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125篇 您的检索式：作者名="Hoek H"

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	题名	作者	年代	出处	被引量
1	Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner显示文摘AIM:To investigate the role of osteopontin(OPN) and its splice variants in the proliferation of hepatocellular carcinoma(HCC).METHODS:The expression of OPN variants in HCC cell lines as well as HCC tissue samples and nontumour tissue was studied using polymerase chain reaction.OPN variant cDNAs were cloned into a mammalian expression vector allowing both transient expression and the production of stable OPN expressing cell lines.OPN expression was studied in these cells using Western blotting,immunofluoresnce and enzyme linked immunosorbent assay.A CD44 blocking antibody and siRNA targeting of CD44 were used to examine the role of this receptor in the OPN stimulated cell growth observed in culture.Huh-7 cells stably expressing either OPN-A,-B or-C were injected subcutaneously into the flanks of nude mice to observe in vivo tumour growth.Expression of OPN mRNA and protein in these tumours was examined using reverse transcriptionpolymerase chain reaction and immunohistochemistry.RESULTS:OPN is expressed in HCC in 3 forms,the full length OPN-A and 2 splice variants OPN-B and-C.OPN variant expression was noted in HCC tissue as well as cognate surrounding cirrhotic liver tissue.Expression of these OPN variants in the HCC derived cell line Huh-7 resulted in secretion of OPN into the culture medium.Transfer of OPN conditioned media to na ve Huh-7 and HepG2 cells resulted in significant cell growth suggesting that all OPN variants can modulate cell proliferation in a paracrine manner.Furthermore the OPN mediated increase in cellular proliferation was dependent on CD44 as only CD44 positive cell lines responded to OPN conditioned media while siRNA knockdown of CD44 blocked the proliferative effect.OPN expression also increased the proliferation of Huh-7 cells in a subcutaneous nude mouse tumour model,with Huh-7 cells expressing OPN-A showing the greatest proliferative effect.CONCLUSION:This study demonstrates that OPN plays a significant role in the proliferation of HCC through interaction with the cell surface receptor CD44.Modulation of this interaction could represent a novel strategy for the control of HCC.	Renee J Phillips Karla J Helbig Kylie H Van der Hoek Devanshi Seth Michael R Beard	2012	World Journal of Gastroenterology2012，18，26：	12
2	Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘	Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek	2014	The Lancet2014，，：	2
3	The use of biological activated carbon filtration for the removal of natural organic matter and organic micropollutants from water 显示文摘	J P van der Hoek J A M H Hofman A Graveland	1999	Water Science and Technology1999，40，9：	1
4	Real-time continuous glucose monitoring system for treatment of diabetes:a systematic review显示文摘	HOEKS L B GREVEN W L D E VALK H W	2011	Diabet Med2011，28，4：	1
5	Long term capacity of biological activated carbon filtration for organics removal 显示文摘	Bonne P A C Hofman J A M H van der Hoek J P	2002	Water Supply2002，2，1：	1
6	Mycoplasma pneumoniae -induced activation and cytokine produ- ction in rodent mast cells 显示文摘	HOEK K L CASSELL G H DUFFY L B	2002	J Allergy Clin Immunol2002，109，3：	1
7	Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes 显示文摘	Shao Z H Li C Q Vanden Hoek T L	1999	JMol Cell Cardiol1999，31，10：	1
8	Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘	Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G	2013	Lancet Oncol2013，14，9：	1
9	Baicalein attenuates oxidant stress in cardiomyocytes 显示文摘	Shao Z H Vanden Hoek T L Qin Y M	2002	Am J Physiol-Heart Circulatory Physiol2002，282，3：	1
10	Model of brain rhythmic activity显示文摘	Lopes da Silva F H Hoeks A Smits H	1974	Biological Cybernetics1974，15，1：	1
11	Role of third party logistic services in customization through postponement 显示文摘	Van Hoek R H	2000	International Journal of Service Industry Management2000，11，4：	1
12	Review of the prevalence and incidence of eating disorders显示文摘	HOEK H W VAN H D	2003	Int J Eat Disord2003，34，：	1
13	A role for the Mycoplasma pneumoniae adhesin P1 in interleukin(IL)-4 synthesis and release from rodent mast cell显示文摘	Hoek K L Duffy L B Cassell G H		0，，04：	1
14	Reconfiguring logistics system through postponement strategies显示文摘	Commandeur H R Voss B	1998	Journal of Business Logistics1998，19，1：	1
15	TNF-ct signalling and inflammation: interactions between old acquaintances 显示文摘	Zelov H Hoek J	2013	InfRes2013，62，7：	1
16	Traffic-related differences in outdoor and indoor concentrations of particles and volatile organic compounds in Amsterdam显示文摘	Fischer P H Hoek G van Reeuwijk H	2000	Atmospheric Environment2000，34，22：	1
17	Characterization of particulate air pollution in urban and non-urban areas in the Netherlands显示文摘	Van Der Zee S Hoek G Harssema H	1998	Atmospheric Environment1998，32，21：	1
18	How do tobacco retail displays affect cessation attempts:findings from a qualitative study显示文摘	Hoek J Gifford H Pirikahu G	2010	Tob Control2010，19，：	1
19	Mean shifts,unit roots and forecasting seasonal time series显示文摘	Paap R Franses P H Hoek H	1997	International Journal of Forecasting1997，13，：	1
20	Effects of interleukin(IL-6)on luteinizing hormone and IL-1beta-induced ovulation and steroidogenesis in the rat ovary显示文摘	van der Hoek K H Woodhouse C M Brannstrom M	1998	Biology of reproduction1998，58，：	1

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