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| 1 | Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease显示文摘AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease patients.METHODS Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELISAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s disease.RESULTS Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than normalcontrols.Whether these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further defined.CONCLUSION Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess. | Indaram AVK Nandi S Weissman S Lam S Bailey B Blumstein M Greenberg R Bank S | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 2 | Cytokines ( IL - 6 , IL - 8 ,TNF) :early and reliable predictors of severe acute pancreatitis 显示文摘 | Pooran N Indaram A Singh P Bank S | 2003 | J Clin Gas2troenterol2003，37，3： | 1 |
| 3 | Mueosal cytokine produetion in radiation-indueed proctosigmoiditis compared with inflalmmatory bowel disease显示文摘 | Indaram AV Visvalingam V Loeke M | 2000 | Am J Gastroenterol2000，95，5： | 1 |
| 4 | Causes of acute and recurrent pancreatitis.Clinical onsiderationsand clues to diagnosis显示文摘 | Bank S Indaram A | | 0，，： | 1 |
| 5 | Cytokines (IL-6,IL-8,TNF):early and reliable predictors of severe acute pancreatitis显示文摘 | Pooran N Indaram A Singh P | 2003 | J Clin Gastroenterol2003，37，3： | 1 |
| 6 | Mucosal cytokine production in radiation-induced proctosigmoiditis com- pared with inflammatory bowel disease显示文摘 | Indaram AV Visvalingam V Locke M | 2000 | Am J Gasteoenterol2000，95，5： | 1 |
| 7 | Cytokines(IL-6, IL-8, TNF) : early and reliable predictors of severe acute pancreatitis 显示文摘 | POORAN N INDARAM A SINGH P | 2003 | J Clin Gastroenterol2003，37，： | 1 |
| 8 | Mucosal cytokine production in radiation-induced proctosigmoiditis compared with inflammatory bowel disease显示文摘 | Indaram AVK Visvalingam V Locke M | 2000 | Am J Gast roenterol2000，95，5： | 1 |
| 9 | Cytokines (IL-6, IL-8, TNF): Early and Reliable Predictors of Severe Acute Pancreatitis显示文摘 | Nakechand Pooran Anant Indaram Pankaj Singh Simmy Bank | 2003 | Journal of Clinical Gastroenterology2003，，3： | 1 |
| 10 | Cytokines (IL6,IL-8,TNF):early and reliable predictors of severe accute pancreatitis显示文摘 | Pooran N Indaram A Singh P | 2003 | J Clin Gastroenterol2003，37，3： | 1 |
| 11 | Mucosal cytokine production in radiation-induced proctosigmoiditis compared with inflammatory bowel disease显示文摘 | Indaram AV Visvalingam V Locke M | 2000 | Am J Gastroentroenterol2000，95，： | 1 |
| 12 | Cytokines(IL-6,IL-8,TNF):early and reliable predictors of severe acute pancreatitis显示文摘 | Pooran N Indaram A Singh P | 2003 | J Clin Gastroenterol2003，37，： | 1 |
| 13 | Cytokines(IL-6,IL-8,TNF): early and reliable predictors of severe acute pancreatitis显示文摘 | Pooran N Indaram A Singh P | 2003 | J Clni Gastroenterol2003，37，3： | 1 |
| 14 | Mucosal cytokine production in radiation-induced proctosigmoiditis compared with inflammatory bowel disease显示文摘 | Indaram AV Visvalingam V Locke M | 2000 | Am J Gastroenterol2000，95，5： | 1 |
| 15 | Cytokines (IL-6, IL-8, TNF) early and reliable predictors of severe acute pancreatitis 显示文摘 | POORAN N INDARAM A SINGH P | 2003 | J Clin Gastroenterol2003，37，： | 1 |
| 16 | Mucosal cytokine production in radiation- induced proctosigmoiditis compared with inflammatory bowel disease显示文摘 | Indaram AVK Visvalingam V Locke M | 2000 | Am J Gastroenterol2000，95，5： | 1 |
| 17 | Cytokines(IL-6,IL-8,TNF):early and reliable predictors of severe acute pancreatitis显示文摘 | Pooran N Indaram A Singh P | | 0，，03： | 1 |
| 18 | Impaired macrophage function underscores susceptibility to Salmonellain mice lacking Irgrnl (LRG-47)显示文摘 | Henry SC Daniell X Indaram M | | 0，，10： | 1 |
| 19 | Mucosal cytokineproduction in radiation-induced proctosigmoid-it is compared withinflammatory bowel disease显示文摘 | Indaram AV Visvalingam V Locke M | 2002 | Gastroenterol2002，95，5： | 1 |
| 20 | Cytokines (IL-6, IL-8, TNF) : early and reliable predictors of severe acute pancreati- tis 显示文摘 | Pooran N Indaram A Singh P | 2003 | J Clin Gastroenterol2003，37，3： | 1 |
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