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| 1 | Damage control orthopaedics: State of the art显示文摘Damage control orthopaedics(DCO) originally consisted of the provisional immobilisation of long bone-mainly femur-fractures in order to achieve the advantages of early treatment and to minimise the risk of complications, such as major pain, fat embolism, clotting, pathological inflammatory response, severe haemorrhage triggering the lethal triad, and the traumatic effects of major surgery on a patient who is already traumatised(the 'second hit' effect). In recent years, new locations have been added to the DCO concept, such as injuries to the pelvis, spine and upper limbs. Nonetheless, this concept has not yet been validated in well-designed prospective studies, and much controversy remains.Indeed, some researchers believe the indiscriminate application of DCO might be harmful and produce substantial and unnecessary expense. In this respect, too,normalised parameters associated with the acid-base system have been proposed,under a concept termed early appropriate care, in the view that this would enable patients to receive major surgical procedures in an approach offering the advantages of early total care together with the apparent safety of DCO. This paper discusses the diagnosis and treatment of severely traumatised patients managed in accordance with DCO and highlights the possible drawbacks of this treatment principle. | Enrique Guerado Maria Luisa Bertrand Juan Ramon Cano Ana María Cerván Adolfo Galán | 2019 | World Journal of Orthopedics2019，10，1： | 16 |
| 2 | Challenges of bone tissue engineering in orthopaedic patients显示文摘Bone defects may impede normal biomechanics and the structural stability of bone as an organ. In many cases, the correction of bone defects requires extensive surgical intervention involving the use of bone-grafting techniques and other procedures in which healing is slow, there is a high risk of infection and considerable pain is provoked- with no guarantee of complete correction of the defect. Therefore, the search for surgical alternatives continues to present a major challenge in orthopaedic traumatology. The reamer-irrigator-aspirator(RIA) system, which was devised to avoid the problems that can arise with autograft harvesting from the iliac crest, consists of collecting the product of the femoral canal after reaming. The RIA technique improves osteogenic differentiation of mesenchymal stem cells, compared to bone marrow aspiration or cancellous bone harvesting from the iliac crest using a spoon. Another approach, the Masquelet technique, consists of reconstructing a long bone defect by means of an induced membrane grown onto an acrylic cement rod inserted to fill the defect; in a second surgical step, once the membrane is constituted, the cement rod is removed and cancellous autograft is used to fill the defect. Both in RIA and in the Masquelet technique, osteosynthesis is usually needed. Bone transportation by compression-distraction lengthening principles is commonly implemented for the treatment of large bone loss. However, complications are frequently encountered with these techniques. Among new techniques that have been proposed to address the problem of large bone loss, the application of stem cells in conjunction with tissue engineering techniques is very promising, as is the creation of personalised medicine(or precision medicine), in which molecular profiling technologies are used to tailor the therapeutic strategy, to ensure the right method is applied for the right person at the right time, after determining the predisposition to disease among the general population. All of the above techniques for addressing bone defects are discussed in this paper. | Enrique Guerado Enrique Caso | 2017 | World Journal of Orthopedics2017，8，2： | 6 |
| 3 | Understanding the pathogenesis of hip fracture in the elderly, osteoporotic theory is not reflected in the outcome of prevention programmes显示文摘Hip fractures are an acute and worsening public health problem. They mainly affect elderly people, a population group that is highly vulnerable to disease and accidents, and to falls in particular. Although it has been suggested that osteoporosis is the cause of hip fractures, they mainly occur after a fall has been suffered. The underlying causes of a fall are not related to osteoporosis, although pharmaceutical companies have coined the term 'osteoporotic fracture' for hip fractures in the elderly. Drug treatments for osteoporosis have not diminished the frequency of these injuries, nor have they prevented the occurrence of a subsequent fracture. Since pharmaceutical interests require osteoporosis to be considered a disease, rather than a normal condition of senescence, they go further by assuming that treatment for osteoporosis is essential, and that this policy will diminish the incidence of hip fractures. On the other hand, the origin and treatment of conditions that may be conducive to provoking falls are very difficult to elucidate. In this paper, we consider some of the medical and social problems that arise in this area, as well as conflicts of interest regarding the aetiopathogenesis and prevention of hip fracture, and propose a new paradigm for the prevention of falls. | Enrique Guerado Rosa M Sandalio Zaira Caracuel Enrique Caso | 2016 | World Journal of Orthopedics2016，7，4： | 3 |
| 4 | Fractures of the acetabulum in elderly patients : an update 显示文摘 | Guerado E Cano JR Cruz E | 2012 | Injury2012，43，2： | 1 |
| 5 | Simultaneous ilioinguinal and Kocher-Langenberk approaches for the treatment of complex acetabular frac-tures显示文摘 | Guerado E Cano JR Cruz E | 2010 | Hip Int2010，20，7： | 1 |
| 6 | Management of calcaneal fractures: what have we learnt over the years 显示文摘 | GUERADO E BERTRAND ML CANO JR | 2012 | Injury2012，43，10： | 1 |
| 7 | What bone graft substitutes should we use in post- trau- matic spinal fusion? 显示文摘 | Enrique Guerado Carl Hans Fuerstenberg | 2011 | Injury2011，42，2： | 1 |
| 8 | Simultaneous ilioinguinal and Kocher-Langenbeck approaches for the treatment of complex acetabular fractures显示文摘 | Guerado E Cano JR Cruz E | | 0，，7： | 1 |
| 9 | Management of calcaneal fractures显示文摘 | Enrique Guerado María Luisa Bertrand Juan Ramón Cano | 2012 | Injury2012，，10： | 1 |
| 10 | Management of calcanealfractures: what have we learnt over the years 显示文摘 | Guerado E Bertrand ML Cano JR | 2012 | Injury2012，43，10： | 1 |
| 11 | Simultaneous ilioinguinal and Kocher- Langenbeck approaches for the treatment of com- plex acetabular fractures 显示文摘 | Guerado E Cano JR Ruz E | 2010 | Hip Int2010，20，7： | 1 |
| 12 | Simultaneous ilioinguinal and Kocher - Langenbeck approaches for the treatment of complex acetabular fractures显示文摘 | Guerado E Cano JR Ruz E | 2010 | Hip Int2010，20，7： | 1 |
| 13 | Management of calcaneal fractures: what have we learnt over the years? 显示文摘 | Guerado ￡tBertrand ML Cano JR | 2012 | Injury2012，43，10： | 1 |
| 14 | Fractures of the acetabulum in elderly patients:An update显示文摘 | Guerado E Cano JR Cruz E | | 0，，： | 1 |
| 15 | What bone graft substitutes should we use in post-traumatic spinal fusion显示文摘 | Enrique Guerado Carl Hans Fuerstenberg | | 0，，2： | 1 |
| 16 | Simultaneous ilioinguinal andKocher-Eangenbcck approaches for the treatment of complexacetabular fractures显示文摘 | Guerado E Cano JR Ruz E | 2010 | Hip Int2010，20，7： | 1 |
| 17 | Simultaneous ilioinguinal and Kocher-Langenbeck approaches for the treatment of complex acetabular fractures显示文摘 | Guerado E Cano JR Ruz E | | 0，，7： | 1 |
| 18 | Simultaneous ilioinguinal and Kocher-Langenbeck approaches for the treatment of complex acetabular fractures显示文摘 | Guerado E Cano JR Cruz E | 2010 | Hip Int2010，20，7： | 1 |
| 19 | Management of calcaneal fractures:What have we learnt over the years显示文摘 | Guerado E Bertrand M Juan Ramo′n Cano | 2012 | Injury2012，43，10： | 1 |
| 20 | Management of calcaneal frac-tures:what have we learnt over the years 显示文摘 | Guerado E Bertrand ML Cano JR | 2012 | Injury2012，43，： | 1 |
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