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| 1 | Intraarticular injections(corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis显示文摘Osteoarthritis(OA)is a complex'whole joint'disease pursued by inflammatory mediators,rather than purely a process of'wear and tear'.Besides cartilage degradation,synovitis,subchondral bone remodeling,degeneration of ligaments and menisci,and hypertrophy of the joint capsule take parts in the pathogenesis.Pain is the hallmark symptom of OA,but the extent to which structural pathology in OA contributes to the pain experience is still not well known.For the knee OA,intraarticular(IA)injection(corticosteroids,viscosupplements,blood-derived products)is preferred as the last nonoperative modality,if the other conservative treatment modalities are ineffective.IA corticosteroid injections provide short term reduction in OA pain and can be considered as an adjunct to core treatment for the relief of moderate to severe pain in people with OA.IA hyaluronic acid(HA)injections might have efficacy and might provide pain reduction in mild OA of knee up to 24 wk.But for HA injections,the costeffectiveness is an important concern that patients must be informed about the efficacy of these preparations.Although more high-quality evidence is needed,recent studies indicate that IA platelet rich plasma injections are promising for relieving pain,improving knee function and quality of life,especially in younger patients,and in mild OA cases.The current literature and our experience indicate that IA injections are safe and have positive effects for patient satisfaction.But,there is no data that any of the IA injections will cause osteophytes to regress or cartilage and meniscus to regenerate in patients with substantial and irreversible bone and cartilage damage. | Egemen Ayhan Hayrettin Kesmezacar Isik Akgun | 2014 | World Journal of Orthopedics2014，5，3： | 36 |
| 2 | Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats显示文摘AIM:To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats. METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreat- ed with resveratrol (10 μmol/L,iv). Liver tissues wweerre obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation. RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase ,and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol-treated livers. CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusion-related liver injury. | Ercan Gedik Sadullah Girgin Hayrettin Ozturk Basra Deniz Obay Hulya Ozturk Huseyin Buyukbayram | 2008 | World Journal of Gastroenterology2008，14，46： | 14 |
| 3 | Bone marrow biopsy findings in brucellosis patients with hematologic abnormalities显示文摘 | Cengiz Demir Mustafa Kasim Karahocagil Ramazan Esen Murat Atmaca Hayriye Gonullu Hayrettin Akdeniz | 2012 | Chinese Medical Journal2012，，11： | 12 |
| 4 | Interaction of L-Arginine-methyl ester and Sonic hedgehog in liver ischemia-reperfusion injury in the rats显示文摘AIM: To investigate the role of Sonic hedgehog (Shh) on the course of liver ischemia and reperfusion (I/R) in rats, and the interaction between treatment with nitric oxide donor L-Arginine-methyl ester (L-Arg) and up-regulation of Shh expression. METHODS: A total of 30 male Sprague-Dawley rats weighing 220-240 g were used in this study. Sham-control group (G1, n = 10): a sham operation was performed (except for liver I/R). I/R-untreated group (G2, n = 10): rats underwent liver ischemia for 1 h followed by reperfusion for 45 min. I/R-L-Arg group (G3, n = 10): after performing the same surgical procedure as in group 2, animals were treated with L-Arg. Liver tissues were taken for determination of malondialdehyde (MDA) levels, and biochemical and histological evaluations were made. RESULTS: Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and γ-glutamyltranspeptidase (GGT) activities were higher in group 2 than in group 3. MDA values and the hepatic injury score decreased in the L-Arg treated group compared to the I/R-untreated group. In group 2, the hepatocytes were swollen with marked vacuolization. Group 3 rats showed well-preserved liver parenchyma, with hepatocytes extending from the central vein. The morphology of the hepatocytes and the sinusoidal structures was normal, without any signs of congestion. Mild Shh positive immunostaining was detected in group 2 animals. The expression of immunoreactive cells was increased markedly in liver tissue from I/R-L-Arg rats.CONCLUSION: Our findings suggest that Shh molecules are critical factors in the pathophysiology of inflammatory liver injury induced by I/R. In addition, NO plays an important role in the immunohistochemical expression of these molecules. | Mehmet Cudi Tuncer Hayrettin Ozturk Huseyin Buyukbayram Hulya Ozturk | 2007 | World Journal of Gastroenterology2007，13，28： | 11 |
| 5 | 添加锡对AS21镁合金显微组织和耐腐蚀性能的影响(英文)显示文摘研究添加锡对AS21 镁合金显微组织和耐腐蚀性能的影响。采用低压压铸法制备分别添加0、0.5、1 和2 wt.% Sn 的AS21 合金。用光学显微镜和扫描电镜进行显微组织表征,通过在3.5% NaCl 溶液中浸渍和电化学腐蚀试验研究合金的耐腐蚀性能。微观检测结果显示,AS21 合金中含有α-Mg、孤立的β-Mg17Al12 和汉字状Mg2Si 金属间化合物相。随着Sn 含量的增加,Mg2Si 相的分布变得更加离散和致密。当Sn 添加量为2 wt.%时,形成遍布于整个组织的富Sn 网状结构,汉字状组织由短棒状的Mg2Si 相排列组成。持续浸泡腐蚀试验表明,随着锡含量的增加,AS21 合金的降解程度不断降低,当锡含量为2 wt.%时,AS21 合金的腐蚀速率降低约65%。电化学腐蚀试验也表明,随着锡含量的增加,AS21 合金的耐蚀性逐渐提高。 | Huseyin ZENGIN Yunus TUREN Hayrettin AHLATCI Yavuz SUN Abdullah Cahit KARAOGLANLI | 2019 | Transactions of Nonferrous Metals Society of China2019，29，7： | 4 |
| 6 | Microstructure,mechanical properties and corrosion resistance of as-cast and as-extruded Mg-4Zn-1La magnesium alloy显示文摘Microstructure,mechanical properties and corrosion resistance of as-cast and as-extruded Mg-4 wt%Zn-1 wt%La magnesium alloys were investigated.The alloys were produced by low-pressure die casting method and extruded at 350℃after homogenization at 400℃for 24 h.The results show that the as-cast alloy mainly consists of primaryα-Mg matrix and Mg-Zn-La ternary second phases(also called T-Phase)along grain boundaries and isolated spherical particles inside the grains.After extrusion at350℃,the average grain size decreases by 81%due to dynamic recrystallization mechanism and T-phase particles are distributed along the extrusion direction.The elongation,yield strength and tensile strength of the as-cast Mg-4Zn-1La alloy increase by 179%,90%and 40%,respectively,as a result of the extrusion process.The as-extruded Mg-4Zn-1La alloy shows better corrosion resistance than the as-cast alloy due to increased grain boundaries and decreased content of T-phase. | Huseyin Zengin Yunus Turen Hayrettin Ahlatci Yavuz Sun | 2020 | Rare Metals2020，39，8： | 4 |
| 7 | Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature显示文摘 | Turan Buzgan Mustafa Kasim Karahocagil Hasan Irmak Ali Irfan Baran Hasan Karsen Omer Evirgen Hayrettin Akdeniz | 2009 | International Journal of Infectious Diseases2009，，6： | 2 |
| 8 | The prognostic importance of serum IL-1β, IL-6, IL-8 and TNF-α levels compared to trauma scoring systems for early mortality in children with blunt trauma显示文摘 | Hayrettin Ozturk Yusuf Yagmur Hulya Ozturk | 2008 | Pediatric Surgery International2008，，2： | 2 |
| 9 | Results of displaced supracondylar humerus fractures treated with open reduction and internal fixation after a mean 22.4 years follow-up显示文摘 | Mehmet F. Guven Gokhan Kaynak Muharrem Inan Gurkan Cal?skan Hiclal B. Unlu Hayrettin Kesmezacar | 2014 | Journal of Shoulder and Elbow Surgery2014，，： | 1 |
| 10 | Electrocardiographic findings of acute organophosphate poisoning显示文摘 | Yusuf Y Yucel Y Hayrettin S | 2009 | J Emerg Med2009，36，1： | 1 |
| 11 | Removal of ^137 Cs from aqueous solutions using different cationic forms of anatural zeolite : Clinoptilolite 显示文摘 | Abdelrahim A Hayrettin Y | 2002 | Separation and Purification Technology2002，28，2： | 1 |
| 12 | Electrocar-diographic Findings of Acute Organophosphate Poisoning显示文摘 | Yusuf Yurumez Yucel Yavuz Hayrettin Saglam | 2009 | Jour-nal of Emergency Medicine2009，36，1： | 1 |
| 13 | Cerebrospinal fluid biomarker candidates of schizophrenia: where do we stand?显示文摘 | Nenad Vasic Bernhard Connemann Robert Wolf Hayrettin Tumani Johannes Brettschneider | 2012 | European Archives of Psychiatry and Clinical Neuroscience2012，，5： | 1 |
| 14 | The effect of the con-tent of the knowledge on adherence to medication in hyper-tension patients - original investigation 显示文摘 | Hayrettin K Mehmet Y Senay U | 2009 | Am J Cardiol2009，9，3： | 1 |
| 15 | The response of processing tomato to deficit irrigation at various phenological stages in a sub- humid environment显示文摘 | HAYRETTIN K AHMET T ALl O D | 2014 | Agricultural Water Management2014，133，： | 1 |
| 16 | Dose-related effects of dexamethasone on liver damage due to bile duct ligation in rats显示文摘AIM: To evaluate the effects of dexamethasone on liver damage in rats with bile duct ligation. METHODS: A total of 40 male Sprague-Dawley rats, weighing 165-205 g, were used in this study. Group 1 (sham-control, n = 10) rats underwent laparotomy alone and the bile duct was just dissected from the surrounding tissue. Group 2 rats (untreated, n = 10) were subjected to bile duct ligation (BDL) and no drug was applied. Group 3 rats (low-dose dexa, n = 10) received a daily dose of dexamethasone by orogastric tube for 14 d after BDL. Group 4 rats (high-dose dexa, n = 10) received a daily dose of dexamethasone by orogastric tube for 14 d after BDL. At the end of the two-week period, biochemical and histological evaluations were processed. RESULTS: The mean serum bilirubin and liver enzyme levels signifi cantly decreased, and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) values were significantly increased in low-dose dexa and high-dose dexa groups when compared to the untreated group. The histopathological score was significantly less in the low-dose and high-dose dexa groups compared to the untreated rats. In the low-dose dexa group, moderate liver damage was seen, while mild liver damage was observed in the high-dose dexa group. CONCLUSION: Corticosteroids reduced liver damage produced by bile duct obstruction. However, the histopathological score was not signifi cantly lower in the high-dose corticosteroid group as compared to the low-dose group. Thus, low-dose corticosteroid provides asignifi cant reduction of liver damage without increased side effects, while high dose is associated not with lower fi brosis but with increased side effects. | Halil Eken Hayrettin Ozturk Hulya Ozturk Huseyin Buyukbayram | 2006 | World Journal of Gastroenterology2006，12，33： | 1 |
| 17 | Removal of 137Csfrom aqueous solutions using different cationic forms of a naturalzeolite:clinoptilolite显示文摘 | Abdelrahim Abusafa Hayrettin Yuce | 2002 | Separation and Purification Technology2002，28，： | 1 |
| 18 | SVD-based on-line exercise ECG signal orthogonalization显示文摘 | Hayrettin Koymen | 1999 | IEEE BME1999，46，31： | 1 |
| 19 | High Temperature Abrasive Wear Behavior of an As-cast Ductile Iron显示文摘 | OZGUR C HAYRETTIN A KAYALI S E | 2005 | Wear2005，258，： | 1 |
| 20 | Sleep Disturbances and Suicidal Behavior in Patients With Major Depression显示文摘 | Mehmed Y Hayrettin K Mustafa S | 1997 | The Journal of Clinical Psychiatry1997，58，： | 1 |
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