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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | Tumor necrosis factor-alpha-inducible 1 kappa B alpha proteolysis mediated by cytosolie m-calpain-A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappa B activation显示文摘 | Han YQ Weinman S Boldogh I | 1999 | J Biol Chem1999，274，2： | 1 |
| 3 | The effect of nitric oxide synthase inhibitor on improved insulin action by pioglitazone in high-fructose-fed rats显示文摘 | Koshinaka K Oshida Y Han YQ Ohsawa I Sato Y | 2004 | Metabolism2004，53，： | 1 |
| 4 | Above-and belowground competition between two submerged macrophytes显示文摘 | Wang JW Yu D Xiong W Han YQ | 2008 | Hydrobiologia2008，607，： | 1 |
| 5 | Expression and significance of Twist basic helix-loop-helix protein over-expression in gastric cancer显示文摘 | Zhang YQ Guo XY Han S | 2007 | Pathology2007，39，5： | 1 |
| 6 | HPLC determination of andrographolide in rat whole blood: study on the pharmacokinetics of andrographolide incorpo- rated in liposomes and tabiets 显示文摘 | Suo XB Han Z Wang YQ | 2007 | Biomedical Chromatography2007，21，： | 1 |
| 7 | Two sRNA RyhB homologs from Yersinia pestis biovar microtus expressed in vivo have differential Hfq-dependent stability显示文摘 | Deng ZL Meng XR Su SC Liu ZZ Ji XL Zhang YQ Zhao XN Wang XY Yang RF Han YP | | 0，，6： | 1 |
| 8 | In vivo and in vitro anti-hepatitis B virus activity of total phenolics from Oenanthe javanica显示文摘 | HAN YQ HUANG ZM YANG XB | 2008 | J Ethnopharmacol2008，118，1： | 1 |
| 9 | Antimyein A18 produced by an endophytic Streptomyces albidoflavus isolated from a mangrove plant显示文摘 | Yan LL Han NN Zhang YQ | 2010 | The Journal of Antibiotics2010，63，5： | 1 |
| 10 | CD44v3 and VEGF-C expression and its relationship with lymph node metastasis in squamous cell carcinomas of the uterine cervix 显示文摘 | Liu YQ Li HF Han JJ | 2014 | Asian Pac J Cancer Prey2014，15，12： | 1 |
| 11 | Suppression effects of betaine- enriched spinach on hyperhomocysteinemia induced by guani- dinoacetic acid and choline deficiency in rats 显示文摘 | Liu YQ Jia Z Han F | 2014 | Scientific World Journal2014，，1： | 1 |
| 12 | Potential pathological and functional links between long noncoding RNAs and hematopoiesis显示文摘 | Han BW Chen YQ | 2013 | Sci Signal2013，6，289： | 1 |
| 13 | Effects of gastrodin on amino acids af- ter cerebral ischemia - reperfusion injury in rat striatum显示文摘 | Bie XD Chen YQ Han J | 2007 | Asia Pac J ClinNutr2007，16，1： | 1 |
| 14 | In vivo and in vitro anti-hep- atitis B virus activity of total phenolics from Oenanthe javanica 显示文摘 | Han YQ Huang ZM Yang XB | 2008 | Journal of Ethnopharmacology2008，118，1： | 1 |
| 15 | A bacterial extract of OM-85 Broncho-Vaxom prevents allergic rhinitis in mice 显示文摘 | Han L Zheng CP Sun YQ | 2014 | Am J Rhinol Allergy2014，28，2： | 1 |
| 16 | Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery 显示文摘 | Han WK Wagener B Zhu YQ el al | 2009 | Clin J Am Soc Nephrol2009，4，5： | 1 |
| 17 | Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery显示文摘 | Han WK Wagener B Zhu YQ | 2009 | Clin J Am Soc Nephrol2009，4，5： | 1 |
| 18 | Antibody dependent enhancement infection of enterovims 71 in vitro and in vivo显示文摘 | Han JF Cao RY Deng YQ | 2011 | Virol J2011，8，1： | 1 |
| 19 | Identification of novel serological tumor markers for human prostate cancer using integrative transcrip-tome and proteome analysis显示文摘 | Han ZD Zhang YQ He HC | | 0，，： | 1 |
| 20 | Antibody dependent enhancement infection of enterovirus 71 in vitro and in vivo显示文摘 | Han JF Cao RY Deng YQ | | 0，，： | 1 |
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