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| 1 | Osteoclast precursor differentiation by MCPIP via oxidative stress,endoplasmic reticulum stress,and autophagy显示文摘Osteoclasts(OCs)are responsible for bone resorption in inflammatory joint diseases.Monocyte chemotactic protein-1(MCP-1)has been shown to induce differentiation of monocytes to OC precursors,but nothing is known about the underlying mechanisms.Here,we elucidate how MCPIP,induced by MCP-1,mediates this differentiation.Knockdown of MCPIP abolished MCP-1-mediated expression of OC markers,tartrate-resistant acid phosphatase,and serine protease cathepsin K.Expression of MCPIP induced p47PHOX and its membrane translocation,reactive oxygen species formation,and induction of endoplasmic reticulum(ER)stress chaperones,up-regulation of autophagy marker,Beclin-1,and lipidation of LC3,and induction of OC markers.Inhibition of oxidative stress attenuated ER stress and autophagy,and suppressed expression of OC markers.Inhibition of ER stress by a specific inhibitor or by knockdown of IRE1 blocked autophagy and induction of OC markers.ER stress inducers,tunicamycin and thapsigargin,induced expression of OC markers.Autophagy inhibition by 3′-methyladenine,LY294002,wortmannin or by knockdown of Beclin-1 or Atg 7 inhibited MCPIP-induced expression of OC markers.These results strongly suggest that MCP-1-induced differentiation of OC precursor cells is mediated via MCPIP-induced oxidative stress that causes ER stress leading to autophagy,revealing a novel mechanistic insight into the role of MCP-1 in OCs differentiation. | Kangkai Wang Jianli Niu Hyunbae Kim Pappachan E.Kolattukudy | 2011 | Journal of Molecular Cell Biology2011，3，6： | 6 |
| 2 | Interaction between stress responses and circadian metabolism in metabolic disease显示文摘Circadian rhythms play crucial roles in orchestrating diverse physiological processes that are critical for health and disease.Dysregulated circadian rhythms are closely associated with various human metabolic diseases,including type 2 diabetes,cardiovascular disease,and non-alcoholic fatty liver disease.Modern lifestyles are frequently associated with an irregular circadian rhythm,which poses a significant risk to public health.While the central clock has a set periodicity,circadian oscillators in peripheral organs,particularly in the liver,can be entrained by metabolic alterations or stress cues.At the molecular level,the signal transduction pathways that mediate stress responses interact with the key determinants of circadian oscillation to maintain metabolic homeostasis under physiological or pathological conditions.In the liver,a number of nuclear receptors or transcriptional regulators,which are regulated by metabolites,hormones,the circadian clock,or environmental stressors,serve as direct links between stress responses and circadian metabolism.In this review,we summarize recent advances in the understanding of the interactions between stress responses(endoplasmic reticulum stress response,oxidative stress response,and inflammatory responses)and circadian metabolism,and the role of these interactions in the development of metabolic diseases. | Zhao Yang Hyunbae Kim Arushana Ali Ze Zheng Kezhong Zhang | 2017 | Liver Research2017，1，3： | 2 |
| 3 | A Novel Method for Initial Rotor Position Estimation for IPM Synchronous Machine Drives 显示文摘 | Hyunbae K Kum-Kang H Lorenz R D | 2004 | Industry Applications IEEE Transactions on2004，40，5： | 1 |
| 4 | The impact of hepatitis B viral load on recurrence after complete necrosis in patients with hepatocellular carcinoma who receive transarterial chemolipiodolization显示文摘 | Jeong WonJang Jong YoungChoi Si HyunBae Seung KewYoon Hyun YoungWoo U ImChang Chang WookKim Soon WooNam Se HyunCho Jin MoYang Chang DonLee | 2007 | Cancer2007，，8： | 1 |
| 5 | Sensorless control of interior permanent - magnet machine drives with zero-phase lag position estimation 显示文摘 | Kim Hyunbae Harke Michael C Lorenz Robert D | 2003 | IEEE Transactions on Industry Applications2003，39，6： | 1 |
| 6 | Sensorless control of interior permanent magnet machine drives with zero-phase-lag position estimation 显示文摘 | HYUNBAE K HARKE M C LORENZ R D | 2003 | IEEE Traus on Industry Applications2003，39，6： | 1 |
| 7 | Sensorless control of interior permanent magnet machine drives with zero-phase lag position estimation 显示文摘 | HYUNBAE K MICHAEL C H ROBERT D L | 2003 | IEEE Transactions on Industry Application2003，39，6： | 1 |
| 8 | A novel method for initial rotor position estimation for IPM synchronous machine drives显示文摘 | HYUNBAE Kim KUM-KANG Huh LORENZ R D | 2004 | IEEE Transactions on Industry Applications2004，40，5： | 1 |
| 9 | Substitutability and accumula- tion of information technology capital in US indus- tries显示文摘 | Hyunbae C Sung B M | 2006 | Southern Economic Journal2006，72，4： | 1 |
| 10 | Creative destruction and firm-specific performance heterogeneity显示文摘 | Hyunbae Chun Jung-Wook Kim Randall Morck Bernard Yeung | 2008 | Journal of Financial Economics2008，，1： | 1 |
| 11 | Sustained low hepatitis B viral load predicts good outcome after curative resection in patients with hepatocellular carcinoma显示文摘 | Ho JungAn Jeong WonJang Si HyunBae Jong YoungChoi Se HyunCho Seung KewYoon June YeolHan Keun HoLee Dong GooKim Eun SunJung | 2010 | Journal of Gastroenterology and Hepatology2010，，12： | 1 |
| 12 | Adsorption of anionic dye and surfactant from water onto organic-morillonite显示文摘 | Jae Hyunbae | 2000 | Separation Science and Technology2000，35，3： | 1 |
| 13 | A Novel Method for Initial Rotor Position Estimation for IPM Synchronous Machine Drives 显示文摘 | Hyunbae Kim Kum-Kang Huh Robert D Lorenz | 2004 | Industry Applications IEEE Transactions2004，40，5： | 1 |
| 14 | IPM-EPDL: An XML-Based Executable Process Definition Language 显示文摘 | Injun Choi Hyunbae Jeong Minseok Song | 2005 | Computers in Industry (S0166-3615)2005，56，1： | 1 |
| 15 | Determinants of R&D Cooperation in Small and Medium-sized Enterprises显示文摘 | Chun Hyunbae and Mun Sung-Bae | 2012 | Small Business Economics2012，39，2： | 1 |
| 16 | Sensorless control of interior permanent-magnet machine drives with zero-phase lag position estimation 显示文摘 | HYUNBAE K HARKE M C LORENZ R D | 2003 | IEEE Transactions on Industry Applications2003，39，6： | 1 |
| 17 | Sensorless control of interior permanent-magnet machine drives with zero- phase lag position estimation 显示文摘 | HYUNBAE KIM MICHAEL C HARKE ROBERT D LORENZ | 2003 | IEEE Transactions on Industry Applications2003，39，6： | 1 |
| 18 | An Instrument Variable Estimate of the Effect of Fertility on the Labor Force Participation of Married Women 显示文摘 | Hyunbae Chun and Oh Jeungil | 2002 | Applied Economics Letters2002，，9： | 1 |
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