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| 1 | Mechanism of sperm capacitation and the acrosome reaction: role of protein kinases显示文摘哺乳动物的精子必须经历一系列生物化学、生理的修正,一起叫的 capacitation,在在 acrosome 反应(AR ) 以前的女繁殖的道。尽管蛋白质 kinases 被显示在 capacitation 和 AR 期间涉及细胞内部的 Ca 2+ 的规定,这些修正的机制很好没被描绘。在现在的评论,我们总结一些涉及 capacitation 的发信号的事件。在 capacitation 过程期间, phosphatidyl-inositol-3-kinase (PI3K ) 是经由一个蛋白质 kinase A (PKA ) 依赖者的 phosphorylated/activated 由蛋白质 kinase C α 的串联,和 downregulated;(PKCα) 。PKCα在 capacitation 的开始是活跃的,导致 PI3K inactivation。在 capacitation 期间, PKCα象 PP1γ 一样; 2 被 PKA 依赖的机制降级,允许 PI3K 的激活。PKA 的激活主要在 capacitation 期间取决于酸式碳酸盐依赖者生产的周期的腺苷 monophosphate (营地) 可溶的 adenylyl cyclase。PKA 的这激活在肌动朊聚合导致增加,必需品为 hyperactivated 活动性的发展处理,它为成功的授精是必要的。肌动朊聚合被果仁 2 以二个方法调停:首先,果仁 2 为 phospholipase D (PLD ) 激活,和秒充当一个余因子,作为绑并且禁止象 gelsolin 那样的切断肌动朊的蛋白质的一个分子。gelsolin 的酷氨酸 phosphorylation 为它的 inactivation 也在由 Src 家庭 kinase (SFK ) 的 capacitation 期间是重要的。在 AR 以前, gelsolin 被免除果仁 2 并且经历 dephosphorylation/activation,导致 AR,导致快 F 肌动朊 depolymerization。 | Debby Ickowicz Maya Finkelstein Haim Breitbart | 2012 | Asian Journal of Andrology2012，14，6： | 17 |
| 2 | Role of DJ-1 in Parkinson′s disease显示文摘 | Lev N Roncevic D Ickowicz D | 2006 | J Mol Neurosci2006，29，3： | 1 |
| 3 | Zn 2+ -stimulation of sperm capacitation and of the acrosome reaction is mediated by EGFR activation显示文摘 | Yulia Michailov Debbi Ickowicz Haim Breitbart | 2014 | Developmental Biology2014，，： | 1 |
| 4 | Guiding principles for the care of older adults with multimorbidity:an approach for c,Guiding principles for the care of older adults with multimorbidity:an approach for clinicians:American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity显示文摘 | Ickowicz E | 2012 | J Am Geriatr Soc2012，60，10： | 1 |
| 5 | Relationship between N' Dama cow body condition score and production performance under an extensive range management system insouthern Senegal: calf weight gain milk production probability of pregnancy, and juvenile menality 显示文摘 | PaulineEzanno Alexandre Ickowicz and Renaud L ancdot | 2005 | Livestock Production science2005，92，3： | 1 |
| 6 | Oxidative insults induce DJ-1 upregulation and redistribution:implications for neuroprotection显示文摘 | Lev N Ickowicz D Melamed E | 2008 | Neurotoxicology2008，29，3： | 1 |
| 7 | Polysaccharide gene transfection agents显示文摘 | Khan W Hosseinkhani H Ickowicz D | 2012 | Acta Biomaterialia2012，8，12： | 1 |
| 8 | DJ-1 protects against dopamine toxicity显示文摘 | Lev N Ickowicz D Barhum Y | 2009 | J Neural Transm2009，116，2： | 1 |
| 9 | Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma 显示文摘 | Ickowicz Schwartz D Gozlan Y Greenbaum L | 2004 | Br J Cancer2004，，90： | 1 |
| 10 | DJ-1protects against dopamine toxicity显示文摘 | Lev N Ickowicz D Barhum Y Lev S Melamed E Offen D | 2009 | J Neural Transm2009，116，： | 1 |
| 11 | Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety显示文摘 | TANNOCK R ICKOWICZ A SCHACHAR R | 1995 | J Am Acad Child Adolesc Psychiatry1995，34，： | 1 |
| 12 | Oxidative insults induce DJ-1 upregulation and redistribution:implications for neuroprotection显示文摘 | Lev N Ickowicz D Melamed E | 2008 | Neurotoxicology2008，29，3： | 1 |
| 13 | Stimulant treatment over five years: adherence, effectiveness, and adverse effects 显示文摘 | Charach A Ickowicz A Schachar R | 2004 | J Am Acad Child Adolesc Psychiatry2004，43，5： | 1 |
| 14 | Differential effects of methylphenidate on working memory in ADHD children with and without co-morbid anxiety显示文摘 | Tannock R Ickowicz A Schachar R | 1995 | J Am Acad Child Adolesc Psychiatry1995，34，： | 1 |
| 15 | Zn2+ -stimulation ofsperm capacitation and of the acrosome reaction is mediatedby EGFR activation显示文摘 | Michailov Y Ickowicz D Breitbart H | 2014 | Dev Biol2014，396，2： | 1 |
| 16 | Delineation of crypto- genie Lennox- Oastaut syndrome and myoclonic astatic epilepsy using multiple correspondence analysis显示文摘 | Kaminska A Ickowicz A Plouin P | 1999 | Epilepsy Res1999，36，： | 1 |
| 17 | Role of DJ-1 in Parkinson' s disease显示文摘 | Lev N Roncevic D Ickowicz D | 2006 | J Mol Neurosci2006，29，3： | 1 |
| 18 | Delineation of cryptogenic Leunox-Gastaut syndrome and myoclonic astatic epilepsy using multiple correspondence analysis显示文摘 | Kaminska A Ickowicz A Plouin P | 1999 | Epilepsy1999，6，1： | 1 |
| 19 | Light-mediated activation reveals a key role for protein kinase A and sarcoma protein kinase in the development of sperm hyper-activated motility 显示文摘 | Shahar S Wiser A Ickowicz D | 2011 | Hum Reprod2011，26，9： | 1 |
| 20 | Arabinogalactan folic acid drug conjugate for targeted delivery and target-activated release of anticancer drugs to folate receptor-overexpressing cells显示文摘 | Pinhassi RI Assaraf YG Farber S Stark M Ickowicz D Drori S Domb AJ Livney YD | 2010 | Biomacromolecules2010，11，： | 1 |
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