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| 1 | Current advances in using tolerogenic dendritic cells as a therapeutic alternative in the treatment of type 1 diabetes显示文摘Type 1 diabetes(T1D)is an autoimmune disease characterized by the destruction of insulin-producingβ-cells of the pancreatic islets by autoreactive T cells,leading to high blood glucose levels and severe long-term complications.The typical treatment indicated in T1D is exogenous insulin administration,which controls glucose levels;however,it does not stop the autoimmune process.Various strategies have been implemented aimed at stoppingβ-cell destruction,such as cellular therapy.Dendritic cells(DCs)as an alternative in cellular therapy have gained great interest for autoimmune disease therapy due to their plasticity to acquire immunoregulatory properties both in vivo and in vitro,performing functions such as anti-inflammatory cytokine secretion and suppression of autoreactive lymphocytes,which are dependent of their tolerogenic phenotype,displayed by features such as semimature phenotype,low surface expression of stimulatory molecules to prime T cells,as well as the elevated expression of inhibitory markers.DCs may be obtained and propagated easily in optimal amounts from peripheral blood or bone marrow precursors,such as monocytes or hematopoietic stem cells,respectively;therefore,various protocols have been established for tolerogenic(tol)DCs manufacturing for therapeutic research in the treatment of T1D.In this review,we address the current advances in the use of tolDCs for T1D therapy,encompassing protocols for their manufacturing,the data obtained from preclinical studies carried out,and the status of clinical research evaluating the safety,feasibility,and effectiveness of tolDCs. | William de Jesús Ríos-Ríos Sorely Adelina Sosa-Luis Honorio Torres-Aguilar | 2021 | World Journal of Diabetes2021，12，5： | 2 |
| 2 | Therapeutic and biological activities of Calotropis procera(Ait.) R.Br.显示文摘Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being increased.The Calotropis procera(C.procera) is a plant original from Africa,commonly found in northeastern Brazil.It is well known for their pharmacological properties,since it produces large amounts of latex.The important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera. | Marcia Calheiros Chaves Silva Antonio Batista da Silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda Lima Oliveira Angela Nadyla Martins Holonda Silvania Maria Mendes de Vasconcelos | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 2 |
| 3 | Solving optimal power flow problems using a probabilistic α-constrained evolutionary approach显示文摘 | Honorio L M Leite da Silva A M Barbosa1D A | | 0，，06： | 1 |
| 4 | Lumbar and Thoracic Epidural Blood Injections to Treat Spontaneous Intracranial Hypotension显示文摘 | Honorio T. Benzon Rimas Nemickas Robert E. Molloy Shireen Ahmad Onur Melen Bruce Cohen | 1996 | Anesthesiology1996，，4： | 1 |
| 5 | Effect of erosive pH cycling on different restorative materials and on enamel restored with these materials显示文摘 | Francisconi LF Honorio HM Rios D | 2008 | Oper Dent2008，33，2： | 1 |
| 6 | RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma turnouts 显示文摘 | Astuti D Agathanggelou A Honorio S | 2001 | Oncogene2001，20，51： | 1 |
| 7 | Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients显示文摘 | Honorio S Agathanggelou A Schuermann M | 2003 | Oncogene2003，22，1： | 1 |
| 8 | The influence of electronic, steric and hydrophobic properties of flavonoid compounds in the inhibition of the xanthine oxidase 显示文摘 | DA SILVA S L DA SILVAA HONORIO K M | 2004 | J Mol Struet (Theochem)2004，684，13： | 1 |
| 9 | Con vergent habitat segregation of Aedes aegypti and Aedes albopic tus (Diptera: Culicidae) in southeastern Brazil and Florida显示文摘 | Braks MA Honorio NA Lourencqo-De Oliveira R | 2003 | J Med Entomol2003，40，6： | 1 |
| 10 | Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients 显示文摘 | Honorio S Agathanggelou A Schuermann M | 2003 | Oncogene2003，22，2： | 1 |
| 11 | Detection of RASSFIA aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in sit from breast cancer patients 显示文摘 | Honorio S AgathanggelouA SchuermannM | 2003 | Oncogene2003，22，1： | 1 |
| 12 | Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients显示文摘 | Honorio S Agathanggelou A Schuermann M | 2003 | Oncogene2003，22，1： | 1 |
| 13 | Influence of theefavirenz micronization on tableting and dissolution 显示文摘 | Pinto EC Carmo FA Honorio Tda S | 2012 | Pharmaceutics2012，4，3： | 1 |
| 14 | Detection of RASSF1A aberrant promoter hypermethylation in sputum from chro- nic smokers and ductal carcinoma in situ from breast cancer pa- tients显示文摘 | Honorio S Agathanggelou A Schuermann M | 2003 | Oncogene2003，22，1： | 1 |
| 15 | Low stocks of coarse woody debris in a southwest Amazonian forest显示文摘 | Baker T R Honorio Coronado E N Phillips O L | | 0，，03： | 1 |
| 16 | 抗血小板和抗凝患者行脊柱介入和疼痛介入治疗指南(一)显示文摘疼痛介入治疗涵盖了较局部神经阻滞更为广泛的内容,两者具有不同的目的和治疗靶点。参加ASRA第11届疼痛医学年会的脊柱、疼痛科及介入科医师参与调查时表示:由于介入技术的发展,ASRA现有的、关于局部神经阻滞中有关抗血小板和抗凝患者的相关指南已经不能满足临床需要。受访者一致认为,由于介入治疗与局部神经阻滞在适应证和操作上存在差异,需针对疼痛介入治疗制订单独的临床指南。对此,ASRA成立了指南委员会,通过查阅脊柱和疼痛治疗相关并发症的文献,委员会根据潜在的出血风险将脊柱和疼痛介入治疗分为低、中、高三个级别。该指南主要适用于中、低风险治疗级别,而高风险操作需要进一步权衡患者安全和最佳预后。指南制订委员会采用极为全面的数据库检索方法收集最新的相关文献,尽可能为读者提供循证推荐。然而,由于许多原始文献缺乏针对疼痛介入治疗来设计的大型研究证据的支持,指南制订委员会难以提供这些证据的强度和级别,尽管有些指南或共识的制订不全基于随机对照研究或大样本患者数据库,但希望这些指南能提供良好的临床建议和类似指南的证据基础。 | Samer Narouze Honorio T.Benzon David A.Provenzano Asokumar Buvanendran José De Andres Timothy R.Deer Richard Rauck Marc A.Huntoon 易晓彬 姚鹏 金毅 卫炯琳 方铮 解轶声 吴安石 鄢建勤 李水清 孙永海 肖军 樊碧发 | 2016 | 中国疼痛医学杂志2016，22，6： | 1 |
| 17 | Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumor squamous cell carcinomas 显示文摘 | Hogg RP Honorio S Martinez A | 2000 | Eur J Carcer2000，38，： | 1 |
| 18 | The prevention andmanagement of postherpetic neuralgia with emphasis on interven-tional procedures 显示文摘 | HONORIO B KIRAN C AMIT D | 2009 | Reg Anesth Pain Med2009，34，5： | 1 |
| 19 | Hologram quantitative structure-activity relationships for a series of farnesoid X receptor activators 显示文摘 | KATHIA M HONORIO | 2005 | Bioorg Med Chem Lett2005，15，12： | 1 |
| 20 | RASSF1 A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours显示文摘 | Astuti D Agathanggelou A Honorio S | 2001 | Oncogene2001，20，51： | 1 |
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