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| 1 | Acute coronary syndromes in young patients: Presentation, treatment and outcome显示文摘 | Andreas W. Schoenenberger Dragana Radovanovic Jean-Christophe Stauffer Stephan Windecker Philip Urban Gregor Niedermaier Pierre-Frédéric Keller Felix Gutzwiller Paul Erne | 2009 | International Journal of Cardiology2009，，3： | 2 |
| 2 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 3 | Drivers of floristic change in large cities:A case study of Frankfurt/Main(Germany)显示文摘 | GREGOR T BNSEL D STARKE-OTTICH I | 2012 | Landscape and urban planning2012，10，2： | 1 |
| 4 | Enterprise Architectures: Enablers of Business Strategy and IS/IT Alignment in Government 显示文摘 | Gregor S Hart D Martin N | 2007 | Information Technology & People2007，20，2： | 1 |
| 5 | Outside Initiatives in the Reconstruction of the Car : the Case of Lightweight Vehicle Milieus in Switzerland显示文摘 | Truffer Bernhard Gregor D | 1997 | Science Technology & Human Value1997，22，2： | 1 |
| 6 | The historical residue trend of PCBs in the Agassiz Ice Cap, Ellesmere Island, Canada显示文摘 | Gregor D J Peters A J Teixeira C | 1995 | The Science of The Environment1995，，： | 1 |
| 7 | The recent depositional trend of polycyclic aromatic hydrocarbons and elemental carbon to the Agassiz Ice Cap, Ellesmere Island, Canada显示文摘 | Peters A J Gregor D J Teixeira C F | 1995 | The Science of the Total Environment1995，，： | 1 |
| 8 | Cultivar identication in Prunus domestica using RARD显示文摘 | GREGOR D HARTMAN W STOSSER R | 1994 | Acta Hortic1994，359，： | 1 |
| 9 | Evolution of the structure of a gas-liquid two-phase flow in a large vertical pipe 显示文摘 | Prasser H M Beyer M Carl H Gregor S Lucas D Pietruske H Schutz P Weiss F P | 2007 | Nuclear Engineering and Design2007，237，： | 1 |
| 10 | The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds toDNA as a dimer显示文摘 | GREGOR P D SAWADOGO M ROEDER R G | 1990 | Genes Dev1990，4，： | 1 |
| 11 | Microbial adhesion and biofilm formation on ureteral stents in vitro and in vivo 显示文摘 | Gregor R John D Yun SK | 1992 | The Journal of Urology1992，14，12： | 1 |
| 12 | Evidence of atmospheric transport and deposition of organochlorine pesticides and polychlorinated biphenyls in Canadian Arctic snow 显示文摘 | Gregor D J Gummer W D | 1989 | Environmental Science & Technology1989，23，： | 1 |
| 13 | Advanced control algorithms embedded in a programmable logic controller显示文摘 | GREGOR D KOSTA B | 2006 | Control Engineering Practice2006，，14： | 1 |
| 14 | Mismatches at the HLA-DR and HLA-B loci are risk faetors for acute rejection after lung transplantation 显示文摘 | Schulman L L Weinberg A D Me Gregor C | 1998 | Am J Respir Crit Care Med1998，157，10： | 1 |
| 15 | Biventricular support with the Jarvik 2000 axial flow pump:a feasibility study显示文摘 | Radovancevic B Gregoric ID Tamez D | | 0，，05： | 1 |
| 16 | Comment on 'Delayed deposition of organochlorine pesticides at a temperate glacier' 显示文摘 | Gregor D J Peters A J | 2000 | Environmental Science and Technology2000，34，： | 1 |
| 17 | The complete genome sequence of Escherichia coli K-12 显示文摘 | BLATTNER F R PLUNKETT G BLOCH C A PERNA N T BURLAND V RILEY M COLLADOVIDES J GLASNER J D RODE C K MAYHEW G F GREGOR J DAVIS N W KIRKPATRICK H A GOEDEN M A ROSE D J MAU B SHAO Y | 1997 | Science1997，277，5331： | 1 |
| 18 | Design of reinforced concrete deep beams显示文摘 | Rogowsky D M Mac Gregor J G | 1986 | Concrete International: Design and Constrnction1986，8，8： | 1 |
| 19 | Soft tissue sarcomas of the head and neck associated with surgical trauma显示文摘 | DIJKSTRA M D BALM A J M GREGOR R T | 1995 | J Laryngol Otol1995，109，： | 1 |
| 20 | The physica1 chemical and mineralogical properties of three cemented layers with in sulfide-bearing mine tailings显示文摘 | Mc Gregor R G Blowes D W | 2002 | Journal of Geochemical Exploration2002，76，3： | 1 |
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