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	题名	作者	年代	出处	被引量
1	Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD.	Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto	2019	World Journal of Gastroenterology2019，25，14：	5
2	Immune aspects of the pathogenesis of inflammatory bowel disease显示文摘	Tadakazu Hisamatsu Takanori Kanai Yohei Mikami Kazuaki Yoneno Katsuyoshi Matsuoka Toshifumi Hibi	2012	Pharmacology and Therapeutics2012，，：	3
3	Applicability of second‐generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study显示文摘	Naoki Hosoe Katsuyoshi Matsuoka Makoto Naganuma Yosuke Ida Yuka Ishibashi Kayoko Kimura Kazuaki Yoneno Shingo Usui Kazuhiro Kashiwagi Tadakazu Hisamatsu Nagamu Inoue Takanori Kanai Hiroyuki Imaeda Haruhiko Ogata Toshifumi Hibi	2013	J Gastroenterol Hepatol2013，，7：	3
4	Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease显示文摘	Takanori Kanai Yasuhiro Nemoto Nobuhiko Kamada Teruji Totsuka Tadakazu Hisamatsu Mamoru Watanabe Toshifumi Hibi	2009	Current Opinion in Gastroenterology2009，，4：	2
5	Comparative investigation on use of(z'R)-4-0-tetrahydropyranyl-adriamycin and adriamycin asintravesical chemctherapy for superifcial bladdertumorl 显示文摘	Niijima T Hisamatsu T	1998	Urology1998，32，2：	1
6	TL1A produced by lamina propria macrophages induces Thl and Thl7 immune responses in cooperation with IL-23 in patients with Crehn's disease显示文摘	Kamada N Hisamatsu T Honda H	2010	Inflamm Bowel Dis2010，16，4：	1
7	Extremely low- profile single-arm wideband spiral antenna radiating a cir- cularly polarized wave 显示文摘	HISAMATSU N RYOHEI S JUNJI Y	2010	IEEE Transactions on Anten- nas and Propagation2010，58，5：	1
8	Comparison of expression of connexin in right atrial myocardium in patients with chronic atrial fibrillation versus those in sinus rhythm 显示文摘	Nao T Ohkusa T Hisamatsu Y	2003	Am J Cardiol2003，91，6：	1
9	A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter 显示文摘	Umeno J Hisamatsu T Esaki M	2015	PLoS Genet2015，11，00：	1
10	Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex显示文摘	Suzuki M Hisamatsu T Podolsky DK	2003	Infect Immun2003，71，6：	1
11	Immune aspects of the pathogenesis of inflammatory bowel disease 显示文摘	Hisamatsu T Kanai T Mikami Y	2013	Pharmacol Ther2013，137，3：	1
12	A case of iga-related enteropathy complicated with gastrointestinal bleeding and progressive iga nephropathy:A possible variant henoch-schonlein purpura显示文摘	Nakamura S Hisamatsu T Kikuchi J		0，，16：	1
13	Electrochemical properties of iron rust 显示文摘	I Suzuki N Masuko Y Hisamatsu	1979	Corrosion Science1979，19，：	1
14	Structural chages of maize starch granules by ball-mill treatment显示文摘	Tamaki S Hisamatsu M Teramishi K	1998	Starch1998，50，8：	1
15	IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease显示文摘	Kobayashi T Okamoto S Hisamatsu T	2008	Gut2008，57，12：	1
16	Structural Chages of Maize Starch Granules by Ball-mill Treatment 显示文摘	Tamaki S Hisamatsu M Teramishi K	1998	Starch1998，50，8：	1
17	Impact of FOXAI expression on the prognosis of patients with hormone receptor - positive breast cancer显示文摘	Hisamatsu Y Tokunaga E Yamashita N	2012	Ann Surg Oneol2012，19，：	1
18	Unique CD14 + intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis显示文摘	Kamada N Hisamatsu T Okamoto S	2008	J Clin Invest2008，118，6：	1
19	Comparativeinve stigation on use of (2' B)-4'-O-tetrahydropyranyl-adriamycin and adfiamyein as intravesieal chemotherapy for superficial bladder tumors 显示文摘	AKAZA H NIIJIMA T HISAMATSU T	1988	Urology1988，32，2：	1
20	Clinical strategies for the blockade of IL-18 in inflammatory bowel diseases显示文摘	Kanai T Kamada N Hisamatsu T	2013	Curr Drug Targets2013，14，12：	1

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