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| 1 | Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis显示文摘AIM To elucidate the role of proton pump inhibitors(PPIs) in collagenous disease, direct effect of PPI on colonocytes was examined.METHODS Collagenous colitis is a common cause of non-bloody, watery diarrhea. Recently, there has been increasing focus on the use of proton PPIs as a risk factor for developing collagenous colitis. Mouse CT26 colonic cells were treated with PPI and/or PPI-induced alkaline media. Expression of fibrosis-associated genes was examined by RT-PCR. In human materials, collagen expression was examined by immunohistochemistry.RESULTS CT26 cells expressed a Na+-H+ exchanger gene(solute carrier family 9, member A2). Treatment with PPI and/or PPI-induced alkaline media caused growth inhibition and oxidative stress in CT26 cells. The treatment increased expression of fibrosis inducing factors, transforming growth factor β and fibroblast growth factor 2. The treatment also decreased expression of a negative regulator of collagen production, replication factor C1, resulting in increased expression of collagen types Ⅲ and Ⅳ in association with lipid peroxide. In biopsy specimens from patients with collagenous colitis, type Ⅲ and Ⅳ collagen were increased. Increase of type Ⅲ collagen was more pronounced in PPI-associated collagenous colitis than in non-PPI-associated disease. CONCLUSION From these findings, the reaction of colonocytes to PPI might participate in pathogenesis of collagenous colitis. | Shiori Mori Yui Kadochi Yi Luo Rina Fujiwara-Tani Yukiko Nishiguchi Shingo Kishi Kiyomu Fujii Hitoshi Ohmori Hiroki Kuniyasu | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | A high quality surface finish grinding process to produce total reflection mirror for x-ray fluorescence analysis显示文摘Total reflection x-ray fluorescence analysis is applied to trace element detection in liquid for effective environmental monitoring.This analytical approach requires x-ray total reflection mirrors.In order to achieve high sensitivity element detection,the mirrors require high surface quality for high x-ray reflectivity.Surface finishing for x-ray mirrors is typically conducted through a series of abrasive processes,such as grinding and polishing,and is thus time consuming.The purpose of this study is to streamline and enhance the surface finishing process based on unique high quality grinding techniques for the production of x-ray total reflection mirrors. | Hitoshi Ohmori Shinjiro Umezu Yunji Kim Yoshihiro Uehara Hiroshi Kasuga Teruko Kato Nobuhide Itoh Syuhei Kurokawa Takayuki Kusumi Yugo Sugawara Shinsuke Kunimura | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 2 |
| 3 | ELID grinding characteristics of glass-ceramic materials显示文摘 | Shaohui Yin Hitoshi Ohmori Yutang Dai Yoshihiro Uehara Fengjun Chen Hengning Tang | 2008 | International Journal of Machine Tools and Manufacture2008，，3： | 2 |
| 4 | Peritoneal metastasis inhibition by linoleic acid with activation of PPARγ in human gastrointestinal cancer cells显示文摘 | Takamitsu Sasaki Kiyomu Fujii Kazuhiro Yoshida Hideo Shimura Tomonori Sasahira Hitoshi Ohmori Hiroki Kuniyasu | 2006 | Virchows Archiv2006，，4： | 1 |
| 5 | Transmesosigmoid Hernia: Report of a Case显示文摘 | Takamitsu Sasaki Koutaro Sakai Daisuke Fukumori Masayuki Sato Hitoshi Ohmori Fumio Yamamoto | 2002 | Surgery Today2002，，12： | 1 |
| 6 | Nano-precision combined process of electrolytic in-process dressing grinding and magnetic assisted polishing on optics glass material显示文摘This study is focused on the application of an effective fabrication method combining electrolytic in-process dressing(ELID) grinding and magnetic assisted polishing(MAP) to nano-precision mirror surface grinding on the optics glass-ceramic named Zerodure that is commonly used in precision optics components. The results show the variation of surface roughness after MAP processes utilizing Fe+CeO2, Fe+CeO2+diamond paste and Fe+diamond paste are applied to ELID ground surfaces. The MAP surface roughnesses for ELID ground surface roughnesses(Ra) of 52.1, 39.8 and 51.1 nm using #1200 grinding wheel are improved to 6.1, 4.6 and 1.9 nm, respectively. The surface roughness of MAP process using Fe+CeO2+diamond paste is superior to that using other processes. Moreover, it takes less than 10 min to conduct the MAP processes. The combined method suggested effectively reduces the working time to get the required surface qualities. | Tae-Soo KWAK Yong-Chul LEE Gyung-Nyun KIM Dae-Bong CHOI Mikio YAMANOI Hitoshi OHMORI | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 1 |
| 7 | Ultra-precision Grinding of Optical Materials and Components Applying ELID显示文摘 | Ohmori Hitoshi | 1995 | Proceedings of SPIE-The International Society for Optical Engineering1995，，11： | 1 |
| 8 | Analysis of mirror surface generation of hard and brittle materials by ELID with superfine grain metallic bond wheels显示文摘 | Hitoshi Ohmori | 1995 | Annals of the CIRP1995，44，1： | 1 |
| 9 | Evaluation of surface characteristics of ground CVD - SiC using cast iron bond diamond wheels 显示文摘 | ZHANG Chunhe OHMORI Hitoshi KATO Teruko | 2001 | Precision Engineering2001，25，： | 1 |
| 10 | Small Bowel Obstruction Caused by Anisakiasis of the Small Intestine: Report of a Case显示文摘 | Takamitsu Sasaki Daisuke Fukumori Hisanobu Matsumoto Hitoshi Ohmori Fumio Yamamoto | 2003 | Surgery Today2003，，2： | 1 |
| 11 | Development of metal free conductive bonded diamond wheel for environmentallyfriendly electrolytic In-process Dressing(ELID) grinding显示文摘 | Itoh Nobuhide Ohmori Hitoshi | 2004 | New Diamond and Frontier Carbon Technology2004，14，4： | 1 |
| 12 | Operative Morbidity Associated with Groin Dissections显示文摘 | Hitoshi Tonouchi Yukinari Ohmori Minako Kobayashi Naomi Konishi Kouji Tanaka Yasuhiko Mohri Hitoshi Mizutani Masato Kusunoki | 2004 | Surgery Today2004，，5： | 1 |
| 13 | Colon Cancer Cell-Derived High Mobility Group 1/Amphoterin Induces Growth Inhibition and Apoptosis in Macrophages显示文摘 | Hiroki Kuniyasu Seiji Yano Takamitsu Sasaki Tomonori Sasahira Sabro Sone Hitoshi Ohmori | 2005 | The American Journal of Pathology2005，，3： | 1 |
| 14 | Trocar site hernia显示文摘 | Hitoshi Tonouchi Yukinari Ohmori Minako Kobayashi | 2004 | ARCH SURG2004，139，11： | 1 |
| 15 | Cylindrical grinding of bearing steel with electrolytic in-process dressing显示文摘 | Qian Jun Wei Li Hitoshi Ohmori | 2000 | Precision Engineering2000，24，2： | 1 |
| 16 | Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet显示文摘 | Takasumi Shimomoto Yi Luo Hitoshi Ohmori Yoshitomo Chihara Kiyomu Fujii Tomonori Sasahira Ayumi Denda Hiroki Kuniyasu | 2012 | Journal of Gastroenterology2012，，10： | 1 |
| 17 | MicroRNA-100-5pindirectly modulates the expression of 116, Ptgsl/2 and Tlr4 mRNA inthe mouse follicular dendritic cell-like cell line, FL-Y 显示文摘 | Susan R Aungier Hitoshi Ohmori Michael | 2015 | Immunology2015，144，1： | 1 |
| 18 | Successful treatment of refractory hepatic lymphorrhea after gastrectomy for early gastric cancer, using surgical ligation and subsequent OK-432 (Picibanil) sclerotherapy显示文摘 | Kouji Tanaka Yukinari Ohmori Yasuhiko Mohri Hitoshi Tonouchi Mina Suematsu Yukiko Taguchi Yukihiko Adachi Masato Kusunoki | 2004 | Gastric Cancer2004，，2： | 1 |
| 19 | Analysis of Surface Generation of Hard and Brittle Materials by ELID(Electronic in-Process Dressing)Grinding with Superfine Grain Metallic Bond Wheels显示文摘 | Hitoshi Ohmori Takeo Nakagawa | 1995 | Annals of the CIRP1995，44，1： | 1 |
| 20 | Study on ELID Grinding for Quartz Blank显示文摘 | Kiyoshi Sawada Akira Yamamoto Hitoshi Ohmori | 2001 | RIKEN Review2001，，34： | 1 |
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