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| 1 | Spectral tomographic imaging with aplanatic metalens显示文摘Tomography is an informative imaging modality that is usually implemented by mechanical scanning,owing to the limited depth-of-field(DOF)in conventional systems.However,recent imaging systems are working towards more compact and stable architectures;therefore,developing nonmotion tomography is highly desirable.Here,we propose a metalens-based spectral imaging system with an aplanatic GaN metalens(NA=0.78),in which large chromatic dispersion is used to access spectral focus tuning and optical zooming in the visible spectrum.After the function of wavelength-switched tomography was confirmed on cascaded samples,this aplanatic metalens is utilized to image microscopic frog egg cells and shows excellent tomographic images with distinct DOF features of the cell membrane and nucleus.Our approach makes good use of the large diffractive dispersion of the metalens and develops a new imaging technique that advances recent informative optical devices. | Chen Chen Wange Song Jia-Wern Chen Jung-Hsi Wang Yu Han Chen Beibei Xu Mu-Ku Chen Hanmeng Li Bin Fang Ji Chen Hsin Yu Kuo Shuming Wang Din Ping Tsai Shining Zhu Tao Li | 2019 | Light(Science & Applications)2019，8，1： | 12 |
| 2 | 半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用显示文摘目的研究半边旗提取物5F对非小细胞肺癌NCI-H460细胞生长的抑制作用。方法MTT法检测5F对NCI-H460细胞的生长抑制作用;用PI-Hoechst荧光双染法和TUNEL法检测细胞凋亡;流式细胞仪检测5F对DNA含量的影响。结果5F抑制NCI-H460细胞的生长,其效果与5F的浓度和作用时间相关,24、48、72h的IC50分别为:21.40、4.52、1.02μg/ml;荧光双染色法显示经5F作用后细胞出现变形,染色质浓缩,产生凋亡小体;细胞被阻滞在G2/M期。结论5F在体外能有效地抑制NCI-H460细胞的生长,其作用可能是通过诱导其凋亡产生的。 | 刘义 吴科锋 李立 George G CHEN Michael KY HSIN Malcolm J UNDERWOOD 梁念慈 | 2009 | 肿瘤防治研究2009，36，1： | 9 |
| 3 | 亚洲地区饲料原料和配合饲料中霉菌毒素水平的调查显示文摘 | Hsin Yi Chen Rebekah Rawlings 奥特奇 | 2008 | 饲料研究2008，31，9： | 8 |
| 4 | 半边旗活性物质5F对非小细胞肺癌NCI-H460细胞IκKβ、IκB、p65及p50 mRNA表达的影响显示文摘目的从NF-κB信号通路着手探讨半边旗活性物质5F诱导非小细胞肺癌NCI-H460细胞凋亡发生的机制。方法MTT法检测5F对NCI-H460细胞的生长抑制作用;用半定量RT-PCR方法检测NCI-H460细胞IκKβ、IκB、p65及p50mRNA表达水平的变化。结果5F抑制NCI-H460细胞的生长,其效果与5F的质量浓度和作用时间相关,24、48、72h的IC50分别为:21.40、4.52、1.02μg/mL;100μg/mL5F作用NCI-H460细胞6h后能引起IκKβ和IκBmRNA表达水平显著降低(P<0.05);p65和p50mRNA水平在作用3h就发生明显减少(P<0.05)。结论5F诱导NCI-H460细胞凋亡的机制可能是通过抑制核因子-κB(NF-κB)信号通路来实现的。 | 刘义 CHEN George G 吕应年 HSIN Michael K Y UNDERWOOD Malcolm J 梁念慈 | 2010 | 中草药2010，41，3： | 3 |
| 5 | Liver stiffness measurement as an alternative to fibrotic stage in risk assessment of hepatocellular carcinoma incidence for chronic hepatitis C patients显示文摘 | Hsin‐Ming Wang Chao‐Hung Hung Sheng‐Nan Lu Chien‐Hung Chen Chuan‐Mo Lee Tsung‐Hui Hu Jing‐Houng Wang | 2013 | Liver Int2013，，5： | 3 |
| 6 | The Beneficial Effect of Regular Endurance Exercise Training on Blood Pressure and Quality of Life in Patients with Hypertension显示文摘 | Jen‐Chen Tsai Hung‐Yu Yang Wei‐Hsin Wang Ming‐Hsiung Hsieh Pei‐Ti Chen Ching‐Chiu Kao Pai‐Feng Kao Chia‐Hui Wang Paul Chan | 2004 | Clinical and Experimental Hypertension2004，，3： | 2 |
| 7 | MicroRNA-18a Prevents Estrogen Receptor-α Expression, Promoting Proliferation of Hepatocellular Carcinoma Cells显示文摘 | Wan–Hsin Liu Shiou–Hwei Yeh Cho–Chun Lu Sung–Liang Yu Hsuan–Yu Chen Chien–Yu Lin Ding–Shinn Chen Pei–Jer Chen | 2009 | Gastroenterology2009，，2： | 2 |
| 8 | Chromatin-binding in vivo of the erythroid kruppel-like factor,EKLF,in the murine globin loci显示文摘EKLF 是一 erythroid 特定,锌为在在权威的系的 erythroid 房间的基因的哺乳动物的贝它滴的激活的包含手指的抄写因素必需品。我们准备了对西方的弄污和免疫降水(IP ) 质量合适的 polyclonal 反老鼠 EKLF 抗体,并且使用了它在老鼠 erythroid 开发期间定义 EKLF 蛋白质的表示模式。我们也为 chromatin-immunoprecipitation (薄片) 使用了这抗体试金。EKLF 被发现以一种 DMSO 可诱导的方式在老鼠 erythroleukemia 房间(MEL ) 在老鼠 beta-major-globin 倡导者和 beta-LCR 的 HS2 地点在 vivo 绑。象三另外的蛋白质一样的 EKLF 的 导致DMSO 的绑定,也就是 RNA 聚合酶 II ,乙酰 ated 嘘一 H3 ,和 methylated 嘘一 H3 ,没在 CB3 被废除,但是显著地降低了,一根 导出MEL 的房间线与 p45/NF-E2 空表示,在 loci 为哺乳动物的滴的激活需要的一个 充实erythroid 的因素。有趣地,在 vivo 的 EKLF 的绑定也在地点在鼠标象 alpha 一样滴被检测,在成年高山哈在倡导者和它的远在上游的规章的元素 alpha-MRE (HS26 ) 的滴。这研究提供直接证据为在在在基因的像贝它的滴聚类的老鼠的主要规章的元素的 vivo EKLF 有约束力数据也在基因规定在哺乳动物的滴关于 EKLF 染色质相互作用的角色有有趣的含意。 | Yu-Chiau Shyu Shau-Ching Wen Tung-Liang Lee Xin Chen Chia-Tse Hsu Hsin Chen Ruei-Lin Chen Jau-Lang Hwang Che-Kun James Shen | 2006 | Cell Research2006，16，4： | 2 |
| 9 | Effects of Maternal Screening and Universal Immunization to Prevent Mother-to-Infant Transmission of HBV显示文摘 | Huey–Ling Chen Lung–Huang Lin Fu–Chang Hu Jian–Te Lee Wen–Terng Lin Yao–Jung Yang Fu–Chen Huang Shu–Fen Wu Solomon Chih–Cheng Chen Wan–Hsin Wen Chia–Hsiang Chu Yen–Hsuan Ni Hong–Yuan Hsu Pei–Lin Tsai Cheng–Lun Chiang Ming–Kwang Shyu Ping–Ing Lee Feng–Yee | 2012 | Gastroenterology2012，，4： | 2 |
| 10 | The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells显示文摘 | Yi-Hong Hsin Chun-Feng Chen Shing Huang Tung-Sheng Shih Ping-Shan Lai Pin Ju Chueh | 2008 | Toxicology Letters2008，，3： | 2 |
| 11 | Emphysematous pyelonephritis: Clinical characteristics and prognostic factors显示文摘 | Yu‐Chuan Lu Bing‐Juin Chiang Yuan‐Hung Pong Chung‐Hsin Chen Yeong‐Shiau Pu Po‐Ren Hsueh Chao‐Yuan Huang | 2014 | Int J Urol2014，，3： | 1 |
| 12 | How to achieve maximum utilization of hydrous ruthenium oxide for supercapacitors显示文摘 | Hu Chichang Chen Weichun Chang Kuo Hsin | 2004 | J Electrochem Soc2004，151，2： | 1 |
| 13 | Production and in-situ metal filling of carbon nanotubes in water 显示文摘 | Hsin Y L Hwang K C Chen F R | 2001 | Advanced Materials2001，13，11： | 1 |
| 14 | The apoptotic effect of nanosilver is mediated by a ROS-and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells显示文摘 | Hsin YH Chen CF Huang S | 2008 | Toxdcol Lett2008，179，3： | 1 |
| 15 | The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells 显示文摘 | Hsin YH Chen CF Huang S | 2008 | Toxicol Lett2008，179，3： | 1 |
| 16 | CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1 显示文摘 | Chia - Geun Chen Yun - LiangYang Hsin - IShih | 2004 | Antimicrob Agents Chemother2004，48，： | 1 |
| 17 | Forecasting Taiwan's major stock indices by the Nash nonlinear grey Bernoulli model显示文摘 | Chen C I Hsin P H Wu C S | 2010 | Expert Systems with Applications2010，37，12： | 1 |
| 18 | Mining Customer Knowledge for Product Line and Brand Extension in Retailing 显示文摘 | Shu -Hsien Liao Chyuan - Meei Chen Chung - Hsin Wu | 2008 | Expert Systems with Applications2008，34，3： | 1 |
| 19 | Removal of Volatile Organ- ic Compounds by Single-Stage and Two-Stage Plasma Catalysis Systems: A Review of the Performance Enhancement Mecha- nisms, Current Status, and Suitable Applications显示文摘 | Hsin Liang Chen How Ming Lee Shiaw Huei Chen Moo Been Chang Sheng Jell Yu Shou Nan Li | 2009 | Environ- mental Science & Technology2009，43，7： | 1 |
| 20 | Elevated p53 promotes the processing of miR‐18a to decrease estrogen receptor‐α in female hepatocellular carcinoma显示文摘 | Chiao‐Ling Li Kun‐Huei Yeh Wan‐Hsin Liu Chi‐Ling Chen Ding‐Shinn Chen Pei‐Jer Chen Shiou‐Hwei Yeh | 2015 | Cancer2015，，4： | 1 |
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