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| 1 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 2 | Characteristics of Turbulent Transfer during Episodes of Heavy Haze Pollution in Beijing in Winter 2016/17显示文摘We analyzed the structure and evolution of turbulent transfer and the wind profile in the atmospheric boundary layer in relation to aerosol concentrations during an episode of heavy haze pollution from 6 December 2016 to 9 January 2017. The turbulence data were recorded at Peking University's atmospheric science and environment observation station. The results showed a negative correlation between the wind speed and the PM2.5 concentration. The turbulence kinetic energy was large and showed obvious diurnal variations during unpolluted(clean) weather, but was small during episodes of heavy haze pollution. Under both clean and heavy haze conditions, the relation between the non-dimensional wind components and the stability parameter z/L followed a 1/3 power law, but the normalized standard deviations of the wind speed were smaller during heavy pollution events than during clean periods under near-neutral conditions. Under unstable conditions, the normalized standard deviation of the potential temperatureσ_θ/|θ_*| was related to z/L, roughly following a –1/3 power law, and the ratio during pollution days was greater than that during clean days. The three-dimensional turbulence energy spectra satisfied a –2/3 power exponent rate in the high-frequency band. In the low-frequency band, the wind velocity spectrum curve was related to the stability parameters under clear conditions, but was not related to atmospheric stratification under polluted conditions. In the dissipation stage of the heavy pollution episode, the horizontal wind speed first started to increase at high altitudes and then gradually decreased at lower altitudes. The strong upward motion during this stage was an important dynamic factor in the dissipation of the heavy haze. | Yan REN Shuwen ZHENG Wei WEI Bingui WU Hongsheng ZHANG Xuhui CAI Yu SONG | 2018 | Journal of Meteorological Research2018，32，1： | 9 |
| 3 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 4 | Coupling effects of tungsten and molybdenum on microstructure and stress-rupture properties of a nickel-base cast superalloy显示文摘In order to comprehensively understand the forming mechanism of abnormal phases solidified in a nickel-base cast superalloy with additives of tungsten and molybdenum, the coupling effects of W and Mo on the microstructure and stress-rupture properties were investigated in this paper. The results indicated that the precipitation of primary α-(W, Mo) phase depended tremendously on the amount of W and Mo addition. When the total amount of W and Mo was greater than 5.79 at%, α-(W, Mo) phase became easily precipitated in the alloy.With increasing of Mo/W ratio, the dendrite-like α-(W, Mo) phases were apt to convert into small bars or blockylike phases at the vicinities of γ′/γ eutectic. The morphological changes of α-(W, Mo) phase can be interpreted as the non-equilibrium solidification of W and Mo in the alloy. Since the large sized α-(W, Mo) phase has detrimental effects on stress-rupture properties in as-cast conditions, secondary cracks may mainly initiate at and then propagate along the interfaces of brittle phases and soft matrix. During exposing at 1100 ℃ for 1000 h, the α-(W, Mo) phases transformed gradually into bigger and harder M_6C carbide, which results in decreasing of stress-rupture properties of the alloy. Finally, the alloy with an addition of 14W-1Mo(wt%) maintained the longest stress lives at high temperatures and therefore it revealed the best microstructure stability after 1100 ℃/1000 h thermal exposure. | Tongjin Zhou Wei Feng Huibin Zhao Yu Meng Huaxia Zhang Hongsheng Ding Zichen Wang | 2018 | Progress in Natural Science:Materials International2018，28，1： | 7 |
| 5 | Approaches to Census Mapping:Chinese Solution in 2010 Rounded Census显示文摘China still use sketch maps as control devices that guarantees consistency and accuracy of population counting in previous census.Although the rapid advancement of geospatial technologies provides many possible solutions of digital census mapping,existing researches do not answer which solution is suitable to China.Subject to many constraints originated from characteristics of China,a practical solution of census mapping based on remote sensing imagery and auxiliary geographic information was proposed and proved to be feasible through evaluation analysis and a three-stage pilot study.Imagery with 2.5 meters and higher resolution,innovative workflow of census areas delineation,easy-to-use census mapping software packages and training organization all together provide the all-around supports for the 2010 rounded census (the 6th census) mapping activities.A digital census geographic framework detailed at the level of enumeration area was established in the 2010 rounded census which fills in the gaps in the field of modern geospatial census in China.The spatially referenced digital census database,especially the detailed census units,is of great value in successive census,sampling survey and many other census-related fields.Future work including quality evaluation of census areas,census mapping solution in the Tibet Autonomous Region are also discussed. | WANG Yingjie LI Hongsheng YU Zhuoyuan LUO Bin | 2012 | Chinese Geographical Science2012，22，3： | 5 |
| 6 | Mea6 controls VLDL transport through the coordinated regulation of COPil assembly显示文摘 | Yaqing Wang Liang Liu Hongsheng Zhang Junwan Fan FengZhang Mei Yu Lei Shi Lin Yang Sin Man Lam Huimin Wang Xiaowei Chen Yingchun Wang Fei Gao Guanghou Shui Zhiheng Xu | 2016 | Cell Research2016，26，7： | 4 |
| 7 | Spatio-temporal variability of phytoplankton assemblages and its controlling factors in spring and summer in the Subei Shoal of Yellow Sea, China显示文摘The Subei Shoal is a special coastal area with complex physical oceanographic properties in the Yellow Sea.In the present study,the distribution of phytoplankton and its correlation with environmental factors were studied during spring and summer of 2012 in the Subei Shoal of the Yellow Sea.Phytoplankton species composition and abundance data were accomplished by Utermohl method.Diatoms represented the greatest cellular abundance during the study period.In spring,the phytoplankton cell abundance ranged from 1.59×10^3 to 269.78×10^3 cell/L with an average of 41.80×10^3 cell/L,and Skeletonema sp.and Paralia sulcata was the most dominant species.In summer,the average phytoplankton cell abundance was 72.59×10^3 cell/L with the range of 1.78×10^3 to 574.96×10^3 cell/L,and the main dominant species was Pseudo-nitzschia pungens,Skeletonema sp.,Dactyliosolen fragilissima and Chaetoceros curvisetus.The results of a redundancy analysis(RDA)showed that turbidity,temperature,salinity,pH,dissolved oxygen(DO),the ratio of dissolved inorganic nitrogen to silicate and SiO4-Si(DIN/SiO4-Si)were the most important environmental factors controlling phytoplankton assemblages in spring or summer in the Subei Shoal of the Yellow Sea. | Yuanzi Huo Honghua Shi Jianheng Zhang Qiao Liu Yuanliang Duan Qing He Kefeng Yu Hongsheng Bi Chunlei Fan Peimin He | 2019 | Acta Oceanologica Sinica2019，38，10： | 4 |
| 8 | A study on atmospheric turbulence structure and intermittency during heavy haze pollution in the Beijing area显示文摘In this study,the characteristics of turbulence transport and intermittency and the evolutionary mechanisms were studied in different pollution stages of heavy haze weather from December 2016 to January 2017 in the Beijing area using the method developed by Ren et al.(2019)as the automatic identification of atmospheric spectral gaps and the reconstruction of atmospheric turbulence sequences.The results reveal that turbulence intermittency is the strongest in the cumulative stage(CS)of heavy haze weather,followed by in the transport stage(TS),and it is the weakest in the dissipation stage(DS).During the development and accumulation of haze pollution,buoyancy contributes negatively to turbulent kinetic energy(TKE),and horizontal wind speed is low.The classical turbulent motion is often affected by submesoscale motion.As a result,the calculation results of turbulence parameters are affected by submesoscale motion,which causes intensified turbulence intermittency.During the dissipation of pollution,the downward momentum transfer induced by low-level jets provides kinetic energy for turbulent motion in the near surface layer.The turbulent mixing effect is enhanced,and intermittency is weakened.Due to the intermittency of atmospheric turbulence,turbulence parameters calculated from the original fluctuation of meteorological elements may be overestimated.The overestimation of turbulence parameters in the CS is the strongest,followed by the TS,and the DS is the weakest.The overestimation of turbulent fluxes results in an overestimation of atmospheric dissipation capability that may cause an underestimation of pollutant concentrations in the numerical simulations of air quality. | Yan REN Hongsheng ZHANG Wei WEI Xuhui CAI Yu SONG Ling KANG | 2019 | Science China Earth Sciences2019，62，12： | 4 |
| 9 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 10 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 11 | Research Progress on Estimation of the Atmospheric Boundary Layer Height显示文摘Atmospheric boundary layer height(ABLH)is an important parameter used to depict characteristics of the planetary boundary layer(PBL)in the lower troposphere.The ABLH is strongly associated with the vertical distributions of heat,mass,and energy in the PBL,and it is a key quantity in numerical simulation of the PBL and plays an essential role in atmospheric environmental assessment.In this paper,various definitions and methods for deriving and estimating the ABLH are summarized,from the perspectives of turbulent motion,PBL dynamics and thermodynamics,and distributions of various substances in the PBL.Different methods for determining the ABLH by means of direct observation and remote sensing retrieval are reviewed,and comparisons of the advantages and disadvantages of these methods are presented.The paper also summarizes the ABLH parameterization schemes,discusses current problems in the estimation of ABLH,and finally points out the directions for possible future breakthroughs in the ABLHrelated research and application. | Hongsheng ZHANG Xiaoye ZHANG Qianhui LI Xuhui CAI Shaojia FAN Yu SONG Fei HU Huizheng CHE Jiannong QUAN Ling KANG Tong ZHU | 2020 | Journal of Meteorological Research2020，34，3： | 3 |
| 12 | A high-Tc dc-SQUID-based single-channel MCG and its performance显示文摘A single-channel high-Tc dc-SQUID magnetometer and gradiometer have been developed to record the magnetic field component perpendicular to the human chest generated by heart-beat. Magnetocardiogram (MCG) measurements have been carried out inside a magnetically shielded room. By sequentially adjusting a non-magnetic patient table with 5 cm pitch in X and Y directions, the field signals on a rectangle grid 5×5 over the chest area were registered in real time trace point by point with a typical dwell time over 30 cardiocycles each. Utilizing standard electrocardiogram (ECG) recordings as timing reference measured simultaneously with the MCG signals, the MCG data were then averaged and combined to form magnetic field patterns every 10 ms or so. Both the current dipole, which is parallel to MCG measuring plane and produces the vertical magnetic field, and its depth were determined as a function of time in a standard way. We have compared the MCG of healthy hearts with that of a heart with right bundle | WANG Huiwu DING Hongsheng ZHANG Lihua HUANG Xuguang CHEN Weichang WANG Ziqiang FENG Ji LIU Yiping ZHAO Shiping REN Yufeng YU Hongwei XU Fengzhi WANG Xiaoyin CHEN Genghua YANG Qiansheng | 2002 | Chinese Science Bulletin2002，47，22： | 2 |
| 13 | Towards a Leprosy-Free Country--China,2011−2018显示文摘Summary What is already known about this topic?Leprosy is a chronic infectious disease that is endemic in several countries.Control of leprosy has had targets set by World Health Organization’s(WHO)Global Strategy 2016–2020 and by China through a national leprosy-control plan(2011–2020).What is added by this report?Data from the Leprosy Management Information System in China was analyzed and showed a national prevalence of 0.178 per 100,000 and detection rate of 0.037 per 100,000 residents in 2018.In addition,all the main targets for 2020 have been met by 2018 except for the proportion of counties or cities to reach a prevalence of less than 1/100,000 and the proportion of children cases with grade 2 disability(G2D).What are the implications for public health practice?There are still challenges remaining to close the gaps between current progress and the targets set forth by the WHO and China.However,lessons learned in China in developing and implementing the national program may be invaluable for future plans to achieve and sustain elimination of leprosy at global and country level. | Meiwen Yu Peiwen Sun Le Wang Hongsheng Wang Heng Gu Xiangsheng Chen | 2020 | China CDC weekly2020，2，4： | 2 |
| 14 | A low dose cell therapy system for treating osteoarthritis:In vivo study and in vitro mechanistic investigations显示文摘Mesenchymal stem cells(MSCs)can be effective in alleviating the progression of osteoarthritis(OA).However,low MSC retention and survival at the injection site frequently require high doses of cells and/or repeated injections,which are not economically viable and create additional risks of complications.In this study,we produced MSC-laden microcarriers in spinner flask culture as cell delivery vehicles.These microcarriers containing a low initial dose of MSCs administered through a single injection in a rat anterior cruciate ligament(ACL)transection model of OA achieved similar reparative effects as repeated high doses of MSCs,as evaluated through imaging and histological analyses.Mechanistic investigations were conducted using a co-culture model involving human primary chondrocytes grown in monolayer,together with MSCs grown either within 3D constructs or as a monolayer.Co-culture supernatants subjected to secretome analysis showed significant decrease of inflammatory factors in the 3D group.RNA-seq of co-cultured MSCs and chondrocytes using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed processes relating to early chondrogenesis and increased extracellular matrix interactions in MSCs of the 3D group,as well as phenotypic maintenance in the co-cultured chondrocytes.The cell delivery platform we investigated may be effective in reducing the cell dose and injection frequency required for therapeutic applications. | Bin Wang Wei Liu Jiao Jiao Li Senlin Chai Dan Xing Hongsheng Yu Yuanyuan Zhang Wenjin Yan Zhihong Xu Bin Zhao Yanan Du Qing Jiang | 2022 | Bioactive Materials2022，7，1： | 2 |
| 15 | Structure and properties of compatibilized recycled poly(ethylene terephthalate)/linear low density polyethylene blends显示文摘 | Hongsheng Zhang Weihong Guo Yingbo Yu | 2007 | European Polymer Journal2007，43，： | 1 |
| 16 | Estimation for ammonia emissions at county level in China from 2013 to 2018显示文摘Ammonia (NH_(3)) can interact with other trace chemicals in the atmosphere,significantly impacting atmospheric chemistry and global climate change.China is a largely agricultural country with high consumption of nitrogen fertilizer and large livestock herds,resulting in high NH_(3) emissions.In this study,a comprehensive county-level inventory of Chinese NH_(3) emissions from 2013 to 2018 was compiled.Based on previous research,an estimate of NH_(3) emissions from household coal combustion was added to the inventory.The estimation of emissions from open biomass burning was improved by using a method based on fire radiative energy (FRE).The total NH_(3) emissions in China increased from 2013 (9.64 Tg) to 2015 (9.75 Tg),and then decreased to 9.12 Tg in 2018.Emissions from fossil fuels reached a peak value in 2018,accounting for 8.4%of total emissions,while fertilizer application and livestock waste were responsible for fewer emissions than in previous years,accounting for 27.7%and 49.9%of the total from non-fossil fuel sources,respectively.The highest emission rates were in central and southwestern China.Seasonally,NH_(3) emissions peaked in spring and summer.The inventory had a 1-km spatial resolution and a monthly temporal resolution,which confirmed its suitability for global and regional air quality simulations. | Wenling LIAO Mingxu LIU Xin HUANG Tiantian WANG Zhenying XU Fang SHANG Yu SONG Xuhui CAI Hongsheng ZHANG Ling KANG Tong ZHU | 2022 | Science China Earth Sciences2022，65，6： | 1 |
| 17 | Modulation of MMP-2 and TIMP-2 by low dose radiation in mice bearing S180 sarcoma显示文摘Objective To investigate the inhibition of low dose radiation(LDR) on S180 sarcomas and its modulation of MMP-2 and TIMP-2 in mice.Methods S180 subcutaneously implanted tumor model mice were randomly divided into two groups: control(N) and low dose radiation(LDR) groups. N mice were sacrificed after 12 h, whereas LDR mice were sacrificed after 12(LDR-12 h), 24(LDR-24 h), 48(LDR-48 h), and 72(LDR-72 h) h. Thereafter, we measured the tumor volumes. Histopathology was performed, and P-V immunohistochemistry was applied to assess MMP-2 and TIMP-2 expression.Results Compared with the control group, the tumor growth was significantly inhibited in the LDR groups(P < 0.05). MMP-2 expression was considerably reduced in LDR-24h(P < 0.05) and LDR-48h(P < 0.05), whereas the change of TIMP-2 was not obvious in the LDR groups(P > 0.05) in contrast to that of the control group.Conclusion LDR can effectively suppress the growth of S180 implanted tumors by reducing MMP-2, which is associated with invasion and metastasis. | Xiangmin Jia Hongsheng Yu | 2016 | Oncology and Translational Medicine2016，2，2： | 1 |
| 18 | YPO, nanocrystals: preparation and size-induced lattice symmetry enhancemen显示文摘 | Liu Qiong Su Yiguo Yu Hongsheng er al | 2008 | Journal of Rare Earths2008，26，11： | 1 |
| 19 | Gelatinization of cornstarch with different amylase/amylopectin content 显示文摘 | Hongsheng Liu Long Yu Fengwei Xie | 2006 | Carbohydrate Polymers2006，65，3： | 1 |
| 20 | Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population显示文摘 | Jing Du Qinghe Xing Lingyun Xu Mingsheng Xu Anli Shu Yongyong Shi Lan Yu Aiping Zhang Lei Wang Hongsheng Wang Xingwang Li Guoyin Feng Lin He | 2006 | Pharmacogenomics2006，，6： | 1 |
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