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| 1 | Natural history of heartburn:A 10-year population-based study显示文摘AIM:To study the natural history and prevalence of heartburn at a 10-year interval,and to study the effect of heartburn on various symptoms and activities.METHODS:A population-based postal study was carried out.Questionnaires were mailed to the same age-and gender-stratified random sample of the Icelandic population(aged 18-75 years) in 1996 and again in 2006.Subjects were classified with heartburn if they reported heartburn in the preceding year and/or week,based on the definition of heartburn.RESULTS:Heartburn in the preceding year was reported in 42.8%(1996) and 44.2%(2006) of subjects,with a strong relationship between those who experienced heartburn in both years.Heartburn in the preceding week was diagnosed in 20.8%.There was a significant relationship between heartburn,dyspepsia and irritable bowel syndrome.Individuals with a body mass index(BMI) below or higher than normal weight were more likely to have heartburn.Heartburn caused by food or beverages was reported very often by 20.0% of subjects.CONCLUSION:Heartburn is a common and chronic condition.Subjects with a BMI below or higher than normal weight are more likely to experience heartburn.Heartburn has a great impact on daily activities,sleep and quality of life. | Linda Bjork Olafsdottir Hallgrimur Gudjonsson Heidur Hrund Jonsdottir Bjarni Thjodleifsson | 2011 | World Journal of Gastroenterology2011，17，5： | 2 |
| 2 | Irritable bowel syndrome: Physicians' awareness and patients' experience显示文摘AIM: To study if and how physicians use the irritable bowel syndrome (IBS) diagnostic criteria and to assess treatment strategies in IBS patients. METHODS: A questionnaire was sent to 191 physicians regarding IBS criteria, diagnostic methods and treatment. Furthermore, 94 patients who were diagnosed with IBS underwent telephone interview. RESULTS: A total of 80/191 (41.9%) physicians responded to the survey. Overall, 13 patients were diag-nosed monthly with IBS by specialists in gastroenterology (SGs) and 2.5 patients by general practitioners (GPs). All the SGs knew of the criteria to diagnose IBS, as did 46/70 (65.7%) GPs. Seventy-nine percent used the patient's history, 38% used a physical examination, and 38% exclusion of other diseases to diagnose IBS. Only 18/80 (22.5%) physicians used specific IBS criteria. Of the patients interviewed, 59/94 (62.8%) knew they had experienced IBS. Two out of five patients knew IBS and had seen a physician because of IBS symptoms. Half of those received a diagnosis of IBS. A total of 13% were satisfied with treatment. IBS affected daily activities in 43% of cases. CONCLUSION: Half of the patients with IBS who consulted a physician received a diagnosis. Awareness and knowledge of diagnostic criteria for IBS differ between SGs and GPs. | Linda Bjork Olafsdottir Hallgrímur Gudjonsson Heidur Hrund Jonsdottir Jon Steinar Jonsson Einar Bjornsson Bjarni Thjodleifsson | 2012 | World Journal of Gastroenterology2012，18，28： | 2 |
| 3 | The role of violent cognition in the relationship between personality and the involvement in violent films and computer games 显示文摘 | Sigurdsson JF Gudjonsson GH Bragason AV | 2006 | Personality and Individual Differences2006，41，2： | 1 |
| 4 | Isolation, immortaliza- tion, and characterization of a human breast epithelial cel line with stem cell properties 显示文摘 | Gudjonsson T Villadsen R Nielsen HL | 2002 | Genes Dev2002，16，6： | 1 |
| 5 | Immunopatho gen- ic mechanisms in psoriasis 显示文摘 | Gudjonsson JE Johnston A Sigmundsdoti H | 2004 | Clin Exp Immunol2004，135，1： | 1 |
| 6 | Novel systemic drugs under investigation for the treatment of psoriasis显示文摘 | Gudjonsson JE Johnston A Ellis CN | 2012 | J Am Acad Dermatol2012，67，1： | 1 |
| 7 | Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis显示文摘 | Thorsteinsdottir S Gudjonsson T Nielsen O H | 2011 | Nat Rev Gastroenterol Hepatol2011，8，7： | 1 |
| 8 | Epi- thelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma 显示文摘 | PETERSEN OW NIELSEN HL GUDJONSSON T | 2003 | Am J Pathol2003，162，2： | 1 |
| 9 | Isolation,immortalization, and characterization of a human breast epithelial cell line with stem cell properties显示文摘 | Gudjonsson T Villadsen R Nielsen HL | 2002 | Gene Dev2002，16，6： | 1 |
| 10 | Distinct clinical differences between HLA-Cw * 0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients 显示文摘 | Gudjonsson JE Karason A Runarsdottir EH | 2006 | J Invest Dermatol2006，126，4： | 1 |
| 11 | Establishment of three human breast epithelial cell lines derived from carriers of the 999de15 BRCA2 Icelandic founder mutation显示文摘 | Rubner F Gudjonsson A J Halldorsson T | | 0，，10： | 1 |
| 12 | Epithelial to mesenchymal transition in human breast cancer can provide a non- malignant stromal显示文摘 | Petersen 0 W Nielsen H L Gudjonsson T | 2003 | Am J Pathol2003，162，2： | 1 |
| 13 | Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study显示文摘 | Gudjonsson JE Thorarinsson AM Sigurgeirsson B | 2003 | Br J Dermatol2003，149，3： | 1 |
| 14 | Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma显示文摘 | Petersen OW Nielsen HL Gudjonsson T | 2003 | Am J Pathol2003，162，2： | 1 |
| 15 | The frequency of CLA+CD8+T cells in the blood of psoriasis patients correlates closely with the severity of their disease 显示文摘 | Gudjonsson JE Jonsdottir I | 2001 | Clin Exp Immunol2001，126，： | 1 |
| 16 | Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C-and HLA-B-typed patients显示文摘 | Gudjonsson JE Karason A Runarsdottir EH | 2006 | J Invest Dermatol2006，126，4： | 1 |
| 17 | Stem cell biology and the cellular pathways of carcinogenesis 显示文摘 | Gudjonsson T Magnusson MK | 2005 | APMIS2005，113，： | 1 |
| 18 | Global gene expression anal- ysis reveals evidence for decreased lipid biosynthesis and in- creased innate immunity in uninvolved psoriatic skin显示文摘 | Gudjonsson JE Ding J Li X | 2009 | J Invest Dermatol2009，129，12： | 1 |
| 19 | Injury proneness and personality显示文摘 | MARUSIC A MUSEK J GUDJONSSON G | 2001 | Nord J Psychiatry2001，55，3： | 1 |
| 20 | Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties显示文摘 | Gudjonsson T Villadsen R Nielsen H L | 2002 | Genes Dev2002，16，6： | 1 |
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