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| 1 | Current protective strategies in liver surgery显示文摘During liver resection surgery for cancer or liver transplantation,the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow),which results in liver injury [ischemiareperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia,ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response),ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion),pharmacological agents to decrease IR injury,genetic modulation of IR injury,and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC,ischaemic postconditioning,various pharma-cological agents,gene therapy,and machine perfusion decrease IR injury,none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning,gene therapy,and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection. | Kurinchi S Gurusamy Hector D Gonzalez Brian R Davidson | 2010 | World Journal of Gastroenterology2010，16，48： | 7 |
| 2 | Physical chemical and biological characterization of a new bacteriocin produced by Bacillus cereus NS02显示文摘Objective:To screen the bacteriocinogenic isolate from buffalo milk and to characterize it on physical,chemical and biological aspects for the application in biopreservation.Methods:Bacillus cereus(B.cereus)was isolated and assessed for its baceteriocinogenic activity.Bacteriocin was produced and purified by ammonium sulphate precipitation,dialysis and gel filtration chromatography.Purified bacteriocin was used to clieck its antimicrobial activity against food borne bacteria.Effect and stability of bacteripcin was determined with the respect to temperature,pH,enzymes,organic solvents and chemicals.Bacteriocin was also subjected to SDS PAGE analysis to determine its molecular weight.In addition,functional groups exist in the bacteriocin was determined by FTIR analysis.Results:B.cereus was identified by 16S rRNA sequence analysis.Bacteriocin showed increased activity against all the bacteria used and its activity unit was found to be 51,200 AU/mL.It was stable to high temperature(100℃)and wide range of pH(3-10),sensitive to proteolytic enzymes and resistant to nonprotcolytic enzymes.It was low molecular weight(3.5-6 kDa)protein and FTIR study revealed the presence of amide group and NH stretching,Conclusions:Bacteriocin produced in this study possesses the highest antimicrobial activity against both gram positive and gram negative bacteria thereby it has immense application as biopreservative agent.FTIR proved its peptide nature. | Senbagam D Gurusamy R Senthilkumar B | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，12： | 4 |
| 3 | Long term properties under marine exposure of steel fiber reinforced concrete containing PFA 显示文摘 | MANGAT D S GURUSAMY K | 1988 | Materials and Structures1988，21，125： | 1 |
| 4 | Chloride diffusion in steelfiber reinforced marine concrete显示文摘 | MANGAT D S GURUSAMY K | 1988 | Cement and Concrete Research1988，18，3： | 1 |
| 5 | Long term properties under marine exposure of steel fiber reinforced concrete containing PFA显示文摘 | MANGAT D S GURUSAMY K | 1988 | Materials and Structures1988，24，5： | 1 |
| 6 | Techniques for liver paren-chymal transaction in liver resection显示文摘 | Gurusamy KS Pamecha V Sharma D | 2009 | Cochrane Database Syst Rev2009，，： | 1 |
| 7 | Techniques for liver parenchymal transection in liver resection 显示文摘 | GURUSAMY K S PAMECHA V SHARMA D | 2009 | Cochrane Database Syst Rev2009，21，00： | 1 |
| 8 | Red wine antioxidant resveratrol-modified cardiac stem ceils regenerate infarcted myocardium 显示文摘 | Gurusamy N Ray D Lekli I | 2010 | J Cell Mol Med2010，14，9： | 1 |
| 9 | Techniques for liverparenchymal transection in liver resection显示文摘 | Gurusamy KS Pamecha V Sharma D | 2009 | Cochrane DatabaseSyst Rev2009，，00： | 1 |
| 10 | Methods of vascular occlusion for elective liver resections显示文摘 | Gurusamy KS Kumar Y Sharma D | | 0，，04： | 1 |
| 11 | Techniques forliver parenchymal transection: a meta-analysis of randomizedcontrollea trials显示文摘 | Pamecha V Gurusamy KS Sharma D | 2009 | HPB (Oxford)2009，11，4： | 1 |
| 12 | Liver resection versus other treatments for neuroendocrine tumours in patients with resectable liver metastases 显示文摘 | Gurusamy KS Ramamoorthy R Sharma D | 2009 | Cochrane Database Syst Rev2009，，： | 1 |
| 13 | Techniques forliver parenchymal transection:a meta-analysis of randomizedcontrolled trials显示文摘 | Pamecha V Gurusamy KS Sharma D | 2009 | HPB(Oxford)2009，11，4： | 1 |
| 14 | Myeloid-specific expression of RON receptor kinase promotes prostate tu- mor growth 显示文摘 | Gurusamy D Gray JK Pathrose P | 2013 | Cancer Res2013，73，6： | 1 |
| 15 | Red wine antioxidant resveratrolmodified cardiac stem cells regenerate in-farcted myocardium显示文摘 | Gurusamy N Ray D Lekli I Das DK | | 0，，： | 1 |
| 16 | The RON recep- tor promotes prostate tumor growth in the TRAMP mouse model 显示文摘 | Thobe MN Gray JK Gurusamy D | 2011 | Oneogene2011，30，50： | 1 |
| 17 | Techniques for liver parenchymal transection:a meta-analysis of randomized controlled trials显示文摘 | Pamecha V Gurusamy KS Sharma D | | 0，，04： | 1 |
| 18 | Ischaemic preconditioning for liver transplantation显示文摘 | Gurusamy KS Kumar Y Sharma D | 2008 | Cochrane Database Syst Rev2008，23，1： | 1 |
| 19 | Techniques for liver parenchymal transection inliver resection显示文摘 | Gurusamy KS Pamecha V Sharma D | 2009 | Cochrane Database Syst Rev2009，，00： | 1 |
| 20 | Areview of contemporary surgical alternatives to permanent colos- tomy显示文摘 | Gurusamy KS Marzouk D Benziger H | 2005 | Int J Surg2005，3，3： | 1 |
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