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| 1 | Association of Fusobacterium nucleatum with immunity andmolecular alterations in colorectal cancer显示文摘The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process with a differing set of somatic molecular alterations, influenced by diet, environmental and microbial exposures, and host immunity. Fusobacterium species are part of the human oral and intestinal microbiota. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum(F. nucleatum) in colorectal carcinoma tissue. Using 511 colorectal carcinomas from Japanese patients, we assessed the presence of F. nucleatum. Our results showed that the frequency of F. nucleatum positivity in the Japanese colorectal cancer was 8.6%(44/511), which was lower than that in United States cohort studies(13%). Similar to the United States studies, F. nucleatum positivityin Japanese colorectal cancers was significantly associated with microsatellite instability(MSI)-high status. Regarding the immune response in colorectal cancer, high levels of infiltrating T-cell subsets(i.e., CD3+, CD8+, CD45RO+, and FOXP3+ cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity. Concerning the association between the gut microbiome and immunity, F. nucleatum has been shown to expand myeloid-derived immune cells, which inhibit T-cell proliferation and induce T-cell apoptosis in colorectal cancer. This finding indicates that F. nucleatum possesses immunosuppressive activities by inhibiting human T-cell responses. Certain micro RNAs are induced during the macrophage inflammatory response and have the ability to regulate host-cell responses to pathogens. Micro RNA-21 increases the levels of IL-10 and prostaglandin E2, which suppress antitumor T-cell-mediated adaptive immunity through the inhibition of the antigen-presenting capacities of dendritic cells and T-cell proliferation in colorectal cancer cells. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells and tumor molecular alterations for colorectal cancer prevention and treatment. Further investigation is needed to clarify the association of Fusobacterium with T-cells and micro RNA expressions in colorectal cancer. | Katsuhiko Nosho Yasutaka Sukawa Yasushi Adachi Miki Ito Kei Mitsuhashi Hiroyoshi Kurihara Shinichi Kanno Itaru Yamamoto Keisuke Ishigami Hisayoshi Igarashi Reo Maruyama Kohzoh Imai Hiroyuki Yamamoto Yasuhisa Shinomura | 2016 | World Journal of Gastroenterology2016，22，2： | 44 |
| 2 | 负载型Pd-Ni双金属纳米颗粒在无溶剂苯甲醇氧化中有效抑制甲苯的生成(英文)显示文摘醇类化合物的选择性氧化是实验室和工业应用中一类重要的官能团转化反应.以分子氧为氧化剂,在液相无溶剂条件下温和氧化符合绿色化学的要求.负载型Pd基催化剂因其优异的催化活性而在该反应中得到广泛应用.但是,单金属Pd催化剂对反应目标产物醛类化合物的选择性还有待提高.例如,在苯甲醇液相无溶剂氧化中,甲苯是在单金属Pd催化剂上的主要副产物.针对这一问题,除了对载体进行改性和修饰外,开发双金属Pd基催化剂也是一种有效的选择性调控策略.虽然已有的Pd-Au双金属催化剂可以在一定程度上降低甲苯的选择性,但是在较高温度和较高转化率下仍然难以控制甲苯的大量生成.本文采用固相合金化法合成了负载型Pd-Ni双金属纳米颗粒.该方法首先以硝酸镍为镍的前驱体浸渍介孔二氧化硅,然后负载钯纳米颗粒.在高温固相还原条件下,作为种子的钯纳米颗粒和镍通过原子迁移和生长,形成Pd-Ni双金属纳米颗粒.扫描透射电镜、能量色散X射线光谱、X射线衍射和X射线光电子能谱等表征证实了Pd-Ni双金属纳米颗粒的生成.上述催化剂用于苯甲醇液相无溶剂氧化,催化结果显示Ni的加入可以抑制副产物甲苯的生成,并且随Ni负载量增加,甲苯的选择性(在80%等转化率下)由22.6%(单金属Pd)降低至1.6%(双金属Pd1Ni20).尽管Ni的加入降低了单金属Pd的活性,但是由于提高了目标产物苯甲醛的选择性,醛的最终产率得到提升.进一步催化研究表明,Ni的加入可以抑制无氧氛围下甲苯的生成,说明Ni可以抑制歧化反应和降低表面氢浓度.这种作用可归结于Pd-Ni双金属的协同效应.该效应得到了CO吸附的傅里叶变换漫反射红外光谱和密度泛函理论研究的证实.双金属的几何效应和电子效应均减弱了苯甲醇在双金属纳米颗粒表面的解离吸附和相互作用,导致苯甲醇的吸附减弱,同时C–O键断裂不易进行.另外,由于Ni的亲氧性,双金属纳米颗粒表面有利于氧的吸附,降低吸附氢的浓度,减少C–H键生成,从而抑制甲苯的生成. | 车建伟 郝梦佳 易武中 Hisayoshi Kobayashi 周宇恒 肖丽萍 范杰 | 2017 | Chinese Journal of Catalysis2017，38，11： | 6 |
| 3 | MicroRNA-31 expression in colorectal serrated pathway progression显示文摘MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers(CRC).We have recently observed that microRNA-31(miR-31)expression is associated with BRAF mutation and prognosis in CRC.Moreover,high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps(HPs).These results suggest that miR-31 may contribute to the progression of serrated lesions.At a follow-up colonoscopy,we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features.Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component.Higher miR-31 expression was observed in the carcinoma component(57-fold increase)and the HP component(8-fold increase)compared with the paired normal mucosa,suggesting that miR-31 may be one of the key molecules in serrated pathway progression. | Hironori Aoki Katsuhiko Nosho Hisayoshi Igarashi Miki Ito Kei Mitsuhashi Takafumi Naito Eiichiro Yamamoto Tokuma Tanuma Masafumi Nomura Hiroyuki Maguchi Toshiya Shinohara Hiromu Suzuki Hiroyuki Yamamoto Yasuhisa Shinomura | 2014 | World Journal of Gastroenterology2014，20，34： | 5 |
| 4 | Preliminary report of treatment with oral contraceptive pills for intermenstrual vaginal bleeding secondary to a cesarean section scar显示文摘 | Masahiro Tahara Takashi Shimizu Hisayoshi Shimoura | 2006 | Fertility and Sterility2006，，2： | 4 |
| 5 | Pt/ZnO在室温水相无碱条件下绿色催化苯甲醇选择性氧化(英文)显示文摘醇类化合物选择性氧化是有机合成中一个非常重要的反应,在精细化工领域具有重要应用.而以水为绿色溶剂,分子氧为绿色氧化剂实现醇类化合物选择性氧化是绿色化学领域的一大挑战.Pt催化剂由于其优异的活化氧气和C-H键的能力在该反应中得到了广泛应用.但是,常规的Pt催化剂通常需要在较高温度和较高氧气压力以及加碱的条件下才能发挥作用,从而引起了催化剂腐蚀等一系列问题.从绿色化学角度出发,进一步优化Pt催化剂,让其能够在室温无碱条件下以空气为氧化剂选择性氧化醇类合成羰基化合物具有重要的研究价值和应用前景.本文通过化学还原法制备了Pt/ZnO催化剂,系统研究了该催化剂在水相无碱条件下选择性氧化苯甲醇生成苯甲醛反应中的催化性能.X射线电子衍射和透射电镜等结果表明,Pt颗粒较小(3.2±0.3 nm),均匀分散在ZnO载体上;X射线光电子能谱表明ZnO载体能够稳定Pt纳米颗粒表面的Pt^0物种.上述催化剂在水相苯甲醇选择性氧化反应中,在室温下即可催化空气高选择性氧化苯甲醇到苯甲醛(选择性>99%),并表现出比Pt/SiO_2,Pt/Al_2O_3,Pt/TiO_2,Pt/Ca(Mg)-ZSM-5等催化剂更为优异的催化活性.这可归结于Pt和ZnO之间的协同作用.该协同作用通过动力学实验和密度泛函理论计算(DFT)得到了证实.氧分压实验表明,在以空气为氧化剂时,O_2的活化并不是限制Pt/ZnO催化活性的关键因素,而动力学同位素效应实验则证实了苯甲醇的C-H键活化是整个反应的决速步骤.通过构建不同的理论模型,分别计算了Pt/ZnO界面处以及纯Pt位点上苯甲醇选择性氧化的反应过程.结果表明,苯甲醇和氧气分子倾向于分别在ZnO和Pt上进行吸附,随后由吸附的氧气分子来活化苯甲醇中的C-H键,进而生成苯甲醛和水.而当ZnO不参与苯甲醇的吸附活化时,整个反应的活化能会大大提高,表明ZnO和Pt之间的协同作用对于整个反应至关重要.此外,Pt/ZnO表现出非常优异的稳定性,循环使用4次后,催化剂结构以及催化活性没有显著变化.进一步向Pt/ZnO催化剂中引入少量Bi元素对Pt的电子结构进行修饰,可以将Pt/ZnO的催化活性提高3倍.所制备的Pt/Bi-ZnO复合物是目前报道的相同条件下催化苯甲醇选择性氧化反应转化频率(45.1 h^(-1))最高的催化剂. | 刘娟娟 邹世辉 吴嘉超 Hisayoshi Kobayashi 赵红挺 范杰 | 2018 | Chinese Journal of Catalysis2018，39，6： | 4 |
| 6 | 使用ATP酶敏感钾离子通道开放剂——尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘1前言动物实验研究表明,反复短暂的冠脉闭塞导致心脏抗心肌缺血的发作,这种现象被称为缺血性预处理。一些研究表明,这种预处理的效果是由于ATP敏感性钾通道的激活(KATP通道)。人类涉及经皮冠状动脉成形术(PTCA)的临床研究发现KATP通道的关闭与格列本脲防止预处理的效果通常出现在反复球囊扩张期间血管成形术模型中,表明ATP敏感性钾通道在预处理中发挥了核心作用。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose Makoto Iwama Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，0，8： | 3 |
| 7 | A New Spirostanol Saponin from Dioscorea futshauensis显示文摘A new spirostanol saponin presenting strong activity of inducing morphological deformation of Pyricularia oryzae mycelia was isolated from Dioscorea futshauensis R. Kunth by bioactivity-guided fractionation. The structure was established as (25S)-spirost-5-en-3β, 27-diol-3-O-[α-L-rhamnopyranosyl (1→2)-β-D -glucopyranosyl (1→3)]-β-D-glucopyranoside on the basis of chemical evidences and spectral analysis, especially by 2D-NMR techniques. | Hong Wei LIU1, Hisayoshi KOBAYASHI2, Ge Xia QU1, Xin Sheng YAO1* 1Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110015 2Institute of Molecular & Cellular Biosciences, The University of Tokyo, Tokyo, Japan 113 | 2001 | Chinese Chemical Letters2001，12，7： | 3 |
| 8 | Analysis of electronic structures of 3d transition metal-doped TiO 2 based on band calculations显示文摘 | Tsutomu Umebayashi Tetsuya Yamaki Hisayoshi Itoh Keisuke Asai | 2002 | Journal of Physics and Chemistry of Solids2002，，10： | 2 |
| 9 | Rare and Precious Chinese Materia Medica: Pseudobulbus Cremastrae seu Pleiones显示文摘Shan Ci Gu(山慈菇Pseudobulbus Cremastrae seu Pleiones),a rare and precious traditional Chinese medicine,has attracted attention for the treatment of various cancers and bacterial infections.According to the Pharmacopoeia of the People's Republic of China,Pseudobulbus Cremastrae seu Pleionesis sourced from the pseudobulbs of three plants in the Orchidaceae family:Cremastra appendiculata(D.Don)Makino,Pleione bulbocodioides(Franch.)Rolfe,and Pleione yunnanensis Rolfe.Extracts from Pseudobulbus Cremastrae seu Pleiones are used for the treatment of tumors,burns,and frostbite.The aims of this review are to provide information on the historical and herbological origins of Pseudobulbus Cremastrae seu Pleiones,to summarize research conducted on its phytochemical and biological activities over the last twenty years,and to detail planting efforts. | Hisayoshi Norimoto Chiaki Murayama Feng Zhao Hong-Yan Wei | 2021 | Chinese Medicine and Culture2021，4，4： | 2 |
| 10 | Adsorption behavior of cobalt (11) on chitosan and its determination by tungsten metal furnace atomic absorption spectrometry显示文摘 | MINAMISAWA Hiroaki IWANAMI Hisayoshi ARAI Nobtunasa | 1999 | Analytica ChimicaActa1999，378，1： | 1 |
| 11 | 查看详情显示文摘 | Hidetoshi I Daisuke S Manabu Y Yasuhiro U Hisayoshi M Tetsuzo U Tsuyoshi T Daisuke U | | 0，，： | 1 |
| 12 | The clinical significance of intrahepatic cystic lesions in postoperative patients with biliary atresia 显示文摘 | Taro G Akio K Hisayoshi K | 2012 | Pediare surg Int2012，28，9： | 1 |
| 13 | Resection of ster- nal tumors and reconstruction of the thorax : a review of 15 patients显示文摘 | Haraguchi S Hioki M Hisayoshi T | 2006 | Surg Today2006，36，3： | 1 |
| 14 | 显示文摘 | Yuki T Takafumi S Hisayoshi W | 2002 | Hepatology2002，36，41： | 1 |
| 15 | An algorithm for diagnosis of system failures in the chemical process显示文摘 | Iri Masao Aoki Katsuaki O' shima Eiji Matsuyama Hisayoshi | 1979 | Computers and Chemical Engineering1979，3，14： | 1 |
| 16 | Synthesis of monodispersed laPO4 particles using the hydrothermal reaction of an La(edta)- chelate precursor and phosphate ions显示文摘 | Yoshinobu Fujishiro Hisayoshi Ito Tsugio Sato Akitugu Okuwaki | 1995 | Journal of Alloys and Compounds1995，，252： | 1 |
| 17 | Design of multiwasvelength resonant cavities for white organic light-emitting diodes 显示文摘 | Takahiro Shiga Hisayoshi Fujikawa Yasunori Taga | 2003 | J Appl Phys2003，93，： | 1 |
| 18 | Risk factors for the local recurrence of hepatocellular carcinoma after a single session of percutaneous radiofrequency ablation显示文摘 | Takeshi Hori Kenji Nagata Satoru Hasuike Masaaki Onaga Mizue Motoda Akihiro Moriuchi Hisayoshi Iwakiri Hirofumi Uto Jyunya Kato Akio Ido Katsuhiro Hayashi Hirohito Tsubouchi | 2003 | Journal of Gastroenterology2003，，10： | 1 |
| 19 | Experimental and Numerical Study on the Collapse Strength of the Bulbous Bow Structure in Oblique Collision显示文摘 | Yamada Yasuhira Endo Hisayoshi | 2008 | Marine Technology and SNAME News2008，，1： | 1 |
| 20 | Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: A metabolomics analysis显示文摘 | Takafumi Saito Masahiro Sugimoto Kaori Igarashi Kaori Saito Li Shao Tomohiro Katsumi Kyoko Tomita Chikako Sato Kazuo Okumoto Yuko Nishise Hisayoshi Watanabe Masaru Tomita Yoshiyuki Ueno Tomoyoshi Soga | 2013 | Metabolism2013，，11： | 1 |
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