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| 1 | An emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV显示文摘Severe fever with thrombocytopenia syndrome(SFTS) is an emerging hemorrhagic fever in rural areas of China and is caused by a new bunyavirus,SFTSV,named after the disease.The transmission vectors and animal hosts of SFTSV are unclear.Ticks are the most likely transmission vectors and domestic animals,including goats,dogs,and cattle,are potential amplifying hosts of SFTSV.The clinical symptoms of SFTS are nonspecific,but major symptoms include fever,gastrointestinal symptoms,myalgia,dizziness,joint pain,chills,and regional lymphadenopathy.The most common abnormalities in laboratory test results are thrombocytopenia(95%),leukocytopenia(86%),and elevated levels of serum alanine aminotransferase,aspartate aminotransferase,creatine kinase,and lactate dehydrogenase.The fatality rate for SFTS is 12% on average,and the annual incidence of the disease is approximately five per 100000 of the rural population. | ZHANG XiaoShuang LIU Yan ZHAO Li LI Bing YU Hao WEN HongLing YU Xue-Jie | 2013 | Science China(Life Sciences)2013，56，8： | 28 |
| 2 | Reproductive toxicity of organic extracts from petrochemical plant effluents discharged to the Yangtze River,China显示文摘Water pollution of the Yangtze River in China became one of challenges that the government is facing today.Increasing numbers of petrochemical plants were built along the river in past decades,and numbers of organic chemicals were discharged into the river.Our goal was to establish in vitro system on rat sertoli cells,spermatogenic cells and leydig cells to investigate the reproductive toxicity potential induced by organic extracts from petrochemical effluents.Our results showed that the organic extract depressed the viability(p<0.01) and destroyed the plasma membrane integrity of sertoli cells and spermatogenic cells to a certain degree.Accordingly,proportion of early apoptotic sertoli cells and late apoptotic spermatogenic cells increased significantly.Although significant morphological changes were not detected for leydig cells,the extract was observed to inhibit their testosterone production(p<0.01).Sertoli cells and spermatogenic cells appeared to be more sensitive and maybe the main targets of the key toxins.These results suggested that the in vitro system on rat testicular cells may be useful to predicate reproductive toxicity potential of organic extracts from petrochemical effluents.More attention should be paid to the petrochemical effluents,because long-term accumulation of these organic compounds in organisms may cause spermatogenesis malfunction and testosterone reduction. | Xiaoyi Wang Wei Shi Jiang Wu Yingqun Hao Guanjiu Hu Hongling Liu Xiaodong Han Hongxia Yu | 2010 | Journal of Environmental Sciences2010，22，2： | 7 |
| 3 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 4 | Probabilistic ecological risk assessment for three chlorophenols in surface waters of China显示文摘Individual and combined assessment of risks of adverse effects to aquatic ecosystems of three chlorophenols(CPs),including 2,4dichlorophenol(2,4-DCP),2,4,6-trichlorophenol(2,4,6-TCP) and pentachlorophenol(PCP),were conducted.A probabilistic approach based on the concentrations of CPs in surface waters of China was used to determine the likelihood of adverse effects.The potential risk of CPs in surface waters of China was determined to be of concern,especially PCP and mixtures of CPs.The risks of adverse effects were examined as the joint probabilities of exposure and response.The joint probability for PCP was 0.271 in the worst case and 0.111 in the median case,respectively.Based on the cumulative probability,5% of aquatic organisms included in the assessment would be affected 21.36% of the time in the worst case and 5.99% of the time in median case,respectively.For the mixtures of CPs,the joint probability were 0.171 in the worst case and 0.503 in median case,respectively and 5% of species would be affected 49.83% of the time for the worst case and 12.72% in the median case,respectively.Risks of effects of the individual CPs,2,4-DCP and 2,4,6-TCP were deemed to be acceptable with a overlapping probability of < 0.1 with 5% of species being affected less than 4% of the time. | Liqun Xing Hongling Liu John E Giesy Xiaowei Zhang Hongxia Yu | 2012 | Journal of Environmental Sciences2012，24，2： | 7 |
| 5 | Flotation performance of a novel Gemini collector for kaolinite at low temperature显示文摘How to sustainably produce bauxite by effective reverse froth flotation of kaolinite at low temperature is an urgent problem to be solved in the field of mineral processing.In this work,a novel amino-based Gemini surfactant butadiyl-1,4-bis(dimethyl dodecylammonium bromide)(BBDB) was prepared and first utilized as a novel collector for kaolinite flotation.Its flotation performance for kaolinite was compared with that of the common monomolecular surfactant 1-dodecylamine(DDA) by micro-flotation tests.The tests results indicated that 95% kaolinite recovery was obtained using 2.0×10^(-4) mol/L BBDB at 25℃ which was half of the dosage when DDA obtained the maximum kaolinite recovery of81%.At extremely low temperature(0℃),3.0×10^(-4) mol/L BBDB could still collect 91% kaolinite,while DDA showed a frustrating ability.The contact angle tests indicated that BBDB could still significantly improve the hydrophobicity of the kaolinite surface(contact angle 71.7°) than DDA(contact angle only25.8°) at 0℃.The Krafft point comparison tests indicated that BBDB had a much lower Krafft point(below0℃) than DDA.Fourier transform infrared spectroscopy(FTIR)-spectrum analysis and zeta potential measurements showed that BBDB was physically adsorbed on the surface of kaolinite through electrostatic interaction. | Shiyong Zhang Zhiqiang Huang Hongling Wang Rukuan Liu Chen Cheng Shuyi Shuai Yajing Hu Zhiqun Guo Xinyang Yu Guichun He Weng Fu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 6 | A survey of HIV infection and related high-risk factors among men who have sex with men in Suzhou,Jiangsu,China显示文摘A cross-sectional study using the snowball sampling method was conducted in May 2008 to investigate human immunodeficiency virus (HIV) infection status and related high risk factors among men who have sex with men (MSM) in Suzhou city of Jiangsu province. The researchers carried out a face-to-face questionnaire interview among MSM, and collected their blood samples to test for HIV and other sexually transmitted diseases (STDs). Among the 280 respondents, 91.1% had homosexual acts in the past 6 months and 87.5% had multiple homosexual partners; 46.4% had heterosexual sex in the past 6 months and 33.1% had multiple heterosexual partners. The rate of continued condom use was 44.3% in homosexual sex in the past 6 months, while the rate in heterosexual sex was 33.9%. Laboratory test results showed that the prevalences of HIV and syphilis were 7.1% (20/280) and 15.0% (42/280), respectively, but no HCV-positive person was found. In the multivariate logistic regression model, subjects with a monthly income of more than RMB $ 1,000 (OR=4.83,95% CI=1.44-16.22), subjects who often went to bars for sexual partners (OR=2.25, 95%CI=1.21-4.20), and subjects who had more than one sexual partner in the past 6 months (OR=0.49, 95%CI=0.25-0.97) and had sex with fixed sexual partners in the past 6 months (OR=0.42, 95%CI=0.25-0.75) were significantly associated with the rate of continued condom use in homosexual sex in the past 6 months. Unprotected sex and multiple sexual partners were more common among MSM in Suzhou city; furthermore, the prevalences of HIV infection and syphilis were relatively high. HIV preventive measures should be designed to address these risk factors and control the spread of HIV among MSM. | Hongling Bai Xiping Huan Weiming Tang Xin Chen Hongjing Yan Xiaoyan Liu Haitao Yang Zhihang Peng Xiuping Zhao Rongbin Yu Hao Yu Feng Chen | 2011 | The Journal of Biomedical Research2011，25，1： | 2 |
| 7 | Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia显示文摘Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment. | Haizhi Yu Yafei Yin Yifang Yi Zhao Cheng Wenyong Kuang Ruijuan Li Haiying Zhong Yajuan Cui Lingli Yuan Fanjie Gong Zhihua Wang Heng Li Hongling Peng Guangsen Zhang | 2020 | Cancer Communications2020，40，10： | 2 |
| 8 | Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells显示文摘The use of two inhibitors of Mek1/2 and Gsk3β(2i)promotes the generation of mouse diploid and haploid embryonic stem cells(ESCs)from the inner cell mass of biparental and uniparental blastocysts,respectively.However,a system enabling long-term maintenance of imprints in ESCs has proven challenging.Here,we report that the use of a two-step a2i(alternative two inhibitors of Src and Gsk3β,TSa2i)derivation/culture protocol results in the establishment of androgenetic haploid ESCs(AG-haESCs)with stable DNA methylation at paternal DMRs(differentially DNA methylated regions)up to passage 60 that can efficiently support generating mice upon oocyte injection.We also show coexistence of H3K9me3 marks and ZFP57 bindings with intact DMR methylations.Furthermore,we demonstrate that TSa2itreated AG-haESCs are a heterogeneous cell population regarding paternal DMR methylation.Strikingly,AGhaESCs with late passages display increased paternal-DMR methylations and improved developmental potential compared to early-passage cells,in part through the enhanced proliferation of H19-DMR hypermethylated cells.Together,we establish AG-haESCs that can longterm maintain paternal imprints. | Hongling Zhang Yuanyuan Li Yongjian Ma Chongping Lai Qian Yu Guangyong Shi Jinsong Li | 2022 | Protein & Cell2022，13，2： | 1 |
| 9 | A facile path from fast synthesis of Li-argyrodite conductor to dry forming ultrathin electrolyte membrane for high-energy-density allsolid-state lithium batteries显示文摘All-solid-state lithium batteries(ASSLBs),utilizing sulfide solid electrolyte,are considered as the promising design on account of their superior safety and high energy density,whereas the time-consuming preparation process of sulfide electrolyte powders and the thickness of electrolyte layer hinder their practical application.Herein,an innovative ultimate-energy mechanical alloying plus rapid thermal processing approach is employed to rapidly synthesize the crystalline Argyrodite-type conductor Li_(5.3)PS_(4.3)ClBr_(0.7)(LPSCIBr)with superior ionic conductivity(11.7 mS cm^(-1)).Furthermore,to realize the higher energy density of the battery,an ultrathin LPSCIBr sulfide electrolyte membrane with superior ionic conductivity of 6.5 mS cm^(-1)is fabricated with the aid of polytetrafluoroethylene(PTFE)binder and the reinforced cellulose mesh.Moreover,a simple solid electrolyte interphase(SEI)is constructed on the surface of lithium metal to enhance anodic stability.Benefiting from the joint efforts of these merits,the modified ASSLBs with a high cell-level energy density of 311 Wh kg^(-1) show an excellent cyclic stability.The assembled all-solid-state Li_(2) S/Li pouch cell can operate even under the severe conditions of bending and cutting,demonstrating the enormous potential of the sulfide electrolyte membrane for ASSLBs application. | Zhao Jiang Hongling Peng Jingru Li Yu Liu Yu Zhong Changdong Gu Xiuli Wang Xinhui Xia Jiangping Tu | 2022 | Journal of Energy Chemistry2022，31，11： | 1 |
| 10 | Tunable color emitting of CaAl 2 Si 2 O 8 : Eu, Tb phosphors for light emitting diodes based on energy transfer显示文摘 | Xue Yu Xuhui Xu Tingming Jiang Hongling Yu Penghui Yang Qing Jiao Jianbei Qiu | 2013 | Materials Chemistry and Physics2013，，： | 1 |
| 11 | The hormetic effect of cadmium on the activity of antioxidant enzymes in the earthworm Eisenia fetida显示文摘 | Yan Zhang Guoqing Shen Yueshu Yu Hongling Zhu | 2009 | Environmental Pollution2009，，11： | 1 |
| 12 | Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies显示文摘Hematopoiesis requires finely tuned regulation of gene expression at each stage of development.The regulation of gene transcription involves not only individual transcription factors(TFs)but also transcription complexes(TCs)composed of transcription factor(s)and multisubunit cofactors.In their normal compositions,TCs orchestrate lineage-specific patterns of gene expression and ensure the production of the correct proportions of individual cell lineages during hematopoiesis.The integration of posttranslational and conformational modifcations in the chromatin landscape,nucleosomes,histones and interacting components via the cofactor-TF interplay is critical to optimal TF activity.Mutations or translocations of cofactor genes are expected to alter cofactor-TF interactions,which may be causative for the pathogenesis of various hematologic disorders.Blocking TF oncogenic activity in hematologic disorders through targeting cofactors in aberrant complexes has been an exciting therapeutic strategy.In this review,we summarize the current knowledge regarding the models and functions of cofactor-TF interplay in physiological hematopoiesis and highlight their implications in the etiology of hematological malignancies.This review presents a deep insight into the physiological and pathological implications of transcription machinery in the blood system. | Zi Wang Pan Wang Yanan Li Hongling Peng Yu Zhu Narla Mohandas Jing Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 13 | Research on Steam Piping Optimal Operation in Large-Scale System 显示文摘 | Hongling Yu Guojun Li Fan Zhu etal | 2007 | Challenges of Power Engineering and Environment2007，，8： | 1 |
| 14 | Developing a one-step triplet-repeat primed PCR assay for diagnosingmyotonic dystrophy显示文摘Myotonic dystrophy type 1 (DM1), or Steiner's disease, is anautosomal dominant disorder caused by the expansion of unstabletrinucleotide repeats (CTG) in the 3' untranslated region of themyotonic dystrophy protein kinase gene (DMPK) (Brook et al.,1992; Mahadevan et al,, 1992). | Xiaoping Lan Na Li Hongling Wan Lintong Luo Yiming Wu Sanxiang Li Yu An Bai-Lin Wu | 2018 | Journal of Genetics and Genomics2018，45，10： | 1 |
| 15 | Robust,flame-retardant and colorful superamphiphobic aramid fabrics for extreme conditions显示文摘High-performance superamphiphobic fabrics are very useful in special fields,such as firefighting,rescue,and polar sports.The complicated preparation process,easily damaged surface structure,and high cost drastically limit their commercial application.In this work,we utilized a simple,low-cost superamphiphobic coating to prepare a superamphiphobic aramid fabric(SAF).The excellent repellency to acid/alkali solutions and low boiling point organic solvents has been demonstrated with the contact angle of>150°and>130°,respectively.Additionally,the original color of the fabric can also be maintained,accompanied by superior flame retardancy,strength and comfort with thermal degradation of 361℃.More importantly,SAF displayed excellent durability via 50 standard machine washes,100-min of ultrasonic washing,10-min of UV irradiation,120-min of high-temperature heating,5000 cycles of abrasion,and destructive abrasion by sharp metal.All the results showed the superior performance of our SAF in protective fabrics under extreme environmental conditions. | LIU Xiang CHEN JunLi SHAO QingQing CAO JiQiang DU ZhaoQun LIU HongLing YU WeiDong | 2021 | Science China(Technological Sciences)2021，64，8： | 0 |
| 16 | Characteristics of TP53 germline variants and their correlations with Li-Fraumeni syndrome or Li-Fraumeni-like syndrome in Chinese tumor patients显示文摘Li-Fraumeni syndrome(LFS),a rare autosomal-dominant inheritance condition,is associated with a family cancer history as well as pathogenic/likely-pathogenic TP53 germline variants(P/LP TP53 GV).The current clinical methods for detecting LFS are limited.Here,we retrospectively investigate P/LP TP53 GV among Chinese cancer patients by next-generation sequencing and evaluate its relationship with a family cancer history.A total of 270 out of 19,226 cancer patients have TP53 GV,including 53 patients with P/LP TP53 GV.Patients with P/LP TP53 GV are mainly found in male with glioma,lung cancer or sarcoma.The median age of diagnosis for P/LP TP53 GV patients is significantly lower than that of non-P/LP TP53 GV patients(31-years vs.53-years;P<0.01).One LFS patient and 3 Li-Fraumeni-like syndrome(LFL)patients are among the 26 followed-up P/LP TP53 GV patients.Among 25 types of P/LP TP53 GV,the highest variant frequencies occurred at codon 175 and 248.p.M237 I,p.R158 H,p.C238 Y and p.C275 R,are firstly identified among the Chinese LFS/LFL patients.This study reports the(P/LP)TP53 GV characteristics of Chinese pan-cancer patients.These findings suggest analyzing the P/LP TP53 GV in cancer patients is an effective strategy for identifying cancer predisposition syndrome. | Panwen Tian Xiaoyan Zhang Sheng Yang Yu Fang Hongling Yuan Wei Li Honglin Zhu Fangping Zhao Jinlei Ding Yunshu Zhu Sizhen Wang Guochen Sun Hongbin Ni Tonghui Ma Ting Lei | 2022 | Journal of Genetics and Genomics2022，49，7： | 0 |
| 17 | Extracorporeal membrane oxygenation in adult patients with sepsis and septic shock: Why, how, when, and for whom显示文摘Sepsis and septic shock remain the leading causes of death in intensive care units.Some patients with sepsis fail to respond to routine treatment and rapidly progress to refractory respiratory and circulatory failure,necessitating extracorporeal membrane oxygenation(ECMO).However,the role of ECMO in adult patients with sepsis has not been fully established.According to existing studies,ECMO may be a viable salvage therapy in carefully selected adult patients with sepsis.The choice of venovenous,venoarterial,or hybrid ECMO modes is primarily determined by the patient’s oxygenation and hemodynamics(distributive shock with preserved cardiac output,septic cardiomyopathy(left,right,or biventricular heart failure),or right ventricular failure caused by acute respiratory distress syndrome).Veno-venous ECMO can be used in patients with sepsis and severe acute respiratory distress syndrome when conventional mechanical ventilation fails,and early application of veno-arterial ECMO in patients with sepsis-induced refractory cardiogenic shock may be critical in improving their chances of survival.When ECMO is indicated,the choice of an appropriate mode and determination of the optimal timing of initiation and weaning are critical,particularly in an experienced ECMO center.Furthermore,some special issues,such as ECMO flow,anticoagulation,and antibiotic therapy,should be noted during the management of ECMO support. | Hongling Zhang Youdong Xu Xin Huang Shunyin Yang Ruiting Li Yongran Wu Xiaojing Zou Yuan Yu You Shang | 2024 | Journal of Intensive Medicine2024，4，1： | 0 |
| 18 | A robust & weak-nucleophilicity electrocatalyst with an inert response for chlorine ion oxidation in large-current seawater electrolysis显示文摘Seawater splitting into hydrogen,a promising technology,is seriously limited by the durability and tolerance of electrocatalysts for chlorine ions in seawater at large current densities due to chloride oxidation and corrosion.Here,we present a robust and weak-nucleophilicity nickel-iron hydroxide electrocatalyst with excellent selectivity for oxygen evolution and an inert response for chlorine ion oxidation which are key and highly desired for efficient seawater electrolysis.Such a weak-nucleophilicity electrocatalyst can well match with strong-nucleophilicity OH-compared with the weak-nucleophilicity Cl^(-),resultantly,the oxidation of OH-in electrolyte can be more easily achieved relative to chlorine ion oxidation,confirmed by ethylenediaminetetraacetic acid disodium probing test.Further,no strongly corrosive hypochlorite is produced when the operating voltage reaches about 2.1 V vs.RHE,a potential that is far beyond the thermodynamic potential of chlorine ion oxidatio n.This concept and approach to reasonably designing weaknucleophilicity electrocatalysts that can greatly avoid chlorine ion oxidation under alkaline seawater environments can push forward the seawater electrolysis technology and also accelerate the development of green hydrogen technique. | Junting Dong Chang Yu Hui Wang Lin Chen Hongling Huang Yingnan Han Qianbing Wei Jieshan Qiu | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 19 | Flotation separation of wolframite from calcite using a new trisiloxane surfactant as collector显示文摘Since wolframite is usually associated with calcite,the separation and enrichment of wolframite by froth flotation remains a great challenge.Herein,a novel trisiloxane surfactant N-(2-aminoethyl)-3-ami nopropyltrisiloxane(AATS)was successful synthesized,which was used for the separation of wolframite from calcite for the first time.The flotation separation performance of AATS was studied by flotation test,and its adsorption mechanism was explored based on contact angle,infrared spectrum analysis(FTIR),zeta potential and density functional theory(DFT)calculation.The results of microflotation test and binary mixed ore flotation test pointed that AATS had excellent selectivity and more prominent collection capacity for the flotation of wolframite when compared with industrial reagent sodium oleate(NaOL).The measurement results of contact angle proved that AATS improved the hydrophobicity of the wolframite surface.The highly selective adsorption mechanism of AATS surfactant on mineral surfaces were further researched and analyzed by FTIR and zeta potential.The results revealed that AATS surfactant had significant adsorption effect on wolframite,yet almost no adsorption on calcite.DFT calculation indicated that AATS produced electrostatic adsorption with wolframite surface through—N+H3 group. | Shuyi Shuai Zhiqiang Huang Vladimir E.Burov Vladimir Z.Poilov Fangxu Li Hongling Wang Rukuan Liu Shiyong Zhang Chen Cheng Wenyuan Li Xinyang Yu Guichun He Weng Fu | 2023 | International Journal of Mining Science and Technology2023，33，3： | 0 |
| 20 | Influences of the tank liquid lateral sloshing and mass time-varying on high clearance self-propelled sprayer ride comfort显示文摘To explore the influence of the lateral sloshing and the time-varying mass of the liquid in the tank on the ride comfort of the high-clearance sprayer,a spring-mass-damping equivalent mechanics that can describe the lateral sloshing of the liquid under different filling ratios was constructed based on the equivalent criterion.The Fluent was used to simulate the moment acting on the wall of the tank by the lateral sloshing of the liquid,and then the parameters of the equivalent mechanical model are obtained by fitting and solving.Comparative analysis of Fluent simulation and bench test on lateral sloshing of tank liquid under different filling ratios.The results show that the lateral sloshing trend of the tank liquid level obtained from the Fluent simulation and the bench test was consistent,which proved the accuracy of the Fluent fluid simulation process and the correctness of the required equivalent mechanical model parameters.Incorporating a liquid sloshing equivalent model,a four-degree-of-freedom vertical dynamic model of the sprayer half-car was established.Subsequently,the performance of the sprayer was systematically analyzed and compared under the excitation of a bump road and a random E-level road.This investigation took into account varying liquid filling ratios of 10%,50%,and 90%.The focus lay on evaluating the vertical acceleration of the sprayer body,dynamic deflection of the suspension,and dynamic load on the tires in response to these road conditions.This analysis is conducted independently of the liquid sloshing factor.The results show that the lateral sloshing of the liquid medicine significantly reduces the ride smoothness of the machine,and makes the vibration response of the machine produce a certain hysteresis effect.With the reduction of the quality of the liquid medicine in the spray tank,the vibration amplitude of the sprayer body gradually decreases,the hysteresis effect is also gradually weakened.The results presented in this study offer a theoretical foundation for the analysis of ride comfort and the optimization of chassis structure in high-clearance sprayers. | Liquan Lu Junchang Zhang Cui Cui Jun Chen Yu Chen Hongling Jing Shuo Zhang Sugirbay Adilet Chenwei Hu Jiayu Cao | 2024 | International Journal of Agricultural and Biological Engineering2024，17，1： | 0 |
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