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| 1 | 黄原胶对马铃薯淀粉糊流变特性的影响显示文摘对3%马铃薯淀粉,黄原胶含量为0.2%、0.4%和0.6%的淀粉糊流变特性进行了探讨。静态流变特性测定结果表明,在实验范围内,不同黄原胶含量的淀粉糊的流变模型为幂率模型,均为假塑性流体。在相同流动方式下,随着黄原胶含量的增加,淀粉糊的粘度增加。动态流变特性测定结果表明,随着温度的增加,不同黄原胶含量淀粉糊的弹性模量、粘性模量逐渐下降,到62℃,两模量降低到某恒定最低值,温度继续增加,两模量急剧增加,到72℃后,两模量增加变缓。随着黄原胶含量的增加,两模量增加。 | 柴春祥 Sundaram Gunasekaran | 2007 | 食品工业科技2007，28，8： | 39 |
| 2 | Changing trends in management of gestational diabetes mellitus显示文摘Gestational diabetes mellitus(GDM)is on the rise globally.In view of the increasing prevalence of GDM and fetal and neonatal complications associated with it,there is a splurge of research in this field and management of GDM is undergoing a sea change.Trends are changing in prevention,screening,diagnosis,treatment and future follow up.There is emerging evidence regarding use of moderate exercise,probiotics and vitamin D in the prevention of GDM.Regarding treatment,newer insulin analogs like aspart,lispro and detemir are associated with better glycemic control than older insulins.Continuous glucose monitoring systems and continuous subcutaneous insulin systems may play a role in those who require higher doses of insulin for sugar control.Evidence exists that favors metformin as a safer alternative to insulin in view of good glycemic control and better perinatal outcomes.As the risk of developing GDM in subsequent pregnancies and also the risk of overt diabetes in later life is high,regular assessment of these women is required in future.Lifestyle interventions or metformin should be offered to women with a history of GDM who develop pre-diabetes.Further studies are required in the field of prevention of GDM for optimizing obstetric outcome. | Gunasekaran Kala Poomalar | 2015 | World Journal of Diabetes2015，6，2： | 32 |
| 3 | Sequential organ failure assessment score is superior to other prognostic indices in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score. | Thomas Zheng Jie Teng Jun Kiat Thaddaeus Tan Samantha Baey Sivaraj K Gunasekaran Sameer P Junnarkar Jee Keem Low Cheong Wei Terence Huey Vishal G Shelat | 2021 | World Journal of Critical Care Medicine2021，10，6： | 9 |
| 4 | Interstitial lung disease and diabetes显示文摘Diabetes mellitus (DM) is a chronic metabolic disease and its prevalence has beensteadily increasing all over the world. DM and its associated micro andmacrovascular complications result in significant morbidity and mortality. Themicrovascular complications are usually manifested as retinopathy, neuropathy,nephropathy and macrovascular complications generally affect the cardiovascularsystem. In addition to these complications, DM also affects the lungs because of itsrich vascularity and abundance in connective tissue (collagen and elastin). DMhas been found to cause microvascular complications and proliferation ofextracellular connective tissue in the lungs, leading to decline in lung function in arestrictive pattern. Interstitial lung disease (ILD) includes a diverse group ofdisease conditions characterized by different degrees of inflammation and fibrosisin the pulmonary parenchyma. Idiopathic pulmonary fibrosis (IPF) is one of thecommon type of idiopathic interstitial pneumonia with a high mortality rate. IPFis characterized by chronic progressive fibrosis leading to progressive respiratoryfailure. In this review we focus on lung as the target organ in DM and theassociation of DM and ILD with special emphasis on IPF. | Venkat Rajasurya Kulothungan Gunasekaran Salim Surani | 2020 | World Journal of Diabetes2020，11，8： | 9 |
| 5 | In vitro antioxidant,anti-diabetic,cholinesterase and tyrosinase inhibitory potential of fresh juice from Citrus hystrix and C.maxima fruits显示文摘In the present study,antioxidant potential,α-amylase,α-glucosidase,cholinesterase and tyrosinase inhibitory activity of fresh juice from indigenous fruits of Citrus hystrix and C.maxima(Red&White var.)were investigated using an in vitro model.The contents of total phenolics,tannins,and total flavonoids ranged between 836.90 and 909.52 mg gallic acid equivalent(GAE)/L,333.33 and 523.21 mg gallic acid equivalent(GAE)/L and 224.88 and 262.22 mg rutin equivalent/L,respectively.The antioxidant activity of fresh juice was evaluated by employing different in vitro assays such as reducing power assay,DPPH•,ABTS•+and•OH radical scavenging capacities,peroxidation inhibition activity,antihemolytic assay.In addition,75.55%–79.75%ofα-amylase and 70.68%–72.83%ofα-glucosidase enzyme inhibition characteristics were found under in vitro starch digestion bioassay.Also,all the juice samples exhibited excellent tyrosinase(76.95%–80.79%),acetylcholinesterase(75.71%–79.74%)andβ-glucuronidase inhibitory activity(68.13%–69.38%).These results indicated that fresh juice of C.hystrix and C.maxima(Red&White var.)could be used as a source of antioxidant agents,functional food and nutraceuticals.©2014 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Arumugam Abirami Gunasekaran Nagarani Perumal Siddhuraju | 2014 | Food Science and Human Wellness2014，3，1： | 8 |
| 6 | 4种马铃薯淀粉糊流变特性的研究显示文摘对4种不同加工方式获得的马铃薯淀粉糊流变特性进行了探讨。静态流变特性测定结果表明,4种淀粉糊的流变模型为幂率模型,均为假塑性流体,每种淀粉糊以相同方式流动需要施加的力不同。在相同流动方式下,淀粉4粘度最大,其次为淀粉2,淀粉1和淀粉3的粘度近似相同。动态流变特性测定结果表明:随着温度的增加,淀粉1、2、4的弹性模量、粘性模量刚开始基本不发生变化,到60℃后,两模量急剧增加到最大值,然后降低到某恒定值。淀粉3的两模量随温度升高逐渐增加到最大值,然后逐渐降低到某恒定值。粘性模量达到最大后,淀粉2的粘性模量最大,其次为淀粉4、淀粉1,淀粉3的最低。弹性模量达到最大后,淀粉4的弹性模量最大,其次为淀粉2、淀粉1,淀粉3最低。 | 柴春祥 Sundaram Gunasekaran | 2007 | 食品与发酵工业2007，33，5： | 7 |
| 7 | 白喉-破伤风-无细胞百日咳-b型流行性感冒嗜血杆菌联合疫苗对中国婴儿安全性和免疫原性的研究显示文摘目的评价白喉-破伤风-无细胞百日咳-b型流行性感冒嗜血杆菌联合疫苗(Diphtheria,Tetanus,Acellular Pertussis and Haemophilus Influenzae Type b Combined Vaccine;DTaP-Hib),对中国婴儿的安全性和免疫原性。方法通过一项安全性研究(研究A)和一项安全性及免疫原性研究(研究B),评价DTaP-Hib联合疫苗接种于3、4、5月龄婴儿的安全性及免疫原性,并与DTaP联合疫苗及Hib疫苗(DTaP+Hib)同时分别接种进行比较。结果共690名健康婴儿接受了DTaP-Hib联合疫苗或DTaP联合疫苗与Hib疫苗分别同时接种的基础免疫。DTaP-Hib联合疫苗的耐受性与DTaP联合疫苗+Hib疫苗分别接种一致,两组局部及全身不良反应发生率差异无统计学意义。在接种DTaP-Hib联合疫苗的受试者中,至少有97.5%在基础免疫后一个月产生了针对白喉、破伤风、Hib的血清学保护性抗体,以及对无细胞百日咳抗原的免疫应答。按照预先制订的标准,DTaP-Hib联合疫苗的免疫应答与DTaP联合疫苗+Hib疫苗分别接种免疫应答应的差异无统计学意义。结论DTaP-Hib联合疫苗接种后可获得预期的安全性和免疫原性。临床试验注册国家食品药品监督管理局《药物临床批件》2003L03331。 | 李艳萍 张庶民 叶强 侯启明 李亚男 李红 徐颖华 马霄 刘幼平 陈晓玲 黄莉荣 Gunasekaran Ramakrishnan 李荣成 赵雷 唐海文 Olivier Van Der Meeren Hans L Bock | 2010 | 中国疫苗和免疫2010，16，2： | 7 |
| 8 | Anti-chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon显示文摘Objective:To obtain Iuteolin and apigenin rich fraction from the ethanolic extract of Cynodon dactylon(L.)(C.dactylon) Pers and evaluate the fraction's cytotoxicity and anti-Chikungunya potential using Vero cells.Methods:The ethanolic extract of C.dactylon was subjected to silica gel column chromatography to obtain anti-chikungunya virus(CHIKV) fraction.Reverse phase-HPLC and GC-MS studies were carried out to identily the major phytochemicals in the fraction using phylochemical standards.Cytotoxicity and the potential of the fraction against CHIKV were evaluated in vitro using Vero cells.Reduction in viral replication was assessed by reverse transcriptase-polymerase chain reaction(RT-PCR) after treating the viral infected Vero cells with the fraction.Results:Reverse Phase-HPLC and GC-MS studies confirmed the presence of flavonoids,luteolin and apigenin as major phytochemicals in the anti-CHIKV ethanolic fraction of C.dactylon- The fraction was found to exhibit potent viral inhibitory activity(about 98%) at the concentration of 50 μg/mL as observed by reduction in cytopathic effect,and the cytotoxic concentration of the fraction was found to be 250 μg/mL.RT-PCR analyses indicated that the reduction in viral mRNA synthesis in fraction treated infected cells was much higher than the viral infected control cells.Conclusions:Luteolin and apigenin rich ethanolic fraction from C.dactylon can be utilized as a potential therapeutic agent against CHIKV infection as the fraction does not show cytotoxicity while inhibiting the virus. | Krishnan Saravana Murali Srinivasan Sivasubramanian Savariar Vincent Shanmugaraj Bala Murugan Bupesh Giridaran Sundaram Dinesh Palani Gunasekaran Kaveri Krishnasamy Ramalingam Sathishkumar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 5 |
| 9 | A comparative study on antioxidant potentials,inhibitory activities against key enzymes related to metabolic syndrome,and anti-inflammatory activity of leaf extract from different Momordica species显示文摘Momordica species are vegetable crops widely distributed in warmer regions of the world.In this work,we describe the antioxidant,enzyme inhibitory and anti-inflammatory effects of the leaves from three different species of Momordica.The present investigation was initially carried out to explore the possible link between antioxidant,enzyme inhibitory property of Momordica leaf extract and their total phenolic and flavonoid contents.The anti-inflammatory activity was tested by using carrageenan-induced paw edema.Our results illustrated an enhanced antioxidant power of wild species comparable with a commercial variety.In addition,the leaf extract of M.dioica(200 mg/kg)presented a significant anti-inflammatory activity toward carrageenan-induced paw edema in Wistar rats in comparison to indomethacin(10 mg/kg).The contents of flavonoids and total phenolic compounds could be correlated with the antioxidant and enzymes inhibition activities.The major bioactive compounds of phenolic acids and flavonoids such as gallic acid,chlorogenic acid,caffeic acid,ferulic acid,ellagic acid,catechin,rutin,and quercetin were identified.Our findings suggest that wild Momordica species contains higher potential antioxidant and anti-inflammatory activities than a commercial variety does,which could be tested as drug candidates against oxidative and inflammation-related pathological processes.©2014 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Gunasekaran Nagarani Arumugam Abirami Perumal Siddhuraju | 2014 | Food Science and Human Wellness2014，3，1： | 4 |
| 10 | Preparation and Characterization of Hydroxyapatite-Coated Selenium Nanoparticles and their Interaction with Osteosarcoma(SaOS-2) Cells显示文摘Nanotechnology has taken a firm step to revolutionize the field of orthopedic implants. Current research on bone implants focuses to develop implants with multifaceted functions viz., osteoinduction, chemoprevention, antimicrobial action etc., especially for cancerous bone resection. The objective of the present study was to synthesize a novel composite for bone implants, possessing the above properties. Selenium was selected owing to its chemopreventive and chemotherapeutic properties. Hydroxyapatite was selected owing to its bioactivity and similarity in composition to bone mineral properties. Selenium nanoparticles were prepared by chemical reduction method and coated with hydroxyapatite.Hydroxyapatite-coated selenium nanoparticle(HASnp) was characterized physico-chemically using fourier transform infrared spectroscopy, X-ray diffractometry, scanning electron microscope, and energy-dispersive X-ray spectroscopy.HASnp was analysed in vitro using SaOS-2 cell line. Enhanced cell proliferation and alkaline phosphatase activity were observed in HASnp-treated cells. The results indicate that HASnp is highly suitable for the use in orthopedic applications. | Thiagarajan Hemalatha Gunasekaran Krithiga Baskar Santhosh Kumar Thotapalli P. Sastry | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，6： | 4 |
| 11 | A Distributed Mechanism for Handling of Adaptive/Intelligent Selfish Misbehaviour at MAC Layer in Mobile Ad Hoc Networks显示文摘Medium access control(MAC) protocols such as IEEE 802.11 are used in wireless networks for sharing of the wireless medium.The random nature of the protocol operation together with the inherent difficulty of monitoring in the open poses significant challenges.All nodes are expected to comply with the protocol rules.But,some nodes in order to gain greater benefits misbehave by not complying with the rules.One such selfish misbehavior is waiting for smaller back-off intervals when compared to the other nodes in the same subnet.Such selfish misbehavior is being tackled in this paper.A diagnosis scheme and a penalty scheme are being proposed for overcoming such selfish-misbehavior at MAC layer of mobile ad hoc networks which could be extended to other types of networks also. | Raja Gunasekaran Vaidheyanathan Rhymend Uthariaraj Uamapathy Yamini Rajagopalan Sudharsan Selvaraj Sujitha Priyadarshini | 2009 | Journal of Computer Science & Technology2009，24，3： | 4 |
| 12 | Hepatoprotective effect of leaf extracts from Citrus hystrix and C.maxima against paracetamol induced liver injury in rats显示文摘The present investigation is aimed to evaluate the hepatoprotective effects of Citrus hystrix and Citrus maxima(Red and White variety)methanolic leaf extracts on paracetamol induced toxicity.Leaf extracts were given in the dose of 200 mg/kg body weight for 7 days and toxicity was induced by paracetamol(2 g/kg)on day 5.Silymarin(100 mg/kg body weight)was used as reference standard.On the 7th day animals were sacrificed and liver function markers(ALT,AST,ALP),total bilirubin and total protein in blood serums and hepatic antioxidants(SOD,CAT,GSH and GPx)in liver homogenate were estimated.The leaf extracts restored the liver function markers and hepatic antioxidants to the normal level than elevated levels noticed on paracetamol control at P<0.001.Reversal of hepatoarchitecture has also been registered.The present study shows that C.hystrix and C.maxima leaf extracts possess hepatoprotective action against paracetamol induced hepatotoxicity.©2015 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Arumugam Abirami Gunasekaran Nagarani Perumal Siddhuraju | 2015 | Food Science and Human Wellness2015，4，1： | 3 |
| 13 | SDN assisted Stackelberg Game model for LTE-WiFi offloading in 5G networks显示文摘The data traffic that is accumulated at the Macro Base Station(MBS)keeps on increasing as almost all the people start using mobile phones.The MBS cannot accommodate all user’s demands,and attempts to offload some users to the nearby small cells so that the user could get the expected service.For the MBS to offload data traffic to an Access Point(AP),it should offer an optimal economic incentive in a way its utility is maximized.Similarly,the APs should choose an optimal traffic to admit load for the price that it gets from MBS.To balance this tradeoff between the economic incentive and the admittance load to achieve optimal offloading,Software Defined Networking(SDN)assisted Stackelberg Game(SaSG)model is proposed.In this model,the MBS selects the users carefully to aggregate the service with AP,so that the user experiencing least service gets aggregated first.The MBS uses the Received Signal Strength Indicator(RSSI)value of the users as the main parameter for aggregating a particular user for a contract period with LTE and WiFi.Each player involved in the game tries to maximize their payoff utilities,and thus,while incorporating those utilities in real-time scenario,we obtain maximum throughput per user which experiences best data service without any lack in Quality of Experience(QoE).Thus,the proposed SaSG model proves better when compared with other game theory models,and hence an optimal data offloading is achieved. | Sudha Anbalagan Dhananjay Kumar Gunasekaran Raja Alkondan Balaji | 2019 | Digital Communications and Networks2019，5，4： | 3 |
| 14 | Food prospects and nutraceutical attributes of Momordica species:A potential tropical bioresources–A review显示文摘Plants with potential therapeutic values have been used from time immemorial to cure various ailments and infectious diseases.Of late,scientific evidences have been provided on the potential therapeutic agent exhibited by certain traditionally used vegetable extracts.The importance of wild edible plants may be traced to antiquity but systemic studies are recent.All the Momordica species have been consumed as vegetable and traditionally used for various disorders.The whole plant parts are ascribed to possess the anti-diabetic effect in traditional medicinal system.The active constituents of Momordica plant parts were cucurbitane type triterpenoids,phenolics,glycosides,and several kinds of peptides including Momordica anti-HIV protein(MAP 30).Recent reports revealed the presence of several kinds of cucurbitane type triterpenoids in leaf,stem and fruits of Momordica species having several pharmacological activities.There is lack of scientific information available on the wild species which also having several bioactive components with potential activities.So the present review compares and highlights the current knowledge of the nutritional value,phytochemistry and physiological effects of wild species with known variety. | Gunasekaran Nagarani Arumugam Abirami Perumal Siddhuraju | 2014 | Food Science and Human Wellness2014，3，3： | 3 |
| 15 | p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats显示文摘Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats.Methods: Ethanol(25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines(IL-6, IL1β, TNF-α), NF-κB activation and imbalance of proand anti-apoptotic proteins(Bcl-2, Bax, caspase 3). Meanwhile, p-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-κB, and proapoptotic proteins and increased Bcl-2 expression. Conclusions: p-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression.p-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity. | Ramakrishnan Sabitha Kumari Nishi Vinoth Prasanna Gunasekaran Govindhan Annamalai Balupillai Agilan Mathan Ganeshan | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，5： | 2 |
| 16 | Combustion analysis of a hydrogen-diesel fuel operated DI diesel engine with exhaust gas recirculation显示文摘石块燃料和成长需求的快速的弄空要求研究人员发现干净、持续的其他的燃料。对发现可更新的需要,低费用和环境地友好的燃料资源永远不能被没有充分表达实情地陈述。产生的一个有效方法和氢的存储将使汽车的制造商能介绍氢造成的引擎在市场上。在这份报纸,一台常规 DI 柴油机引擎被修改作为煤气的引擎操作。引擎歧管的吸入与 recirculated 一起与氢被供应用尽气体和空气。氢的注射率与 2 酒吧的一个注射压力与 2 L/min 和 10 L/min 在三个层次被维持。许多象热一样的燃烧参数释放率(HRR ) ,点火延期,燃烧持续时间,压力上升(ROPR ) 的率,累积的热版本率(CHR ) ,和周期的压力变化被测量。HRR 山峰压力随 EGR 率的增加减少了,当燃烧持续时间与 EGR 率增加了时。周期的压力变化也随 EGR 率的增加增加了。 | M. LOGANATHAN A. VELMURUGAN TOM PAGE E. JAMES GUNASEKARAN P. TAMILARASAN | 2017 | Frontiers in Energy2017，11，4： | 2 |
| 17 | Gelation of whey protein and xanthan mixture: Effect of heating rate on rheological properties显示文摘 | J. Li M.M. Ould Eleya S. Gunasekaran | 2005 | Food Hydrocolloids2005，，5： | 2 |
| 18 | A framework for supply chain performance measurement显示文摘 | A Gunasekaran C Patel Ronald E McGaughey | 2003 | International Journal of Production Economics2003，，3： | 2 |
| 19 | Performance measures and metrics in a supply chain environment显示文摘 | A. Gunasekaran C. Patel E. Tirtiroglu | 2001 | International Journal of Operations & Production Management2001，，1： | 2 |
| 20 | Some physicochemical and functional properties of alfalfa soluble leaf proteins显示文摘 | B.P. Lamsal R.G. Koegel S. Gunasekaran | 2006 | LWT - Food Science and Technology2006，，9： | 2 |
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