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| 1 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 2 | Intervertebral disc development and disease-related genetic polymorphisms显示文摘The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;NP)and concentric rings(annulus fibrosus;AF).The NP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic lineage.In vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until recently.However,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical fields.Beyond its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and somites.The pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue regeneration.Genetic factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the spine.In summary,the spinal column is a landmark development in evolution.Genes directing the development of the IVD may also contribute to its maintenance,degeneration,and regeneration.Likewise,structural genes as well as genes responsible for maintenance of the structure are related to IVD degeneration.Finally,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context. | Jason W.Ashley Motomi Enomoto-Iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang | 2016 | Genes & Diseases2016，3，3： | 3 |
| 3 | 儿科医生对肾移植儿童的管理显示文摘近年来,由于肾移植成功儿童数量的不断增加,儿科医生在日常诊疗中遇到越来越多的肾移植患儿。尽管移植后最初的管理通常由移植团队完成,但在此之后这些儿童最终会回到自己所在社区门诊的儿科医生处就诊。尤其是对那些住所离移植中心很远的孩子,儿科医生的医疗管理至关重要。由于这些孩子需要长期的免疫抑制治疗,也更容易发生很多特殊的问题,因此儿科医生及基层医务人员必须了解且有能力进行移植后儿童的管理。本文列出了儿科医生需要掌握的同种异体肾移植儿童的管理规范及在临床上需要注意的相关问题。 | Keith K. Lau Lucy Giglia Howard Chan Anthony K. Chan 姚跃(译) | 2012 | 中国当代儿科杂志2012，14，2： | 2 |
| 4 | Sacral Nerve Stimulation for Fecal Incontinence: Results of a 120-Patient Prospective Multicenter Study显示文摘 | Steven D. Wexner John A. Coller Ghislain Devroede Tracy Hull Richard McCallum Miranda Chan Jennifer M. Ayscue Abbas S. Shobeiri David Margolin Michael England Howard Kaufman William J. Snape Ece Mutlu Heidi Chua Paul Pettit Deborah Nagle Robert D. Madoff | 2010 | Annals of Surgery2010，，3： | 1 |
| 5 | Infection Rates in a Large Investigational Trial of Sacral Nerve Stimulation for Fecal Incontinence显示文摘 | Steven D. Wexner Tracy Hull Yair Edden John A. Coller Ghislain Devroede Richard McCallum Miranda Chan Jennifer M. Ayscue Abbas S. Shobeiri David Margolin Michael England Howard Kaufman William J. Snape Ece Mutlu Heidi Chua Paul Pettit Deborah Nagle Robert | 2010 | Journal of Gastrointestinal Surgery2010，，7： | 1 |
| 6 | Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels显示文摘 | Michael Cusick Emily Y Chew Chi-Chao Chan Howard S Kruth Robert P Murphy Frederick L Ferris | 2003 | Ophthalmology2003，，11： | 1 |
| 7 | Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the right inverted terminal repeat显示文摘 | Smith G L Chan Y S Howard S T | 1991 | J Gen Virol1991，72，： | 1 |
| 8 | Vitamintherapy in IgA Nephropathy:A double-blind,placebo-study显示文摘 | James C M Chan John D Mahan Howard Trachoma | 2003 | Pediatr Nephrol2003，18，： | 1 |
| 9 | Endocrine modulation of the neurotoxicity of gp120:implications for AIDS-related dementia complex显示文摘 | Brooke S Chan R Howard S | 1997 | Proc Nad Acad Sci USA1997，94，： | 1 |
| 10 | Endocrine modulation of the neurotoxicity of gp120:implications for AIDS-related dementia complex显示文摘 | Brooke S Chan R Howard S | | 0，，17： | 1 |
| 11 | Association Between Palliative Resection of the Primary Tumor and Overall Survival in a Population-Based Cohort of Metastatic Colorectal Cancer Patients显示文摘 | Gillian Gresham Daniel J. Renouf Matthew Chan Hagen F. Kennecke Howard J. Lim Carl Brown Winson Y. Cheung | 2014 | Annals of Surgical Oncology2014，，12： | 1 |
| 12 | Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment显示文摘 | Denise A. Chan Tiara L.A. Kawahara Patrick D. Sutphin Howard Y. Chang Jen-Tsan Chi Amato J. Giaccia | 2009 | Cancer Cell2009，，6： | 1 |
| 13 | Knowledge and attitudes toward corneal donation among Singaporean youth: a cross-sectional study显示文摘Background:To assess the knowledge of Singaporean youth regarding corneal donation and gauge their willingness to donate their corneas.Methods:We conducted a cross-sectional study among 500 students from five tertiary institutions in Singapore.All students answered self-administered questionnaires which included seven questions that tested knowledge and three questions that determined willingness to donate corneas.Results:Among 500 Singaporean youth aged 18 to 25,most students(73.2%)answered 3 or fewer of the 7 questions about corneal donation correctly.With regards to the willingness to donate,155(31%)were willing to donate their corneas,111(22.2%)were not willing to donate their corneas,and 234(46.8%)were undecided.Willingness to donate corneas was associated with an older age group(21 to 25 years old),those who are non-Muslims,and have good basic knowledge.Particularly,students with good basic knowledge were 1.71 times more likely to willingly donate their corneas.Conclusion:The knowledge of the Singaporean youth regarding corneal donation and transplantation is poor.Since insufficient information was cited as the most common reason for being undecided in regards to corneal donation,specific and tailored programs to increase knowledge and awareness are needed to convince the youth to support corneal donation. | Carisa Mariella Alvarez Paraz Ha Thi Thu Truong Darren Kyauk Sai Howard Yu Cajucom-Uy Cherry Lay Li Chan Selina Md Kassim | 2016 | Eye and Vision2016，3，1： | 1 |
| 14 | Sacral Nerve Stimulation for Fecal Incontinence: Results of a 120-Patient Prospective Multicenter Study显示文摘 | Steven D. Wexner John A. Coller Ghislain Devroede Tracy Hull Richard McCallum Miranda Chan Jennifer M. Ayscue Abbas S. Shobeiri David Margolin Michael England Howard Kaufman William J. Snape Ece Mutlu Heidi Chua Paul Pettit Deborah Nagle Robert D. Madoff | 2010 | Annals of Surgery2010，，3： | 1 |
| 15 | Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease显示文摘BACKGROUND Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease(NAFLD)management.The fibrosis-8(FIB-8)score,recently developed by incorporating four additional variables into the fibrosis-4(FIB-4)score,showed better performance in predicting significant fibrosis in NAFLD.AIM To validate the FIB-8 score in a biopsy-proven NAFLD cohort and compare the diagnostic performance of the FIB-8 and FIB-4 scores and NAFLD fibrosis score(NFS)for predicting significant fibrosis.METHODS We collected the data of biopsy-proven NAFLD patients from three Asian centers in three countries.All the patients with available variables for the FIB-4 score(age,platelet count,and aspartate and alanine aminotransferase levels)and FIB-8 score(the FIB-4 variables plus 4 additional parameters:The body mass index(BMI),albumin to globulin ratio,gamma-glutamyl transferase level,and presence of diabetes mellitus)were included.The fibrosis stage was scored using nonalcoholic steatohepatitis CRN criteria,and significant fibrosis was defined as at least fibrosis stage 2.RESULTS A total of 511 patients with biopsy-proven NAFLD and complete data were included for validation.Of these 511 patients,271(53.0%)were female,with a median age of 51(interquartile range:41,58)years.The median BMI was 29(26.3,32.6)kg/m2,and 268(52.4%)had diabetes.Among the 511 NAFLD patients,157(30.7%)had significant fibrosis(≥F2).The areas under the receiver operating characteristic curves of the FIB-8 and FIB-4 scores and NFS for predicting significant fibrosis were 0.774,0.743,and 0.680,respectively.The FIB-8 score demonstrated significantly better performance for predicting significant fibrosis than the NFS(P=0.001)and was also clinically superior to FIB-4,although statistical significance was not reached(P=0.073).The low cutoff point of the FIB-8 score for predicting significant fibrosis of 0.88 showed 92.36%sensitivity,and the high cutoff point of the FIB-8 score for predicting significant fibrosis of 1.77 showed 67.51%specificity.CONCLUSION We demonstrated that the FIB-8 score had significantly better performance for predicting significant fibrosis in NAFLD patients than the NFS,as well as clinically superior performance vs the FIB-4 score in an Asian population.A novel simple fibrosis score comprising commonly accessible basic laboratories may be beneficial to use for an initial assessment in primary care units,excluding patients with significant liver fibrosis and aiding in patient selection for further hepatologist referral. | Thaninee Prasoppokakorn Wah-Kheong Chan Vincent Wai-Sun Wong Panyavee Pitisuttithum Sanjiv Mahadeva Nik Raihan Nik Mustapha Grace Lai-Hung Wong Howard Ho-Wai Leung Pimsiri Sripongpun Sombat Treeprasertsuk | 2022 | World Journal of Gastroenterology2022，28，15： | 0 |
| 16 | A machine learning model for colorectal liver metastasis post-hepatectomy prognostications显示文摘Background:Currently,surgical resection is the mainstay for colorectal liver metastases(CRLM)management and the only potentially curative treatment modality.Prognostication tools can support patient selection for surgical resection to maximize therapeutic benefit.This study aimed to develop a survival prediction model using machine learning based on a multicenter patient sample in Hong Kong.Methods:Patients who underwent hepatectomy for CRLM between 1 January 2009 and 31 December 2018 in four hospitals in Hong Kong were included in the study.Survival analysis was performed using Cox proportional hazards(CPH).A stepwise selection on Cox multivariable models with Least Absolute Shrinkage and Selection Operator(LASSO)regression was applied to a multiply-imputed dataset to build a prediction model.The model was validated in the validation set,and its performance was compared with that of Fong Clinical Risk Score(CRS)using concordance index.Results:A total of 572 patients were included with a median follow-up of 3.6 years.The full models for overall survival(OS)and recurrence-free survival(RFS)consist of the same 8 established and novel variables,namely colorectal cancer nodal stage,CRLM neoadjuvant treatment,Charlson Comorbidity Score,pre-hepatectomy bilirubin and carcinoembryonic antigen(CEA)levels,CRLM largest tumor diameter,extrahepatic metastasis detected on positron emission-tomography(PET)-scan as well as KRAS status.Our CRLM Machine-learning Algorithm Prognostication model(CMAP)demonstrated better ability to predict OS(C-index=0.651),compared with the Fong CRS for 1-year(C-index=0.571)and 5-year OS(C-index=0.574).It also achieved a C-index of 0.651 for RFS.Conclusions:We present a promising machine learning algorithm to individualize prognostications for patients following resection of CRLM with good discriminative ability. | Cynthia Sin Nga Lam Alina Ashok Bharwani Evelyn Hui Yi Chan Vernice Hui Yan Chan Howard Lai Ho Au Margaret Kay Ho Shireen Rashed Bernard Ming Hong Kwong Wentao Fang Ka Wing Ma Chung Mau Lo Tan To Cheung | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
| 17 | Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents显示文摘The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet elucidated.In this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy adolescents.At 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 doses.The antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of BNT162b2.Compared to adults,humoral responses for the third dose were non-inferior or superior in adolescents.The S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or non-inferior.Interestingly,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and BA.5.Sera from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise BA.1.Our study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease. | Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 18 | My mother is looking blue显示文摘Dear editor,A 76-year-old Chinese female presented by ambulance to the Emergency Department complaining of dizziness,headache and fatigue.Her son claimed that the patient“turned blue”three hours prior to onset of the patient’s symptoms.Paramedics noted the patient’s SpO2 was 83%on room air with no improvement with a nonrebreather mask.Past medical history was signifi cant for diabetes and hypertension.Family,social and medication history were non-contributory. | Howard Tat Chun Chan Anselm Wang Hei Hui Colin Graham Joseph Walline | 2019 | World Journal of Emergency Medicine2019，10，4： | 0 |
| 19 | 北京侨福芳草地显示文摘2000年岁末,北京市中心,来自香港的侨福集团为一座地标性建筑提出了一项挑战性的策划,旨在改变大型综合商业开发项目的成规。它所引得的回应,也是一项时尚、节能且环保的设计,由徐腾(Winston Shu)领衔的香港建筑事务所IDA一手命制。整个开发项目有微气候调节,运用与北京季候变化相一致的可持续自然手段,实现了水准空前的热舒适度与灵活的使用空间。 | 徐腾 Ulrich Blum Nicole Ip Alicia Tan Pusey Chan Stephane Lacroix Moses Tan Kin Choy Christa Lange Jochen Tombers Howard Chung Peter Liu Louisa Williams Colin Foster Rosita Nicknafs Patrick Yue Simon Griffiths Ed Peter Connie Ho William Tam | 2013 | 城市环境设计2013，，8： | 0 |
| 20 | Peter Zumthor 一首洗炼的诗显示文摘每次看见Peter Zumthor的作品,我总在想象,我们有没有可能有这样的建筑:以效率和密集先行的城市,又是否可以容得下一个像他这样,每一个作品动辄费上十年时间的建筑师。将香港和欧洲瑞士去作比较,也许是不切实际的事,虽然香港跟瑞士有着相近的人口数目。然而这位以'rich but restraint modernism',作品每每如一首用字造句极度洗炼的诗歌的瑞士裔建筑大师,作风明显地比现下足迹遍及全球的'star architect'们来得更低调,其创作上的思维,说不定也可以对香港这个以反应快和效率高,却每每缺乏深层的内蕴,可堪玩昧的细节,甚至精准专业性的城市,有一点点启示。就让我们由他新近完成,位于德国科隆市内的Kolumba Museum开始,慢慢游,细意咀嚼。 | 三三 Gary Chang Raymond Chan Howard Chang | 2008 | 明日风尚2008，0，3： | 0 |
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