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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain显示文摘 | Hofer M Pagliusi SR Hohn A | 1990 | EM BO1990，9，： | 2 |
| 3 | Competition for cytokines : T (reg) cells take all 显示文摘 | Scheffold A Murphy KM Hofer T | 2007 | Nat Immunol2007，8，： | 1 |
| 4 | Arginine-vasopressinin neonates with vasodilatory shock after cardiopulmonary bypass显示文摘 | Lechner E Hofer A Mair R | 2007 | Eur J Pediatr2007，166，12： | 1 |
| 5 | Assessment of stroke volume variation for prediction fluid responsiveness using the modified Flo- Trac and PiCCO plus system 显示文摘 | Hofer CK Senn A Weibel L | 2008 | Crit Care2008，12，3： | 1 |
| 6 | Platform-driven development of product families:linking theory with practice显示文摘 | HALMAN J I M HOFER A P VAN VUUREN W | 2003 | Journal of Product Innovation Management2003，20，2： | 1 |
| 7 | Narrowband(311-nm) UV-B therapy for small plaque parap~fiasis and early-stage mycosis fungoides显示文摘 | Hofer A Cerroni L Kerl H | 1999 | Arch Dermatol1999，135，11： | 1 |
| 8 | Expression of MTAI promotes motility and invasiveness of PANC--I pancreatic carcinoma cells显示文摘 | Hofer MD Menke A Genze F | 2004 | Br J Cancer2004，90，2： | 1 |
| 9 | The potential of layout platforms for modular complex products and systems 显示文摘 | HOFER A P HALMAN J I M | 2005 | Journal of Engineering Design2005，16，2： | 1 |
| 10 | 2Expression of MTA1 promotesmotility and invasiveness of PANC21 pancreatic carcinoma cells显示文摘 | Hofer MD Menke A | 2004 | B ritish J2 Cancer2004，90，2： | 1 |
| 11 | Gender Differences in Regional Cerebral Activity During thePerception of Emotion: A Functional MRI Study 显示文摘 | HOFER A SIEDENTOPF C M ISCHEBECK A | 2006 | Neuroimage2006，32，2： | 1 |
| 12 | Multiple regions of alpha-synuclein are associated with Parkinson′s disease显示文摘 | MUELLER J C FUCHS J HOFER A | | 0，，04： | 1 |
| 13 | Inflammatory mechanisms in ischemic stroke: therapeutic approaches 显示文摘 | Lakhan SE Kirchgessner A Hofer M | 2009 | J Transl Med2009，7，： | 1 |
| 14 | The determination of new venture performance:An extended model显示文摘 | Chrisman J J Bauerschmidt A Hofer C W | 1998 | Entrepreneurship: Theory and Practice1998，23，1： | 1 |
| 15 | The efficacy of excimer laser (308 nm) for vitiligo at different body sites显示文摘 | Hofer A Hassan AS Legat FJ | 2006 | J Eur Acad Dermatol Venereol2006，20，5： | 1 |
| 16 | The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis 显示文摘 | Weger W Hofer A Stanger O | 2008 | Exp Dermatol2008，17，9： | 1 |
| 17 | Assessment of stroke volume variation for prediction of fluid responsiveness using the modified FloTrac and PiCCOplus system显示文摘 | Hofer CK Senn A Weibel L | 2008 | Crit Care2008，12，3： | 1 |
| 18 | Inflammatory mechanisms in is- chemic stroke : therapeutic approaches 显示文摘 | Lakhan SE Kirchgessner A Hofer M | 2009 | J Transl Med2009，7，： | 1 |
| 19 | Effect of a social companion on the ultrasonic vocalizations and contact responses of 3 - day-old rat pups 显示文摘 | Carden S E Hofer M A | 1992 | Behav Neurosci1992，106，2： | 1 |
| 20 | Competition for cytokines: T(reg) cells take all显示文摘 | SCHEFFOLD A MURPHY KM HOFER T | 2007 | Nature Immunology2007，8，12： | 1 |
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