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| 1 | Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans显示文摘AIM:To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus(DM) .METHODS:Eligibility for this study included patients with type 2 DM(ICD-9 code 250.0) who were discharged from Department of Veteran Affairs hospitals between 1990 and 2000.Non-matched control patients without DM were selected from the same patient treatment files during the same period.Demographic information included age,sex and race.Secondary diagnoses included known risk factors based on their ICD-9 codes.By multivariate logistic regression,the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without DM.RESULTS:A total of 1172496 case and control subjects were analyzed.The mean age for study and control subjects was 65.8 ± 11.3 and 64.8 ± 12.6 years,respectively.The frequency of pancreatic cancer in subjects with DM was increased(0.9%) in comparison to control subjects(0.3%) with an OR of 3.22(95% CI:3.03-3.42) .The incidence of gallbladder andextrahepatic biliary cancers was increased by twofold in diabetic patients when compared to controls.The OR and 95% CI were 2.20(1.56-3.00) and 2.10(1.61-2.53) ,respectively.CONCLUSION:Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer. | M Mazen Jamal Eugene J Yoon Kenneth J Vega Mehrtash Hashemzadeh Kenneth J Chang | 2009 | World Journal of Gastroenterology2009，15，42： | 10 |
| 2 | Simplified microsatellite instability detection protocol provides equivalent sensitivity to robust detection strategies in Lynch syndrome patients显示文摘Objective:Germline mutations in mismatch repair(MMR)genes cause Lynch syndrome(LS).LS is an inherited disease,and an important consequence of MMR deficiency is microsatellite instability(MSI)phenotype.MSI phenotype influences the efficacy of5 fluorouracil(5-FU)chemotherapy.Reproducible,cost effective,and easy to perform laboratory tests are required to include MSI detection in routine laboratory practice.Evaluation of CAT25 as monomorphic short tandem repeat sequence enables CAT25 to be an efficient screening tool among hereditary nonpolyposis colorectal cancer(HNPCC)patients compared with other methods used currently.Methods:Based on Amsterdam II criteria,31 patients in 31 families were shortlisted from a total number of 1,659 colorectal cancer patients.MSI status was examined in these patients using CAT25 and a commercially available Promega MSI five-markerbased detection system as well as immunohistochemical(IHC)staining of four important MMR proteins.Patients were scored as high microsatellite instable(MSI-H),low(MSI-L),or stable(MSS).MSI status determined by CAT25 single mononucleotide marker was compared with that of five mononucleotide markers,Promega commercial kit,and IHC method.Results:MMR protein deficiency was observed on 7/31 probands using IHC methodology and 6/31 categorized as MSI-H using commercial kit or CAT25 single marker.The sensitivity and specificity of the CAT25 single marker were the same as those detected by five-marker Promega commercial kit in our patients.Conclusions:Based on our results,the performance of the CAT25 single mononucleotide marker for MSI status determination in our HNPCC patients is the same as that of the five-marker-based commercial kit. | Hadi Babaei Mehrdad Zeinalian Mohammad Hassan Emami Mortaza Hashemzadeh Najmeh Farahani Rasoul Salehi | 2017 | Cancer Biology & Medicine2017，14，2： | 3 |
| 3 | The E×B drift instability in Hall thruster using 1D PIC/MCC simulation显示文摘The E×B drift instability is studied in Hall thruster using one-dimensional particle in cell(PIC)simulation method.By using the dispersion relation,it is found that unstable modes occur only in discrete bands in k space at cyclotron harmonics.The results indicate that the number of unstable modes increases by increasing the external electric field and decreases by increasing the radial magnetic field.The ion mass does not affect the instability wavelength.Furthermore,the results confirm that there is an instability with short wavelength and high frequency.Finally,it is shown that the electron and ion distribution functions deviate from the initial state and eventually the instability is saturated by ion trapping in the azimuthal direction.Also for light mass ion,the frequency and phase velocity are very high that could lead to high electron mobility in the axial direction. | Zahra Asadi Mehdi Sharifian Mojtaba Hashemzadeh Mahmood Borhani Zarandi Hamidreza Ghomi Marzdashti | 2020 | Chinese Physics B2020，29，2： | 2 |
| 4 | 采用人工神经网络基因复合算法预测氧化铜矿柱浸工艺铜浸出率(英文)显示文摘采用人工神经网络(ANN)以及人工神经网络和基因复合(GANN)算法来优化氧化铜矿柱浸工艺参数。采用三种高度的浸矿柱(2,4,6 m)和尺寸为<25.4 mm和<50.8 mm的两种矿物来进行浸出实验。在台架实验规模下,对浸矿柱高度、矿粒尺寸、硫酸流速、浸出时间等工艺参数对铜浸出率的影响进行研究,对浸出条件进行优化以得到最大的浸出率。研究结果表明,铜的浸出率随硫酸流速和浸出时间的增加而增加,随矿粒尺寸和浸矿柱高度的减小而增加。对人工神经网络(ANN)、人工神经网络和基因复合(GANN)算法的效率进行了比较,结果表明,人工神经网络和基因复合(GANN)算法比人工神经网络(ANN)算法更有效。采用新提出的算法模型来预测铜的浸出率误差更低。 | Fatemeh Sadat HOSEINIAN Aliakbar ABDOLLAHZADE Saeed Soltani MOHAMADI Mohsen HASHEMZADEH | 2017 | Transactions of Nonferrous Metals Society of China2017，27，3： | 2 |
| 5 | TiO_(2)纳米颗粒对7075铝合金表面等离子体电解氧化涂层性能的影响显示文摘采用等离子体电解氧化(PEO)技术,利用单极脉冲波形在含有胶体TiO_(2)纳米颗粒的溶胶电解液中制备Al_(2)O_(3)−TiO_(2)复合涂层。溶胶溶液是将1、3和5 g/L的草酸钛酸钾(PTO)溶解在硅酸盐溶液中制得。利用扫描电镜、能量色散光谱、X射线衍射和拉曼光谱对涂层进行表征。采用极化和阻抗技术研究涂层的腐蚀行为。结果表明,TiO_(2)通过微放电方式进入涂层,并掺杂到氧化铝相中。TiO_(2)掺入量较高时,表面微孔减少;反之,掺入量较低时则微孔增多。TiO_(2)含量越高,涂层的外层越致密,内层越厚。电化学测试结果表明,与在不含PTO溶液中制备的涂层相比,在含3 g/L PTO溶液中制备的涂层腐蚀性能得到大幅提高。在不含PTO溶液中制备的涂层含有γ-Al_(2)O_(3),δ-Al_(2)O_(3)和非晶相,而PTO的存在促进α-Al_(2)O_(3)的生成。 | Mehri HASHEMZADEH Keyvan RAEISSI Fakhreddin ASHRAFIZADEH Amin HAKIMIZAD Monica SANTAMARIA | 2021 | Transactions of Nonferrous Metals Society of China2021，31，12： | 2 |
| 6 | Mortality pattern according to autopsy findings among traffic accident victims in Yazd, Iran显示文摘 | Yashar Moharamzad Hamidreza Taghipour Nader Hodjati Firoozabadi Abolfazl Hodjati Firoozabadi MojtabaHashemzadeh Mehdi Mirjalili and Abed Namavari Mojtaba Hashemzadeh Mehdi Mirjalili Abed Namavari | 2008 | Chinese Journal of Traumatology2008，11，6： | 2 |
| 7 | Graphene quantum dot modified glassy carbon electrode for the determination of doxorubicin hydrochloride in human plasma显示文摘Low toxic graphene quantum dot(GQD) was synthesized by pyrolyzing citric acid in alkaline solution and characterized by ultraviolet-visible(UV-vis) spectroscopy,X-ray diffraction(XRD),atomic force microscopy(AFM),spectrofluorimetery and dynamic light scattering(DLS) techniques.GQD was used for electrode modification and electro-oxidation of doxorubicin(DOX) at low potential.A substantial decrease in the overvoltage(- 0.56 V) of the DOX oxidation reaction(compared to ordinary electrodes) was observed using GQD as coating of glassy carbon electrode(GCE).Differential pulse voltammetry was used to evaluate the analytical performance of DOX in the presence of phosphate buffer solution(pH 4.0) and good limit of detection was obtained by the proposed sensor.Such ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor. | Nastaran Hashemzadeh Mohammad Hasanzadeh Nasrin Shadjou Jamal Eivazi-Ziaei Maryam Khoubnasabjafari Abolghasem Jouyban | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 2 |
| 8 | A comparative study of hydrothermal and sol–gel methods in the synthesis of Mn O2 nanostructures显示文摘 | HASHEMZADEH F MOTLAGH M M K MAGHSOUDIPOUR A | 2009 | J Sol–Gel Sci Technol2009，51，16： | 1 |
| 9 | Noveldesign and synthesis of modified structure ofcarvedilol 显示文摘 | Hashemzadeh M Movahed MR Russu WA | 2011 | Recent Pat Cardiovasc Drug Discov2011，6，3： | 1 |
| 10 | Predictors and outcome of gastrointestinal complications after cardiac surgery显示文摘 | HASHEMZADEH K HASHEMZADEH S | 2012 | Minerva Chir2012，67，4： | 1 |
| 11 | Comparison of platinum-based neoadjuvant chemotherapy and primary debulking surgery in patients with advanced ovarian cancer 显示文摘 | Sayyah- Melli M Zonoozi G K Hashemzadeh S et a1 | 2013 | J Obstet Gynaecol India2013，63，6： | 1 |
| 12 | Repair of aortic coarctation in adults: the fate of hypertension显示文摘 | Hashemzadeh K Hashemzadeh S Kakaei F | 2008 | Asian Cardiovasc Thorac Ann2008，16，1： | 1 |
| 13 | Novel design and synthesis of modified structure of carvedilol 显示文摘 | Hashemzadeh M Movahed MR Russu WA | 2011 | Recent Pat Cardiovasc Drug Discov2011，6，3： | 1 |
| 14 | Pleurodesis by erythromycin, tetracycline, Aerosil (TM) 200,and erythromycin plus Aerosil (TM) 200 in a rat model : a preliminary study显示文摘 | Hashemzadeh S Hashemzadeh K Mamaghani KA | 2012 | Daru2012，20，1： | 1 |
| 15 | The combination of an- nular pancreas and duodenum inversum presenting with delayed gas- tric emptying,pain, and feeding intolerance 显示文摘 | Azhough R Bayat A Hashemzadeh S | 2009 | Am J Gastroentero2009，104，5： | 1 |
| 16 | Novel antiplatelet agent ticagrelor in the management of acute coronary syndrome显示文摘 | Ramaraj R Movahed MR Hashemzadeh M | | 0，，： | 1 |
| 17 | The adsorption of malachite green (MG) as a cationic dye onto functionalized multi walled carbon nanotubes显示文摘 | Mohammad Shirmardi Amir Hossein Mahvi Bayram Hashemzadeh Abolfazl Naeimabadi Ghasem Hassani Mehdi Vosoughi Niri | 2013 | Korean Journal of Chemical Engineering2013，，8： | 1 |
| 18 | The Combination of Annular Pancreas and Duodenum Inversum Presenting With Delayed Gastric Emptying, Pain, and Feeding Intolerance显示文摘 | Azhough R Bayat A Hashemzadeh S etal | 2009 | Am J Gastroentero2009，3，31： | 1 |
| 19 | Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians:Haplotype characterization and relevance of the 2-repeat allele显示文摘 | Reist C Ozdemir V Wang E Hashemzadeh M Mee S & Moyzis R | | 0，，04： | 1 |
| 20 | Novel antiplatelet agent ticagrelor in the management of acute coronary syndrome 显示文摘 | RAMARAJR MOVAHED MR HASHEMZADEH M | 2011 | J Interv Cardiol2011，24，3： | 1 |
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