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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials显示文摘 | Ignjatovic N Tomic S Dakic M | | 0，，： | 2 |
| 3 | New biocomposite filler for reconstruction of bone tissue changed by osteoporosis显示文摘 | IGNJATOVIC N AJDUKOVIC Z USKOKOVIC D | 2005 | J Mater Sci Mater Med2005，16，7： | 1 |
| 4 | The designing of properties of hydroxyapatite/poly-l-lactide composite materials by hot pressing显示文摘 | Ignjatovic N Delijic K Vukcevic M | 2001 | Z Metallkd2001，92，： | 1 |
| 5 | Optimising monitoring in the management of Crohn’s disease: A physician’s perspective显示文摘 | Pavol Papay Ana Ignjatovic Konstantinos Karmiris Heda Amarante Pal Milheller Brian Feagan Geert D’Haens Philippe Marteau Walter Reinisch Andreas Sturm Flavio Steinwurz Laurence Egan Julián Panés Edouard Louis Jean-Frédéric Colombel Remo Panaccione | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 6 | A study of HAp/ PLLA composite as a substitute for bone powder using FTIR spectroscopy显示文摘 | Ignjatovic N Savic V Najman S | 2001 | Biomaterials2001，22，： | 1 |
| 7 | sythesis and properties of hydroxyapatite/polylactide composite biomaterials显示文摘 | Ignjatovic N Tomic S Dakic M | 1999 | Biomaterials1999，20，： | 1 |
| 8 | Synthesis and proper- ties of hydroxyapatite/poly - L - lactide composite biomate- rials 显示文摘 | Ignjatovic'N Tomic' S Dakic' M | 1999 | Biomaterials1999，20，9： | 1 |
| 9 | State of the art in the diagnosis and treatment of the upper urothelial cancer显示文摘 | I Ignjatovic R Cukuranovic N Markovic | 2002 | Medicine and Biology2002，9，3： | 1 |
| 10 | Radiation-induced degradation of hydroxyapatite/poly L-lactide composite biomaterial 显示文摘 | Suljovrujic E Ignjatovic N Uskokovic D | 2007 | Radiation Physics and Chemistry2007，76，4： | 1 |
| 11 | Controlled Assembly of Poly(D,L-lactide-co-glycolide)/Hydroxyapatite Coreshell Nanospheres Under Ultrasonic Irradiation显示文摘 | Jevtic M Radulovic A Ignjatovic N | 2009 | Acta Biomater2009，5，1： | 1 |
| 12 | A Study of Hap/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy显示文摘 | Ignjatovic N Savic V Najman S | 2001 | Biomaterials2001，22，： | 1 |
| 13 | Structure and characteristics of the hot pressed hydroxyapatite/poly-L-actide composite biomaterial显示文摘 | Ignjatovic N Suljovrujic E Stojanovic Z | 2002 | Sci Sint2002，34，： | 1 |
| 14 | A randomized, controlled trial of narrow-band imaging vs high-definition white light for ade- noma detection in patients at high risk of adenomas 显示文摘 | East JE Ignjatovic A Suzuki N | 2012 | Colorectal Dis2012，14，11： | 1 |
| 15 | Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials 显示文摘 | Ignjatovic N Tomic S Dakic M | 1999 | Biomaterials1999，20，9： | 1 |
| 16 | A Study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy显示文摘 | Ignjatovic N Savic V Najman S | 2001 | Biomaterials2001，22，： | 1 |
| 17 | Synthesis and application of hydroxyapatite/polylactide composite hiomaterial 显示文摘 | Ignjatovic N Uskokovic D | 2004 | Appl Surf Sci2004，238，14： | 1 |
| 18 | Gamma irradiation processing of hydroxyapatite/poly-L - lactide composite biomaterial 显示文摘 | SULJOVRUJIC E IGNJATOVIC N USKOKOVIC D | 2003 | Radiat Phys Chem2003，67，34： | 1 |
| 19 | Gamma irradiation processing of hydroxyapatite/poly-L-lactide composite biomaterial 显示文摘 | Suljovrujic E Ignjatovic N Uskokovic D | 2003 | Radiation Physics and Chemistry2003，67，34： | 1 |
| 20 | A randomized, controlled trial of narrow-band imaging vs high-definition white light for adenoma detection in patients at high risk of adenomas 显示文摘 | East JE Ignjatovic A Suzuki N | 2012 | Coloreetal Dis2012，14，11： | 1 |
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