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| 1 | Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)is a condition in which excess fat accumulates in the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic steatosis.The pathogenesis of NAFLD and nonalcoholic steatohepatitis(NASH)has not been fully elucidated.The'two-hit'hypothesis is probably a too simplified model to elaborate complex pathogenetic events occurring in patients with NASH.It should be better regarded as a multiple step process,with accumulation of liver fat being the first step,followed by the development of necroinflammation and fibrosis.Adipose tissue,which has emerged as anendocrine organ with a key role in energy homeostasis,is responsive to both central and peripheral metabolic signals and is itself capable of secreting a number of proteins.These adipocyte-specific or enriched proteins,termed adipokines,have been shown to have a variety of local,peripheral,and central effects.In the current review,we explore the role of adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD.We particularly focus on adiponectin,leptin and ghrelin,with a brief mention of resistin,visfatin and retinol-binding protein 4 among adipokines,and tumor necrosis factor-α,interleukin(IL)-6,IL-1,and briefly IL-18 among proinflammatory cytokines.We update their role in NAFLD,as elucidated in experimental models and clinical practice. | Sanja Stojsavljevi? Marija Gomer?i? Pal?i? Lucija Virovi? Juki? Lea Smir?i? Duvnjak Marko Duvnjak | 2014 | World Journal of Gastroenterology2014，20，48： | 42 |
| 2 | Mini-loop ligation of a bleeding duodenal Dieulafoy's lesion显示文摘Two percent of gastrointestinal hemorrhages are caused by Dieulafoy's lesions, which are located in duodenum in only 15% of cases. There are no recommendations regarding the prime endoscopic treatment technique for this condition. A 61-year-old woman presented with melena without signs of hemodynamic instability. During an urgent upper endoscopy, blood oozing from the normal mucosa of the duodenum was seen and this was classified as a Dieulafoy's lesion. A mini-loop was opened at the rim of a transparent ligation chamber, at the end of the endoscope, and after aspiration of the lesion, closed and detached. Complete hemostasis was achieved without early or postponed complications. In every day clinical practice, mini-loop ligation is rarely used because of possible complications, such as site ulceration, organ perforation, re-bleeding and possible inexperience of the operator. To the best of our knowledge this is the first case of successful treatment of bleeding duodenal Dieulafoy's lesion by mini-loop ligation. | Marija Gomeri Pali Neven Ljubii | 2013 | World Journal of Gastroenterology2013，19，22： | 3 |
| 3 | The influence of antiepileptic drugs on cognition : A comparison of levetiracetam with topiramate 显示文摘 | Gomer B Wagner K Frings L | 2007 | Epilepsy Behav2007，10，3： | 1 |
| 4 | The influence of levetiracetam with topiramate 显示文摘 | GOMER B WAGNER K FRINGS L | 2007 | Epilepsy Behav2007，10，3： | 1 |
| 5 | Review:Photodynamic therapy显示文摘 | DOUGHERTY J J GOMER C J HENDERSON B W | 1998 | J Natl Cancer Inst1998，90，12： | 1 |
| 6 | Photodynamic therapy显示文摘 | Gomer CJ Henderson BW | 1998 | J Nat Can1998，90，： | 1 |
| 7 | Review:Photodynamic Therapy显示文摘 | Dougherty T J Gomer C J Henderson BW | 1998 | Natl Cancer Inst Monogr1998，90，12： | 1 |
| 8 | Photodynamic therapy: combined modality approaches targeting the tumor microenvironment 显示文摘 | Gomer C J Ferrario A Luna M | 2006 | Lasers Surg Med2006，38，5： | 1 |
| 9 | Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor显示文摘 | Weishaupt KR Gomer CJ Dougherty TJ | 1976 | Cancer Res1976，36，71： | 1 |
| 10 | Photodynamic therapy显示文摘 | Dougherty TJ Gomer C J Henderson BW | 1998 | J Natl Cancer Inst1998，90，： | 1 |
| 11 | Photodynamic therapy显示文摘 | Dougherty T J Gomer C J Henderson B W | 1998 | Journal of the National Cancer Institute1998，90，12： | 1 |
| 12 | Cellular targets and molecular responses associated with photodynamic therapy 显示文摘 | GOMER C J LUNA M FERRARIO A | 1996 | Clin Laser Med Surg1996，14，5： | 1 |
| 13 | Photodynamic therapy显示文摘 | Dougherty TJ Gomer CJ Jori G | 1998 | J National Cancer Inst1998，90，12： | 1 |
| 14 | Review: photodynamic therapy显示文摘 | DOUGHERTY T J GOMER C J HENDERSON B M | 1998 | J Natl Cancer Inst1998，90，： | 1 |
| 15 | 显示文摘 | Fisher A M R Murphree A L Gomer C J | 1995 | Laser Surg Med1995，17，： | 1 |
| 16 | Cellular targets and molecular responses associated with photodynamic therapy显示文摘 | Gomer C J Luna M Ferrario A | 1996 | J Clin Laser Med Surg1996，14，： | 1 |
| 17 | A cell-cycle phase-associated cell-type choice mechanism monitors the cell cycle rather than using an independent timer显示文摘 | Gomer R A Ammann R R | | 0，，1： | 1 |
| 18 | PSF and CSF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium显示文摘 | Clark M Gomer R H | 1995 | Experientia1995，51，： | 1 |
| 19 | Photodynamic therapy显示文摘 | Dougherty TJ Gomer C J Henderson BW | 1998 | J Nail Cancer Inst1998，90，： | 1 |
| 20 | Extensions of the field-emission fluctuation method for the determination of surface diffusion coefficients显示文摘 | R. Gomer | 1986 | Applied Physics A Solids and Surfaces1986，，1： | 1 |
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