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| 1 | Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer显示文摘BACKGROUND Cytoreductive surgery(CRS)in combination with hyperthermic intraperitoneal chemotherapy(HIPEC)improves patient survival in colorectal cancer(CRC)with peritoneal carcinomatosis(PC).Commonly used cytotoxic agents include mitomycin C(MMC)and oxaliplatin.Studies have reported varying results,and the evidence for the choice of the HIPEC agent and uniform procedure protocols is limited.AIM To evaluate therapeutic benefits and complications of CRS+MMC vs oxaliplatin HIPEC in patients with peritoneal metastasized CRC as well as prognostic factors.METHODS One hundred and two consecutive patients who had undergone CRS and HIPEC for CRC PC between 2007 and 2019 at the Medical Center of the University Freiburg regarding interdisciplinary cancer conference decision were retrospectively analysed.Oxaliplatin and MMC were used in 68 and 34 patients,respectively.Each patient’s demographics and tumour characteristics,operative details,postoperative complications and survival were noted.Complications were stratified and graded using Clavien/Dindo analysis.Prognostic outcome factors were identified using univariate and multivariate analysis of survival.RESULTS The two groups did not differ significantly regarding baseline characteristics.We found no difference in median overall survival between MMC and oxaliplatin HIPEC.Regarding postoperative complications,patients treated with oxaliplatin HIPEC suffered increased complications(66.2%vs 35.3%;P=0.003),particularly intestinal atony,intraabdominal infections and urinary tract infection,and had a prolonged intensive care unit stay compared to the MMC group(7.2 d vs 4.4 d;P=0.035).Regarding univariate analysis of survival,we found primary tumour factors,nodal positivity and resection margins to be of prognostic value as well as peritoneal cancer index(PCI)-score and the completeness of cytoreduction regarding peritoneal carcinomatosis.Multivariate analysis of survival confirmed primary distant metastasis and primary tumour resection status to have a significant impact on survival and likewise peritoneal cancer index-scoring regarding peritoneal carcinomatosis.CONCLUSION In this single-institution retrospective review of patients undergoing CRS with either oxaliplatin or MMC HIPEC,overall survival was not different,though oxaliplatin was associated with a higher postoperative complication rate,indicating treatment favourably with MMC.Further studies comparing HIPEC regimens would improve evidence-based decision-making. | Julia Spiegelberg Hannes Neeff Philipp Holzner Mira Runkel Stefan Fichtner-Feigl Torben Glatz | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 3 |
| 2 | Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses显示文摘AIM: To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS: Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reperfusion. One group received the amino acid L-arginine before constructing the anastomosis (n = 9). On postoperative day 4, the rats were re-laparotomized, and bursting pressure, hydroxyproline concentration, intra-abdominal adhesions, and a histological score concerning the mucosal ischemic injury were collected. The data are given as median (range).RESULTS: On postoperative day 4, median bursting pressure was 124 mmHg (60-146 mmHg) in the control group. The experimental groups did not show a statistically significant difference (P > 0.05). Regarding the hydroxyproline concentration, we did not find any significant variation in the experimental groups. We detected significantly less mucosal injury in the RIPC groups. Furthermore, we assessed more extensive intra-abdominal adhesions in the preconditioned groups than in the control group. CONCLUSION: RIPC directly before performing small bowel anastomosis does not affect anastomotic stability in the early period, as seen in ischemic preconditioning. | Philipp Anton Holzner Birte Kulemann Simon Kuesters Sylvia Timme Jens Hoeppner Ulrich Theodor Hopt Goran Marjanovic | 2011 | World Journal of Gastroenterology2011，17，10： | 2 |
| 3 | HOXA11 DNA methylation-a novel prognostic biomarker in ovarian cancer显示文摘 | FIEGL H W1NDBICHLAER G MUELLER- HOLZNER E | 2008 | Int J Cancer2008，123，： | 1 |
| 4 | Tourism and Economic Development : The Beach Disease? 显示文摘 | Mario Holzner | 2011 | Tourism Management2011，，32： | 1 |
| 5 | Prognostic of CD44 splice variant expression in ovarian cancer显示文摘 | Uhl Steidl M Miiller Holzner E Zeimet AG | 1995 | Oncology1995，52，5： | 1 |
| 6 | The effects of a computer assisted cognitive training on neuropsychological parameters,mood and dysfunctional cognitions in depressive patients显示文摘 | Trebo E Holzner B Pircher M | | 0，，03： | 1 |
| 7 | Breast cancer in women:Evaluation of benign and malignant axillary lymph nodes with contrast - enhanced ultrasound 显示文摘 | Steppan I Reimer D Miiller - Holzner E | 2010 | Ultraschall Med2010，31，1： | 1 |
| 8 | Quality of life in breast cancer patients-not enougy attention for long-term survivors? 显示文摘 | Bernhard Holzner Georg Kemmler Martin Kopp | 2001 | Psyehosomatics Washington2001，42，2： | 1 |
| 9 | Tourism and economic development: The beach disease? 显示文摘 | Holzner M( 2011 ) | 2011 | Tourism Management2011，，： | 1 |
| 10 | The International Challenge to Education显示文摘 | Holzner Burkart | 1994 | International Education Forum1994，，4： | 1 |
| 11 | The AMT reliability and efficiency will be the key of the Chinese promotion显示文摘 | Joachim Holzner | 2008 | Spare Parts and Components2008，，8： | 1 |
| 12 | Search equilibrium and social and private returns to education显示文摘 | Christian Holzner Andrey Launov | 2010 | European Economic Review Volume 54 Issue 12010，2010，： | 1 |
| 13 | Circulating tumorspecific DNA:a marker for monitoring efficacy of adjuvant therapy in cancer patients显示文摘 | Fiegl H Millinger S Mueller Holzner E | 2005 | Cancer Res2005，65，4： | 1 |
| 14 | Distress in primary caregivers and patients listed for liver transplantation显示文摘 | Malik P Kohl C Holzner B | 2014 | Psychiatry Res2014，215，1： | 1 |
| 15 | Combined uptake of FDG and FMISO correlates with radiation therapy out-come in head-and-neck cancer patients 显示文摘 | Thorwarth D Eschmann SM Holzner F | 2006 | Radiother Oncol2006，80，2： | 1 |
| 16 | Ovarian preservation in the surgical treatment of cervical carcinoma显示文摘 | Windbichler GH Muller Holzner E Nicolussi Leck G | 1999 | Am J Obstet Gynecol1999，180，： | 1 |
| 17 | Preoperative expectations and postoper -ative quality of life in liver transplant survivors显示文摘 | Holzner B Kemmler G Kopp M | | 0，，01： | 1 |
| 18 | Thermal scanning probe lithography-a review显示文摘Fundamental aspects and state-of-the-art results of thermal scanning probe lithography(t-SPL)are reviewed here.t-SPL is an emerging direct-write nanolithography method with many unique properties which enable original or improved nano-patterning in application fields ranging from quantum technologies to material science.In particular,ultrafast and highly localized thermal processing of surfaces can be achieved through the sharp heated tip in t-SPL to generate high-resolution patterns.We investigate t-SPL as a means of generating three types of material interaction:removal,conversion,and addition.Each of these categories is illustrated with process parameters and application examples,as well as their respective opportunities and challenges.Our intention is to provide a knowledge base of t-SPL capabilities and current limitations and to guide nanoengineers to the best-fitting approach of t-SPL for their challenges in nanofabrication or material science.Many potential applications of nanoscale modifications with thermal probes still wait to be explored,in particular when one can utilize the inherently ultrahigh heating and cooling rates. | Samuel Tobias Howell Anya Grushina Felix Holzner Juergen Brugger | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
| 19 | Tourism and Economic Development:The Beach Disease显示文摘 | Holzner M | | 0，，04： | 1 |
| 20 | A hybrid brain-computer in-terface for smart home control显示文摘 | Edlinger G Holzner C Guger C | | 0，，： | 1 |
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