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8篇 您的检索式：作者名="Hanisch O"

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		题名	作者	年代	出处	被引量
	1	Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype.	Kristina Roessler Stefan P.M(o\|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o\|¨)lscher Hans P.Dienes Stephan E.Baldus	2005	World Journal of Gastroenterology2005，11，21：	15
	2	Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP 显示文摘	Hanisch O Tatakis D Boskovic M	1997	Int J Oral Maxillofac Implants1997，12，5：	1
	3	Effect of recombinant human bone morphogenetic protein-2 in dehiscence defects with non-submerged immediate implants: An experimental study in Cynomolgus monkeys 显示文摘	Hanisch O Sorensen RG Kinoshita A	2003	J Periodontol2003，74，5：	1
	4	Postprandial hyperoxaluria and intestinal oxalate absorption in idiopathic renal stone disease显示文摘	SCHWILLE P O HANISCH E SCHOLZ D	1984	J Urol1984，132，4：	1
	5	Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates显示文摘	Tatakis DN Rohrer MD Wohrle PS Wozney JM Wikesjo UM	1997	Int J Oral Maxillofac Implants1997，12，6：	1
	6	Microglial phenotype: is the commitment reversible? 显示文摘	Schwartz M Butovsky O Bruck W Hanisch UK	2006	Trends Neurosci2006，29，2：	1
	7	Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP显示文摘	Tatakis DN Boskovic MM Rohrer MD Wikesjo UM	1997	Int J Oral Maxillofac Implants1997，12，6：	1
	8	Experimental peri-im- plant tissue breakdown aroud hydrnxyapalite-coated implants 显示文摘	Hanisch O Cortella CA Boskovic M M	1997	Periudontol1997，68，：	1

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