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| 1 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013，19，35： | 26 |
| 2 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 7 |
| 3 | Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis显示文摘 | Helen M. Parker Nathan A. Johnson Catriona A. Burdon Jeffrey S. Cohn Helen T. O’Connor Jacob George | 2011 | Journal of Hepatology2011，，4： | 3 |
| 4 | Xylanase, protease and superdosing phytase interactions in broiler performance, carcass yield and digesta transit time显示文摘The interaction of xylanase, protease and superdosing(1,500 FTU/kg) phytase in a 2×2×2 factorial arrangement was studied in broilers fed sorghum-based diets. A total of 2,800 one-day-old unsexed Ross308 chicks were housed in 56 pens with 50 birds per pen, with or without inclusion of xylanase, protease and phytase, totaling 8 treatments and 7 replicates per treatment. Body weight(BW) and feed intake(FI)were measured at 21 and 42 days of age, and mortality corrected feed conversion ratio(FCR) was calculated for each period and cumulatively. Tibia ash and carcass yield were determined in 2 birds per replicate at 21 and 42 days of age, respectively. Digesta transit time was determined at 21, 28, 35 and 42 days of age using 5 birds per replicate. Results showed that superdosing phytase increased BW and FI at42 days of age(P < 0.05) and xylanase improved FCR(P < 0.05). Xylanase and phytase also positively influenced carcass yield and breast weight, respectively. Overall, inclusion of superdosing phytase increased transit time when included in a diet containing xylanase, and no change with protease inclusion. In conclusion, the beneficial effects of xylanase, protease and superdosing phytase in broiler performance were not additive. This limitation is likely not related to the lack of efficacy of any one of the individual enzymes but to a limitation of the bird to respond additively to successive additions of enzymes. | Tiago T.dos Santos Helen V.Masey O'Neill Gemma González-Ortiz Daniel Camacho-Fernández Carlos López-Coello | 2017 | Animal Nutrition2017，，2： | 2 |
| 5 | Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘 | Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi | 2014 | Gastroenterology2014，，： | 2 |
| 6 | Prognostic significance of detection of microscopic peritoneal disease in colorectal cancer: A systematic review显示文摘 | Helen M. Mohan Donal B. O’Connor James M. O’Riordan Des C. Winter | 2013 | Surgical Oncology2013，，： | 2 |
| 7 | The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally relate in different species显示文摘 | Masayuki O Helene B Rolf K | 1989 | The EMBO J1989，8，： | 1 |
| 8 | Polyhedron 显示文摘 | Michael Devereux Denis O' Shea Mark O' Connor Helen Grehan Gavin Connor | 2007 | 26:4073-40842007，26，： | 1 |
| 9 | Thermodynamic analysis of lysozyme adsorbed to silica 显示文摘 | L Helen O Sven B Jos | 2004 | Collid and Interface Science2004，276，： | 1 |
| 10 | Evaluation of intraocular pressure in the immediate period after phacoemulsification显示文摘 | Bradford J Shingleton Resham A Wadhwani Mark W O’Donoghue Susan Baylus Helen Hoey | 2001 | Journal of Cataract & Refractive Surgery2001，，4： | 1 |
| 11 | The force, power, and energy of the 100 meter sprint 显示文摘 | Helene O Yamashita M T | 2010 | American Journal of Physics2010，78，3： | 1 |
| 12 | 显示文摘 | Dassie D Helene O | 1990 | Nucl Phys A1990，513，： | 1 |
| 13 | Sa1899 Fecal Recovery of Ingested Cellular DNA: Implications for Noninvasive Detection of Upper Gastrointestinal Neoplasms显示文摘 | Benjamin B. Strauss Tracy C. Yab Helen M. O William R. Taylor Douglas W. Mahoney Julie A. Simonson John D. Christensen Suresh T. Chari David A. Ahlquist | 2014 | Gastroenterology2014，，5： | 1 |
| 14 | Evaluation of mucoadhesion for two polyelectrolyte gels in simulated physiological conditions using a rheological method显示文摘 | Helene H(a)gerstr(o)m Mattias Paulsson Katarina Edsman | | 0，，03： | 1 |
| 15 | Cystatin C improves the detection of mild renal dysfunction in older parients显示文摘 | O'Riordan Shelagh E Webb Michelle C Stowe Helen J Simpson David E Kandarpa Madhu | 2003 | Ann clin biochem2003，40，23： | 1 |
| 16 | An overview of bio-based polymers for packaging materials显示文摘Synthetic polymers are the most widely used materials for packaging because of their ease of processing,low cost,and low density.However,many of these materials are not easily recyclable and are difficult to degrade completely in nature,creating environmental problems.Thus,there is a tendency to substitute such polymers with natural polymers and copolymers that are easily bio-degraded and less likely to cause environmental pollution.There has been a greater interest in poly-lactic acid(PLA),poly-hydroxyalkanoates(PHAs),cellulose and starch based polymers and copolymers as the emerging biodegradable material candidates for the future.This paper reviews the present state-of-the-art biodegradable polymers made from renewable resources and discusses the main features of their properties and design. | Yuanfeng Pan Madjid Farmahini-Farahani Perry O’Hearn Huining Xiao Helen Ocampo | 2016 | Journal of Bioresources and Bioproducts2016，1，3： | 1 |
| 17 | Bioorg Med Chem显示文摘 | Allan M J Tariq H K Hugh M Helen M I O | 2002 | 10:2 6252002，10，： | 1 |
| 18 | Atomic force microscopy of biomolecules 显示文摘 | Helen O Hansma | 1996 | J Vac Sci Technol1996，14，2： | 1 |
| 19 | Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis显示文摘 | Stuart McPherson Julie R. Jonsson Helen D. Barrie Peter O’Rourke Andrew D. Clouston Elizabeth E. Powell | 2008 | Journal of Hepatology2008，，6： | 1 |
| 20 | Soil organisms and carbon, nitrogen and phosphorus mineralisation in Norway spruce and mixed Norway Spruce-Birch stands显示文摘 | Peter S Brandtberg P O Helene L | 1999 | Biology and Fertility of Soil1999，28，4： | 1 |
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