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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | 深圳水围柠盟人才公寓显示文摘在深圳,城中村一直都是一个热门的话题,多种观点相互碰撞。在过去的一二十年里,城中村的改造就意味着大规模的拆迁,彻底推倒重建,拆迁改善了生活环境,创造了财富,但导致了城市空间匀质化,同时,造成了一些社会问题,更割断了城市的历史。目前深圳市新出台的政策是通过综合整治,让城中村全面进入柔性改造的通道,鼓励在原来的用地上开展城中村的综合整治。然而新政策出台不久之后,却又发生了原住民反对综合整治,要求城市更新的情况。说明政策的转变对城中村的居民和开发企业都产生了很大的影响,“综合整治”和“拆除重建”的投入产出模型完全不同,两种模式的转变,意味着居民的诉求和企业的战略都应当做出相应的调整,在新形势下共同努力,继续探索。为此,我们选登了通过综合整治获得比较成功的水围村项目,该项目保留了城市的肌理、文脉和集体记忆,同时,也提升了消防、市政配套,及改善了生活设施。并增加空中连廊、电梯,创造出了一个符合现代标准的宜居空间立体的社区。该项目改造后,由政府返租补贴,并以低于市场的价格出租,以确保改造后的房源租金在可负担的范围内。水围村项目为城中村的改造提供了一种可能,并引发了社会各界对城中村改造的再思考,这也反映出有关城中村的争论还在继续,城中村的改造还需要不断的探索…… | Chris Lai Jasmine M.Y.Tsoi Kwan Yee Wong Cindy Yan David Wen Demi Han Zachary Bao Jack Ou Nita Lin Red Liu Ann Hu Morning Dong Ananda de Vos Helene Pohl Arnound Stavenuiter Bert Oostdijk 王晓勇 | 2019 | 世界建筑导报2019，34，1： | 2 |
| 3 | Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis显示文摘 | Emilie A. Bard-Chapeau Shuangwei Li Jin Ding Sharon S. Zhang Helen H. Zhu Frederic Princen Diane D. Fang Tao Han Beatrice Bailly-Maitre Valeria Poli Nissi M. Varki Hongyang Wang Gen-Sheng Feng | 2011 | Cancer Cell2011，，5： | 2 |
| 4 | Antifungal effect of dairy propi- onibacteria-contribution of organic acids 显示文摘 | Helen L Hans J Johan S | 2005 | International Journal of Food Microbiology2005，98，： | 1 |
| 5 | Competing for Capital in A Lump World显示文摘 | Hans Jarle Kind Karen Helene Midelfart Knarvik Guttorm Schjelderup | 2000 | Journal of Public Economics2000，，78： | 1 |
| 6 | Prognostic value of immunohistochemical expressions of p53, HER-2/ neu, and bcl-2 in stage I non[ndash ]small-cell lung cancer显示文摘 | Helen Han Rodney J. Landreneau Tibetha S. Santucci Ming Y. Tung Robin S. Macherey Stanley E. Shackney Charles D. Sturgis Stephen S. Raab Jan F. Silverman | 2002 | Human Pathology2002，，1： | 1 |
| 7 | Vascular endothelial growth factor expression in stage Ⅰ non-small cell lung cancer correlates with neoangiogenensis and a poor prognosis显示文摘 | Helen Han Jan F Silverman Tibetha S | 2001 | Ann Surg Oncol2001，8，1： | 1 |
| 8 | Competing for capital in a ‘lumpy’ world显示文摘 | Hans Jarle Kind Karen Helene Midelfart Knarvik Guttorm Schjelderup | 2000 | Journal of Public Economics2000，，3： | 1 |
| 9 | Vascular Endothelial Growth Factor Expression in Stage I Non-Small Cell Lung Cancer Correlates With Neoangiogenesis and a Poor Prognosis显示文摘 | Helen Han MD Jan F. Silverman MD Tibetha S. Santucci RN Robin S. Macherey RN Thomas A. dAmato MD Ming Y. Tung MS Robert J. Weyant DDS Rodney J. Landreneau MD | 2001 | Annals of Surgical Oncology2001，，1： | 1 |
| 10 | Clusterin is protective in pancreatitis through anti-apoptotic and anti-inflammatory properties显示文摘 | Vuk Savkovi? Helen Gantzer Ulrich Reiser Lena Selig Sebastian Gaiser Ulrich Sack Günter Kl?ppel Joachim M?ssner Volker Keim Friedemann Horn Hans B?deker | 2007 | Biochemical and Biophysical Research Communications2007，，2： | 1 |
| 11 | Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes显示文摘 | Peter Ammann Marco Maggiorini Osmund Bertel Edgar Haenseler Helen I Joller-Jemelka Erwin Oechslin Elisabeth I Minder Hans Rickli Thomas Fehr | 2003 | Journal of the American College of Cardiology2003，，： | 1 |
| 12 | Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia显示文摘Despite high initial response rates,acute myeloid leukemia(AML)treated with the BCL-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires resistance.We performed gene/protein expression,metabolomic and methylation analyses of isogenic AML cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCL-1 protein,as a major acquired mechanism of VEN resistance. | Qi Zhang Bridget Riley-Gillis Lina Han Yanan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra LRamage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata L.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic Marina Konopleva | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 13 | Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice显示文摘 | Thomason Helen A Zhou Huiqing Kouwenhoven Evelyn N Dotto Gian-Paolo Restivo Gaia Nguyen Bach-Cuc Little Hayley Dixon Michael J van Bokhoven Hans Dixon Jill | 2010 | Journal of Clinical Investigation2010，，5： | 1 |
| 14 | Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenensis and a poor prognosis显示文摘 | Helen Han Silverman J Tibetha S | 2001 | Ann Surg Oncol2001，8，1： | 1 |
| 15 | Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenensis and a poor prognosis显示文摘 | Helen Han Jan F Silverman Tibetha S | 2001 | Annals of Surgical Oncology2001，8，： | 1 |
| 16 | Detection and molecular characterisation of Pyrenopeziza brassicae isolates resistant to methyl benzimidazole carbamates显示文摘 | Helen E Carter Hans J Cools Jonathan S West Michael W Shaw Bart A Fraaije | 2013 | Pest Manag Sci2013，，9： | 1 |
| 17 | Prognostic significance of DNA cytometry in carcinoma of the uterine cervix FIGO stage IB and II显示文摘 | Hans Jü rgen Grote Nicolaus Friedrichs Natalia Pomjanski Helen Friderike Guhde Olaf Reich Alfred B? cking | | Analytical Cellular Pathology . 2001 (3,4)0，，： | 1 |
| 18 | Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles:Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus显示文摘Diabetic wound healing has become a serious healthcare challenge.The high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction,resulting in chronic inflammation,abnormal vascular function,and tissue necrosis.To solve these issues,we developed a double-network hydrogel,constructed with pluronic F127 diacrylate(F127DA)and hyaluronic acid methacrylate(HAMA),and enhanced by SS31-loaded mesoporous polydopamine nanoparticles(MPDA NPs).As components,SS31,a mitochondria-targeted peptide,maintains mitochondrial function,reduces mitochondrial reactive oxygen species(ROS)and thus regulates macrophage polarization,as well as promoting cell proliferation and migration,while MPDA NPs not only scavenge ROS and exert an anti-bacterial effect by photothermal treatment under near-infrared light irradiation,but also control release of SS31 in response to ROS.This F127DA/HAMA-MPDA@SS31(FH-M@S)hydrogel has characteristics of adhesion,superior biocompatibility and mechanical properties which can adapt to irregular wounds at different body sites and provide sustained release of MPDA@SS31(M@S)NPs.In addition,in a diabetic rat full thickness skin defect model,the FH-M@S hydrogel promoted macrophage M2 polarization,collagen deposition,neovascularization and wound healing.Therefore,the FH-M@S hydrogel exhibits promising therapeutic potential for skin regeneration. | Qing-Song Deng Yuan Gao Bi-Yu Rui Xu-Ran Li Po-Lin Liu Zi-Yin Han Zhan-Ying Wei Chang-Ru Zhang Fei Wang Helen Dawes Tong-He Zhu Shi-Cong Tao Shang-Chun Guo | 2023 | Bioactive Materials2023，，9： | 0 |
| 19 | Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia显示文摘Correction to:Signal Transduction and Targeted Therapy(2022)7:1–13,http://gffzzd3cc09b8251d45dfscc0n5unvwuw96bno.ffgz.tsg.suse.edu.cn/10.1038/s41392-021-00870-3 In the original version of this article,given name of 4th author Yannan Jia was incorrectly published as Yanan Jia.The original article has been corrected.Open Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source. | Qi Zhang Bridget Riley-Gillis Lina Han Yannan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth Dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie C.Weng Cassandra L.Ramage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata L.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic Marina Konopleva | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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