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| 1 | Usefulness of noninvasive transient elastography for assessment of liver fibrosis stage in chronic hepatitis C显示文摘AIM:To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C (CHC). METHODS: Two hundred and thirty-seven patients with CHC were included in this study. Liver biopsy was performed under ultrasonography on 217 of the patients, excluding twenty with clear clinical evidence of liver cirrhosis. Fifty subjects without liver disease were enrolled as a control group (stage 0). Twenty- five patients with sustained virological response (SVR) to interferon (IFN) therapy were also enrolled. These patients underwent liver biopsy before IFN therapy. Examination of liver stiffness (LS) was performed by elastography. RESULTS: Medians (50% levels) of LS were 4.1 (3.5-4.9), 6.3 (4.8-8.5), 8.8 (6.8-12.0), 14.6 (10.5-18.6), and 22.2 (15.4-28.0), respectively, in the fibrosis stages 0-4 (P < 0.001). LS was significantly correlated with four serum fibrosis markers. LS values in patients with SVR were 3.8 (3.5-5.6), 5.2 (4.4-6.8), 6.8 (6.1-7.6), and 6.1 (3.6-7.9), respectively, in the fibrosis stages 1-4. In all stages, LS for patients with SVR was significantly lower than that for patients who did not undergo IFN therapy. LS was significantly correlated with serum concentrations of hyaluronic acid, type Ⅳ collagen, type Ⅳ collagen 7S, and type Ⅲ procollagen N peptide. CONCLUSION: LS correlated well with the histologicalstage of fibrosis. Changes in liver fibrosis stage may thus be estimated noninvasively using transient elastography. | Tadashi Takeda Takahiro Yasuda Yuji Nakayama Mika Nakaya Megumi Kimura Mariko Yamashita Ayumi Sawada Koji Abo Setsuko Takeda Hiroki Sakaguchi Susumu Shiomi Hitoshi Asai Shuichi Seki | 2006 | World Journal of Gastroenterology2006，12，48： | 16 |
| 2 | 楼梯间内人流合并特性研究(英文)显示文摘探讨了楼梯间内人流合并的影响以及随着人员密度的变化,合流方向和楼梯间与大厅之间门开启与关闭状态对人流合并难易程度的影响。研究结果表明:(1)人员密度小时合流较容易;(2)如果加入人流与楼梯内人员疏散方向相同时,人流合并较容易;(3)门处于开启状态时,合流较容易。如果门处于关闭状态,人员的疏散速度将降低30%。 | NAOHIRO TAKEICHI YOSHIYUKI YOSHIDA TOMONORI SANO TAKESHI KIMURA HITOSHI WATANABE YOSHIFUMI OHMIYA5 | 2007 | 消防科学与技术2007，26，4： | 2 |
| 3 | Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy显示文摘 | Daisuke Watanabe Kiyoshi Suzuma Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Masafumi Kurimoto Tomoaki Murakami Tetsushi Kimura Hitoshi Takagi | 2005 | American Journal of Ophthalmology2005，，3： | 1 |
| 4 | Role of inducible nitric oxide synthase in pig liver transplantation 1 1 Supported by Grant-in-Aid (08671462) for Scientific Research from the Ministry of Education, Science and Culture of Japan.显示文摘 | Hitoshi Kimura Tadashi Katsuramaki Masato Isobe Minoru Nagayama Makoto Meguro Kazuma Kukita Akihiro Nui Koichi Hirata | 2003 | Journal of Surgical Research2003，，1： | 1 |
| 5 | Antiplatelet Therapy and Stent Thrombosis After Sirolimus-Eluting Stent Implantation显示文摘 | Takeshi Kimura Takeshi Morimoto Yoshihisa Nakagawa Toshihiro Tamura Kazushige Kadota Hitoshi Yasumoto Hideo Nishikawa Yoshikazu Hiasa Toshiya Muramatsu Taiichiro Meguro Naoto Inoue Hidehiko Honda Yasuhiko Hayashi Shunichi Miyazaki Shigeru Oshima Takashi H | 2009 | Circulation2009，，7： | 1 |
| 6 | Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714显示文摘 | Makoto Meguro Tadashi Katsuramaki Hitoshi Kimura Masato Isobe Minoru Nagayama Kazuma Kukita Akihiro Nui Koichi Hirata | 2003 | Transplantation2003，，5： | 1 |
| 7 | Prognostic Factor Analysis in Pars Plana Vitrectomy for Retinal Detachment Attributable to Macular Hole in High Myopia: A Multicenter Study显示文摘 | Hideo Nakanishi Shoji Kuriyama Isao Saito Morio Okada Mihori Kita Yasuo Kurimoto Hideya Kimura Hitoshi Takagi Nagahisa Yoshimura | 2008 | American Journal of Ophthalmology2008，，2： | 1 |
| 8 | Evaluation of seismic behavior of box culvert buried in the ground through centrifuge model tests and numerical analysis显示文摘Japan has yet to establish a seismic design for road box culverts(RBCs)because past major earthquakes did not damage them.In recent years,structures with enlarged sectional dimensions(the purpose of which is to optimize the internal space in RBCs)have become common.However,the unknown seismic strength of such large RBCs makes RBC seismic designs increasingly necessary.Several seismic design methods have been developed for and applied to rectangular underground structures,e.g.,cut-and-cover tunnels,which are structurally similar to RBCs.Although these methods are applicable to RBCs,it is uncertain whether they can be applied directly because there are currently no evaluation results from model tests on RBCs,which have unique structural features,e.g.,no haunch at the bottom of the sidewalls.Therefore,we verify a seismic behavior of an RBC and develop a method for evaluating it in order to establish a seismic design for RBCs.We conducted centrifuge model tests subjected to seismic force and a numerical analysis using an elastoplastic finite analysis method,in addition,we validated this analysis by comparing the test and analytical results.The test results show RBCs will most likely develop rocking rotation when the ground strain exceeds approximately 0.08%.A comparison of the numerical and experimental results shows that this analysis can estimate the shear deformation behavior with approximately 90%accuracy in square cross-section cases.Meanwhile,this analysis has tendency to underestimate the axial forces in each case and to overestimate the bending moments of some members in the case of wide cross-sections. | Hitoshi Yatsumoto Yasuo Mitsuyoshi Yasuo Sawamura Makoto Kimura | 2019 | Underground Space2019，4，2： | 1 |
| 9 | Factors Associated with the Development of Reflux Esophagitis After Helicobacter pylori Eradication显示文摘 | Katsuhiko Tsukada MD Hiroyuki Katoh MD Tatsuya Miyazaki MD Minoru Fukuchi MD Hiroyuki Kuwano MD Hitoshi Kimura MD Yasuyuki Fukai MD Takanori Inose MD Teiji Motojima MD Naotaka Toda MD Shuji Yamada MD | 2006 | Digestive Diseases and Sciences2006，，3： | 1 |
| 10 | Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy显示文摘 | Daisuke Watanabe Kiyoshi Suzuma Izumi Suzuma Hirokazu Ohashi Tomonari Ojima Masafumi Kurimoto Tomoaki Murakami Tetsushi Kimura Hitoshi Takagi | 2005 | American Journal of Ophthalmology2005，，3： | 1 |
| 11 | Genetic Alterations in Esophageal Cancer显示文摘 | Hiroyuki Kuwano Hiroyuki Kato Tatsuya Miyazaki Minoru Fukuchi Norihiro Masuda Masanobu Nakajima Yasuyuki Fukai Makoto Sohda Hitoshi Kimura Ahmad Faried | 2005 | Surgery Today2005，，1： | 1 |
| 12 | Application of low-pressure negative pressure wound therapy to ischaemic wounds显示文摘 | Yoshiaki Kasai Hitoshi Nemoto Naohiro Kimura Yoshinori Ito Noriyoshi Sumiya | 2011 | Journal of Plastic Reconstructive & Aesthetic Surgery2011，，3： | 1 |
| 13 | Usefulness and Limitation of Multiple Endoscopic Biopsy Sampling fer Epidermal Growth Factor Receptor and c-erbB-2 Testing in Patients with Gastric Adenocarcinoma显示文摘 | Mikihiko Kimura Hitoshi Tsuda Daisaku Morita | 2005 | Japanese Journal of Clinical Oncology2005，35，6： | 1 |
| 14 | Black soybean seed coat polyphenols prevent B(a)P-induced DNA damage through modulating drug-metabolizing enzymes in HepG2 cells and ICR mice显示文摘 | Tianshun Zhang Songyan Jiang Chao He Yuki Kimura Yoko Yamashita Hitoshi Ashida | 2013 | Mutation Research - Genetic Toxicology and Environmental Mutagenesis2013，，： | 1 |
| 15 | The bglA Gene of Aspergillus kawachii Encodes Both Extracellular and Cell Wall-Bound β-Glucosidases显示文摘 | Kazuhiro Iwashita Tatsuya Niagara Hitoshi Kimura | 1999 | Applied and Environmental Microbiology1999，65，12： | 1 |
| 16 | Right recumbent position on gastric emptying of water evidenced by ^(13)C breath testing显示文摘AIM:To compare the impact of the right recumbent position with the sitting position on gastric emptying of water. METHODS:In eight healthy male volunteers,the 13C acetate breath test was performed twice to assess gastric emptying of 100 mL tap water.Subjects were seated in one test and lying on their right side in the other.In both positions,pulmonary 13CO2 exhalation curves were obtained by plotting breath data against time.Percent gastric retention curves were created by analyzing data using the Wagner-Nelson protocol. RESULTS:No significant posture effect was found in pulmonary 13CO2 output curves(P=0.2150),whereas a significant effect was seen in gastric retention curves (P=0.0315).The percent retention values at 10 min and 15 min were significantly smaller when subjects were in the right recumbent position compared with the seated position(P<0.05).Our results verified the accelerating effect of the right recumbent position on gastric emptying of non-nutritive solutions.Concerning clinical implications,this study suggests that placing patients with acute pain on their right side after oral administration of analgesic drugs in solution is justified as an effective practice for rapid pain relief.For patients with gastrointestinal reflux symptoms,sleeping in the right recumbent position may reduce nocturnal symptoms,as delayed gastric emptying can cause reflux symptoms. CONCLUSION:Gastric emptying of water occurs more quickly when a subject lies on the right side compared with sitting. | Masaki Sanaka Yoshihisa Urita Takatsugu Yamamoto Tsuguru Shirai Satoshi Kimura Hitoshi Aoyagi Yasushi Kuyama | 2013 | World Journal of Gastroenterology2013，19，3： | 1 |
| 17 | Clinicopathological Features of Serrated Adenocarcinoma Defined by Makinen in Dukes’ B Colorectal Carcinoma显示文摘 | Shida Yosuke Fujimori Takahiro Tanaka Hiroyuki Fujimori Yukari Kimura Ryusuke Ueda Hirofumi Ichikawa Kazuhito Tomita Shigeki Nagata Hitoshi Kubota Keiichi Tsubaki Masahiro Kato Hiroyuki Yao Takashi Sugai Tamotsu Sugihara Kenichi Ohkura Yas | 2012 | Pathobiology2012，，4： | 1 |
| 18 | Driving force and structural strength evaluation of a flexible mechanical system with a hydrostatic skeleton显示文摘The purpose of this study was to build a flexible mechanical system with a hydrostatic skeleton.The main components of this system are two type flexible bags.One is a structural bag with constant inner pressure.The other is an actuator bag with controlled inner pressure.To design the system,it was necessary to estimate both structural deformation and driving force.Numerical analysis of flexible bags,however,is difficult because of large nonlinear deformation.This study analyzed structural strength and driving force of flexible bags with the nonlinear finite element analysis (FEA) software ABAQUS.The stress concentration dependency on the bag shape is described and the driving force is calculated to include the large deformation.From the analytical results,this study derives an empirical equation of driving force.The validity of the equation was confirmed by condition-changed analyses and experimental results. | Daisuke MARUYAMA Hitoshi KIMURA Michihiko KOSEKI Norio INOU | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，4： | 1 |
| 19 | Treatment strategy for pancreatic head cancer with celiac axis stenosis in pancreaticoduodenectomy:A case report and review of literature显示文摘BACKGROUND During pancreaticoduodenectomy in patients with celiac axis(CA)stenosis due to compression by the median arcuate ligament(MAL),the MAL has to be divided to maintain hepatic blood flow in many cases.However,MAL division often fails,and success can only be determined intraoperatively.To overcome this problem,we performed endovascular CA stenting preoperatively,and thereafter safely performed pancreaticoduodenectomy.We present this case as a new preoperative treatment strategy that was successful.CASE SUMMARY A 77-year-old man with a diagnosis of pancreatic head cancer presented to our department for surgery.Preoperative assessment revealed CA stenosis caused by MAL.We performed endovascular stenting in the CA preoperatively because we knew that going into the operation without a strategy could lead to ischemic complications.Double-antiplatelet therapy(DAPT)–which is needed when a stent is inserted–was then administered in parallel with neoadjuvant chemotherapy(NAC).This allowed us to administer DAPT for a sufficient period before the main pancreaticoduodenectomy procedure while obtaining therapeutic effects from NAC.Subtotal stomach-preserving pancreaticoduodenectomy was thenperformed.The operation did not require any unusual techniques and was performed safely.Postoperatively,the patient progressed well,without any ischemic complications.Histopathologically,curative resection was confirmed,and the patient had no recurrence or complications due to ischemia up to six months postoperatively.CONCLUSION Preoperative endovascular stenting,with NAC and DAPT,is effective and safe prior to pancreaticoduodenectomy in potentially resectable pancreatic cancer. | Eiji Yoshida Yasutoshi Kimura Takuro Kyuno Ryoko Kawagishi Kei Sato Tsuyoshi Kono Takehiro Chiba Toshimoto Kimura Hitoshi Yonezawa Osamu Funato Makoto Kobayashi Kenji Murakami Akinori Takagane Ichiro Takemasa | 2022 | World Journal of Gastroenterology2022，28，8： | 1 |
| 20 | Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamouscell carcinoma显示文摘 | Hiroaki Kato Tokuzo Arao Kazuko Matsumoto Yoshihiko Fujita Hideharu Kimura Hidetoshi Hayashi Kouhei Nishiki Mitsuru Iwama Osamu Shiraishi Atsushi Yasuda Masayuki Shinkai Motohiro Imano Haruhiko Imamoto Takushi Yasuda Kiyotaka Okuno Hitoshi Shiozaki Kazuto | 2013 | International Journal of Oncology2013，，4： | 1 |
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