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| 1 | Comparison of gemcitabine plus nab-paclitaxel and FOLFIRINOX in metastatic pancreatic cancer显示文摘BACKGROUND Gemcitabine plus nab-paclitaxel(GA)and modified FOLFIRINOX(FFX)have been widely used as standard first-line treatment in pancreatic cancer.However,it is unclear which regimen is more efficacious.AIM To evaluate a retrospective analysis comparing the efficacy and safety of FFX and GA as first-line chemotherapeutic regimens in patients with metastatic pancreatic cancer.METHODS We retrospectively analyzed and compared outcomes in 101 patients who presented with pancreatic cancer and were treated with either GA(n=54)or FFX(n=47).Moreover,we performed subgroup analysis based on the neutrophil/lymphocyte ratio(NLR)and Eastern Cooperative Oncology Group(ECOG)performance status.RESULTS There were no significant differences between two groups in baseline characteristics,except for the ECOG performance status.The median progression-free survival(PFS)(6.43 mo vs 4.90 mo,P=0.058)was comparable between two groups;however,median overall survival(OS)(10.17 mo vs 6.93 mo,P=0.008)was longer in patients who received GA regimen.In patients with ECOG 0(PFS:8.93 mo vs 5.43 mo,P=0.002;OS:16.10 mo vs 6.97 mo,P=0.000)and those with NLR<3(PFS:8.10 mo vs 6.57 mo,P=0.008;OS:12.87 mo vs 9.93 mo,P=0.002),GA regimen showed higher efficacy.CONCLUSION GA regimen may be recommended to the patients with NLR<3 or ECOG 0 status although GA and FFX showed comparable efficacy outcomes in patients with metastatic pancreatic cancer. | Sung Yong Han Dong Uk Kim Young Mi Seol Suk Kim Nam Kyung Lee Seung Baek Hong Hyung-Il Seo | 2020 | World Journal of Clinical Cases2020，8，17： | 5 |
| 2 | A sulfur self-doped multifunctional biochar catalyst for overall water splitting and a supercapacitor from Camellia japonica flowers显示文摘A versatile use of a sulfur self-doped biochar derived from Camellia japonica(camellia)flowers is demonstrated as a multifunctional catalyst for overall water splitting and a supercapacitor.The native sulfur content in the camellia flower facilitates in situ self-doping of sulfur,which highly activates the camellia-driven biochar(SA-Came)as a multifunctional catalyst with the enhanced electron-transfer ability and long-term durability.For water splitting,an SA-Came-based electrode is highly stable and shows reaction activities in both hydrogen and oxygen evolution reactions,with overpotentials of 154 and 362 mV at 10 mA cm^(−2),respectively.For supercapacitors,SA-Came achieves a specific capacitance of 125.42 F g^(−1)at 2 A g^(−1)and high cyclic stability in a three-electrode system in a 1 M KOH electrolyte.It demonstrated a high energy density of 34.54 Wh kg^(−1)at a power density of 1600 W kg^(−1)as a symmetric hybrid supercapacitor device with a wide working potential range of 0-1.6 V. | Chengkai Xia Subramani Surendran Seulgi Ji Dohun Kim Yujin Chae Jaekyum Kim Minyeong Je Mi-Kyung Han Woo-Seok Choe Chang Hyuck Choi Heechae Choi Jung Kyu Kim Uk Sim | 2022 | Carbon Energy2022，4，4： | 3 |
| 3 | Acute distal common bile duct angle is risk factor for postendoscopic retrograde cholangiopancreatography pancreatitis in beginner endoscopist显示文摘BACKGROUND Post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP)is a critical and poorly managed complication of ERCP.Endoscopists need to understand the risk factors for PEP.However,the majority of studies investigating ERCP-related risk factors have included well-trained endoscopists,with the issue of endoscopist experience on PEP incidence not having been systematically evaluated.AIM To explore the risk factors for PEP in beginner endoscopists without supervision.METHODS We performed a retrospective analysis of 293 patients,with naïve papilla and no history of pancreatitis,treated using bile duct cannulation.Patients were classified according to the endoscopist’s experience(beginner vs expert).The angle of the distal common bile duct(CBD)was measured as the angle between the lower wall of the bile duct and a vertical line extending to the lower wall of the bile duct on coronal view computed tomography.RESULTS After propensity matching,there were no differences between patients treated by the expert and beginner endoscopist with regard to age,sex,mean bile duct dilatation,and ratio of benign disease.The distal CBD angle was classified as acute(>30º)or obtuse(≤30º),based on the mean angle of 29.9ºfor the group.An acute distal CBD angle was a significant risk factor for PEP for beginner(P=0.049),but not expert.CONCLUSION For beginner endoscopists first performing unsupervised ERCP,cases with an obtuse distal CBD angle may be more appropriate to lower the risk of PEP. | Sung Yong Han Dong Uk Kim Moon Won Lee Young Joo Park Dong Hoon Baek Gwang Ha Kim Geun Am Song | 2020 | World Journal of Clinical Cases2020，8，1： | 3 |
| 4 | External synchronization of two dynamical systems with uncertain parameters显示文摘External synchronization is addressed as two or more dynamical systems with synchronous motions,which is also regarded as master-slave system.In this paper,two dynamical systems,one employs a hysteretic term to model the friction phenomenon,the other involves a hardening stiffness component with the third order of displacement due to flexible deformation,are controlled to converge to the same trajectory.The control strategy is extended from feedback control for all parameters known to adaptive control for linear parameters unknown and all parameters unknown.The slave system can keep synchronous motions with the movements of master via the designed control strategy even all the parameters are not known.The stability of synchronization error,the transient process into synchronization and the effects of parameters on the designed controller using different control strategies are investigated.The simulation results unfold the feasibility and effectiveness of this synchronization method. | HAN QingKai 1,SUN XiaoYu 2,YANG XiaoGuang 3 &WEN BangChun 1 1 School of Mechanical Engineering&Automation,Northeastern University,Shenyang 110004,China 2 School of Electrical Engineering,Shenyang University of Technology,Shenyang 110023,China 3School of Mechanical Engineering,The University of Birmingham,Birmingham,B15 2TT,UK | 2010 | Science China(Technological Sciences)2010，53，3： | 3 |
| 5 | Growth-promoting activity of Hominis Placenta extract on regenerating sciatic nerve显示文摘瞄准:Hominis 胎盘(HP ) 的摘录作为一个代理人在东方药被使用了改进生理的功能。现在的学习被进行调查在一个试验性的臀部的神经损害动物模型的 HP 处理是否在在损害以后改革周围神经纤维上生产支持生长的效果。方法:在 HP 被注入一个臀部的神经损害地点以后,在蛋白质层次的变化被西方的弄污和染色分析的免疫荧光在再生神经区域分析。为对轴索新生的量的评价,一种后退的跟踪技术被用来识别相应于改革轴突的神经元细胞体,并且在有教养的背侧根的神经突长出的程度轧了感觉神经元从经历了一处臀部的神经挤压伤的动物准备了的神经胶质( DRG )在神经原收集前的 7 d 被分析。结果:在受伤臀部的神经的轴索的联系生长的蛋白质(GAP-43 ) 的正式就职层次被 HP 处理提高。HP 处理(Cdc2 ) 也,在调整两极分裂周期 2 上面,蛋白质在受伤臀部的神经的远侧的树桩铺平。导致的 Cdc2 蛋白质在 Schwann 房间被检测,建议那项 Cdc2 激酶活动可以涉及改革经由 Schwann 房间增长的轴突的支持生长的活动。由后退的跟踪的房间身体测量显示 HP 治疗在改革马达轴突产生了重要增加。最后,有教养的 DRG 感觉神经元的 HP 处理显著地增加了神经突树枝状和延伸。结论:HP 支持受伤臀部的轴突的新生由在调整象 GAP-43 和 Cdc2 那样的新生相关的蛋白质因素的合成上面。 | Tae-beom SEO In-sun HAN Jin-hwan YOON In-chan SEOL Yun-sik RIM Hyun-kyung JO Joung-jo AN Kwon-eui HONG Young-bae SEO Dong-hee KIM Seung-kiel PARK Deok-chun YANG Uk NAMGUNG | 2006 | Acta Pharmacologica Sinica2006，27，1： | 2 |
| 6 | Fast ray tracing method in 3-D structure and its proof of positive definiteness显示文摘Based on Fermat’s principle, two-point ray tracing method was studied in three-dimensional structure. By means of first order Taylor’s incomplete series expansion (i.e. no expansion to the length of the ray), a symmetry block tridiagonal matrix equation set was deduced. Further, the positive definiteness of coefficient matrix was discussed, and the positive definiteness was accurately proved in a mathematical way. It assured that the algorithm was well-posed. Associated with iterative method, the solution to ray tracing can be got through step-by-step linearized iteration of the nonlinear problem. An algorithm of the whole path iterative ray tracing method in three-dimensional velocity structure was obtained. This method shows a clear and simple as well as explicit computation formula, which makes ray tracing computation easily applicable in practice. The correction vector is obtained through finding the solution to the positive definite block tridiagonal equation set, which ensures the method is robust convergence. This study offers a new kind of feasible and efficient ray tracing method for three dimensional seismic migration and tomography. Meanwhile, it also provides the prerequisite guarantee to design a fast algorithm. | 高尔根 Uk HAN 滕吉文 | 2007 | Journal of Central South University of Technology2007，14，1： | 2 |
| 7 | Computer simulation of rolling wear on bionic non-smooth convex surfaces显示文摘The study of bionics has found that the skins of many burrow animals which live in soil and stone conditions have an anti wear function, and which is related to their body surfaces’non-smooth morphology. In the present study, bionic non-smooth surfaces are used in roll surface design, and roll models with convex non-smooth surfaces are developed. The rolling wear of non-smooth roll in steel rolling is simulated by the FEM software-ANSYS. The equivalent stress, the node friction stress, and the node contact pressure between the roll and the rolling piece are calculated; and the anti-wear mechanism is analyzed. | HAN Zhi-wu1, LIUZu-bin2, YANG Zhuo-juan1, YAN Yu-ying3, REN Lu-quan1 1. Key Laboratory for Terrain-machine Bionics Engineering (Ministry of Education, China), Jilin University, Changchun 130022, P. R. China 2. Changchun Institute of Automobile, Changchun 130051, P. R. China 3. School of the Built Environment, The University of Nottingham, University Park, Nottingham NG7 2RD, UK 1 | 2004 | Journal of Bionic Engineering2004，1，4： | 2 |
| 8 | GnRH impairs diabetic wound healing through enhanced NETosis显示文摘It has been reported that neutrophil extracellular traps(NETs)impair wound healing in diabetes and that inhibiting NET generation(NETosis)improves wound healing in diabetic mice.Gonadotropin-releasing hormone(GnRH)agonists are associated with a greater risk of diabetes.However,the role of GnRH in diabetic wound healing is unclear.We determined whether GnRH-promoted NETosis and induced more severe and delayed diabetic wound healing.A mouse model of diabetes was established using five injections with streptozotocin.Mice with blood glucose levels>250 mg/dL were then used in the experiments.GnRH agonist treatment induced delayed wound healing and increased NETosis at the skin wounds of diabetic mice.In contrast,GnRH antagonist treatment inhibited GnRH agonist-induced delayed wound healing.The expression of NETosis markers PAD4 and citrullinated histone H3 were increased in the GnRH-treated diabetic skin wounds in diabetic mice and patients.In vitro experiments also showed that neutrophils expressed a GnRH receptor and that GnRH agonist treatment increased NETosis markers and promoted phorbol myristate acetate(PMA)-induced NETosis in mouse and human neutrophils.Furthermore,GnRH antagonist treatment suppressed the expression of NETosis markers and PMA-induced NETosis,which were increased by GnRH treatment.These results indicated that GnRH-promoted NETosis and that increased NETosis induced delayed wound healing in diabetic skin wounds.Thus,inhibition of GnRH might be a novel treatment of diabetic foot ulcers. | Yun Sang Lee Sung Un Kang Myung-Hoon Lee Haeng-Jun Kim Chang-Hak Han Ho-Ryun Won Young Uk Park Chul-Ho Kim | 2020 | Cellular & Molecular Immunology2020，17，8： | 2 |
| 9 | Risk Factors Associated with Complication Following Laparoscopy-Assisted Gastrectomy for Gastric Cancer: A Large-Scale Korean Multicenter Study显示文摘 | Min Chan Kim MD Wook Kim MD Hyung Ho Kim MD Seung Wan Ryu MD Seong Yeob Ryu MD Kyo Young Song MD Hyuk Joon Lee MD Gyu Seok Cho MD Sang Uk Han MD Woo Jin Hyung MD | 2008 | Annals of Surgical Oncology2008，，10： | 2 |
| 10 | Zn-doped nickel iron(oxy)hydroxide nanocubes passivated by polyanions with high catalytic activity and corrosion resistance for seawater oxidation显示文摘Electrochemical water splitting to produce hydrogen fuel is a promising renewable energy-conversion technique.Large-scale electrolysis of freshwater may deplete water resources and cause water scarcity worldwide.Thus,seawater electrolysis is a potential solution to the future energy and water crisis.In seawater electrolysis,it is critical to develop cost-effective electrocatalysts to split seawater without chloride corrosion.Herein,we present zinc-doped nickel iron(oxy)hydroxide nanocubes passivated by negatively charged polyanions(NFZ-PBA-S)that exhibits outstanding catalytic activity,stability,and selectivity for seawater oxidation.Zn dopants and polyanion-rich passivated surface layers in NFZ-PBA-S could effectively repel chlorine ions and enhance corrosion resistance,enabling its excellent catalytic activity and stability for seawater oxidation. | So Jung Kim Heechae Choi Jeong Ho Ryu Kang Min Kim Sungwook Mhin Arpan Kumar Nayak Junghwan Bang Minyeong Je Ghulam Ali Kyung Yoon Chung Kyeong-Han Na Won-Youl Choi Sunghwan Yeo Jin Uk Jang HyukSu Han | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 11 | Stability of anterior openbite correction with multiloop edgewise archwire therapy:A cephalometric follow-up study显示文摘 | Kim YH Han UK Lim DD | 2000 | Am J Orthod Dentofacial Orthop2000，118，1： | 1 |
| 12 | Stability of anterior openbite correction with muhiloop edgewise archwire therapy:A cephalo- metric follow-up study 显示文摘 | Kim YH Han UK Lira DD | 2000 | Am J Orthod Dentofacial Orthop2000，118，1： | 1 |
| 13 | Morbidity and mortality after laparoscopy-assisted and open distal gastrectomy for stage I gastric cancer: Results from a multicenter randomized controlled trial (KLASS-01)显示文摘 | Hyuk-Joon Lee Hyung-Ho Kim Sang Uk Han | 2015 | J Clin Oncol2015，3，： | 1 |
| 14 | Stability of anterior openbite correction with rnultiloop edgewise archwire therapy: a cephalometric follow - up study 显示文摘 | Kim YH Han UK Lim DD | 2000 | Am J orthod Dentofacial Orthod2000，18，1： | 1 |
| 15 | Stability od anterior openbite correction with muhiloop edgewise arehwire therapy: aeephalometric follow-up study显示文摘 | Kim YH Han UK Lim DD | 2000 | Am J Orthod Dentofaeial Orthop2000，118，： | 1 |
| 16 | Stability of anterior openbite correction with muhiloop edgewise arehwire thera- py~A eephalometrie follow--up study 显示文摘 | Kim YH Han UK Lim DD | 2000 | Am J Orthod Dentofacial Orthop2000，118，1： | 1 |
| 17 | Synthesis and characterization of nano-sized nitride particles by using an atmospheric microwave plasma technique显示文摘 | Chan Uk Bang Yong Cheol Hong Han Sup Uhm | 2007 | Surface and Coating Technology2007，201，： | 1 |
| 18 | Synthesis and characterization of nano-sized nitride particles by using an atmospheric microwave plasma technique显示文摘 | Chan Uk Bang Yong Cheol Hong Han Sup Uhm | 2007 | Surface and Coating Technology2007，201，： | 1 |
| 19 | Minimally Invasive Treatment of Gastric Gastrointestinal Stromal Tumors: Laparoscopic and Endoscopic Approach显示文摘 | In Ho Jeong Ji Hun Kim Sang Rim Lee Jin Hong Kim Jae Chul Hwang Sung Jae Shin Kee Myung Lee Hoon Hur Sang Uk Han | 2012 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2012，，3： | 1 |
| 20 | Rapid crystallization-driven high-efficiency phase-pure deep-blue Ruddlesden–Popper perovskite light-emitting diodes显示文摘Perovskite light-emitting diodes(PeLEDs)are considered as promising candidates for nextgeneration solution-processed full-color displays.However,the external quantum efficiencies(EQEs)and operational stabilities of deep-blue(<460 nm)PeLEDs still lag far behind their red and green counterparts.Herein,a rapid crystallization method based on hot-antisolvent bathing is proposed for realization of deep-blue PeLEDs.By promoting immediate removal of the precursor solvent from the wet perovskite films,development of the quasi-two-dimensional(2D)Ruddlesden–Popper perovskite(2D-RPP)crystals with n values>3 is hampered completely,so that phase-pure 2D-RPP films with bandgaps suitable for deep-blue PeLEDs can be obtained successfully.The uniquely developed rapid crystallization method also enables formation of randomly oriented 2D-RPP crystals,thereby improving the transfer and transport kinetics of the charge carriers.Thus,high-performance deep-blue PeLEDs emitting at 437 nm with a peak EQE of 0.63%are successfully demonstrated.The color coordinates are confirmed to be(0.165,0.044),which match well with the Rec.2020 standard blue gamut and have excellent spectral stability. | Gyumin Jang Hyowon Han Sunihl Ma Junwoo Lee Chan Uk Lee Wooyong Jeong Jaehyun Son Dongki Cho Ji-Hee Kim Cheolmin Park Jooho Moon | 2023 | Advanced Photonics2023，5，1： | 1 |
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