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18篇 您的检索式：作者名="Gran V"

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		题名	作者	年代	出处	被引量
	1	Transcriptional regulation of the survivin gene显示文摘	Boidot R Végran F Lizard-Nacol S	2014	Mol Biol Rep2014，41，1：	1
	2	In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant显示文摘	Combes V Simon AC Gran GE	1999	J Clin Invest1999，104，：	1
	3	Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice显示文摘	Sonveaux Pierre Végran Frédérique Schroeder Thies Wergin Melanie C Verrax Julien Rabbani Zahid N De Saedeleer Christophe J Kennedy Kelly M Diepart Caroline Jordan Bénédicte F Kelley Michael J Gallez Bernard Wahl Miriam L Feron Olivier Dewhir	2008	Journal of Clinical Investigation2008，，12：	1
	4	Denitrification in estuarine sediments in the eastern Gulf of Finland,Baltic Sea显示文摘	GRAN V PITK NEN H	1999	Hydrobiologia1999，393，10：	1
	5	IL-24 is expressed by rat and Human macrophages 显示文摘	Gam H Sehmidt A Gran V	2002	Immunobiology2002，205，3：	1
	6	Detection of DNA damage in gametocytes of zebra mussel using comet assay 显示文摘	Mirjana Pavlica Gran I V Klobu Nina Moja	2001	Mutation Research/Genetic Toxicology and Environmental Mutagenesis2001，490，2：	1
	7	Mechanical properties of superhard TiB2 coatings prepared by DC magnetron sputtering显示文摘	MIKULA M GRAN(C)I(C) B BUR(S)(I)KOV(A) V	2007	Vacuum2007，82，2：	1
	8	Overexpression of caspase-3s splice variant in locally advanced breast carcinoma is associated with poor response to neoadjuvant chemotherapy显示文摘	Boidot R Oudin C	2006	Clin Cancer Res2006，12，：	1
	9	The transcription factor IRF1dictates the IL-21-dependent anticancer functions of TH9 cells显示文摘	Végran F Berger H Boidot R	2014	Nat Immunol2014，15，8：	1
	10	Transcriptional regulation of the survivin gene显示文摘	BOIDOT R VGRAN F LIZARD-NACOL S	2014	Mol Biol Rep2014，41，：	1
	11	Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice显示文摘	Sonveaux P Végran F Schroeder T	2008	J Clin Invest2008，118，12：	1
	12	Overexpression of caspase-3ssplice variant in locally advanced breast carcinoma is associated withpoor response to neoadjuvant chemotherapy显示文摘	Végran F Boidot R Oudin C	2006	Clin Cancer Res2006，12，19：	1
	13	Skin involvement in chronic myelomonocytic leukaemia as a predictor of transformation into acute myeloid leukaemia显示文摘	Pont V Miquel FJ Gran TC	2001	J Eur Acad Dermatol Venereol2001，15，3：	1
	14	Dacarbazine-mediated upregu-lation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth显示文摘	Hervieu A Rébé C Végran F		0，，02：	1
	15	Gene expression profile and response to trastuzumab-docetaxel-based treat-ment in breast carcinoma显示文摘	Végran F Boidot R Coudert B	2009	Br J Cancer2009，101，8：	1
	16	Targeting lactate-fueledrespiration selectively kills hypoxic tumor cells in mice显示文摘	Sonveaux P Végran F Schroeder T	2008	J Clin In-vest2008，118，12：	1
	17	Human ectonucleotidase-expressing CD25high Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions显示文摘	Marion Thibaudin Marie Chaix Romain Boidot Frédérique Végran Valentin Derangère Emeric Limagne Hélène Berger Sylvain Ladoire Lionel Apetoh Fran?ois Ghiringhelli	2016	OncoImmunology2016，，：	1
	18	Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein显示文摘Precision medicine is defined by the administration of drugs based on the tumor's particular genetic characteristics. It is developing quickly in the field of cancer therapy. For example, KRAS, NRAS and BRAF genetic testing demonstrates its efficiency for precision medicine in colorectal cancer(CRC). Besides for these well-known mutations, the purpose of performing larger genetic testing in this pathology is unknown. Recent reports have shown that using the poly ADP ribose polymerase(PARP) inhibitor olaparib in patients with homologous repair enzyme deficiency gave positive clinical results in breast, ovarian and prostate cancers. We have reported here the cases of 2 patients with multi-treated metastatic CRC who underwent somatic and constitutional exome analyses. The analyses revealed a loss of function mutation in a homologous repair enzyme resulting in the loss of heterozygosity for both patients(Check2 for the first patient and RAD51 C for the second one). Both patients were treated with off-label usage of olaparib. While the first patient showed clinical benefit, reduction of carcinoembryonic antigen tumor marker and radiologic response, the second patient quickly presented a progression of the tumor. Additional genetic analyses revealed a frameshift truncating mutation of the TP53BP1 gene in the patient who progressed. Interestingly, deficiency in TP53BP1 was previously described to confer resistance to olaparib in mice breast cancer models. Our findings suggest that exome analysis may be a helpful tool to highlight targetable mutations in CRC and that olaparib may be efficient in patients with a homologous repair deficiency.	Francois Ghiringhelli Corentin Richard Sandy Chevrier Frédérique Végran Romain Boidot	2016	World Journal of Gastroenterology2016，22，48：	0

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