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| 1 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 2 | Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits. | Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet | 2023 | aBIOTECH2023，4，2： | 2 |
| 3 | Homocysteine enhances neutrophil- endothelial interactions in both cultured human cells and ratsin vivo 显示文摘 | Dudman NP Temple SE Guo XW | 1999 | Circulation Research1999，84，4： | 1 |
| 4 | Functional and cellular responses in a novel rodent model of anterior ischemie optic neuropathy 显示文摘 | Bernstein SL Guo Y Kelman SE | 2003 | Invest Ophthalmol Vis Sci2003，44，10： | 1 |
| 5 | Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of DLX2 and DLX5 transcription factors显示文摘 | Harris SE Guo DY Harris MA | 2003 | Front Biosci2003，8，4： | 1 |
| 6 | Peroxisome prolifer- ator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhe- sion to orbital fibroblasts 显示文摘 | Guo N Woeller CF Feldon SE Phipps RP | 2011 | J Biol Chem2011，286，18： | 1 |
| 7 | RAGE ligand upregulation of VEGF secretion in ARPE-19 cells显示文摘 | Ma W Lee SE Guo J Qu W Hudson BI Sehmidt AM | 2007 | Invest Ophthalmol Vis Sci2007，48，3： | 1 |
| 8 | Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis:role of DIx2 and Dlx5 transcription factors显示文摘 | Hams SE Guo D Harris MA | 2003 | Front Biosci2003，8，： | 1 |
| 9 | The impact of hepatitis C in- fection on ischemic heart disease via ischemic electrocardiogram 显示文摘 | Lin MS Guo SE Chen MY | 2014 | Am J Med Sci2014，347，6： | 1 |
| 10 | Homocysteine enhances neutrophil-endothelial interactions in both cultured human cells and rats in vivo显示文摘 | Dudman NP Temple SE Guo XW | 1999 | Circ Res1999，84，4： | 1 |
| 11 | Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors显示文摘 | Harris SE Guo D Harris MA | 2003 | Front Biosci2003，，： | 1 |
| 12 | High-resolution DTI with 2D interleaved multislice reduced FOV single-shot diffusion-weighted EPI (2D ss-rFOV-DWEPI)显示文摘 | Jeong EK Kim SE Guo J | 2005 | Magnetic Resonance in Medicine2005，54，6： | 1 |
| 13 | Predictors of exercise frequency in breast cancer survivors in Taiwan 显示文摘 | HSU HT DODD MJ GUO SE | 2011 | J Clin Nurs2011，20，1314： | 1 |
| 14 | Comparative gene genealogies indicate that two clonal lineages of Cryptococcus gattii in British Columbia resemble strains from other geographical areas 显示文摘 | Kidd SE Guo H Bartlett KH Xu J Kronstad JW | 2005 | Eukaryot Cell2005，4，10： | 1 |
| 15 | Peroxisome proliferator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced,hyaluronan-dependent,T cel adhesion to orbital fibroblasts显示文摘 | Guo N Woel er CF Feldon SE | | 0，，21： | 1 |
| 16 | Bi-directional modulation of bed nucleus of stria terminalis neurons by 5-HT: molecular expression and functional properties of excitatory 5-HT receptor subtypes显示文摘 | Guo JD Hammack SE Hazra R | 2009 | Neuroscience2009，164，： | 1 |
| 17 | Functional and cellular responses in a novel rodent model of anterior ischemic optic neuropathy显示文摘 | Bernstein SL Guo Y Kelman SE | 2003 | Invest Ophthalmol Vis Sci2003，44，10： | 1 |
| 18 | Peroxisome proliferator- activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhesion to orbital fibroblasts 显示文摘 | Guo N Woeller CF Feldon SE | 2011 | J Biol Chem2011，286，18： | 1 |
| 19 | Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix显示文摘 | Guo L Moss SE Alexander RA | 2005 | Invest Ophthalmol Vis Sci2005，，： | 1 |
| 20 | The p53 Arg72Pro and MDM2 -309 polymor- phisms and risk of breast cancer in the nurses' health studies 显示文摘 | COX DG DEER D GUO Q TWOROGER SS HANKINSO SE HUNTER DJ | 2007 | Cancer causes control2007，18，6： | 1 |
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