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| 1 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 2 | TwinMag II:Improving an advanced sputtering tool显示文摘 | Heister U Krempel-Hesse J Szczyrbowski J | 2000 | Vacuum2000，59，23： | 1 |
| 3 | A Numerical Study of Primary Instability on Viscous High Speed Jets 显示文摘 | Hongbok Park Stephen D Heister | 2006 | Computers & Fluids2006，35，： | 1 |
| 4 | An IVSI-ll6 (A-->G) acceptor splice site mutation in the alpha 2 globin gene causing alpha + thalassaemia in two Dutch families显示文摘 | Harteveld CL Heister JG Giordano PC | 1996 | Br J Haematol1996，95，3： | 1 |
| 5 | A numerical treatment for attached cavitation显示文摘 | Chen Y Heister S D | 1994 | ASME Journal of Fluids Engineering1994，116，3： | 1 |
| 6 | Introduction : Proof - Theoretic Semantics显示文摘 | Kahle R Schroeder - Heister P | 2006 | Synthese2006，，148： | 1 |
| 7 | Experi- mental investigation of high-burning-rate com- posite solid propellants显示文摘 | Manship T D Heister S D O'Neil P D | 2012 | Journal of Propulsion and Power2012，28，6： | 1 |
| 8 | Spray modeling using Lagrangian droplet tracking in a homogeneous flow model显示文摘 | PHAM T L HEISTER S D | 2002 | Journal of the International Institutions for Liquid Atomization and Spray Systems2002，12，： | 1 |
| 9 | A new laboratory set-up for measurements of electrical,hydraulic,and osmotic fluxes in clays显示文摘 | Heister Katja Kleingeld Pieter J Keijzer Thomas J S | 2005 | Engineering Geology2005，77，34： | 1 |
| 10 | A numerical treatment for attached cavitation显示文摘 | Chen Y Heister S D | 1994 | ASME Journal of Fluids Engineering1994，116，3： | 1 |
| 11 | Application of a genetic algorithm to the optimization of hybrid rockets 显示文摘 | Schoonover P L Crossley W A Heister S D | 2000 | Journal of Spacecraft and Rockets2000，37，5： | 1 |
| 12 | Development of biogeochemical interfaces in an artificial soil incubation experiment: Aggregation and formation of organo-smineral associations显示文摘 | Geertjie Johanna Pronk Katja Heister Ding Guochun | 2012 | Geoderma2012，，10： | 1 |
| 13 | TwinMag Ⅱ Improving an Advanced Sputtering Tool 显示文摘 | Heister U Krempel-Hesse J Szczyrbowski J | 2000 | Vacuum2000，59，： | 1 |
| 14 | Modeling cavitatingventuri flows 显示文摘 | XU C HEISTER S D COLLICOTF S C | 2002 | Journal of Propulsion and Power2002，18，6： | 1 |
| 15 | A numerical treatment for attached cavitation 显示文摘 | CHEN Y HEISTER S D | 1998 | Jounal of Fluids Engineering1998，，116： | 1 |
| 16 | The developmental decrease in REM sleep: The role of transmitters and electrical coupling显示文摘 | Garcia-Rill E Charlesworth A Heister D | 2008 | Sleep2008，31，5： | 1 |
| 17 | TwinMagTM lI : attempts to improve an excellent sputter tool 显示文摘 | Heister U Krempe-Hesse J Szczyrbowski J | 1999 | ThinSolid Films1999，351，： | 1 |
| 18 | Der Ringversuch 2003/ 2004 zur Kalibrierung yon Prazisionsnivellieren 显示文摘 | SCHAUERTE W HEISTER H | 2005 | Allgemeine Vermessungs-Nachrichten ( AVN )2005，，6： | 1 |
| 19 | A numerical treatment for attached cavitation显示文摘 | Chen Y Heister S D | 1994 | Journal of Fluids Engineering1994，116，： | 1 |
| 20 | A numerical treatment for attached cavitation显示文摘 | Chen Y Heister S D | 1998 | Jounal of Fluids Engineering1998，，116： | 1 |
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