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| 1 | Assimilating the along-track sea level anomaly into the regional ocean modeling system using the ensemble optimal interpolation显示文摘The ensemble optimal interpolation(EnOI) is applied to the regional ocean modeling system(ROMS) with the ability to assimilate the along-track sea level anomaly(TSLA). This system is tested with an eddy-resolving system of the South China Sea(SCS). Background errors are derived from a running seasonal ensemble to account for the seasonal variability within the SCS. A fifth-order localization function with a 250 km localization radius is chosen to reduce the negative effects of sampling errors. The data assimilation system is tested from January 2004 to December 2006. The results show that the root mean square deviation(RMSD) of the sea level anomaly decreased from 10.57 to 6.70 cm, which represents a 36.6% reduction of error. The data assimilation reduces error for temperature within the upper 800 m and for salinity within the upper 200 m, although error degrades slightly at deeper depths. Surface currents are in better agreement with trajectories of surface drifters after data assimilation. The variance of sea level improves significantly in terms of both the amplitude and position of the strong and weak variance regions after assimilating TSLA. Results with AGE error(AGE) perform better than no AGE error(NoAGE) when considering the improvements of the temperature and the salinity. Furthermore, reasons for the extremely strong variability in the northern SCS in high resolution models are investigated. The results demonstrate that the strong variability of sea level in the high resolution model is caused by an extremely strong Kuroshio intrusion. Therefore, it is demonstrated that it is necessary to assimilate the TSLA in order to better simulate the SCS with high resolution models. | LYU Guokun WANG Hui ZHU Jiang WANG Dakui XIE Jiping LIU Guimei | 2014 | Acta Oceanologica Sinica2014，33，7： | 4 |
| 2 | The Nature and Predictability of the East Asian Extreme Cold Events of 2020/21显示文摘Three extreme cold events invaded China during the early winter period between December 2020 to mid-January 2021 and caused drastic temperature drops,setting new low-temperature records at many stations during 6−8 January 2021.These cold events occurred under background conditions of low Arctic sea ice extent and a La Niña event.This is somewhat expected since the coupled effect of large Arctic sea ice loss in autumn and sea surface temperature cooling in the tropical Pacific usually favors cold event occurrences in Eurasia.Further diagnosis reveals that the first cold event is related to the southward movement of the polar vortex and the second one is related to a continent-wide ridge,while both the southward polar vortex and the Asian blocking are crucial for the third event.Here,we evaluate the forecast skill for these three events utilizing the operational forecasts from the ECMWF model.We find that the third event had the highest predictability since it achieves the best skill in forecasting the East Asian cooling among the three events.Therefore,the predictability of these cold events,as well as their relationships with the atmospheric initial conditions,Arctic sea ice,and La Niña deserve further investigation. | Guokun DAI Chunxiang LI Zhe HAN Dehai LUO Yao YAO | 2022 | Advances in Atmospheric Sciences2022，39，4： | 4 |
| 3 | Progress in the development of a fully implantable brain–computer interface:the potential of sensing-enabled neurostimulators显示文摘With the advances in neurophysiological recording technology and active implantable medical device development,sensing-enabled neurostimulators have become an emerging technology of the fully implantable brain–computer interface(BCI).These implantable neurostimulators are designed for deep brain stimulation(DBS),a well-established treatment for movement disorders and a promising treatment for psychiatric disorders.By integrating neural recording,sensing-enabled neurostimulators can sample local field potentials(LFPs)through the available contacts of the DBS electrode while delivering stimulation. | Yue Chen Guokun Zhang Linxiao Guan Chen Gong Bozhi Ma Hongwei Hao Luming Li | 2022 | National Science Review2022，9，10： | 3 |
| 4 | Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Malkhaz Mizandari Madhava Pai Feng Xi Vlastimil Valek Andrasina Tomas Pietro Quaretti Rita Golfieri Cristina Mosconi Ao Guokun Charis Kyriakides Robert Dickinson Joanna Nicholls Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，3： | 3 |
| 5 | Influence of the Arctic on the Predictability of Eurasian Winter Extreme Weather Events显示文摘The linkage between the Arctic and midlatitudes has received much attention recently due to the rapidly changing climate.Many investigations have been conducted to reveal the relationship between the Arctic and Eurasian extreme events from the perspective of climatological statistics.As a prediction source for extreme events in Eurasia,Arctic conditions are crucial for extreme event predictions.Therefore,it is urgent to explore the Arctic influence on the predictability of Eurasian extreme events due to the large uncertainties in Arctic conditions.Considering the sensitivity and nonlinearity of the atmospheric circulations in midlatitude to Arctic conditions,it is necessary to investigate the Arctic influences on Eurasian extreme weather events in case studies at weather time scales.Previous studies indicate that only perturbations in specific patterns have fast growth.Thus,the conditional nonlinear optimal perturbation approach is recommended for exploring the uncertainties in Arctic initial and boundary conditions and their synergistic effect on Eurasian extreme events.Moreover,the mechanism for extreme event formation may differ in different cases.Therefore,more extreme cases should be investigated to reach robust conclusions. | Guokun DAI Mu MU | 2020 | Advances in Atmospheric Sciences2020，37，4： | 3 |
| 6 | Single-Molecule Kinetics of Nanoparticle Catalysis显示文摘Owing to their structural dispersion,the catalytic properties of nanoparticles are challenging to characterize in ensemble-averaged measurements.The single-molecule approach enables studying the catalysis of nanoparticles at the single-particle level with real-time single-turnover resolution.This article reviews our single-molecule fluorescence studies of single Au-nanoparticle catalysis,focusing on the theoretical formulations for extracting quantitative reaction kinetics from the single-turnover resolution catalysis trajectories.We discuss the single-molecule kinetic formulism of the Langmuir-Hinshelwood mechanism for heterogeneous catalysis,as well as of the two-pathway model for product dissociation reactions.This formulism enables the quantitative evaluation of the heterogeneous reactivity and the differential selectivity of individual nanoparticles that are usually hidden in ensemble measurements.Extension of this formulism to single-molecule catalytic kinetics of oligomeric enzymes is also discussed. | Weilin Xu Hao Shen Guokun Liu Peng Chen | 2009 | Nano Research2009，2，12： | 2 |
| 7 | Up-Regulation of Akt and Nav1.8 in BmK I-Induced Pain显示文摘Dear Editor,As the key contributor to the rising phase of action potentials in dorsal root ganglion(DRG)neurons,voltagegated sodium channels(VGSCs)are important in physiological and pathological pain conditions.For instance,abnormal expression of VGSCs in DRG neurons is | Guokun Zhou Yunlu Jiao You Zhou Shichao Qin Jie Tao Feng Jiang Zhi-Yong Tan Yong-Hua Ji | 2018 | Neuroscience Bulletin2018，34，3： | 2 |
| 8 | Local knockdown of Navl.6 relieves pain behaviors induced by BmK I显示文摘 | Shichao Qin Feng Jiang You Zhou Guokun Zhou Pin Ye Yonghua Ji | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 2 |
| 9 | Oxygen‑Defect Enhanced Anion Adsorption Energy Toward Super‑Rate and Durable Cathode for Ni–Zn Batteries显示文摘The alkaline zinc-based batteries with high energy density are becoming a research hotspot.However,the poor cycle stability and low-rate performance limit their wide application.Herein,ultra-thin CoNiO2 nanosheet with rich oxygen defects anchored on the vertically arranged Ni nanotube arrays(Od-CNO@Ni NTs)is used as a positive material for rechargeable alkaline Ni–Zn batteries.As the highly uniform Ni nanotube arrays provide a fast electron/ion transport path and abundant active sites,the Od-CNO@Ni NTs electrode delivers excellent capacity(432.7 mAh g^(−1))and rate capability(218.3 mAh g^(−1) at 60 A g^(−1)).Moreover,our Od-CNO@Ni NTs//Zn battery is capable of an ultra-long lifespan(93.0%of initial capacity after 5000 cycles),extremely high energy density of 547.5 Wh kg^(−1) and power density of 92.9 kW kg^(−1)(based on the mass of cathode active substance).Meanwhile,the theoretical calculations reveal that the oxygen defects can enhance the interaction between electrode surface and electrolyte ions,contributing to higher capacity.This work opens a reasonable idea for the development of ultra-durable,ultra-fast,and high-energy Ni–Zn battery. | Jia Yao Houzhao Wan Chi Chen Jie Ji Nengze Wang Zhaohan Zheng Jinxia Duan Xunying Wang Guokun Ma Li Tao Hanbin Wang Jun Zhang Hao Wang | 2021 | Nano-Micro Letters2021，13，11： | 2 |
| 10 | Phytase expressian in transgenie soybeans: stable transformation with a vector-less contruet 显示文摘 | Gao Xiaorong Wang Guokun Su Qiao | 2007 | Biotechnology Letters2007，29，11： | 1 |
| 11 | Circulating mi-croRNA:a novel potential biomarker for early diagnosis ofacute myocardial infarction in humans 显示文摘 | Wang Guokun Zhu Jiaqi Zhang Juntao | 2010 | European HeartJournal2010，31，6： | 1 |
| 12 | CT血流动力学用于乳腺癌诊断的ROC曲线分析(英文)显示文摘Objective:The aim of this study was evaluate the diagnostic value of computed tomography(CT) perfusion in breast cancer by the method of receiver operator characteristic curve(ROC) analysis.Methods:Eighty-one cases with breast masses found by health examination or mammography were scanned by multi-slice spiral CT(MSCT) perfusion and hemodynamic parameters of blood flow(BF), mean transit time(MTT) and blood volume(BV) were calculated by deconvolution arithmetic.According to the pathologic results, two groups, benign and malignant were classified and statistical analysis were performed between them.The ROC characteristics of BF, MTT, BV were compared for each and the diagnostic value of the hemodynamic parameters were confirmed.Results:In the malignant group, BF was(0.735 ± 0.440) mL/min/mL, MTT was(22.771 ± 7.647) s and BV was 0.234 ± 0.082.In the benign group, BF was(0.466 ± 0.527) mL/min/mL, MTT was(26.712 ± 12.934) s and BV was 0.179 ± 0.117.There was a significant difference for BF and BV between the benign and malignant groups.When the hemodynamic parameters were used to discriminate the breast lesions, the area under the ROC curve(AUCROC) of BF was 0.832 ± 0.086, the maximum, while AUCROC of BV was 0.695 ± 0.092.There was no significant statistical difference between BF and BV.AUCROC of MTT was 0.473 ± 0.102, which was minimal.Since the threshold of BF was 0.381 mL/min/mL, the sensitivity was 82.3%, the specificity was 73.2%, the positive likelihood ratio(LR) was 3.071 and the negative LR was 0.242.The threshold of BV was 0.190 with sensitivity 73.3%, specificity 56.5%, positive likelihood ratio 1.685 and negative LR 0.473.Conclusion:BF and BV among CT hemodynamic parameters have certain diagnostic value in breast cancer, but BF or BV can not yet be single index to confirm or deny the diagnosis. | Xiaodong Yuan Guokun Ao Changbin Quan Jing Zhang Peijun Wang Yuan Tian | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 1 |
| 13 | Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Malkhaz Mizandari Madhava Pai Feng Xi Vlastimil Valek Andrasina Tomas Pietro Quaretti Rita Golfieri Cristina Mosconi Ao Guokun Charis Kyriakides Robert Dickinson Joanna Nicholls Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，3： | 1 |
| 14 | Novel Percutaneous Radiofrequency Ablation of Portal Vein Tumor Thrombus: Safety and Feasibility显示文摘 | Malkhaz Mizandari Guokun Ao Yaojun Zhang Xi Feng Qiang Shen Minshan Chen WanYee Lau Joanna Nicholls Long Jiao Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，1： | 1 |
| 15 | When tile signal is not from the original molecule to be detected: chemical transformation of para-aminothiophenol on Ag during the SERS measuremem 显示文摘 | Huang Yifan Zhu Hongping Liu Guokun | 2010 | J Am ChemSoc2010，132，： | 1 |
| 16 | LncRNA-m18as1 competitively binds with miR-18a-5p to regulate follicle-stimulating hormone secretion through the Smad2/3 pathway in rat primary pituitary cells显示文摘Long noncoding RNAs(lncRNAs)are expressed in different species and different tissues,and perform different functions,but little is known about their involvement in the synthesis or secretion of follicle-stimulating hormone(FSH).In general,we have revealed lnc RNA-micro RNA(mi RNA)-messenger RNA(m RNA)interactions that may play important roles in rat primary pituitary cells.In this study,a new lncRNA was identified for the first time.First,we analyzed the gene expression of lncRNA-m18as1 in different tissues and different stages by reverse transcription-quantitative polymerase chain reaction(RT-qPCR)and observed the localization of lncRNA-m18as1 with fluorescence in situ hybridization,which indicated that this lncRNA was distributed mainly in the cytoplasm.Next,we used RT-qPCR and enzyme-linked immunosorbent assay(ELISA)to analyze the regulation of FSH synthesis and secretion after overexpression or knockdown of lncRNA-m18as1 and found that lncRNA-m18as1 was positively correlated with FSH synthesis and secretion.In addition,mothers against decapentaplegic homolog 2(Smad2)was highly expressed in our sequencing results.We also screened miR-18a-5p from our sequencing results as a miRNA that may bind to lncRNA-m18as1 and Smad2.We used RNA immunoprecipitation-qPCR(RIP-qPCR)and/or dual luciferase assays to confirm that lncRNA-m18as1 interacted with miR-18a-5p and miR-18a-5p interacted with Smad2.Fluorescence in situ hybridization(FISH)showed that lncRNA-m18as1 and miR-18a-5p were localized mainly in the cytoplasm.Finally,we determined the relationship among lncRNA-m18as1,miR-18a-5p,and the Smad2/3 pathway.Overall,we found that lncRNA-m18as1 acts as a molecular sponge of miR-18a-5p to regulate the synthesis and secretion of FSH through the Smad2/3 pathway. | Weidi ZHANG Wenzhi REN Dongxu HAN Guokun ZHAO Haoqi WANG Haixiang GUO Yi ZHENG Zhonghao JI Wei GAO Bao YUAN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，6： | 0 |
| 17 | Influence of Arctic Sea-ice Concentration on Extended-range Forecasting of Cold Events in East Asia显示文摘Utilizing the Community Atmosphere Model,version 4,the influence of Arctic sea-ice concentration(SIC)on the extended-range prediction of three simulated cold events(CEs)in East Asia is investigated.Numerical results show that the Arctic SIC is crucial for the extended-range prediction of CEs in East Asia.The conditional nonlinear optimal perturbation approach is adopted to identify the optimal Arctic SIC perturbations with the largest influence on CE prediction on the extended-range time scale.It shows that the optimal SIC perturbations are more inclined to weaken the CEs and cause large prediction errors in the fourth pentad,as compared with random SIC perturbations under the same constraint.Further diagnosis reveals that the optimal SIC perturbations first modulate the local temperature through the diabatic process,and then influence the remote temperature by horizontal advection and vertical convection terms.Consequently,the optimal SIC perturbations trigger a warming center in East Asia through the propagation of Rossby wave trains,leading to the largest prediction uncertainty of the CEs in the fourth pentad.These results may provide scientific support for targeted observation of Arctic SIC to improve the extended-range CE prediction skill. | Chunxiang LI Guokun DAI Mu MU Zhe HAN Xueying MA Zhina JIANG Jiayu ZHENG Mengbin ZHU | 2023 | Advances in Atmospheric Sciences2023，40，12： | 0 |
| 18 | The Influence of Arctic Sea Ice Concentration Perturbations on Subseasonal Predictions of North Atlantic Oscillation Events显示文摘The influence of Arctic sea ice concentration (SIC) on the subseasonal prediction of the North Atlantic Oscillation (NAO) event is investigated by utilizing the Community Atmospheric Model version 4. The optimal Arctic SIC perturbations which exert the greatest influence on the onset of an NAO event from a lead of three pentads (15 days) are obtained with a conditional nonlinear optimal perturbation approach. Numerical results show that there are two types of optimal Arctic SIC perturbations for each NAO event, with one weakening event (marked as type-1) and another strengthening event (marked as type-2). For positive NAO events, type-1 optimal SIC perturbations mainly show positive SIC anomalies in the Greenland, Barents, and Okhotsk Seas, while type-2 perturbations mainly feature negative SIC anomalies in these regions. For negative NAO events, the optimal SIC perturbations have almost opposite patterns to those in positive events, although there are some differences among these SIC perturbations due to different atmospheric initial conditions. Further diagnosis reveals that the optimal Arctic SIC perturbations first modify the surface turbulent heat flux and the temperature in the lower troposphere via diabatic processes. Afterward, the temperature in the low troposphere is mainly affected by dynamic advection. Finally, potential vorticity advection plays a crucial role in the 500-hPa geopotential height prediction in the northern North Atlantic sector during pentad 4, which influences NAO event prediction. These results highlight the importance of Arctic SIC on NAO event prediction and the spatial characteristics of the SIC perturbations may provide scientific support for target observations of SIC in improving NAO subseasonal predictions. | Guokun DAI Mu MU Zhe HAN Chunxiang LI Zhina JIANG Mengbin ZHU Xueying MA | 2023 | Advances in Atmospheric Sciences2023，40，12： | 0 |
| 19 | Single-cell transcriptome reveals core cell populations and androgen-RXFP2 axis involved in deer antler full regeneration显示文摘Deer antlers constitute a unique mammalian model for the study of both organ formation in postnatal life and annual full regeneration.Previous studies revealed that these events are achieved through the proliferation and differentiation of antlerogenic periosteum(AP)cells and pedicle periosteum(PP)cells,respectively.As the cells resident in the AP and the PP possess stem cell attributes,both antler generation and regeneration are stem cell-based processes.However,the cell composition of each tissue type and molecular events underlying antler development remain poorly characterized.Here,we took the approach of single-cell RNA sequencing(scRNA-Seq)and identified eight cell types(mainly THY1^(+)cells,progenitor cells,and osteochondroblasts)and three core subclusters of the THY1^(+)cells(SC2,SC3,and SC4).Endothelial and mural cells each are heterogeneous at transcriptional level.It was the proliferation of progenitor,mural,and endothelial cells in the activated antler-lineage-specific tissues that drove the rapid formation of the antler.We detected the differences in the initial differentiation process between antler generation and regeneration using pseudotime trajectory analysis.These may be due to the difference in the degree of stemness of the AP-THY1+and PP-THY1^(+)cells.We further found that androgen-RXFP2 axis may be involved in triggering initial antler full regeneration.Fully deciphering the cell composition for these antler tissue types will open up new avenues for elucidating the mechanism underlying antler full renewal in specific and regenerative medicine in general. | Hengxing Ba Xin Wang Datao Wang Jing Ren Zhen Wang Hai-Xi Sun Pengfei Hu Guokun Zhang Shengnan Wang Chao Ma Yusu Wang Enpeng Wang Liang Chen Tianbin Liu Ying Gu Chunyi Li | 2022 | Cell Regeneration2022，11，1： | 0 |
| 20 | Design of A Hot Redundant Communication Network for Drive Control Systems of Mobile Launch Platforms显示文摘In order to ensure that a mobile launch platform is able to transport a launch vehicle which is assembled vertically on a complex orbit,a communication network for the drive control system was designed.Based on the char-acteristics of equipment of the drive control system and its position,Industrial Ethernet and Profibus were selected.To meet the requirements for reliability and maintainability of aerospace products,the communication network featured a hot redundant to avoid single point failure risk,so that if any point in the system fails,the control strategy of standby switches using heartbeat detection and parity check would ensure the normal communication and failure diagnostics,which could enable the transport mission of the launch vehicle to be completed smoothly. | LI Daoping ZHU Maioxin LI Chunlin CHEN Yaozu ZHENG Guokun | 2023 | Aerospace China2023，24，3： | 0 |
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