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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Determination of lorutu- dine and its active metabolite in human plasma by high-perform- ance liquid chromatography with mass spectrometry detection 显示文摘 | VLASE L IMRE S MUNTEAN D | 2007 | J Pharm Biomed Anal2007，44，3： | 1 |
| 3 | Cell therapy for human ischemic heart diseases: Critical review and summary of the clinical experiences显示文摘 | Noemi Pavo Silvia Charwat Noemi Nyolczas András Jakab Zsolt Murlasits Jutta Bergler-Klein Mariam Nikfardjam Imre Benedek Teodora Benedek Imre J. Pavo Bernard J. Gersh Kurt Huber Gerald Maurer Mariann Gy?ngy?si | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 4 | Anthraquinone pigments from Rumex cristatus 显示文摘 | Erturk S Ozbas M Imre S | 2001 | Acta Pharm Turcica2001，43，1： | 1 |
| 5 | Brominated sesquiterpenes from the red alga Laurencia obtusa 显示文摘 | Topcu G Aydogmus Z Imre S | 2003 | J Nat Prod2003，66，11： | 1 |
| 6 | Modeling of Reversibleγ/αTransformations of Low Carbon Steels in the Intercritical Temperature Range显示文摘A phenomenological kinetic model has been developed for the prediction of non-isothermal reversible incomplete transformations in low-carbon hypoeutectoid steels. The theoretical basis of the proposed method has its origin in a possible extension of the traditional Austin-Rickett kinetic differential equation. To critically assess the applicability of the model, a number of experiments based on computer simulations have been performed to predict the austenite/ferrite proeutectoid transformation in the temperature range of Aei to Ae3 on plain carbon hypoeutectoid steels. A comparison with published experimental data has verified that the model developed is reasonable both quantitatively and with respect to well-established trends. Extension of the method of prediction appears promising when the non-isothermal reactions occurring during heat treatment (such as carbide precipitation and dissolution) can be assumed to proceed in a reversible manner. | Tamás RTl Imre FELDE Hakan GR | 2004 | 材料热处理学报2004，25，05B： | 1 |
| 7 | Aerylamide from Maillard reaction products显示文摘 | RICHARD H S IMRE B NATALIA V | 2002 | Nature2002，419，： | 1 |
| 8 | Drift study of deuterium -exchanged graphite oxide显示文摘 | Tam~s Szab6 Ott6 Berkesi Imre D6k~ny | 2005 | Carbon2005，43，15： | 1 |
| 9 | Size-selective filtration and taxon-specific digestion of plankton algae by silver carp (Hypophthalmichthys molitrix Val.)显示文摘 | Lajos V?r?s Imre Oldal Mátyás Présing Katalin V.- Balogh | | Hydrobiologia0，，： | 1 |
| 10 | Acomparative study of hemorheological parametersin transient isehemie attack and acute ischemic stroke patients: possible predictive value显示文摘 | Szikszai Z Fekete I Imre S G | 2003 | Clinical Hemorheology and Microcirculation2003，28，1： | 1 |
| 11 | Calcium Distribution in the Vessel Wall and Intima-Media Thickness of the Human Carotid Arteries显示文摘 | Mária Tünde Magyar Zita Szikszai Zsófia Kertész Sándor Molnár Imre Uzonyi Gusztáv áron Szíki László Csiba | 2007 | Ultrasound in Medicine & Biology2007，，8： | 1 |
| 12 | Wireless Myths, Realities, and Fu- tures: From 3G/4G to Optical and Quantum Wireless显示文摘 | HANZO L HAAS H IMRE S | 2012 | Proceedings of the IEEE2012，100，5： | 1 |
| 13 | Bronchioloalveolar lung cancer:occurrence, surgical treatment and survival显示文摘 | Jozsef F Imre T Tamas S | 2003 | Eur J Cardiothorac Surg2003，23，5： | 1 |
| 14 | Churg-Strauss syndrome显示文摘 | Imre N Mary E S Alan L | 2003 | Lancet2003，361，： | 1 |
| 15 | Nonlinear model-building of a low - power gas turbine 显示文摘 | PIROSKA A IMRE S GABOR S | 2001 | Periodica Polytechnica Ser Transp Eng2001，29，12： | 1 |
| 16 | Anthraquinone pigments from Rumex cristotus 显示文摘 | ERTURK S OZBAS M IMRE S | 2001 | Acta Pharm Turcica2001，43，1： | 1 |
| 17 | Reactome:a knowledge base of biologic pathways and processes显示文摘 | Imre V Peter D Esther S | 2007 | Genome Biology2007，8，3： | 1 |
| 18 | Source controlled semi-reliable multimedia streaming using selective retransmission in DCCP/IP networks 显示文摘 | HUSZK A IMRE S | 2008 | Computer Communications2008，31，11： | 1 |
| 19 | Effect of the nutrient composition on dye decolorisation and extracellular enzyme production by Lentinus edodes on solid medium显示文摘 | No'ra Hatvani Imre Me's | 2002 | Enzyme and Microbial Technology2002，30，： | 1 |
| 20 | Gene therapy for collateral vessel development显示文摘 | Guido M Marco S Imre K | 1997 | Cardiovascular Research1997，35，3： | 1 |
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