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| 1 | META-R:A software to analyze data from multi-environment plant breeding trials显示文摘META-R(multi-environment trial analysis in R)is a suite of R scripts linked by a graphical user interface(GUI)designed in Java language.The objective of META-R is to accurately analyze multi-environment plant breeding trials(METs)by fitting mixed and fixed linear models from experimental designs such as the randomized complete block design(RCBD)and the alpha-lattice/lattice designs.META-R simultaneously estimates the best linear and unbiased estimators(BLUEs)and the best linear and unbiased predictors(BLUPs).Additionally,it computes the variance-covariance parameters,as well as some statistical and genetic parameters such as the least significant difference(LSD)at 5%significance,the coefficient of variation in percentage(CV),the genetic variance,and the broad-sense heritability.These parameters are very important in the selection of top performing genotypes in plant breeding.META-R also computes the phenotypic and genetic correlations among environments and between traits,as well as their statistical significance.The genetic correlations between environments or traits can be visualized in a biplot graph or a tree diagram(dendrogram).Genetic correlations are very important for identifying environments with similar behavior or making indirect selection and identifying the most highly associated traits.META-R performs multi-environment analyses by using the residual maximum likelihood(REML)method;these analyses can be done by environment,across environments by grouping factors(stress conditions,nitrogen content,etc.)and across environments;the analyses across environments can be done with a pre-defined degree of heritability. | Gregorio Alvarado Francisco M.Rodríguez Angela Pacheco Juan Burgueño JoséCrossa Mateo Vargas Paulino Pérez-Rodríguez Marco A.Lopez-Cruz | 2020 | The Crop Journal2020，8，5： | 4 |
| 2 | Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer显示文摘Fibrosing cholestatic hepatitis(FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver,renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic chemotherapy.FCH constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological findings.Here,we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced immunosuppression.This is the first reported case in the literature of FCH after conventional chemotherapy for a solid tumor.In addition to a detailed report of the case,a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed. | Jaime Ceballos-Viro José M López-Picazo José L Pérez-Gracia Jesús J Sola Gregorio Aisa Ignacio Gil-Bazo | 2009 | World Journal of Gastroenterology2009，15，18： | 3 |
| 3 | Factors associated with early virological response to peginterferon-α-2a/ribavirin in chronic hepatitis C显示文摘AIM: To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to pegin-terferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS: We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated with peginterferon α-2a plus ribavirin were included. EVR was defined as undetectable hepatitis C virus (HCV)-ribonucleic acid (RNA) or ≥ 2 log HCV-RNA decrease after 12 wk of treatment. A bivariate analysis of sociodemographic and clinical variables associated with EVR was carried out. Independent factors associated with an EVR were analyzed using a multiple regression analysis that included the following baseline demographic and clinical variables: age (≤ 40 years vs > 40 years), gender, race, educational level, marital status and family status, weight, alcohol and tobacco consumption, source of HCV infection, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and gamma glutamyl transpeptidase (GGT) (≤ 85 IU/mL vs > 85 IU/mL), serum ferritin, serum HCV-RNA concentration (< 400 000 vs ≥ 400 000), genotype (1/4 vs 3/4), cirrhotic status and ribavirin dose (800/1000/1200 mg/d).RESULTS: A total of 1014 patients were included in the study. Mean age of the patients was 44.3 ± 9.8 years, 70% were male, and 97% were Caucasian. The main sources of HCV infection were intravenous drug abuse (25%) and blood transfusion (23%). Seventyeight percent were infected with HCV genotype 1/4 (68% had genotype 1) and 22% with genotypes 2/3. The HCV-RNA level was > 400 000 IU/mL in 74% of patients. The mean ALT and AST levels were 88.4 ± 69.7 IU/mL and 73.9 ± 64.4 IU/mL, respectively, and mean GGT level was 82 ± 91.6 IU/mL. The mean ferritin level was 266 ± 284.8 μg/L. Only 6.2% of patients presented with cirrhosis. All patients received 180 mg of peginterferon α-2a. The most frequently used ribavirin doses were 1000 mg/d (41%) and 1200 mg/d (41%). The planned treatment duration was 48 wk for 92% of patients with genotype 2/3 and 24 wk for 97% of those with genotype 1/4 (P < 0.001). Seven percent of patients experienced at least one reduction in ribavirin or peginterferon α-2a dose, respectively. Only 2% of patients required a dose reduction of both drugs. Treatment was continued until week 12 in 99% of patients. Treatment compliance was ≥ 80% in 98% of patients. EVR was achieved in 87% of cases (96% vs 83% of patients with genotype 2/3 and 1/4, respectively; P < 0.001). The bivariate analysis showed that patients who failed to achieve EVR were older (P < 0.005), had higher ALT (P < 0.05), AST (P < 0.05), GGT (P < 0.001) and ferritin levels (P < 0.001), a diagnosis of cirrhosis (P < 0.001), and a higher baseline viral load (P < 0.05) than patients reaching an EVR. Age < 40 years [odds ratios (OR): 0.543, 95%CI: 0.373-0.790, P < 0.01], GGT < 85 IU/mL (OR: 3.301, 95%CI: 0.192-0.471, P < 0.001), low ferritin levels (OR: 0.999, 95%CI: 0.998-0.999, P < 0.01) and genotype other than 1/4 (OR: 4.716, 95%CI: 2.010-11.063, P < 0.001) were identified as independent predictors for EVR in the multivariate analysis. CONCLUSION: CHC patients treated with peginterferon-α-2a/ribavirin in clinical practice show high EVR. Older age, genotype 1/4, and high GGT were associated with lack of EVR. | Javier García-Samaniego Miriam Romero Rafael Granados Remedios Alemán Miguel Jorge Juan Dolores Suárez Ramón Pérez Gregorio Castellano Carlos González-Portela | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 4 | Mobility analysis of the 3-UPU parallel mechanism assembled for a pure translational motion显示文摘 | Gregorio R D Vincenzo P C | 2002 | Translations of the ASM E Journal of Mechanical Design2002，124，6： | 1 |
| 5 | Percutaneous treatment of superior vena cava syndrome using metallic stents显示文摘 | DE GREGORIO ARIZA MA GAMBOA P GIMENO MJ | 2003 | Eur Radiol2003，13，： | 1 |
| 6 | Token bucket characterization of long-range dependent traffic显示文摘 | GREGORIO P ANURAG G MARIO G | 2002 | Computer Communication2002，25，11： | 1 |
| 7 | Staging and survival of colorectal cancer:are we making progress显示文摘 | Ponzde Leon M Benatti P Di Gregorio C | 2000 | Dig Liv Dis2000，32，： | 1 |
| 8 | Molecular diagnosis of infective endocarditis by re- al-time broad-range polymerase chain reaction (PCR) and sequencing directly from heart valve tissue 显示文摘 | Marin M Mufioz P Sdnchez M del Rosal M Alcal6 L Rodrlguez-Cr6ixems M Bouza E Group for the Manage- ment of Infective Endocarditis of the Gregorio Marafi6n Hospital | 2007 | Medicine2007，86，4： | 1 |
| 9 | Adiponectin expression from human adipose tissue:relation to obesity,insulin resistance,and tumor necrosis factor 2alpha expression显示文摘 | Kern P A Di Gregorio G B Lu T | 2003 | D iabet2003，52，7： | 1 |
| 10 | TACS:A Trust Model for P2P Networks显示文摘 | Felix G M Gregorio M P Antonio F G S | 2009 | Wireless Personal Communications2009，51，1： | 1 |
| 11 | Adiponectin expression from human adipose tissue: relation to obesity,insulin resistance, and tumor necrosis factor alpha expression显示文摘 | Kern P A Di Gregorio G B Lu T Rassouli N Ranganathan G | 2003 | Diabetes2003，52，： | 1 |
| 12 | Mobility analysis of the 3-UPU parallel mechanism assembled for a pure translational motion 显示文摘 | Gregorio R D Vincenzo P C | 2002 | Translations of the ASME Journal of Mechanical Design2002，124，6： | 1 |
| 13 | Financial Devel- opment and Economic Growth 显示文摘 | De Gregorio J Guidotti P E | 1995 | World Development1995，23，3： | 1 |
| 14 | Changes in production of lignin degrading enzymes during interactions between mycelia of the tropical decomposer basidiomycetes MarasmieUus troyanus and Marasmius pallescens 显示文摘 | Ferreira Gregorio A P Da Silva I R Sedarati M R | 2006 | Mycol Res2006，110，： | 1 |
| 15 | Percutaneous treatment of superior vena cava syndrome using metallic stents显示文摘 | De Gregorio Ariza MA Gamboa P Gimeno MJ | 2003 | Eur Radiol2003，13，4： | 1 |
| 16 | STIM1,an essential and conserved component of store-operated Ca2+channel function显示文摘 | Roos J Di Gregorio P J Yeromin A V | 2005 | J Cell Biol2005，169，3： | 1 |
| 17 | Non-smoking coke oven workers show an occupational PAHs exposure-related increase in urinary mutagens 显示文摘 | Simioli P Lupi S Gregorio P | 2004 | Mutat Res2004，562，： | 1 |
| 18 | Genetic testing among high-risk individuals in families with hereditary nonpolyposis colorectal cancer显示文摘 | Ponz De Leon M Benatti P Di Gregorio C | 2004 | Br J Cancer2004，90，4： | 1 |
| 19 | Nogo CAA 3' UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder显示文摘 | GREGORIO S P MURY F B OJOPI E B | 2005 | Schizophrenia Re- search2005，75，1： | 1 |
| 20 | Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays显示文摘 | De Gregorio E Spellman P T Rubin GM | 2001 | Proc Natl Acad Sci USA2001，98，12： | 1 |
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