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| 1 | Nephropathy in dietary hyperoxaluria:A potentially preventable acute or chronic kidney disease显示文摘Hyperoxaluria can cause not only nephrolithiasis and nephrocalcinosis,but also renal parenchymal disease histologically characterized by deposition of calcium oxalate crystals throughout the renal parenchyma,profound tubular damage and interstitial inflammation and fibrosis.Hyperoxaluric nephropathy presents clinically as acute or chronic renal failure that may progress to endstage renal disease(ESRD).This sequence of events,well recognized in the past in primary and enteric hyperoxalurias,has also been documented in a few cases of dietary hyperoxaluria.Estimates of oxalate intake in patients with chronic dietary hyperoxaluria who developed chronic kidney disease or ESRD were comparable to the reported average oxalate content of the diets of certain populations worldwide,thus raising the question whether dietary hyperoxaluria is a primary cause of ESRD in these regions.Studies addressing this question have the potential of improving population health and should be undertaken,alongside ongoing studies which are yielding fresh insights into the mechanisms of intestinal absorption and renal excretion of oxalate,and into the mechanisms of development of oxalate-induced renal parenchymal disease.Novel preventive and therapeutic strategies for treating all types of hyperoxaluria are expected to develop from these studies. | Robert H Glew Yijuan Sun Bruce L Horowitz Konstantin N Konstantinov Marc Barry Joanna R Fair Larry Massie Antonios H Tzamaloukas | 2014 | World Journal of Nephrology2014，3，4： | 3 |
| 2 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 3 | Significance of Antioxidants for Seafood Safety and Human Health显示文摘 | Kulawik Piotr Ozogul Fatih Glew Robert | 2012 | Journal of Agricultural and Food Chemistry2012，，3： | 1 |
| 4 | Nutrient Content of Four Edible Wild Plants from West Africa显示文摘 | Robert S. Glew Dorothy J. Vanderjagt L.-T. Chuang Y.-S. Huang M. Millson Robert H. Glew | 2005 | Plant Foods for Human Nutrition2005，，4： | 1 |
| 5 | Advanced wasting in peritoneal dialysis patients显示文摘AIM To identify patients with end-stage renal disease treated by peritoneal dialysis(PD) who had zero body fat(BF) as determined by analysis of body composition using anthropometric formulas estimating body water(V) and to compare nutritional parameters between these patients and PD patients whose BF was above zero.METHODS Body weight(W) consists of fat-free mass(FFM) andBF.Anthropometric formulas for calculating V allow the calculation of FFM as V/0.73,where 0.73 is the water fraction of FFM at normal hydration.Wasting from loss of BF has adverse survival outcomes in PD.Advanced wasting was defined as zero BF when V/0.73 is equal to or exceeds W.This study,which analyzed 439 PD patients at their first clearance study,used the Watson formulas estimating V to identify patients with V_(Watson)/0.73 ≥ W and compared their nutritional indices with those of PD patients with V_(Watson)/0.73 < W.RESULTS The study identified at the first clearance study two male patients with V_(Watson)/0.73 ≥ W among 439 patients on PD.Compared to 260 other male patients on PD,the two subjects with advanced wasting had exceptionally low body mass index and serum albumin concentration.The first of the two subjects also had very low values for serum creatinine concentration and total(in urine and spent peritoneal dialysate) creatinine excretion rate while the second subject had an elevated serum creatinine concentration and high creatinine excretion rate due,most probably,to non-compliance with the PD prescription.CONCLUSION Advanced wasting(zero BF) in PD patients,identified by the anthropometric formulas that estimate V,while rare,is associated with indices of poor somatic and visceral nutrition. | Zhi Xu Glen H Murata Robert H Glew Yijuan Sun Darlene Vigil Karen S Servilla Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，3： | 1 |
| 6 | Changes in sugars, organic acids and amino acids in medlar (Mespilus germanica L) during fruit development and maturation显示文摘 | FAIK A AYAZ ROBERT H GLEW | 2003 | Food Chemistry2003，83，3： | 1 |
| 7 | Trans fatty acids and conjugated linoleic acids in the milk of urban women and nomadic Fulani of northern Nigeria显示文摘 | Robert H Glew Joseph H Herbein Monica H Moya | 2006 | Clinica Chimica Acta2006，，367： | 1 |
| 8 | Fatty acid and amino acid compositions of selected wild-edible mushrooms consumed in Turkey显示文摘 | Fai˙k A. Ayaz Luther T. Chuang Hülya Torun Ahmet Colak Ertu?rul Sesli˙ Jack Presley Barrett R. Smith Robert H. Glew | 2011 | International Journal of Food Sciences and Nutrition2011，，04： | 1 |
| 9 | Reproducibility of serial creatinine excretion measurements in peritoneal dialysis显示文摘AIM To test whether muscle mass evaluated by creatinine excretion(EXCr) is maintained in patients with end-stage kidney disease(ESKD) treated by peritoneal dialysis(PD),we evaluated repeated measurements of EXCr in a PD population.METHODS One hundred and sixty-six PD patients(94 male,72 female) receiving the same PD dose for the duration of the study(up to approximately 2.5 years) had repeated determinations of total(in urine plus spent dialysate) 24-h EXCr(EXCr T) to assess the adequacy of PD by creatinine clearance.All 166 patients had two EXCr T determinations,84 of the 166 patients had three EXCr T determinations and 44 of the 166 patients had four EXCr T measurements.EXCr T values were compared using the paired t test in the patients who had two studies and by repeated measures ANOVA in those who were studied three or four times.RESULTS In patients who were studied twice,with the first and second EXCr T measurements performed at 9.2 ± 15.2 mo and 17.4 ± 15.8 mo after onset of PD,respectively,EXCr T did not differ between the first and second study.In patients studied three times and whose final assessment occurred 24.7 ± 16.3 mo after initiating PD,EXCr T did not differ between the first and second study,but was significantly lower in the third study compared to the first study.In patients who were studied four times and whose fourth measurement was taken 31.9 ± 16.8 mo after onset of PD,EXCr T did not differ between any of the studies.The average EXCr T value did not change significantly,with the exception of the third study in the patients studied thrice.However,repeated determinations of EXCr T in individuals showed substantial variability,with approximately 50% of the repeated determinations being higher or lower than the first determination by 15% or more.CONCLUSION The average value of EXCr T remains relatively constant for up to 2.5 years of follow-up in PD patients who adhere to the same PD schedule.However,repeated individual EXCr T values vary considerably in a large proportion of the patients.Further studies are needed to evaluate the clinical significance of varying EXCr T values and the stability of EXCr T beyond 2.5 years of PD follow-up. | ZhiXu Glen H Murata Yijuan Sun Robert H Glew Clifford Qualls Darlene Vigil Karen SServilla Thomas A Golper Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，4： | 0 |
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