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| 1 | Excessive gestational weight gain in early pregnancy and insufficient gestational weight gain in middle pregnancy increased risk of gestational diabetes mellitus显示文摘Background:Gestational weight gain(GWG)is associated with the risk of gestational diabetes mellitus(GDM).However,the effect of weight gain in different trimesters on the risk of GDM is unclear.This study aimed to evaluate the effect of GWG on GDM during different trimesters.Methods:A birth cohort study was conducted from 2017 to 2020 in Shenzhen,China.In total,51,205 participants were included comprising two models(early pregnancy model and middle pregnancy model).Gestational weight(kg)was measured at each prenatal clinical visit using a standardized weight scale.Logistic regression analysis was used to assess the risk of GDM.Interaction analysis and mediation effect analysis were performed in the middle pregnancy model.Results:In the early pregnancy model,the risk of GDM was 0.858 times lower(95%confidence interval[CI]:0.786,0.937)with insufficient GWG(iGWG)and 1.201 times higher(95%CI:1.097,1.316)with excessive GWG after adjustment.In the middle pregnancy model,the risk of GDM associated with iGWG increased 1.595 times(95%CI:1.418,1.794)after adjustment;for excessive GWG,no significant difference was found(P=0.223).Interaction analysis showed no interaction between GWG in early pregnancy(GWG-E)and GWG in middle pregnancy(GWG-M)(F=1.268;P=0.280).The mediation effect analysis indicated that GWG-M plays a partial mediating role,with an effect proportion of 14.9%.Conclusions:eGWG-E and iGWG-M are associated with an increased risk of GDM.Strict control of weight gain in early pregnancy is needed,and sufficient nutrition should be provided in middle pregnancy. | Aiqi Yin Fuying Tian Xiaoxia Wu Yixuan Chen Kan Liu Jianing Tong Xiaonian Guan Huafan Zhang Linlin Wu Jianmin Niu | 2022 | Chinese Medical Journal2022，，9： | 5 |
| 2 | Ability of a Specific ERK Signal-Pathway Inhibitor to Reverse P-Glycoprotein- Mediated Vincristine Resistance in Colon Cancer Cell Unes显示文摘OBJECTIVE To investigate the effect of a specific inhibitor PD098059 of the extracellular-signal regulated protein kinase (ERK) pathway on the P-glycoprotein (P-gp)-mediated resistance of colon cancer cell lines SW480/VCR and CoLo205NCR.METHODS SW480NCR and CoLo205NCR cells were generated byexposuring SW480 and CoLo205 cells to vincristine (VCR) (30 ng/ml) for 72h, which resulted in a comparatively higher level of P-gp expression.Western blotting was used to analyze P-gp, MRP, LRP, GST-'rr and TOPOIIexpression after exposuring the SW480 and CoLo205 cells to VCR (30 ng/ml)for 72 hrs. P-gp and pERK1/2 expressions was analyzed in SW480NCR andCoLo205/VCR cells treated with or without the specific inhibitor of MEK,PD098059. The MTT assay was used to determine the susceptibility ofSW480NCR and CoLo205NCR cells to VCR, treated with or withoutPD098059.I^F.SULI'S The results showed that VCR induced a comparatively higher levelof P-gp expression in the cell lines, but not that of MRP, LRP, GST-n- orTOPOII. P-gp expression levels were depressed significantly in SW480/VCR and COLO205/VCR cells by the specific inhibitor of MEK, PD098059.The IC50 (248 +19.6 and 215 +10.7 ng/ml) to VCR of SW480/VCR andCoLo205/VCR cells exhibited a 2.16 and 2.03-fold higher resistancecompared to the negative control group (SW480 and CoLo205 cells)(115+15.6 and 106 +11.9 ng/ml), but a 1.35 and 1.21 -fold higher resistance thanthe group treated with VCR (30 ng/ml)+ PD098059 (184 + 21.8 and 177+19.4 ng/ml).CONCLUSION This study shows that the expression of P-gp can beinduced by exposuring cells to VCR, and that this induction can be reversedby inhibiting the ERK signaling pathway at the point of MEK by its specificinhibitor, PD098059. The ERK signal-transduction pathway may play a rolein modulating mdrl expression in colon cancer. | FengJin HuaFan BoChen PingLu FanYao HuimianXu ShubaoWang | 2004 | Chinese Journal of Clinical Oncology2004，1，4： | 2 |
| 3 | CR/EPDM Blends with Steel Friction and Wear Characteristics under Dry Sliding显示文摘 | Zhao Lianhua Bao Lingxie Li Huafan | 2013 | Applied Mechanics and Materials2013，341，： | 1 |
| 4 | Effects of Three Target‐Controlled Concentrations of Sufentanil on MACBAR of Sevoflurane显示文摘 | ZhengLiu Jia‐FengWang YanMeng Xiao‐HuaFan Xiao‐MingDeng Jin‐BaoLi Guo‐JunCai | 2012 | CNS Neuroscience & Therapeutics2012，，： | 1 |
| 5 | Evaluation of biaxial stress in diamond films 显示文摘 | Qi Huafan Fernandes A Pereira E | 1999 | Diamond and Related Materials1999，，8： | 1 |
| 6 | Joint procurement and production decisions in remanufacturing under quality and demand uncer- tainty 显示文摘 | Samar K Huafan M | 2009 | International Journ~ of Production Economics2009，120，1： | 1 |
| 7 | Joint procurement andproduction decisions in remanufacturing under quality anddemand uncertainty显示文摘 | Mukhopadhyay S K Huafan M | 2009 | International Journal of ProductionEconomics2009，120，1： | 1 |
| 8 | Joint procurement and production decisions in remanufacturing under quality and demand uncertainty显示文摘 | Samar K Huafan M | 2009 | International Journal of Production Economics2009，120，1： | 1 |
| 9 | Joint procurement and production decisions in remanufacturing under quality and demand uncertainty 显示文摘 | Mukhopadhyay S K Ma Huafan | 2009 | International Journal of Production economics2009，120，1： | 1 |
| 10 | Joint procurement and production decisions in remanufacturing under quality anddemand uncertainty显示文摘 | Samar K Mukhopadhyay Huafan Ma | 2009 | International Journal Of Production Eeonomies2009，，： | 1 |
| 11 | Joint Procurement and Production Decisions in Remanufacturing under Quality and Demand Uncertainty显示文摘 | Samar K Mukhopadhyay Huafan Ma | 2009 | International Journal of Production Economics2009，120，： | 1 |
| 12 | Computer-Aid- ed Development of a Magnetron Source With High Target Uti- lization 显示文摘 | Qi Huafan David Galipeau UI Qinzhou | 2011 | Vacuum2011，85，： | 1 |
| 13 | The role of quality uncertainty in remanufacturing decisions显示文摘 | Mukhopadhyay S K Ma Huafan | 2009 | Interna- tional Journal of Business and Systems Research2009，3，4： | 1 |
| 14 | Joint procurement and production decisions in remanufacturing under quality and demand uncertainty显示文摘 | Samar K Mukhopadhyay Huafan Ma | 2009 | Int J Production Economics2009，，120： | 1 |
| 15 | Joint procurement and production decisions in remanufacturing under quality and demand uncertainty显示文摘 | Mukhopadhyay Samar K Ma Huafan | 2009 | International Journal of Production Economics2009，120，1： | 1 |
| 16 | Entropy and Utopia@Zero Hour:Modernity and the Manhattan Project显示文摘This paper critically reexamines the canonical utopic scene from the end of Johann Wolfgang von Goethe's Faust II(1832)through the writings of the British-born Yale physicist Dr.William Francis Gray Swann(1884-1962),who composed one hundred years later a book on the philosophy of contemporary physical science titled The Architecture o f the Universe(1934).In his text,Swann invokes the instrumentalization of atomic energy in a bargain to defeat a cosmic anxiety borne from the modem temporal experience of entropy,a pact whose culmination is akin to Faust's seminal turning away of the ghost Sorge(Care),with strong ramifications for the future postatomic world order.The physical initiation of this“zero hour”is best known through the work of Swann’s Ph.D.student,Ernest Orlando Lawrence,who went on to pioneer the mass separation of electromagnetic isotopes at Oak Ridge.This paper will posit the Manhattan Project as part of the legacy of a pre-war universal imaginary,in order to introduce a new critical reading o f utopia in Germany's greatest poet. | Gary Huafan He | 2020 | Journal of Foreign Languages and Cultures2020，4，1： | 0 |
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