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| 1 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 2 | Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia显示文摘AIM To assess the use of serum levels of angiopoietin-1(Ang1), Ang2 and tumor necrosis factor-α(TNFα) as predictive factors for small bowel angiodysplasia(SBA).METHODS Serum samples were collected from patients undergoing capsule endoscopy for any cause of obscure gastrointestinal bleeding(OGIB) or anaemia. Based on small bowel findings patients were divided into 3 groups:(1) SBA;(2) other bleeding causes; and(3) normal, according to diagnosis. Using ELISA technique we measured serum levels of Ang1, Ang2 and TNFα and compared mean and median levels between the groups based on small bowel diagnosis. Using receiver operator curve analysis we determined whether any of the factors were predictive of SBA.RESULTS Serum samples were collected from a total of 120 patients undergoing capsule endoscopy for OGIB or anaemia: 40 with SBA, 40 with other causes of small bowel bleeding, and 40 with normal small bowel findings. Mean and median serum levels were measured and compared between groups; patients with SBA had significantly higher median serum levels of Ang2(3759 pg/mL) compared to both other groups, with no significant differences in levels of Ang1 or TNFα based on diagnosis. There were no differences in Ang2 levels between the other bleeding causes(2261 pg/mL) and normal(2620pg/mL) groups. Using Receiver Operator Curve analysis, an Ang2 level of > 2600 pg/mL was found to be predictive of SBA, with an area under the curve of 0.7. Neither Ang1 or TNFα were useful as predictive markers.CONCLUSION Elevations in serum Ang2 are specific for SBA and not driven by other causes of bleeding and anaemia. Further work will determine whether Ang2 is useful as a diagnostic or prognostic marker for SBA. | Grainne Holleran Mary Hussey Sinead Smith Deirdre McNamara | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 3 |
| 3 | A prospective 52week mucosal healing assessment of small bowel Crohn’s disease as detected by capsule endoscopy显示文摘 | Barry Hall Grainne Holleran Jun-Liong Chin Sinead Smith Barbara Ryan Nasir Mahmud Deirdre McNamara | 2014 | Journal of Crohn’s and Colitis2014，，： | 3 |
| 4 | Measurements of Acute Cerebral Infarction: A Clinical Examination Scale显示文摘 | Thomas Brott Harold P. Adams Charles P. Olinger John R. Marler William G. Barsan José Biller Judith Spilker Renee Holleran Robert Eberle Vicki Hertzberg Marvin Rorick Charles J. Moomaw Michael Walker | 1989 | Stroke1989，，7： | 2 |
| 5 | Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation 显示文摘 | Treister NS Woo SB O'Holleran EW | 2005 | Biol Blood Marrow Transplant2005，11，9： | 1 |
| 6 | Difficult venous access in children:taking control显示文摘 | Kuensting LL DeBoer S Holleran R | | 0，，05： | 1 |
| 7 | Effects of dynamic step- ping training on nonlocomotor tasks in individuals poststroke显示文摘 | Straube DD Holleran CL Kinnaird CR | 2014 | Phys Ther2014，94，7： | 1 |
| 8 | Inhibition of human scleral fibroblast proliferation with heparin显示文摘 | Del Vecchio PJ Bizios R Holleran LA | 1988 | Invest Ophthalmol Vis Sci1988，29，： | 1 |
| 9 | Private incentives foradopting food safety and quality assurance显示文摘 | Holleran E M E Bredahl L Zaibet | 1999 | Food Policy1999，，24： | 1 |
| 10 | Complexity of the thoracic spine pedicle anatomy显示文摘 | Panjabi MM O Holleran JD Crisco JJ 3rd | 1997 | Eur Spine J1997，6，1： | 1 |
| 11 | Internal architecture of the thoracic pediele显示文摘 | Kothe R O'Holleran J Liu W | 1996 | Spine1996，21，： | 1 |
| 12 | Small bowel angiodysplasia and novel disease associations: a cohort study显示文摘 | Grainne Holleran Barry Hall Mary Hussey Deirdre McNamara | 2013 | Scandinavian Journal of Gastroenterology2013，，4： | 1 |
| 13 | Autonomic nervous system influences on QT interval in normal subjects显示文摘 | Magnano AR Holleran S Ramakrishnan R | 2002 | J Am Coll Cardiol2002，39，11： | 1 |
| 14 | Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance显示文摘 | Elizabeth R. Glaze Amy L. Lambert Adaline C. Smith John G. Page William D. Johnson David L. McCormick Alan P. Brown Barry S. Levine Joseph M. Covey Merrill J. Egorin Julie L. Eiseman Julianne L. Holleran Edward A. Sausville Joseph E. Tomaszewski | 2005 | Cancer Chemotherapy and Pharmacology2005，，6： | 1 |
| 15 | Properties of polymer modified binders and relationship to mix and pavement performance显示文摘 | MACCARRONE S HOLLERAN G GNANASEELAN G P | 1995 | AAPT1995，76，： | 1 |
| 16 | Characterization of Angiotensin II Molecular Determinants Involved in AT1 Receptor Functional Selectivity显示文摘 | Domazet I Holleran B J Richard A | 2015 | Mol Pharmacol2015，87，6： | 1 |
| 17 | Inhibition of human scleral fibroblast proliferation with heparin显示文摘 | Del Vecehio PJ Bizios R Holleran LA | | 0，，： | 1 |
| 18 | Change in lipid profile in celiac disease:beneficial effect of gluten-free diet显示文摘 | Brar P Kwon GY Holleran S | 2006 | Am J Med2006，119，9： | 1 |
| 19 | Barrier function regulates ep- idermal lipid and DNA synthesis 显示文摘 | Proksch E Holleran WM Menon GK | 1993 | Br J Dermatol1993，128，5： | 1 |
| 20 | Internal architecture ofthe thoracic pedicle显示文摘 | Kothe R O′ Holleran J Liu W | 1996 | Spine1996，21，3： | 1 |
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