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| 1 | MicroRNA-21 as a potential colon and rectal cancer biomarker显示文摘Colorectal cancer(CRC)is one of the most common malignant diseases worldwide and the prognosis is still poor although much progress has been achieved in recent years.In order to reduce CRC-related deaths,many studies are aimed at identifying novel screeningand prognosis-related biomarkers.MicroRNAs(miRNAs)are a class of 18-27-nucleotide single-stranded RNA molecules that regulate gene expression at the posttranscriptional level.It has been demonstrated that miRNAs regulate a variety of physiological functions,including development,cell differentiation,proliferation,and apoptosis.They play important roles in various physiologic and developmental processes and in the initiation and progression of various human cancers.It has been shown that miRNAs can critically regulate tumor cell gene expression,and evidence suggests that they may function as both oncogenes and tumor suppressor genes.In CRC,miRNAs-21 is one of the most important miRNAs and is rapidly emerging as a novel biomarker in CRC,with good potential as a diagnostic and therapeutic target.In this review,we summarize the latest research findings of the clinicopathological relevance of miRNAs-21 in CRC initiation,development,and progress,highlighting its potential diagnostic,prognostic,and therapeutic application,as well as discuss-ing future prospects. | Tao Li Mei Ha Leong Bruce Harms Gregory Kennedy Lin Chen | 2013 | World Journal of Gastroenterology2013，19，34： | 16 |
| 2 | Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance显示文摘 | Kim Dae Hwan Shin Nari Kim Gwang Ha Song Geum Am Jeon Tae-Yong Kim Dong-Heon Lauwers Gregory Y Park Do Youn | 2013 | Archives of Pathology & Laboratory Medicine2013，，8： | 2 |
| 3 | Optimal shared-savings contracts in supply chains:linear contracts and double moral hazard显示文摘 | Charles J Corbett Gregory A Decroix Albert Y Ha | 2005 | European Journal of Operational Research2005，163，3： | 1 |
| 4 | Optimal shared-savings contracts in supply chains: Linear contracts and double moral hazard显示文摘 | Charles J. Corbett Gregory A. DeCroix Albert Y. Ha | 2004 | European Journal of Operational Research2004，，3： | 1 |
| 5 | Optimal shared-savings contracts in supply chains: Linear contracts and double moral hazard显示文摘 | Charles J. Corbett Gregory A. DeCroix Albert Y. Ha | 2004 | European Journal of Operational Research2004，，3： | 1 |
| 6 | Lymph node metastasis from intestinal-type early gastric cancer: experience in a single institution and reassessment of the extended criteria for endoscopic submucosal dissection显示文摘 | Hyun Jeong Kang Dae Hwan Kim Tae-Yong Jeon Soo-Han Lee Nari Shin Sue-Hye Chae Gwang Ha Kim Geum Am Song Dong-Heon Kim Amitabh Srivastava Do Youn Park Gregory Y. Lauwers | 2010 | Gastrointestinal Endoscopy2010，，3： | 1 |
| 7 | Origin of Domain Structure in Hexagonal Silicon Carbide Boules Grown by the Physical Vapor Transport Method显示文摘 | Seoyong Ha Noel T Nuhfer Gregory S Rohrer Marc De Graef Marek Skowronski | 2000 | Journal of Crystal Growth2000，220，： | 1 |
| 8 | Macrophage responses to silk显示文摘 | Bruce P Gregory HA Jingsong C | 2003 | Biomaterials2003，24，： | 1 |
| 9 | Association of Impaired Heart Rate Recovery with Cardiopulmonary Complications after Lung Cancer Resection Surgery显示文摘 | Duc Ha Humberto Choi Katrina Zell Daniel P. Raymond Kevin Stephans Xiao-Feng Wang Gregory Videtic Kevin McCarthy Omar A. Minai Peter J. Mazzone | 2014 | The Journal of Thoracic and Cardiovascular Surgery2014，，： | 1 |
| 10 | Optimal shared-savings contracts in supply chains: Linear contracts and double moral hazard显示文摘 | Charles J. Corbett Gregory A. DeCroix Albert Y. Ha | 2004 | European Journal of Operational Research2004，，3： | 1 |
| 11 | MultiSciView: Multivariate Scientific X-ray Image Visual Exploration with Cross-Data Space Views显示文摘X-ray images obtained from synchrotron beamlines are large-scale,high-resolution and high-dynamic-range grayscale data encoding multiple complex properties of the measured materials.They are typically associated with a variety of metadata which increases their inherent complexity.There is a wealth of information embedded in these data but so far scientists lack modem exploration tools to unlock these hidden treasures.To bridge this gap,we propose MultiSciView,a multivariate scientific x-ray image visualization and exploration system for beamline-generated x-ray scattering data.Our system is composed of three complementary and coordinated interactive visualizations to enable a coordinated exploration across the images and their associated attribute and feature spaces.The first visualization features a multi-level scatterplot visualization dedicated for image exploration in attribute,image,and pixel scales.The second visualization is a histogram-based attribute cross filter by which users can extract desired subset patterns from data.The third one is an attribute projection visualization designed for capturing global attribute correlations.We demonstrate our framework by ways of a case study involving a real-world material scattering dataset.We show that our system can efficiently explore large-scale x-ray images,accurately identify preferred image patterns,anomalous images and erroneous experimental settings,and effectively advance the comprehension of material nanostructure properties. | Wen Zhong Wei Xu Kevin G.Yager Gregory S.Doerk Jian Zhao Yunke Tian Sungsoo Ha Cong Xie Yuan Zhong Klaus Mueller Kerstin Kleese Van Dam | 2018 | Visual Informatics2018，2，1： | 0 |
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