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| 1 | Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity显示文摘AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic patients.METHODS Twenty patients(12 men and 8 women; median age, 66.8 years; range, 46-81 years) with decompensated cirrhosis(Child-pugh score > 7) underwent cognitive neuropsychological testing, endotoxin analysis, and fecal microbiome assessment at baseline and after 4 wk of treatment with rifaximin 400 mg thrice a day. HE was determined by serum ammonia level and number connection test(NCT)-A. Changes in whole blood endotoxin activity(EA) was analyzed by endotoxinactivity assay. Fecal microbiome was assessed by 16 S ribosome RNA(rR NA) gene sequencing.RESULTS Treatment with rifaximin for 4 wk improved hyperammonemia(from 90.6 ± 23.9 μg/d L to 73.1 ± 33.1 μg/dL; P < 0.05) and time required for NCT(from 68.2 ± 17.4 s to 54.9 ± 20.3 s; P < 0.05) in patients who had higher levels at baseline. Endotoxin activity was reduced(from 0.43 ± 0.03 to 0.32 ± 0.09; P < 0.05) in direct correlation with decrease in serum ammonia levels(r = 0.5886, P < 0.05). No statistically significant differences were observed in the diversity estimator(Shannon diversity index) and major components of the gut microbiome between the baseline and after treatment groups(3.948 ± 0.548 at baseline vs 3.980 ± 0.968 after treatment; P = 0.544), but the relative abundances of genus Veillonella and Streptococcus were lowered.CONCLUSION Rifaximin significantly improved cognition and reduced endotoxin activity without significantly affecting the composition of the gut microbiome in patients with decompensated cirrhosis. | Kosuke Kaji Hiroaki Takaya Soichiro Saikawa Masanori Furukawa Shinya Sato Hideto Kawaratani Mitsuteru Kitade Kei Moriya Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji | 2017 | World Journal of Gastroenterology2017，23，47： | 14 |
| 2 | Spontaneous regression of hepatic inflammatory pseudotumor with primary biliary cirrhosis:Case report and literature review显示文摘肝的煽动性的假肿瘤(IPT ) 是煽动性的房间渗入的增殖的纤维组织描绘的稀罕良性的非肿瘤的损害。IPT 的准确病原学仍然保持不清楚。尽管有全身的煽动性的混乱的 IPT 的协会很好被建立了,有胆管炎的一种特殊关系是显然稀罕的。我们与主要胆汁性肝硬变(PBC ) 报导肝的 IPT 的自发的回归的一个案例。迄今为止,仅仅有 PBC 的 IPT 的二个案例被报导了。在我们的情况中,然而, IPT 在有效治疗导致的 PBC 的胆管炎的改进的功课期间发展了,不同于二个以前报导的案例。我们的案例显示 IPT 的发展也不联系到胆管炎或亢奋的 gamma-globulinemia 的活动,自从我们的案例被证实当胆汁的酶和免疫球蛋白比承认上的相应价值高得多时,没有 IPT 的放射线学的联盟者。我们有二个以前报导的案例的案例的比较建议与 PBC 发生的 IPT 不代表一样的疾病实体或是为 PBC 的一个旁观者。 | Hiroshi Koide Ken Sato Toshio Fukusato Kenji Kashiwabara Noriaki Sunaga Takafumi Tsuchiya Saeko Morino Naondo Sohara Satoru Kakizaki Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，10： | 12 |
| 3 | Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume ”显示文摘MK615, a compound extracted from the Japanese apricot 'Prunus mume ' has been reported to have in vitro anti-tumor activities against several cancer cell lines,including hepatocellular carcinoma(HCC). However, the clinical effects and feasibility of administering MK615for patients with HCC were unknown. We experienced a case with advanced HCC for which MK615 was effective against both lymph node and pulmonary metastases. A 60-year-old female underwent surgical resection of a 9 cm HCC in the right lobe. The pathological diagnosis was moderately differentiated HCC with vascular invasion. The HCC recurred in the liver 8 mo after the surgery. Radiofrequency ablation and transarterial infusion chemotherapy were performed, but the recurrence was not controlled. One year after the intrahepatic recurrence, pulmonary and lymph metastasis appeared.Sorafenib was administered, but was not effective.Then, MK615 was administered as a final alternative therapy after informed consent was obtained from the patient. Three months later, her alpha-fetoprotein level decrease and both the lymph node and pulmonary metastases decreased in size. The patient has survived for more than 17 mo after the MK615 administration, and was in good condition. Although further investigations are necessary to clarify its safety and efficacy in humans, MK615 may be useful for the treatment of HCC,without serious adverse effects. | Takashi Hoshino Hitoshi Takagi Atsushi Naganuma Eri Koitabashi Sanae Uehara Naomi Sakamoto Tomohiro Kudo Ken Sato Satoru Kakizaki | 2013 | World Journal of Hepatology2013，5，10： | 7 |
| 4 | Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival显示文摘瞄准:80 年或更多与肝细胞癌(HCC ) 识别病人的临床、预示的特征。方法:有 HCC 的 1310 个病人的一个总数在这研究被包括。80 年或更多的 91 个病人在 HCC 的诊断的时候被定义为极其老的组。>
或 = 的 234 个病人 50 年但是不到 60 年被认为是非老的组。结果:两性比率(到女性的男性) 比在非老的组在极其老的组(0.90:1 ) 是显著地更低的(3.9:1, P <
0.001 ) 。为 HBsAg 的积极的率在极其老的组和为显然在极其老的组增加的 HBsAg 和 HCVAb 否定的病人的比例是显著地更低的(P <
0.001 ) 。在下列参数没有有效差量:肿瘤,分级的孩子呸,肿瘤阶段,门静脉血栓形成或腹水的存在,和为 HCVAb 的积极的率的直径和数字。极其老的病人经常没收到外科疗法(P <
0.001 ) 并且他们是更可能的收到保守疗法(P <
0.01 ) 。基于与在二个组之间的全面病人比较的 Kaplan-Meier 方法在幸存曲线没有有效差量。然而,幸存曲线在有阶段 I/II 的极其老的病人是显著地更坏的,上演 I/II,孩子呸分级与非老的组比较的肝硬化。死亡的原因没在病人之中不同,并且大多数盒子甚至在极其老的病人死于肝相关的疾病。结论:在有好肝功能和好表演地位的病人,为 HCC 的好攻击的治疗可能改进幸存率,甚至在极其老的病人。 | Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 5 | Multilinear Fractional Integrals on Morrey Spaces显示文摘In the present paper we obtain and extend the boundedness property of the Adams type for multilinear fractional integral operators. Also, we deal with the Olsen type inequality. | Takeshi IIDA Enji SATO Yoshihiro SAWANO Hitoshi TANAKA | 2012 | Acta Mathematica Sinica,English Series2012，28，7： | 3 |
| 6 | Comparison between surgical outcomes of colorectal cancer in younger and elderly patients显示文摘AIM:To compare the outcome of surgical treatment of colorectal adenocarcinoma in elderly and younger patients.METHODS:The outcomes of 122 patients with colorectal adenocarcinoma who underwent surgical treatment between January 2004 and June 2009 were analyzed.The clinicopathological and blood biochemistry data of the younger group(<75 years) and the elderly group (≥75 years) were compared.RESULTS:There were no significant differences between the two groups in operation time,intraoperative blood loss,hospital stay,time to resumption of oral intake,or morbidity.The elderly group had a significantly higher rate of hypertension and cardiovascular disease.The perioperative serum total protein and albumin levels were significantly lower in the elderly than in the younger group.The serum carcinoembryonic antigen level was lower in the elderly than in the younger group,and there was a significant decreasing trend after the operation in the elderly group.CONCLUSION:The short-term outcomes of surgical treatment in elderly patients with colorectal adenocarcinoma were acceptable.Surgical treatment in elderly patients was considered a selectively effective approach. | Longxue Jin Norio Inoue Naoki Sato Susumu Matsumoto Hitoshi Kanno Yuko Hashimoto Kazuhiro Tasaki Kinya Sato Shun Sato Katsutoshi Kaneko | 2011 | World Journal of Gastroenterology2011，17，12： | 3 |
| 7 | Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography显示文摘 | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Eriko Goto Takahisa Sato Takamasa Ohki Jun Imamura Tadashi Goto Fumihiko Kanai Naoya Kato Hitoshi Ikeda Shuichiro Shiina Takao Kawabe Masao Omata | 2009 | Hepatology2009，，： | 2 |
| 8 | 多层螺旋CT计算心室容积的准确性及最佳层厚选择显示文摘目的(1)确定Simpson方法计算心室容积的最佳层厚;(2)评价多层螺旋CT计算心室容积的准确性。方法采用多层螺旋CT(东芝Aquilion)扫描系统对14个人的左室铸型和15个右室铸型进行扫描。分别以2.0、3.5、5.0、7.0及10.0mm层厚重建左、右心室短轴多平面重组(multiplanarreformattedimage,MPR)图像。采用标准Simpson法计算左、右心室铸型的容积。心室铸型的实际容积通过铸型排除水的容量来计算。结果各层厚计算的心室容积均高估相应心室的实际容积[左心室高估值介于(3.21±5.95)ml至(12.58±8.56)ml之间,右心室高估值介于(10.22±8.45)ml至(23.91±12.24)ml之间]。各层厚计算的心室容积均与相应的实际心室容积高度相关(左心室r值均>0.97,右心室r值均>0.95);心室容积的高估程度与选择的层厚呈显著正相关(左心室r=0.998,右心室r=0.996)。当层厚降至5mm时,计算的心室容积对实际容积的高估值与2mm层厚相比不再差异有统计学意义。结论采用多排Simpson法计算左、右心室容积时,5mm层厚是最有效率的层厚。MSCT可以准确计算左、右心室容积。 | 崔炜 Takeshi Kondo Hirofumi Anno 郭玉印 Takahisa Sato Masayoshi Sarai Hitoshi Shinozaki Satoshi Kakizawa Atsushi Sugiura Keita Oshima Kazuhiro Katada Hitoshi Hishida | 2005 | 中华放射学杂志2005，39，12： | 2 |
| 9 | Overexpression of NK2 inhibits liver regeneration after partial hepatectomy in mice显示文摘AIM: To investigate the in vivo effects of NK2 on liver regeneration after partial hepatectomy (PH). METHODS: Survival after PH was observed with 21 NK2 transgenic mice and 23 wild-type (WT) mice over 10 d. Liver regeneration was analyzed using histology and immunohistochemistry. Expressions of genes were analyzed using Northern blot analysis, immunoprecipitation and immunoblotting, and reverse transcriptase polymerase chain reaction assay. KaplanMeier method and the log-rank test were used for ahalyzing the survival after PH. Differences in the resultsof immunohistochemistry and percentage of liver regeneration was determined by the Student's t-test. RESULTS: More than half of NK2 transgenic mice died within 48 h after PH. After PH, increased deposition of small lipid droplets in hepatocytes was evident and hepatic proliferation was inhibited in NK2 transgenic mice. The hepatic expression and kinase activity of HGF receptor, c-Met, were unchanged among WT mice and NK2 transgenic mice after PH. The expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in liver tissues were prolonged in NK2 transgenic mice that died after PH.CONCLUSION: Our findings indicate that overexpression of NK2 inhibits liver regeneration after PH. | Toshiyuki Otsuka Norio Horiguchi Daisuke Kanda Takashi Kosone Yuichi Yamazaki Kazuhisa Yuasa Naondo Sohara Satoru Kakizaki Ken Sato Hitoshi Takagi Glenn Merlino Masatomo Mori | 2005 | World Journal of Gastroenterology2005，11，47： | 2 |
| 10 | Clinical characteristics of null responders to Peg-IFNα2b/ ribavirin therapy for chronic hepatitis C显示文摘AIM: To predict which chronic hepatitis C patients are likely to be late-responders, we herein investigated the clinical characteristics of null-responders at 36 wk with hepatitis C virus (HCV) genotype Ib and a high viral load during the course of pegylated interferon (Peg-IFN)/ ribavirin ther apy. METHODS: One hundred forty-two patients with genotype Ib HCV and a high viral load were included in this study. Peg-IFNα2b (1.5 μg/kg once a week) and ribavirin (600-1000 mg per day according to body weight) were administered for 48 wk. We def ined nullresponders as the cases that never cleared serum HCV RNA as determined using RT-PCR until 36 wk. Other patients were def ined as responders. We compared the clinical characteristics (age, gender, body mass index, previous treatment) and HCV RNA titer during the therapy between null-responders and responders.RESULTS: The HCV RNA clearance rate was 17.9% (24/134), 46.3% (62/134), 60.6% (86/142), 86.6% (123/142), and 88.0% (125/142) at 4, 8, 12, 24, and 36 wk, respectively. There were 17 patients (12.0%) who were still null-responders at 36 wk. There were no differences in the clinical characteristics between the responders and null-responders except for the titer and decline rates of HCV RNA at 1 wk and 4 wk. The HCV RNA titers at 1 wk and after 4 wk of treatment were significantly higher in the null-responders in comp arison to the responders (P <0.01). The serum HCV RNA titers of the responders decreased by 1.3 log after 1 wk of treatment, and 1.6 log after 4 wk of treatm ent, respectively. On the other hand, the titers of the null responders decreased by only 0.5 log after 1 wk, and 0.7 log after 4 wk of treatment, respectively. The decrease rates of HCV RNA after 1 and 4 wk of treatm ent were signif icantly worse for null responders than for the responders (P <0.01). CONCLUSION: The HCV RNA titer at 1 wk and 4 wk after initiating treatment may be useful for predicting null-responders to Peg-IFNα2b/ribavirin therapy. However, further investigation is needed to determine the optimal time at which the decision to discontinue the Peg-IFNα2b/ribavirin therapy for null-responders can be made. | Hideyuki Suzuki Satoru Kakizaki Norio Horiguchi Takeshi Ichikawa Ken Sato Hitoshi Takagi Masatomo Mori | 2010 | World Journal of Hepatology2010，2，11： | 2 |
| 11 | Evaluation of diagnostic cytology via endoscopic naso-pancreatic drainage for pancreatic tumor显示文摘AIM: To evaluate the usefulness of cytology of the pancreatic juice obtained via the endoscopic naso-pancreatic drainage tube(ENPD-C).METHODS: ENPD was performed in cases where a diagnosis could not be made other than by using en-doscopic retrograde cholangiopancreatography and in cases of pancreatic neoplasms or cystic tumors, includ-ing intraductal papillary mucinous neoplasm(IPMN) suspected to have malignant potential. 35 patients(21 males and 14 females) underwent ENPD between January 2007 and June 2013. The pancreatic duct was imaged and the procedure continued in one of ENPD-C or ENPD-C plus brush cytology(ENPD-BC). We checked the cytology result and the final diagnosis.RESULTS: The mean patient age was 69 years(range, 48-86 years). ENPD-C was performed in 24 cases andENPD-C plus brush cytology(ENPD-BC) in 11 cases. The ENPD tube was inserted for an average of 3.5 d. The final diagnosis was confirmed on the basis of the resected specimen in 18 cases and of follow-up findings at least 6 mo after ENPD in the 18 inoperable cases. Malignancy was diagnosed in 21 cases and 14 patients were diagnosed as having a benign condition. The ratios of class Ⅴ/Ⅳ:Ⅲ:Ⅱ/Ⅰ?findings were 7:7:7 in malignant cases and 0:3:11 in benign cases. The sensitivity and specificity for all patients were 33.3% and 100%, re-spectively. The cytology-positive rate was 37.5%(6/16) for pancreatic cancer. For IPMN cases, the sensitivity and specificity were 33% and 100%, respectively.CONCLUSION: Sensitivity may be further increased by adding brush cytology. Although we can diagnosis cancer in cases of a positive result, the accuracy of ENPD-C remains unsatisfactory. | Tomoyuki Iwata Katsuya Kitamura Akira Yamamiya Yu Ishii Yoshiki Sato Tomohiro Nomoto Akitoshi Ikegami Hitoshi Yoshida | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，8： | 1 |
| 12 | Transmesosigmoid Hernia: Report of a Case显示文摘 | Takamitsu Sasaki Koutaro Sakai Daisuke Fukumori Masayuki Sato Hitoshi Ohmori Fumio Yamamoto | 2002 | Surgery Today2002，，12： | 1 |
| 13 | Magnetic properties of carbon nanotubes grown on Fe catalyst layer by microwave plasma enhanced chemical vapor deposition显示文摘 | Yuji Fujiwara Hitoshi Takegawa Hideki Sato | 2004 | J Appl Phys2004，95，： | 1 |
| 14 | Investigation of Musashi-1 Expressing Cells in the Murine Model of Dextran Sodium Sulfate-Induced Colitis显示文摘 | Tadahisa Fukui MD Hiroaki Takeda MD Hong-Jin Shu MD Katsuyoshi Ishihama MD Sayaka Otake MD Yasukuni Suzuki MD Shoichi Nishise MD Nanami Ito MD Takeshi Sato MD Hitoshi Togashi MD Sumio Kawata MD | 2006 | Digestive Diseases and Sciences2006，，7： | 1 |
| 15 | Prophylactic treatment of cytomegalovirus infection with traditional herbs显示文摘 | Tomoyo A. Yukawa Masahiko Kurokawa Hitoshi Sato Yoshihiro Yoshida Seiji Kageyama Tomomi Hasegawa Tuneo Namba Masami Imakita Toyoharu Hozumi Kimiyasu Shiraki | 1996 | Antiviral Research1996，，2： | 1 |
| 16 | Primary liver cancers with nonalcoholic steatohepatitis显示文摘 | Hiroaki Hashizume Ken Sato Hitoshi Takagi Tomoyuki Hirokawa Akira Kojima Naondo Sohara Satoru Kakizaki Yasushi Mochida Tatsuo Shimura Yutaka Sunose Susumu Ohwada Masatomo Mori | 2007 | European Journal of Gastroenterology & Hepatology2007，，10： | 1 |
| 17 | β‐amyloid in lewy body disease is related to Alzheimer’s disease‐like atrophy显示文摘 | Hitoshi Shimada Hitoshi Shinotoh Shigeki Hirano Michie Miyoshi Koichi Sato Noriko Tanaka Tsuneyoshi Ota Kiyoshi Fukushi Toshiaki Irie Hiroshi Ito Makoto Higuchi Satoshi Kuwabara Tetsuya Suhara | 2012 | Mov Disord2012，，： | 1 |
| 18 | Tachycardia-dependent augmentation of “notched J waves” in a general patient population without ventricular fibrillation or cardiac arrest: Not a repolarization but a depolarization abnormality?显示文摘 | Yoshifusa Aizawa Masahito Sato Hitoshi Kitazawa Yoshiyasu Aizawa Seiji Takatsuki Eiji Oda Masaaki Okabe Keiichi Fukuda | 2015 | Heart Rhythm2015，，2： | 1 |
| 19 | Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats显示文摘 | Vilasinee Hirunpanich Anocha Utaipat Noppawan Phumala Morales Nuntavan Bunyapraphatsara Hitoshi Sato Angkana Herunsale Chuthamanee Suthisisang | 2005 | Journal of Ethnopharmacology2005，，： | 1 |
| 20 | The superiority of ratio-based lymph node staging in gastric carcinoma显示文摘 | Kentaro Inoue MD Yasushi Nakane MD Hitoshi Iiyama MD Mutsuya Sato MD Tatsuya Kanbara MD Koji Nakai MD Syunichiro Okumura MD Keigo Yamamichi MD Koshiro Hioki MD | 2002 | Annals of Surgical Oncology2002，，1： | 1 |
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