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| 1 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet2010，，9726： | 4 |
| 2 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | 2010 (9726)2010，，9726： | 3 |
| 3 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 4 | Impact of mobile health and medical applications on clinical practice in gastroenterology显示文摘Mobile health apps (MHAs) and medical apps (MAs) are becoming increasinglypopular as digital interventions in a wide range of health-related applications inalmost all sectors of healthcare. The surge in demand for digital medical solutionshas been accelerated by the need for new diagnostic and therapeutic methods inthe current coronavirus disease 2019 pandemic. This also applies to clinicalpractice in gastroenterology, which has, in many respects, undergone a recentdigital transformation with numerous consequences that will impact patients andhealth care professionals in the near future. MHAs and MAs are considered tohave great potential, especially for chronic diseases, as they can support the selfmanagementof patients in many ways. Despite the great potential associated withthe application of MHAs and MAs in gastroenterology and health care in general,there are numerous challenges to be met in the future, including both the ethicaland legal aspects of applying this technology. The aim of this article is to providean overview of the current status of MHA and MA use in the field ofgastroenterology, describe the future perspectives in this field and point out someof the challenges that need to be addressed. | Sven Kernebeck Theresa S Busse Maximilian D Bottcher Jurgen Weitz Jan Ehlers Ulrich Bork Didactics Educational Research in Health | 2020 | World Journal of Gastroenterology2020，26，29： | 2 |
| 5 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet . 2010 (9726)2010，，： | 2 |
| 6 | feces and feathers can indicateintra-individual changes in the diet of migratory songbirds 显示文摘 | Podlesak D W McWilliams S R Hatch K A Stable isotopes in breath blood | 2005 | OecoLogia2005，142，4： | 1 |
| 7 | Correlation of the Tei index with invasive measurement of ventricular function in a porcine mode 显示文摘 | La Corte J C Cabreriza S E Rabk in D G | 2003 | Am soe Echocardiogr2003，16，5： | 1 |
| 8 | Guidelines on the man- agement of massive blood loss显示文摘 | British Committee for standards in Haematology St- ainsby D MacLennan S | 2006 | British Journal of Haematology2006，135，5： | 1 |
| 9 | Uric acid validation and appli- hemodynamic staging 显示文摘 | Anker S D and survival Doehner W Rauchhaus in chronic heart fail cation in metabolic functional ure and M | 2003 | Circulation2003，107，15： | 1 |
| 10 | Endothelial cells in physiology and in the pathophysiology of vascular disorders显示文摘 | POLLAK E S BUCK C A | 1998 | Blood1998，91，10： | 1 |
| 11 | Performance of optical flow techniques显示文摘 | Barron J L Fleet D J Beauchem in S | 1994 | International Journal of Computer Vision1994，12，1： | 1 |
| 12 | Impairment of Phot Osynthesis by Chilling- tem Peratures in Tomat o显示文摘 | Mart in B Ort D Ik Boyer J S | 1981 | Plant Physiol1981，68，2： | 1 |
| 13 | 000-mobocular-weighl membrane protein modulates virus release显示文摘 | Liljestrom P Lusa S Huylebroeck D In vitro mutagenesis of full-length cDNA clone of Semliki Foresl virus: the 6 | 1991 | J Virol1991，65，： | 1 |
| 14 | Cells and biomaterials for inter-vertebral disc regeneration显示文摘 | Grad S Alini M Eg^in D | 2010 | Synth Lect Tissue Eng2010，2，1： | 1 |
| 15 | Ex- oestr-ogen and progester- mammary gland during de- velopment, function and involution显示文摘 | Schams D Kohlenberg S pression and localisation of one receptors in the bovine Amselgruber W | 2003 | Journal of En docrinology2003，，177： | 1 |
| 16 | A new catalyst for the catalytic gasification of biomass 显示文摘 | ARAUZO J RADLE IN D PISKORZ J SCOTT D S | 1994 | Energy Fuels1994，8，6： | 1 |
| 17 | Role of geranylgeranylation and Rho proteins显示文摘 | Essig M Nguyen G Prie D et aL 3-Hydroxy-3-methyl glutaryl coenzyme A reductase inhibittors increase fibrinolytic activity in rat aorticendothelial cell s | 1998 | Circ Res1998，83，7： | 1 |
| 18 | The associa tion between supracondylar-intercondylar distal femoral fractures and coronal plane fractures显示文摘 | NoRK S E SEGINA D N AFLATO(IN K | 2005 | The Journal of Bone & Joint Sur- gery2005，87，3： | 1 |
| 19 | High frequency somaticembryogenesis and plant regeneration in zygotic embryo culturesof Japanese honeysuckle 显示文摘 | Kim S W Oh SC In D S | 2003 | Plant Cell Tissue and OrganCulture2003，72，： | 1 |
| 20 | BrJ Neuregurg显示文摘 | Choi D Lay S Olfactory enshcathing cells in the nasal mucosa of the rat and human | 2008 | 22(2):301-3022008，22，2： | 1 |
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