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| 1 | Chemical vapor deposition growth of monolayer MoSe2 nanosheets显示文摘 | Jonathan C. Shaw Hailong Zhou Yu Chen Nathan O. Weiss Yuan Liu Yu Huang Xiangfeng Duan | 2014 | Nano Research2014，7，4： | 26 |
| 2 | A quasi-global 1/10° eddy-resolving ocean general circulation model and its preliminary results显示文摘In this study,a quasi-global(excluding the Arctic Ocean) eddy-resolving ocean general circulation model(OGCM) is established based on the latest version of the LASG/IAP Climate system Ocean Model(LICOM2.0).The horizontal resolution and vertical resolution are increased to 1/10° and 55 layers,respectively.Forced by the surface fluxes from the reanalysis and observed data,the model has been integrated for approximately 20 model years(20 a).During the last 8 a,the model is driven by daily mean wind stresses from QuikSCAT and heat fluxes from reanalysis data from 2000 to 2007.The basic performance of the OGCM is analyzed using the last 8 a simulation output.Compared with the simulation of the coarse-resolution OGCM,the eddy-resolving OGCM not only better simulates the spatial-temporal features of mesoscale eddies and the paths and positions of western boundary currents but also reproduces the large meander of the Kuroshio Current and its interannual variability.Another aspect,namely,the complex structures of equatorial Pacific currents and currents in the coastal ocean of China,are better captured due to the increased horizontal and vertical resolution. | YU YongQiang LIU HaiLong LIN PengFei | 2012 | Chinese Science Bulletin2012，57，30： | 18 |
| 3 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 4 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 5 | Heterotic Group Classification of 63 Inbred Lines and Hybrid Purity Identification by Using SSR Markers in Winter Cabbage(Brassica Oleracea L. var. capitata)显示文摘Winter cabbage is an important crop cultivated through winter in the region near the Yangtze River, enabling the supply of fresh cabbage there at that time of year. However, a problem has emerged regarding the newly developed parents of winter cabbage, which is completely different from spring and autumn cabbage, namely, how to combine these parents to breed an elite hybrid. To classify the heterotic groups and improve the efficiency of parent selection in winter cabbage breeding, 20 polymorphic SSR markers were selected to screen 63 winter cabbage inbred lines. Seventeen pairs among the 20 SSR markers amplified polymorphic bands. These primers amplified two to six bands,with an average of 2.8 bands per primer, and a total of 47 polymorphic bands were generated in the 63 inbred lines. These lines included flatheaded morphotype and round-headed morphotype, thus they were separately classified into heterotic groups based on the SSR markers. The flat-headed morphotype contained 21 inbred lines and was classified into three heterotic groups, named Hanchun 4, Jiali, and Dongsheng, in accordance with the representative germplasm contained in each group. The round-headed morphotype contained 42 inbred lines and was classified into five heterotic groups, named Parte, Bejo1039, YK-143, SCA002, and Golden B90. Meanwhile, parent analysis of 20 developed elite combinations showed that their parents were all distributed in different heterotic groups, indicating that the group classification was reasonable,which can provide a basis for further parent selection in winter cabbage breeding. Furthermore, polymorphic SSR primers were successfully used to identify the hybrid purity of three elite varieties. | LI Xing YU Hailong LI Zhiyuan LIU Xiaoping FANG Zhiyuan LIU Yumei YANG Limei ZHUANG Mu LV Honghao ZHANG Yangyong | 2018 | Horticultural Plant Journal2018，4，4： | 11 |
| 6 | Quality assessment of randomized controlled trials reporting on knee osteoarthritis treated with warming needle moxibustion显示文摘OBJECTIVE: To evaluate the quality of randomized controlled trials(RCTs) testing the efficacy of warming needle moxibustion on knee osteoarthritis(KOA).METHODS: Nine databases were searched systematically including: the Cochrane Library(1/1993-10/2012), Pub Med(1/1980-10/2012), EMBASE(1/1990-10/2012), SCI Expanded(1/1986-10/2012), Science Direct(1/1979-10/2012), Chinese Biomedical Literature Database disc(1/1978-10/2012), China National Knowledge Infrastructure Database(1/1979-10/2012), China Science and Technology Journal Database(a full text issue database of China, 1/1989-10/2012), and Wanfang Database(a full text issue database of China, 1/1990-10/2012). Traditional reference retrieval was also conducted. Language was limited to Chinese and English. We identified 37 RCTs that used warming needle moxibustion as an intervention and they were assessed with the Consolidated Standards for Reporting of Trials Statement 2010(CONSORT 2010) and Standards for Reporting Interventions Controlled Trials of Acupuncture 2010(STRICTA 2010).RESULTS: Of the 37 reports, only seventeen(45.95%) mentioned the random allocation of sequence methods, nine used unacceptable methods, and only one(2.70%) gave the description of the mechanism of allocation concealment. One study(2.70%) mentioned blinding, one(2.70%) had a sample size calculation, and twenty-three(62.16%) used reasonable statistical methods. Thirteen(35.14%) described the background and reason for the RCTs, three(8.11%) gave a description of lost or eliminated patients, and two(5.41%) reported accidental situations. Only three(8.11%)gave analysis of the RCT limitations. No report mentioned intentional analysis.CONCLUSION: The quality of the RCTs assessed in this study was from moderate to low. The design of RCTs, the methods of statistical analysis, and the description of reports information needs to be improved. CONSORT 2010 and STRICTA 2010 should be used to standardize the reporting of acupuncture RCTs in the future. | Hailong Yu Yitong Wang Yi Guo Hong Wang Bo Chen Xue Zhao | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 10 |
| 7 | LICOM Model Datasets for the CMIP6 Ocean Model Intercomparison Project显示文摘The datasets of two Ocean Model Intercomparison Project(OMIP)simulation experiments from the LASG/IAP Climate Ocean Model,version 3(LICOM3),forced by two different sets of atmospheric surface data,are described in this paper.The experiment forced by CORE-II(Co-ordinated Ocean–Ice Reference Experiments,Phase II)data(1948–2009)is called OMIP1,and that forced by JRA55-do(surface dataset for driving ocean–sea-ice models based on Japanese 55-year atmospheric reanalysis)data(1958–2018)is called OMIP2.First,the improvement of LICOM from CMIP5 to CMIP6 and the configurations of the two experiments are described.Second,the basic performances of the two experiments are validated using the climatological-mean and interannual time scales from observation.We find that the mean states,interannual variabilities,and long-term linear trends can be reproduced well by the two experiments.The differences between the two datasets are also discussed.Finally,the usage of these data is described.These datasets are helpful toward understanding the origin system bias of the fully coupled model. | Pengfei LIN Zhipeng YU Hailong LIU Yongqiang YU Yiwen LI Jirong JIANG Wei XUE Kangjun CHEN Qian YANG Bowen ZHAO Jilin WEI Mengrong DING Zhikuo SUN Yaqi WANG Yao MENG Weipeng ZHENG Jinfeng MA | 2020 | Advances in Atmospheric Sciences2020，37，3： | 9 |
| 8 | Utilization of Ogura CMS germplasm with the clubroot resistance gene by fertility restoration and cytoplasm replacement in Brassica oleracea L显示文摘Clubroot disease,a major plant root disease caused by Plasmodiophora brassicae,has become one of the most destructive diseases among cultivated cruciferous vegetables.However,clubroot-resistant Brassica oleracea materials are rare.A few clubroot-resistant cabbage varieties are available on the market,but all are Ogura cytoplasmic male sterile(CMS)types.Therefore,in this study,to reutilize the clubroot-resistant Ogura CMS germplasm of cabbage,a new fertility-restored Ogura CMS material,16Q2-11,was used as a bridge to transfer the clubroot resistance(CR)gene from the Ogura CMS cytoplasm to the normal cytoplasm by a two-step method(a fertility restoration and cytoplasm replacement method).In the first cross for fertility restoration of Ogura CMS clubroot-resistant cabbage(FRCRC),16Q2-11 was used as a restorer to cross with Ogura CMS materials containing the CR gene CRb2.Eleven Rfo-positive progenies were generated,of which four contained CRb2:F8-514,F8-620,F8-732 and F8-839.After inoculation with race 4 of P.brassicae,these four CRb2-positive individuals showed resistance.Furthermore,F8-514 and F8-839 were then used as male parents in the second cross of FRCRC to cross with cabbage inbred lines,resulting in the successful introgression of the CRb2 gene into the inbred lines.All offspring produced from this step of cross,which had a normal cytoplasm,showed a high resistance to race 4 of P.brassicae and could be utilized for the breeding of clubrootresistant cabbage varieties in the future.This is the first time that the Ogura CMS restorer has been used to restore the fertility of Ogura CMS clubroot-resistant cabbages,which could improve germplasm diversity in cabbage and provide a reference method for using CMS germplasm in Brassica crops. | Wenjing Ren Zhiyuan Li Fengqing Han Bin Zhang Xing Li Zhiyuan Fang Limei Yang Mu Zhuang Honghao Lv Yumei Liu Yong Wang Hailong Yu Yangyong Zhang | 2020 | Horticulture Research2020，7，1： | 7 |
| 9 | Optimal Planning of Community Integrated Energy Station Considering Frequency Regulation Service显示文摘With the extensive integration of high-penetration renewable energy resources,more fast-response frequency regulation(FR)providers are required to eliminate the impact of uncertainties from loads and distributed generators(DGs)on system security and stability.As a high-quality FR resource,community integrated energy station(CIES)can effectively respond to frequency deviation caused by renewable energy generation,helping to solve the frequency problem of power system.This paper proposes an optimal planning model of CIES considering FR service.First,the model of FR service is established to unify the time scale of FR service and economic operation.Then,an optimal planning model of CIES considering FR service is proposed,with which the revenue of participating in the FR service is obtained under market mechanism.The flexible electricity pricing model is introduced to flatten the peak tieline power of CIES.Case studies are conducted to analyze the annual cost and the revenue of CIES participating in FR service,which suggest that providing ancillary services can bring potential revenue. | Cheng Li Peng Li Hao Yu Hailong Li Jinli Zhao Shuquan Li Chengshan Wang | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，2： | 7 |
| 10 | A Quantitative Evaluation of Shale Gas Content in Different Occurrence States of the Longmaxi Formation: A New Insight from Well JY-A in the Fuling Shale Gas Field,Sichuan Basin显示文摘Comprehensive quantitative evaluation of shale gas content and the controlling factors in different occurrence states is of great significance for accurately assessing gas-bearing capacity and providing effective well-production strategies. A total of 122 core samples from well JY-A in the Fuling shale gas field were studied to reveal the characteristics of S_1 l shale,15 of which were selected to further predict the shale gas content in different occurrence states, which are dependent on geological factors in the thermal evolution process. Geological parameters were researched by a number of laboratory programs, and the factors influential in controlling shale gas content were extracted by both PCA and GRA methods and prediction models were confirmed by the BE method using SPSS software. Results reveal that the adsorbed gas content is mainly controlled by TOC, Ro, SSA, PD and pyrite content, and the free gas content is mainly controlled by S_2, quartz content, gas saturation and formation pressure for S_1 l in well JY-A. Three methods, including the on-site gas desorption method, the empirical formula method, and the multiple regression analysis method were used in combination to evaluate the shale gas capacity of well JY-A, all of which show that the overall shale gas content of well JY-A is in the range of 2.0–5.0 m^3/t and that the free gas ratio is about 50%, lower than that of well JY-1. Cause analysis further confirms the tectonics and preservation conditions of S_1 l in the geological processes, especially the influence of eastern boundary faults on well JY-A, as the fundamental reasons for the differences in shale gas enrichment in the Jiaoshiba area. | TANG Ling SONG Yan LI Qianwen PANG Xiongqi JIANG Zhenxue LI Zhuo TANG Xianglu YU Hailong SUN Yue FAN Shichao ZHU Lin | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 7 |
| 11 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 12 | Two regimes of Atlantic multidecadal oscillation: cross-basin dependent or Atlantic-intrinsic显示文摘The Atlantic Multidedal Oscillation(AMO) is a prominent mode of sea surface temperature variability in the Atlantic and incurs significant global influence. Most coupled models failed to reproduce the observed 50–80-year AMO, but were overwhelmed by a 10–30-year AMO. Here we show that the 50–80-year AMO and 10–30-year AMO represent two different AMO regimes. The key differences are:(1) the 50–80-year AMO involves transport of warm and saline Atlantic water into the Greenland-Iceland-Norwegian(GIN)Seas prior to reaching its maximum positive phase, while such a transport is weak for the 10–30-year AMO;(2) the zonality of atmospheric variability associated with the 50–80 year AMO favors the transport of warm and saline water into the GIN Seas;(3) the disappearance of Pacific variability weakens the zonality of atmospheric variability and the transport of warm and saline water into the GIN Seas, leading to the weakening of the 50–80-year AMO. In contrast, the 10–30-year AMO does not show dependence on the variability in Pacific and in the GIN Seas and may be an Atlantic-intrinsic mode. Our results suggest that differentiating these AMO regimes and a better understanding of the cross-basin connections are essential to reconcile the current debate on the nature of AMO and hence to its reliable prediction, which is still lacking in most of coupled models. | Pengfei Lin Zipeng Yu Jianhua Lü Mengrong Ding Aixue Hu Hailong Liu | 2019 | Science Bulletin2019，64，3： | 6 |
| 13 | Experimental Study and Numerical Simulation of Directionally Solidified Turbine Blade Casting显示文摘汽轮机片样品铸造物的方向性的团结过程在工作被调查。可变退却率用一致 rate.A 在一个退却过程并且与其它相比被使用为热放射转移和方向性的团结过程的微观结构模拟的数学模型基于 CA-FD 被开发方法。温度分发和微观结构被模仿并且与试验性的结果相比。迷路的谷物被预言并且与试验性的结果相比。站台的不平的温度分发是迷路的谷物的形成的主要原因。 | Jing YU Qingyan XU Baicheng LIU Jiarong LI Hailong YUAN Haipeng JIN | 2008 | Journal of Materials Science & Technology2008，24，3： | 4 |
| 14 | Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana显示文摘The specific functions of the genes encoding arginine biosynthesis enzymes in plants are not well characterized. We report the isolation and characterization of Arabidopsis thaliana N-acetylglutamate kinase(NAGK), which catalyzes the second step of arginine biosynthesis. NAGK is a plastid-localized protein and is expressed during most developmental processes in Arabidopsis. Heterologous expression of the Arabidopsis NAGK gene in a NAGK-deficient Escherichia coli strain fully restores bacterial growth on arginine-deficient medium. nagk mutant pollen tubes grow more slowly than wild type pollen tubes and the phenotype is restored by either specifically through complementation by NAGK in pollen, or exogenous supplementation of arginine. nagk female gametophytes are defective in micropylar pollen tube guidance due to the fact that female gametophyte cell fate specification was specifically affected. Expression of NAGK in synergid cells rescues the defect of nagk female gametophytes. Lossof-function of NAGK results in Arabidopsis embryos not developing beyond the four-celled embryo stage. The embryo-defective phenotype in nagk/NAGK plants cannot be rescued by watering nagk/NAGK plants with arginine or ornithine supplementation. In conclusion,our results reveal a novel role of NAGK and arginine in regulating gametophyte function and embryo development, and provide valuable insights into arginine transport during embryo development. | Jie Huang Dan Chen Hailong Yan Fei Xie Ying Yu Liyao Zhang Mengxiang Sun Xiongbo Peng | 2017 | Journal of Integrative Plant Biology2017，59，9： | 4 |
| 15 | Meta analysis of olfactory ensheathing cell transplantation promoting functional recovery of motor nerves in rats with complete spinal cord transection显示文摘OBJECTIVE:To evaluate the effects of olfactory ensheathing cell transplantation on functional recovery of rats with complete spinal cord transection.DATA SOURCES: A computer-based online search of Medline(1989–2013),Embase(1989–2013),Cochrane library(1989–2013),Chinese Biomedical Literature Database(1989–2013),China National Knowledge Infrastructure(1989–2013),VIP(1989–2013),Wanfang databases(1989–2013) and Chinese Clinical Trial Register was conducted to collect randomized controlled trial data regarding olfactory ensheathing cell transplantation for the treatment of complete spinal cord transection in rats.SELECTION CRITERIA: Randomized controlled trials investigating olfactory ensheathing cell transplantation and other transplantation methods for promoting neurological functional recovery of rats with complete spinal cord transection were included in the analysis.Meta analysis was conducted using Rev Man 4.2.2 software.MAIN OUTCOME MEASURES: Basso,Beattie and Bresnahan scores of rats with complete spinal cord transection were evaluated in this study.RESULTS: Six randomized controlled trials with high quality methodology were included.Meta analysis showed that Basso,Beattie and Bresnahan scores were significantly higher in the olfactory ensheathing cell transplantation group compared with the control group(WMD = 3.16,95% CI(1.68,4.65); P < 0.00001).CONCLUSION: Experimental studies have shown that olfactory ensheathing cell transplantation can promote the functional recovery of motor nerves in rats with complete spinal cord transection. | Jun Liu Ping Chen Qi Wang Yu Chen Hailong Yu Junxiong Ma Mingming Guo Meihui Piao Weijian Ren Liangbi Xiang | 2014 | Neural Regeneration Research2014，9，20： | 4 |
| 16 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 17 | Comparative Transcriptome Analysis Reveals Different Host Cell Responses to Acute and Persistent Foot-and-Mouth Disease Virus Infection显示文摘Foot-and-mouth disease virus(FMDV) rapidly causes cytopathic effects in susceptible cells. Incomplete viral clearance during the acute infection leads to persistent infection. The relationship between host gene expression and the persistent infection remains unclear. In this study, we analyzed the transcriptome profiles of BHK-21 cells acutely and persistently infected with FMDV to identify differences in gene expression. GO and KEGG enrichment analyses showed that the 8,378 differentially expressed genes were significantly enriched in categories including metabolism, biosynthesis, ribosome function, and endocytosis. In persistently infected BHK-21 cells, ribosome-and translation-related genes were significantly down-regulated. There were more differentially expressed immune-related genes during persistent infection than during acute infection. Two hundred and seventy-four genes were differentially expressed in both acutely and persistently infected BHK-21 cells. Among these genes, heat shock protein family B member 1(Hspb1) knockdown significantly inhibited FMDV replication. Our research provides a basis for further research to understand the mechanisms of persistent FMDV infection including the genes involved in FMDV replication. | Jiadai Li Lingling Han Yao Hao Yuncong Yuan Mingzhen Wang Xiu Xin Hailong Wang Fang Yu Congyi Zheng Chao Shen | 2020 | Virologica Sinica2020，35，1： | 4 |
| 18 | Reduced graphene oxide/silicon nanowire hetero- structures with enhanced photoactivity and superior photoelectrochemical stability显示文摘Silicon nanowires (SiNWs) have been widely studied as light harvesting antennas in photocatalysts due to their ability to absorb broad-spectrum solar radiation, but they are typically limited by poor photoelectrochemical stability. Here, we report the synthesis of reduced graphene oxide-SiNW (rGO-SiNW) heterostructures to achieve greatly improved photocatalytic activity and stability. The SiNWs were synthesized through a metal-assisted electroless etching process and functionalized with reduced graphene oxide (rGO) flakes through a chemical absorption process. Here, the rGO not only functions as a physical protection layer to isolate the SiNWs from the harsh electrochemical environment but also serves as a charge mediator to facilitate the charge separation and transport processes. Furthermore, the rGO may also function as a redox catalyst to ensure efficient utilization of photo-carriers for the desired chemical reactions. Photocatalytic dye degradation studies show that the photoactivity of the heterostructures can be significantly enhanced with an initial activation process and maintained without apparent decay over repeated reaction cycles. Electrochemical and photo- electrochemical studies indicate that the enhanced photoactivity and photostability can be attributed to the more efficient separation of photoexcited charge carriers in SiNWs and the reduced self-oxidation of the surface of the SiNWs during the photocatalytic dye degradation process. The ability to significantly improve the photocatalytic activity and stability in rGO-SiNW heterostructures can not only lead to more opportunities for the application of silicon-based photocatalysts/ photoelectrodes for solar energy harvesting but also provide new insights into the stabilization of other unstable photocatalytic | Xing Zhong Gongming wang Benjamin Papandrea Mufan Li Yuxi Xu Yu Chen Chih-Yen Chen Hailong Zhou Teng Xue Yongjia Li Dehui Li Yu Huang Xiangfeng Duan | 2015 | Nano Research2015，8，9： | 4 |
| 19 | Mild Breakthrough Infection in a Healthcare Professional Working in the Isolation Area of a Hospital Designated for Treating COVID-19 Patients—Shaanxi Province,China,March,2021显示文摘Summary What is already known about this topic?Healthcare workers are at high risk of acquiring COVID-19 from occupational exposure to COVID-19 virus during their daily medical service work.Excellent infection prevention and control measures and adequate personal protective equipment(PPE)are essential to reduce the risk of hospital-acquired COVID-19. | Chaofeng Ma Songtao Xu Yecheng Yao Pengbo Yu You Xu Rui Wu Hailong Chen Xiaoping Dong | 2021 | China CDC weekly2021，3，19： | 4 |
| 20 | Indonesian Throughflow in an eddy-resolving ocean model显示文摘The performance of the eddy-resolving LICOM2.0 in simulating the Indonesian Throughflow has been evaluated against the INSTANT data in the present study.The mean vertical structures of the along strait velocities are simulated well in LICOM2.0,but the large velocities at the bottom of the Lifamatola Passage and the Timor Passage cannot be reproduced by LICOM2.0.The causes are considered to be both the errors in the topography and the tidal mixing at the bottom.Despite several biases in the mean velocities,the mean inflow and outflow volume transports in LICOM2.0 are almost identical to the INSTANT data.Compared with the lower resolution LICOM,the most significant improvement is the better simulation of the partitions of the inflow and outflow transports in individual straits.The outflow for low-resolution LICOM is mainly through the Ombai and Lombok Strait,whereas that for LICOM2.0 is mainly through the Timor Passage.The variability of the vertical structure of velocities and the volume transport are also investigated.LICOM2.0 overestimates the magnitude of the upper-layer currents and the amplitude of the variation.We also found that the largest correlation coefficient occurs in the shallowest strait,the Lombok,whereas the lowest occurs in the Timor Passage,especially in the upper layer.The latter may be caused by the unrealistic transport through the Torres Strait in LICOM2.0. | FENG Xue LIU HaiLong WANG FuChang YU YongQiang YUAN DongLiang | 2013 | Chinese Science Bulletin2013，58，35： | 4 |
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