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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases显示文摘AIM:To investigate the histologic features of the liver in nonalcoholic fatty liver disease (NAFLD) cases according to the presence of metabolic syndrome or its individual components. METHODS:We enrolled 81 patients (40 male,41 fe-male) who were diagnosed with fatty liver by ultraso-nographic scan and fulfi lled the inclusion criteria. First anamnesis,anthropometric,clinical,laboratory and imaging features of all participants were recorded and then liver biopsy was performed after gaining consent from patients. Diagnosis of metabolic syndrome was dependent on patients having 3 or more out of 5 risk criteria defined by the WHO. Biopsy specimens were assessed according to Brunt et al's classification. RESULTS:Sixty-nine of the 81 patients had nonalco-holic steatohepatitis (NASH),11 had simple fatty liver and 1 had cirrhosis according to histologic evaluation. Comparisons were made between two groups of NASH patients,those with and without metabolic syndrome. We did not detect statistically significant differences in liver histology between NASH patients with and wit-hout metabolic syndrome. CONCLUSION:NASH can progress without metabolic risk factors or the presence of metabolic syndrome. | Hüseyin Saadettin Uslusoy Selim Giray Nak Macit Gülten Zeynep Blylkll | 2009 | World Journal of Gastroenterology2009，15，9： | 12 |
| 3 | Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients显示文摘AIM: To investigate the diagnostic eff icacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP). METHODS: A total of 63 consecutive patients with cirrhotic ascites (38 male, 25 female) tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic ? uid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm3. RESULTS: Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specifi city, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically signif icant effects on diagnostic accuracy. CONCLUSION: Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP. | Serkan Torun Enver Dolar Yusuf Yilmaz Murat Keskin Murat Kiyici Melda Sinirtas Emre Sarandol Selim Gurel Selim Giray Nak Macit Gulten | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 4 | Non-alcoholic steatohepatitis with normal aminotransferase values显示文摘AIM:To investigate the aspects of liver histology in patients with non-alcoholic steatohepatitis(NASH)who had normal aminotransferase levels. METHODS:Thirty-four patients diagnosed with liver steatosis by ultrasonographic examination participated in the study.We compared all nonalcoholic fatty liver disease and NASH cases,according to aminotransferase level,aspartate aminotransferase (AST)/alanine aminotransferase(ALT)ratio and presence of metabolic syndrome. RESULTS:Sixteen of 25 patients with high aminotransferase levels were diagnosed with NASH and nine with simple fatty liver according to liver histology. Among the nine patients with normal aminotransferase levels,seven had NASH and two had simple fatty liver. The patients with normal and high liver enzyme levels had almost the same prevalence of NASH and metabolic syndrome.Liver histology did not reveal any difference according to aminotransferase levels and AST/ALT ratio. CONCLUSION:Aminotransferase levels and AST/ALT ratio do not seem to be reliable predictors for NASH. Despite numerous non-invasive biomarkers,all patients with fatty liver should undergo liver biopsy. | Hüseyin Saadettin Uslusoy Selim Giray Nak Macit Gülten Zeynep B|y|kl| | 2009 | World Journal of Gastroenterology2009，15，15： | 7 |
| 5 | Same-day colonoscopy preparation with Senna alkaloids and bisacodyl tablets:A pilot study显示文摘AIM:To evaluate the efficacy of same-day bowel preparation with Senna alkaloids combined with bisacodyl tablets in routine colonoscopy procedures.METHODS:Between March and June 2013,a sameday bowel preparation was implemented in our endoscopy unit.The preparation consisted of a semi-liquid,fiber-free diet one day prior to the procedure,with two bisacodyl tablets after lunch and dinner,and 250 mL of Senna alkaloid with 1.5 L of drinking water at 6 am the day of the procedure.The quality control parameters of colonoscopy were evaluated and implemented according to the guidelines of the American Society for Gastrointestinal Endoscopy.The pre-procedure,duringprocedure and post-procedure patient data were collected and analyzed:(1) pre-procedure(age,gender,comorbid diseases,colonoscopy indications,complete lack of compliance with the bowel preparation protocol);(2) during-procedure(sedation dose,duration of colonoscopy,withdrawal time,cecal intubation rate,polyp detection rate,Boston Bowel Preparation Scores and presence of foam and clear liquid); and(3) postprocedure(visual analogue scale score,pain during the procedure,patient satisfaction and premature withdrawal due to the insufficient bowel preparation).RESULTS:A total of 75 patients were included in this study with a mean age of 54.64 ± 13.29 years; 53.3%(40/75) were female and 46.7%(35/75) were male.A complete lack of compliance with the bowel preparation protocol was seen in 6.7% of patients(5/75).The mean total duration of colonoscopy was 16.12 ± 6.51 min,and the mean withdrawal time was 8.89 ± 4.07 min.The cecal intubation rate was 93.8%(61/64) and the polyp detection rate was 40%(30/75).The mean Boston Bowel Preparation Score was 7.38 ± 1.81,with the following distribution:right colon,2.34 ± 0.89; transverse colon,2.52 ± 0.67; left colon,2.52 ± 0.63.The mean visual analogue scale score was 4.59 ± 1.57.Due to insufficient bowel preparation,seven patients(7/75; 9.3%) were asked to repeat the procedure.Of these,five patients had poor or modest compliance with the protocol,and two patients reported constipation.Premature withdrawal due to insufficient bowel preparation was 2.7%(2/75).The overall satisfaction with the protocol was 86.7%(65/75),with patients reporting they would prefer the same protocol in a repeat procedure.CONCLUSION:The same-day administration of Senna alkaloids appears to be a safe and effective bowel cleansing protocol for colonoscopy procedures. | Erdinc Yenidogan Ismail Okan Huseyin Ayhan Kayaoglu Gokhan Giray Akgul Mufit Sansal Servet Tali Zeki Ozsoy Mustafa Sahin | 2014 | World Journal of Gastroenterology2014，20，41： | 7 |
| 6 | Recurrent ischemic stroke as an initial manifestation of an concealed pancreatic adenocarcinoma: Trousseau's syndrome显示文摘在稀罕例子,摸可以 preceed 癌症的诊断并且是 malignancy.Cerebral 梗塞主要复杂化淋巴瘤,癌,和稳固的肿瘤的位于 \O 下面的第一条临床的证据。恶意相关的 thromboembolism 能介绍同样尖锐的服的梗塞, nonbacterial thrombotic 心内膜炎和迁移的 thrombophlebitis。它通常被归因于一个癌症相关的 hypercoagulable 时期,长期的 dissemiated intravascular coagulopathy (DIC ) ,或肿瘤栓塞。我们从 undiagnosed 报导了 malignancy-releated thromboembolism 的一个案例在由于长期的 DIC 与周期性的 ischemic 击介绍了的一个 54 岁的人的胰腺的腺癌。尽管有 anticoagulation therapy.This 大小写的适当机构,他死于内在的恶意强调服的梗塞可以是 undiagnosed 癌症的第一表明。如果有实验室或临床的证据,与 DIC 联系,有未知病原学的服的梗塞的病人应该为一个恶意的过程被调查。在有 thromboembolic 疾病的癌症病人的 anticoagulation 的最佳的方法(晒) 仍然保持不清楚。 | Semih Giray Feyzi Birol Sarica Zulfikar Arlier Nebil Bal | 2011 | Chinese Medical Journal2011，，4： | 4 |
| 7 | Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma显示文摘 | Burcu Gurer Giray Gurol Emekdas Seda Tezcan Mahmut Ulger Mehmet Sami Serin Orhan Sezgin Engin Altintas Eyup Naci Tiftik | 2014 | Molecular Biology Reports2014，，7： | 2 |
| 8 | Isolated abducens nerve plasy caused by contralateral vertebral artery doli-choectasia显示文摘 | Giray S Pelit A Kizilkilic O | 2005 | Neurol India2005，53，2： | 1 |
| 9 | Immunohistochemical detection of transforming growth factor-alpha, epidermal growth factor,and vascular endothelial growth factor expression in hyperstimulated rat ovary 显示文摘 | Ozcakir HT Giray SG Ozbilgin MK | 2005 | Acta Obstet Gynecol Scand2005，84，9： | 1 |
| 10 | Increase of the extraction yields of coals by the addition of aromatic amines显示文摘 | Giray E S V Chen C Takanohashi T | 2000 | Fuel2000，79，： | 1 |
| 11 | The prevalence of Enterobiusvermicularis in school children an affecting factors 显示文摘 | Giray H Keskinoglu P | 2006 | Turkiye Parazitol Derg2006，30，2： | 1 |
| 12 | Profiles of serum microRNAslmiR-125b-Sp and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma 显示文摘 | Giray BG Emekdas G Tezcan S | 2014 | Mol Biol Rep2014，41，7： | 1 |
| 13 | Intraocular pressure measurement over soft contact lens by rebound tonometer: a comparative study显示文摘AIM: To evaluate the intraocular pressure(IOP)measurements by Icare rebound tonometer over a contact lens in comparison with Goldmann applanation tonometry(GAT). METHODS: Fifty patients using contact lens were included in this study. One of the eyes of the patients was selected randomly and their IOP were measured by rebound tonometer with and without contact lens(RTCL,RT respectively) and by GAT, as well as their central corneal thickness(CCT) by optical pachymeter. The results of both methods were compared by correlation analysis, general linear method repeated measure and Bland-Altman analysis.RESULTS: Mean IOP values measured by RTCL, RT and GAT were 15.68 ±3.7, 14.50 ±3.4 and 14.16 ±2.8(P <0.001), respectively. Mean IOP by RTCL was significantly higher than the measurements implemented by RT and GAT(P <0.001), while there was no difference between the measurements by GAT and RT(P =0.629). There was a good level of positive correlation between GAT and RTCL as well as RT(r =0.786 P <0.001, r =0.833 P <0.001, respectively). We have observed that CCT increase did not show any correlation with the differences of the measurements between RTCL and RT(P =0.329), RTCL and GAT(P =0.07) as well as RT and GAT(P =0.189) in linear regression model.CONCLUSION: The average of the measurements over contact lens by rebound tonometer was found to be higher than what was measured by GAT. Although this difference is statistically significant, it may be clinically negligible in the normal population. | Senay Asik Nacaroglu Emine Seker Un Mehmet Giray Ersoz Yelda Tasci | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 1 |
| 14 | The prevalence of enterobius vermicularis in schoolchildren and affecting factors显示文摘 | Giray H Keskinoglu P | 2006 | Turk Parazitol Derg2006，30，2： | 1 |
| 15 | Faocmask thera- py with rigid anchorage in a patient with maxillary hypoplasia and severe oligodontia: A case report 显示文摘 | Enacar A Giray B Pehlivanoglu M | 2003 | Am J Orthod Dentofacial Orthop2003，123，5： | 1 |
| 16 | Facemask therapy with rigid anchorage in a patient with maxillary hypoplasia and severe ollgodontia显示文摘 | Enacar A Giray B Pehlivanoglu M | 2006 | Am J Orthod Dento2 facial Orthop2006，123，5： | 1 |
| 17 | Spontaneous primary in- traventricular hemorrhage in adults~ clinical data, etiolo- gy and outcome显示文摘 | Giray S Sen O Sarica FB | 2009 | Turk Neurosurg2009，19，4： | 1 |
| 18 | Impact of early versus late enteral nutrition on cell mediated im- munity and its relationship with glucagon like peptide-1 in in- tensive care unit patients: a prospective study显示文摘 | OKAN BAKINER EMRE BOZKIRLI SEMIH GIRAY | 2013 | Crit Care2013，17，3： | 1 |
| 19 | The influence of process parameters on desulfurization of two Turkish lignites by selective oxidation显示文摘 | Sonmez O Giray E S | 2001 | Fuel Processing Technology2001，，70： | 1 |
| 20 | Facemask therapywith rigid anchorage in a patient with maxillary hypoplasiaand severe oligodontia显示文摘 | Enacar A Giray B Pehlivanoglu M | 2003 | Am J Orthod Dentofacial Orthop2003，123，5： | 1 |
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