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| 1 | Perinatal and early life risk factors for inflammatory bowel disease显示文摘AIM:To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.METHODS:Record linked abstracts of birth registrations,maternity,day case and inpatient admissions in a defined population of southern England.Investigation of 20 perinatal factors relating to the maternity or the birth:maternal age,Crohn's disease (CD) or ulcerative colitis (UC) in the mother,maternal social class,marital status,smoking in pregnancy,ABO blood group and rhesus status,pre-eclampsia,parity,the infant's presentation at birth,caesarean delivery,forceps delivery,sex,number of babies delivered,gestational age,birthweight,head circumference,breastfeeding and Apgar scores at one and five minutes.RESULTS:Maternity records were present for 180 children who subsequently developed IBD.Univariate analysis showed increased risks of CD among children of mothers with CD (P=0.011,based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy.Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio=2.04,95% CI=1.06-3.92) and for older mothers aged 35+ years (4.81,2.32-9.98).Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated.It also showed that,for UC,there were no significant associations with the perinatal factors studied.CONCLUSION:This study shows an association between CD in mother and child;and elevated risks of CD in children of older mothers and of mothers who smoked. | Stephen E Roberts Clare J Wotton John G Williams Myfanwy Griffith Michael J Goldacre | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 2 | A framework for biological criteria for Florida streams using benthic macroinvertebrates 显示文摘 | BARBOUR M T GERRITSEN J GRIFFITH G E | 1996 | Journal of the North American Benthological Society1996，15，2： | 1 |
| 3 | A framework for biological criteria for Florida streams using benthic macroinvertebrates显示文摘 | Barbour M T Gerritsen J Griffith G E | 1996 | Journal of the North American Benthological Society1996，15，： | 1 |
| 4 | Evolution of quasiparticle charge in the fractional quantum hall regime 显示文摘 | Griffiths T G Comforti E Heiblum M | 2000 | Phvs Rev Lett2000，85，18： | 1 |
| 5 | A survey of clinical experience with ciprofloxacin, a new quinolone antimicrobial 显示文摘 | Arcieri G Griffith E Grueawaldt G | 1988 | The Journal of Clinical Pharmacology1988，28，2： | 1 |
| 6 | Anterior shoulder dislocation:Quantification of glenoid bone loss with CT显示文摘 | Griffith J F Antonio G E Tong C W | | 0，，05： | 1 |
| 7 | PKC-delta is an apoptotic lamin kinase显示文摘 | CROSS T GRIFFITHS G DEACON E | 2000 | Oncogene2000，19，19： | 1 |
| 8 | Vibrational spectra of the hydrated carbonate miderals ikaite, monohydrocalcite, lansfordite and nesquehonite 显示文摘 | Coleyshaw E E Crump G Griffith W P | 2003 | Spectrochimica Acta Part A : Molecular and Biomolecular Spectroscopy2003，59，10： | 1 |
| 9 | Management of the distal ureter during nephroureterectomy for upper urinary tract transition- al cell carcinoma: a review显示文摘 | GKOUGKOUSIS E G MELLON J K GRIFFITHS T R | 2010 | Urol Int2010，85，： | 1 |
| 10 | Linking drought-resistance mechanisms to drought avoidance in upland rice using a QTL approach: progress and new opportunities to integrate stomatal and mesophyll responses 显示文摘 | Price A H Cairns J E Horton P Jones H G Griffiths H | 2005 | Journal of Experimental Botany2005，53，371： | 1 |
| 11 | Reversible plastic strain during cyclic loading-unloading of Mg and Mg-Zn alloys 显示文摘 | MANN G E SUMITOMO T CACERES C H GRIFFITHS J R | 2007 | Materials Science and Engineering A2007，456，12： | 1 |
| 12 | A framework for bio- logical criteria for florida streams using benthic macroinvertebrate 显示文摘 | Barbour M T Gerritsen J Griffith G E | 1996 | Journal of the North American Benthological Society1996，15，2： | 1 |
| 13 | Vibrational spectra of the hydrated carbonate minerals ikaite, monohydrocalcite, lansfordite and nesquehonite 显示文摘 | Coleyshaw E E Crump G Griffith W P | 2003 | Spectrochimica Acta Part A2003，59，： | 1 |
| 14 | Support conditions for experimental modal analysis显示文摘 | Came T G Griffith D T Casias M E | 2007 | Sound and Vibration2007，41，6： | 1 |
| 15 | Making antibodies by phage display technology显示文摘 | Griffiths A D Hawkins R E | 1994 | Annu Rev Immunol1994，12，： | 1 |
| 16 | Aframework for biological criteria for Florida streamsusing benthic macroinvertebrates 显示文摘 | Barbour M T Gerritsen J Griffith G E | 1996 | Journal of theNorth American Benthological Society1996，15，： | 1 |
| 17 | Control and coordination of bladder and urethral function in the brain stem of cat 显示文摘 | Griffiths D Holstege G Dalm E | 1990 | Neurourol Urodyn1990，9，： | 1 |
| 18 | Intracellular symbiotes of the Homoptera显示文摘 | Houk E Griffiths G | 1980 | Annu Rev Entomol1980，25，： | 1 |
| 19 | Perforin and granzyme A expression identifying cytolytic lymphycytes in rheumatoid arthritis显示文摘 | GRIFFITHS G M ALPERT S LAMBERT E | 1992 | Proc Natl Acad Sci U S A1992，89，： | 1 |
| 20 | Reduced type Ⅰand type Ⅲ procollagens in photodamaged adult human skin显示文摘 | Talwar H S Griffiths C E M Fisher G J | 1995 | J Invest Dermatol1995，105，： | 1 |
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