 | Journal of Autoimmunity2010，，3： | 1 |
| 17 | Validation of an HPLC-MS/ MS method for the simultaneous determination of phenylmercapturic acid, benzylmercapturic acid and o-methylbenzyl mereapturic acid in urine as biomarkers of exposure to benzene, toluene and xylenes 显示文摘 | Sabatini L Barbieri A Indiveri P | 2008 | J Chromatogr B Analyt Technol Biomed Life Sei2008，863，1： | 1 |
| 18 | Swedish wheeled omnidirectional mobile robots: Kinematics analysis and control显示文摘 | Indiveri G | 2009 | IEEE Transactions on Robotics2009，25，1： | 1 |
| 19 | Modeling and identification of open frame variable configuration unmanned underwater vehicles显示文摘 | CACCIA M INDIVERI G VERUGGIO G | 2000 | Ocean Engineering2000，25，2： | 1 |
| 20 | Swedish wheeled omni - directional mobile robots:kinematics analysis and control显示文摘 | Giovanni Indiveri | 2009 | IEEE Tran~etions on Robotics2009，25，1： | 1 |
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