|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nano-Graphene Oxide for Cellular Imaging and Drug Delivery显示文摘Two-dimensional graphene offers interesting electronic,thermal,and mechanical properties that are currently being explored for advanced electronics,membranes,and composites.Here we synthesize and explore the biological applications of nano-graphene oxide(NGO),i.e.,single-layer graphene oxide sheets down to a few nanometers in lateral width.We develop functionalization chemistry in order to impart solubility and compatibility of NGO in biological environments.We obtain size separated pegylated NGO sheets that are soluble in buffers and serum without agglomeration.The NGO sheets are found to be photoluminescent in the visible and infrared regions.The intrinsic photoluminescence(PL)of NGO is used for live cell imaging in the near-infrared(NIR)with little background.We found that simple physisorption viaπ-stacking can be used for loading doxorubicin,a widely used cancer drug onto NGO functionalized with antibody for selective killing of cancer cells in vitro.Owing to its small size,intrinsic optical properties,large specifi c surface area,low cost,and useful non-covalent interactions with aromatic drug molecules,NGO is a promising new material for biological and medical applications. | Xiaoming Sun Zhuang Liu Kevin Welsher Joshua Tucker Robinson Andrew Goodwin Sasa Zaric Hongjie Dai | 2008 | Nano Research2008，1，3： | 118 |
| 2 | Enhanced Performance of Osteoblasts by Silicon Incorporated Porous TiO_2 Coating显示文摘Silicon (Si) incorporated porous TiO 2 coating (Si-TiO 2) prepared on titanium (Ti) by micro-arc oxidation (MAO) technique was demonstrated to be cytocompatible in previous studies.In view of the potential clinical applications,a detailed in vitro study of the biological activity of Si-TiO 2 coating,in terms of osteoblast (MC3T3-E1 cells) morphology,proliferation,differentiation and mineralization was performed.Immunofluorescent staining indicated that cells seeded on the Si-TiO 2 coating showed improved adhesion with developing mature cytoskeletons,which contained numerous distinct and well-defined actin stress fibers in the cell membranes compared with those on the TiO 2 coating and Ti plate.Results from proliferation assay showed that the proliferation rate of cells seeded on the Si-TiO 2 coating was significantly faster than that on the TiO 2 coating and Ti plate.Furthermore,the analysis of osteogenic gene expression demonstrated that the Si-TiO 2 coating stimulated the expression of osteoblast-related genes and promoted differentiation and mineralization of MC3T3-E1 cells.In addition,the Si-TiO 2 coating differentially regulated Wnt signaling pathway by up-regulating the expression of low-density lipoprotein (LDL) receptor-related protein 5 (Lrp5),and downregulating the expression of Dickkopf-1 (Dkk1).All together,these results indicate that the investigated titanium with Si-TiO 2 coating is biocompatible and a good candidate material used as implants. | Quanming Wang Hongjie Hu Yuqing Qiao Zhengxiang Zheng Junying Sun | 2012 | Journal of Materials Science & Technology2012，28，2： | 5 |
| 3 | A theranostic agent for cancer therapy and imaging in the second nearinfrared window显示文摘Thera no stic nano particles are integrated systems useful for simulta neous diag nosis and imaging guided delivery of therapeutic drugs, with wide ranging pote ntial applicati ons in the clinic. Here we developed a thera no stic nan oparticle (~24 nm size by dynamic light scatteri ng) p-FE-PTX-FA based on polymeric micelle encapsulating an organic dye (FE) fluorescing in the 1,000-1,700 nm second near-infrared (NIR-Ⅱ) window and an an ti-ca ncer drug paclitaxel. Folic acid (FA) was conjugated to the nan oparticles to afford specific binding to molecular folate receptors on muri ne breast can cer 4T1 tumor cells. In vivo, the nan oparticles accumulated in 4T1 tumor through both passive and active targeting effect. Under an 808 nm laser excitation, fluorescence detection above 1,300 nm afforded a large Stokes shift, allowing targeted molecular imaging tumor with high signal to background ratios, reaching a high tumor to normal tissue signal ratio (T/NT) of (20.0±2.3). Further, 4T1 tumors on mice were completed eradicated by paclitaxel released from p-FE-PTA-FA within 20 days of the first injection. Pharmacokinetics and histology studies indicated p-FE-PTX-FA had no obvious toxic side effects to major organs. This represented the first NIR-Ⅱ theranostic age nt developed. | Zhuoran Ma Hao Wan Weizhi Wang Xiaodong Zhang Takaaki Uno Qianglai Yang Jingying Yue Hongpeng Gao Yeteng Zhong Ye Tian Qinchao Sun Yongye Liang Hongjie Dai | 2019 | Nano Research2019，12，2： | 4 |
| 4 | An electrodeposition approach to metal/metal oxide heterostructures for active hydrogen evolution catalysts in near-neutral electrolytes显示文摘Neutral water splitting is attractive for its use of non-corrosive and environmentally friendly electrolytes.However,catalyst development for hydrogen and oxygen evolution remains a challenge under neutral conditions.Here we report a simple electrodeposition and reductive annealing procedure to produce a highly active Ni-Co-Cr metal/metal oxide heterostructured catalyst directly on Ni foam.The resulting electrocatalyst for hydrogen evolution reaction (HER) requires only 198 mV of overpotential to reach 100 mNcm2 in 1 M potassium phosphate (pH =7.4) and can operate for at least two days without significant performance decay.Scanning transmission electron microscopy coupled with electron energy loss spectroscopy (STEM-EELS) imaging reveals a Ni-Co alloy core decorated with blended oxides layers of NiO,CoO and Cr2O3.The metal/metal oxide interfaces are suggested to be responsible for the high HER activity. | Michael J.Kenney Jianan Erick Huang Yong Zhu Yongtao Meng Mingquan Xu Guanzhou Zhu Wei-Hsuan Hung Yun Kuang Mengchang Lin Xiaoming Sun Wu Zhou Hongjie Dai | 2019 | Nano Research2019，12，6： | 4 |
| 5 | Development of Perennial Wheat Through Hybridization Between Wheat and Wheatgrasses: A Review显示文摘 | Lei Cui Yongkang Ren Timothy D. Murray Wenze Yan Qing Guo Yuqi Niu Yu Sun Hongjie Li | 2018 | Engineering2018，4，4： | 4 |
| 6 | Extracellular Elastin Molecule Modulates Alzheimer’s AβDynamics In Vitro and In Vivo by Affecting Microglial Activities显示文摘Alzheimer’s disease(AD)is a neurodegenerative disorder,and the etiology of AD has not been completely elucidated.It remains unknown how the components from the brain’s extracellular matrix(ECM),particularly fibrous entities,may influence the pathogenesis of AD.Herein,we report that treatment with elastin-like polypeptides(ELPs),a component of the brain ECM,significantly increases the extracellular levels of AD-related amyloid-beta(Aβ)peptides and decreases intracellular Aβlevels in human microglial cell model HMC3 cells(HMC3). | Jingjing Li Yao Sun Yingxia Liang Jun Ma Bo Li Chao Ma Rudolph ETanzi Hongjie Zhang Kai Liu Can Zhang | 2021 | CCS Chemistry2021，3，7： | 2 |
| 7 | Biological composite fibers with extraordinary mechanical strength and toughness mediated by multiple intermolecular interacting networks显示文摘Numerous strategies involving multiple cross-linking networks have been applied for fabricating robust hydrogels.Inspired by this,the development of mechanically strong and tough biological fibers by the incorporation of intermolecular linking networks is becoming important.Herein,we present a versatile strategy for the fabrication of protein-saccharide composite fibers through protein-initiated double interacting networks.Three types of lysine-rich bioengineered proteins were introduced and the present multiple cross-linking interactions including electrostatic forces and covalent bonds significantly enhanced the mechanical properties of as-obtained composite fibers.In stark contrast to pristine saccharide or other polymer fibers,the as-obtained composite fibers exhibited outstanding mechanical performance,showing a breaking strength of~768 MPa,Young’s modulus of~24 GPa,and toughness of~69 MJ∙m^(–3),respectively.Thus,this established approach has great potentials to fabricate new generation renewable biological fibers with high performance. | Sikang Wan Wenhao Cheng Jingjing Li Fan Wang Xiwen Xing Jing Sun Hongjie Zhang Kai Liu | 2022 | Nano Research2022，15，10： | 2 |
| 8 | Modulation of Beta Oscillations for Implicit Motor Timing in Primate Sensorimotor Cortex during Movement Preparation显示文摘Motor timing is an important part of sensorimotor control. Previous studies have shown that beta oscillations embody the process of temporal perception in explicit timing tasks. In contrast, studies focusing on beta oscillations in implicit timing tasks are lacking. In this study, we set up an implicit motor timing task and found a modulation pattern of beta oscillations with temporal perception during movement preparation. We trained two macaques in a repetitive visually-guided reach-to-grasp task with different holding intervals. Spikes and local field potentials were recorded from microelectrode arrays in the primary motor cortex, primary somatosensory cortex, and posterior parietal cortex. We analyzed the association between beta oscillations and temporal interval in fixedduration experiments(500 ms as the Short Group and1500 ms as the Long Group) and random-duration experiments(500 ms to 1500 ms). The results showed that the peak beta frequencies in both experiments ranged from15 Hz to 25 Hz. The beta power was higher during the hold period than the movement(reach and grasp) period.Further, in the fixed-duration experiments, the mean poweras well as the maximum rate of change of beta power in the first 300 ms were higher in the Short Group than in the Long Group when aligned with the Center Hit event. In contrast, in the random-duration experiments, the corresponding values showed no statistical differences among groups. The peak latency of beta power was shorter in the Short Group than in the Long Group in the fixed-duration experiments, while no consistent modulation pattern was found in the random-duration experiments. These results indicate that beta oscillations can modulate with temporal interval in their power mode. The synchronization period of beta power could reflect the cognitive set maintaining working memory of the temporal structure and attention. | Hongji Sun Xuan Ma Liya Tang Jiuqi Han Yuwei Zhao Xuejiao Xu Lubin Wang Peng Zhang Luyao Chen Jin Zhou Changyong Wang | 2019 | Neuroscience Bulletin2019，35，5： | 2 |
| 9 | Engineered protein nanodrug as an emerging therapeutic tool显示文摘Functional proteins are the most versatile macromolecules.They can be obtained by extraction from natural sources or by genetic engineering technologies.The outstanding selectivity,specificity,binding activity,and biocompatibility endow engineered proteins with outstanding performance for disease therapy.Nevertheless,their stability is dramatically impaired in blood circulation,hindering clinical translations.Thus,many strategies have been developed to improve the stability,efficacy,bioavailability,and productivity of therapeutic proteins for clinical applications.In this review,we summarize the recent progress in the fabrication and application of therapeutic proteins.We first introduce various strategies for improving therapeutic efficacy via bioengineering and nanoassembly.Furthermore,we highlight their diverse applications as growth factors,nanovaccines,antibody-based drugs,bioimaging molecules,and cytokine receptor antagonists.Finally,a summary and perspective for the future development of therapeutic proteins are presented. | Yuanxin Li Jing Sun Jingjing Li Kai Liu Hongjie Zhang | 2022 | Nano Research2022，15，6： | 2 |
| 10 | Chronic electrical stimulation induces functional network changes in cortical neuron cultures显示文摘Recent studies demonstrated that a functional brain network could be regarded as a complex network.With the help of network theory,neuroscientists can identify common organizational principles of the functional brain networks.As a consequence,some non-random organizational features,such as'small world'(most of the nodes are not connected directly but can communicate with few intermediate relay steps)and'rich club'(nodes that are rich in connections tend to form strongly interconnected clubs),have been found in functional brain network.Recently,the'small world'organizational feature of neuronal functional networks in vitro was found to be influenced by external applications.However,little is known about the influence of chronic electrical stimulation on functional networks of dissociated cortical cultures during network development.In the present study,cortical cultures were electrically stimulated at a frequency of 0,0.02,and 0.2 Hz,between 7 and 26 days in vitro(DIV).The spontaneous activity of the cortical cultures was recorded using MEAs.Next,a cross-covariance method and graph theory were applied to investigate organizational feature of functional networks.Our results showed that over 3 weeks of stimulation,the network density significantly increased with maturation in the control and 0.02 Hz stimulation groups,but not in 0.2 Hz stimulation groups.Moreover,all the cultures had a small-world topology at 14,18,22,and 26 DIV,free from the effect of chronic electrical stimulation.Besides,we found an asymmetry effect that partial electrical stimulation inhibited the formation of node connections in stimulated areas.This effect was more pronounced at 0.2 Hz than at 0.02 Hz stimulation.Our results suggest that electrical stimulation does not affect the small-world properties of neural cultures.Instead,electrical stimulation modulates connectivity patterns,and neurons within the stimulated area are less connected than neurons outside the stimulated area. | WU SongFang WANG LuBin ZHAO YuWei SUN HongJi LANG YiRan WANG ChangYong HAN JiuQi WANG Yan HAN Yao | 2020 | Science China(Technological Sciences)2020，63，4： | 2 |
| 11 | Proteinaceous Fibers with Outstanding Mechanical Properties Manipulated by Supramolecular Interactions显示文摘Proteinaceous fibers based on spidroins have attracted widespread attention due to their lightweight and mechanically strong properties.Presently,mechanical modulation is mainly dependent on the ultrahigh molecular weight of recombinant proteins.This makes it difficult to construct and express the target proteins.It is thus significant to develop alternative strategies for the fabrication of robust biological fibers.Herein,we demonstrate one new type of engineered protein fibers using electrostatic complexation of the cationic elastins and anionic dihydroxyphenylalanine surfactants.Interestingly,the mechanical performance of the resulting fibers can be modulated by multiple supramolecular interactions in the system including electrostatic force,hydrogen bonding,metal coordination,cation-πand other aromatic interactions.Consequently,significant alternation of the fibers’breaking strength(from 32 to 160 MPa),Young’s modulus(from 0.8 to 17 GPa),and toughness(from 1.2 to 99 MJ·m-3)has been achieved.Moreover,the fibers exhibit high plasticity;for example,the formation of different helical structures,and strong fluorescence after the introduction of Tb chelation.Therefore,this study offers new strategies for the mechanical regulation of engineered protein fibers. | Jing Sun Bo Li Fan Wang Jing Feng Chao Ma Kai Liu Hongjie Zhang | 2021 | CCS Chemistry2021，3，6： | 2 |
| 12 | Hand, foot, and mouth disease in China, 2008–12: an epidemiological study显示文摘 | Weijia Xing Qiaohong Liao Cécile Viboud Jing Zhang Junling Sun Joseph T Wu Zhaorui Chang Fengfeng Liu Vicky J Fang Yingdong Zheng Benjamin J Cowling Jay K Varma Jeremy J Farrar Gabriel M Leung Hongjie Yu | 2014 | The Lancet Infectious Diseases2014，，： | 1 |
| 13 | Antimony uptake, translocation and speciation in rice plants exposed to antimonite and antimonate显示文摘 | Jinghua Ren Lena Q. Ma Hongjie Sun Fei Cai Jun Luo | 2013 | Science of the Total Environment2013，，： | 1 |
| 14 | Model Selection in Spatial Autoregressive Models with Varying Coefficients显示文摘Spatial autoregressive (SAR)models with varying coefficients are useful for capturing heterogeneous effects of the impacts of covariates as well as spatial interaction in empirical studies,and a wide range of popular models can be seen as its special cases,such as linear SAR models.In this study,we will propose a unified model selection method for the SAR model with varying coefficients to achieve two targets simultaneously:(1)variable selection (eliminate irrelevant covariates),and (2) identification of the covariates with constant effect among the relevant covariates.To do so,we follow the idea of group LASSO to incorporate two penalty functions to simultaneously do model selection and estimation.Monte Carlo experiments show that the proposed method performs well in finite samples.Finally,we illustrate the method with an application to the housing data of Chinese cities. | Hongjie Wei Yan Sun Meidi Hu | 2018 | Frontiers of Economics in China-Selected Publications from Chinese Universities2018，13，4： | 1 |
| 15 | A novel multistage anoxic/aerobic process with sludge regeneration zone (R-MAO) for advanced nitrogen removal from domestic sewage显示文摘To achieve advanced nitrogen removal from actual municipal sewage,a novel multistage anoxic/aerobic process with sludge regeneration zone(R-MAO)was developed.The reactor was used to treat actual domestic sewage and the nitrogen removal capacity of the sludge regeneration zone(R zone)was investigated during the long-term operation.The best performance was obtained at the R zone’s Oxidation-Reduction Potential(ORP)of-50±30 mV and hydraulic residence times(HRT)of 1.2 hr.The average effluent COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N of the R-MAO process were 18.0±2.3,7.5±0.6,1.0±0.5 and 4.6±0.4 mg/L,respectively,with the corresponding removal efficiency of COD,TN and NH_(4)^(+)-N were 92.9%±1.0%,84.1%±1.5% and 97.5%±1.1%.Compared to the sole MAO system,the TN removal efficiency of the R-MAO increased by 10.1%.Besides,under the optimal conditions,the contribution of the R zone in the R-MAO that removal COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N were 0.36,0.15,0.032 and 0.82 g/day.High-throughput sequencing results showed that uncultured_bacterium_f_Burkholderiaceae(5.20%),OLB8(1.04%)and Ottowia(1.03%)played an important role in denitrification in the R zone.This study provided effective guidance for the design and operation of the R-MAO process in domestic sewage treatment. | Lin Cao Rong Sun Wenyi Dong Hongjie Wang Zhongyi Dai Xue Wang Jin Xie Hua Li | 2023 | Journal of Environmental Sciences2023，，2： | 1 |
| 16 | Phytechomistry显示文摘 | Chen Yiping Lin Zhongwen Zhang Hongjie and Sun Handong | 1990 | Print in Great Brain1990，29，10： | 1 |
| 17 | Plant growth forsewage sludge ecological stabilization 显示文摘 | CUI Yubo SUN Hongjie YANG Minglei | 2012 | Journal of ResidualsScience & Technology2012，9，1： | 1 |
| 18 | A WebGIS system for relating genetic soil classification of China to soil taxonomy显示文摘 | Xuezheng Shi Guoxiang Yang Dongsheng Yu Shengxiang Xu Eric D. Warner Gary W. Petersen Weixia Sun Yongcun Zhao William E. Easterling Hongjie Wang | 2010 | Computers and Geosciences2010，，6： | 1 |
| 19 | Formation Mechanism and Occurrence Law of Pod Shattering in Soybean:A Review显示文摘Seed shattering refers to the phenomenon in which the pods split along the abdominal and back sutures before the crop is received,so that the seeds are spread.Seed shattering is vital to the reproduction of their offspring in wild plants,but it is also the main cause of crop yield loss reason.Pod-explosion resistance is a complex process of physical and physiological and biochemical reactions.Soybean seed shattering phenomenon is widespread,which severely restricts the development of soybean industry.Seed shattering(pod cracking or fruit dropping)is essential for the reproduction of its offspring in wild plants,but it is also the main cause of crop yield loss.This article analyzes the morphology and structure of pods related to seed shattering from the morphology of pods.On the basis of the regularity of the occurrence of seed shattering and the summary of phenotypic index identification methods,physiologically introduced the regulation mechanism of key enzymes and endogenous hormones on seed shattering.The localization,labeling and cloning of seed shattering genes are introduced in molecular biology.The study focused on reviewing the latest advances in the research on soybean seed shattering characteristics,and discussed with the research results of related crops.Finally,the research and application of soybean seed shattering resistance were prospected for several aspects. | Jinfeng Liu Yuzhe Zhang Yushi Jiang Hongji Sun Ruijie Duan Jing Qu Dan Yao Siyan Liu Shuyan Guan | 2022 | Phyton-International Journal of Experimental Botany2022，91，7： | 1 |
| 20 | Simulation of g factor for size optimization and coupling in phased array coil design显示文摘在 signal-to0noise 比率(SNR ) 和平行成像的 g 因素上的一个数组的卷元素的几何参数的效果被分析,并且为最大的 SNR 和 g 因素的最佳的参数被分析了。测试结果显示为平行成像的那个 g 因素极大地被增加, SNR 为联合被减少。根据优化,六隧道的平行的卷为躯干成像被设计了。 | SONG Xiaoyu ZHANG Hongjie WANG Le BAO Shanglian SUN Yanrong ZU Donglin | 2006 | Progress in Natural Science:Materials International2006，16，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员