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| 1 | Preparation of reduced sensitivity co-crystals of cyclic nitramines using spray flash evaporation显示文摘The present day weapon technology demands novel energetic materials that exhibit simultaneous high explosive yield and reduced sensitivity.This article demonstrates application of spray evaporation to prepare reduced sensitive co-crystals of high performance nitramine explosives like HMX and CL-20 with a relatively less insensitive explosive 1,1-diamino-2,2-dinitroethylene or FOX-7.Stronger intermolecurar hydrogen bonding in FOX-7 is responsible for limited solubility in nost of o rganic solvents.Large solubility differences of FOX-7 with HMX and CL-20 restricts ifs co-crystallization through classical methods that yields thermodynamically favorable product.Spray flash evaporation,a kinetic crystallization method,has been therefore adopted and could successfully produce CL-20/FOX-7(2:1) and HMX/FQX-7(4:1) co-crystals.The fine powdered materials obtained were characterized by SEM,powder XRD,Raman spectro scopy,DSC-TGA etc.Multipoint Raman spectra showed consistent occurrence of spectral features indicating stoichiometric co-existence of ingredients in the crystal lattices.DSC analysis showed absence of all thermally assisted solidsolid phase transformation in the co-crystals as they were observed in pristine materials.The thermal stability calculated in terms of activation barrier fordecomposition,revealed the CL-20/FOX-7 co-crystal to be interlediately stable on comparison to their constituents while,the HMX/FOX-7 co-crystal is more stable.Compared to pure HMX and CL-20,both the co-crystals have shown higher insensitivity to impact force,suggesting them to be suitable for future generation insensitive munitions. | Mrinal Ghosh AKSikder Shaibal Banerjee MBTalawar NSikder | 2020 | Defence Technology(防务技术)2020，16，1： | 6 |
| 2 | Emerging insights into HAUSP (USP7) in physiology, cancerand other diseases显示文摘Herpesvirus-associated ubiquitin-specific protease(HAUSP)is a USP family deubiquitinase.HAUSP is a protein of immense biological importance as it is involved in several cellular processes,including host-virus interactions,oncogenesis and tumor suppression,DNA damage and repair processes,DNA dynamics and epigenetic modulations,regulation of gene expression and protein function,spatio-temporal distribution,and immune functions.Since its discovery in the late 1990s as a protein interacting with a herpes virus regulatory protein,extensive studies have assessed its complex roles in p53-MDM2-related networks,identified numerous additional interacting partners,and elucidated the different roles of HAUSP in the context of cancer,development,and metabolic and neurological pathologies.Recent analyses have provided new insights into its biochemical and functional dynamics.In this review,we provide a comprehensive account of our current knowledge about emerging insights into HAUSP in physiology and diseases,which shed light on fundamental biological questions and promise to provide a potential target for therapeutic intervention. | Seemana Bhattacharya Dipankar Chakraborty Malini Basu Mrinal K Ghosh | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 3 | Nanocomposites: An ideal coatingmaterial to reduce the sensitivity of hydraziniumnitroformate(HNF)显示文摘 | Athar Javaid Ghosh Mrinal Dendage PundalikS | 2010 | Propellants Explosives Pyrotechnics2010，35，2： | 1 |
| 4 | Governance value analysis and marketing strategy 显示文摘 | Ghosh Mrinal George John | 1999 | Journal of Marketing1999，63，： | 1 |
| 5 | Transaction costs, opportunism, and governance: Contextual considerations and future research opportunities显示文摘 | Aric Rindfleisch Kersi Antia Janet Bercovitz James R. Brown Joseph Cannon Stephen J. Carson Mrinal Ghosh Susan Helper Diana C. Robertson Kenneth H. Wathne | 2010 | Marketing Letters2010，，3： | 1 |
| 6 | Predictors of Insulin Resistance and Metabolic Complications in Polycystic Ovarian Syndrome in an Eastern Indian Population显示文摘 | Anindya Dasgupta Aparna Khan Ushasi Banerjee Mrinalkanti Ghosh Mrinal Pal Kanika M. Chowdhury Sayantan Dasgupta | 2013 | Indian Journal of Clinical Biochemistry2013，，2： | 1 |
| 7 | Controlled Markov processes on the infinite planning horizon: Weighted and overtaking cost criteria显示文摘 | Emmanuel Fernández-Gaucherand Mrinal K. Ghosh Steven I. Marcus | 1994 | ZOR Zeitschrift fü Operations Research Methods and Models of Operations Research1994，，2： | 1 |
| 8 | Natural Products: Promising Resources for Cancer Drug Discovery显示文摘 | Susmita Mondal Santu Bandyopadhyay Mrinal K. Ghosh Sibabrata Mukhopadhyay Siddhartha Roy Chitra Mandal | 2012 | Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents)2012，，1： | 1 |
| 9 | Governance Value Analysis and Marketing Strategy显示文摘 | Mrinal George John | 1999 | Journal of Marketing1999，，63： | 1 |
| 10 | Targeting PD-1/PD-L1 in cancer immunotherapy:An effective strategy for treatment of triple-negative breast cancer(TNBC)patients显示文摘Maintaining the balance between eliciting immune responses against foreign pro-teins and tolerating self-proteins is crucial for maintenance of homeostasis.The functions of programmed death protein 1(PD-1)and its ligand programmed death ligand 1(PD-L1)are to inhibit immune responses so that over-reacting immune cells does not cause any damage to its own body cells.However,cancer cells hijack this mechanism to attenuate immune cells functions and create an immunosuppressive environment that fuel their continuous growth and proliferation.Over the past few years’rapid development in cancer immunotherapy has opened a new avenue in cancer treatment.Blockade of PD-1 and PD-L1 has become a potential strategy that rescue the functions of immune cells to fight against cancer with high efficacy.Initially,immune checkpoint monotherapies were not very successful,making breast cancer less immunogenic.Although,recent reports support the presence of tumor infiltrating lympho-cytes(TILs)in breast cancer that make it favorable for PD-1/PD-L1 mediated immunotherapy,which is effective in PD-L1 positive patients.Recently,anti-PD-1(pembrolizumab)and anti-PD-L1(atezolizumab)gets FDA approval for breast cancer treatment and make PD-1/PD-L1 immunotherapy is meaningful for further research.Likewise,this article gathered understand-ing of PD-1 and PD-L1 in recent years,their signaling networks,interaction with other mole-cules,regulations of their expressions and functions in both normal and tumor tissue microenvironments are crucial to find and design therapeutic agents that block this pathway and improve the treatment efficacy.Additionally,authors collected and highlighted most of the important clinical trial reports on monotherapy and combination therapy. | Sunny Kumar Mouli Chatterjee Pratyasha Ghosh Kirat K.Ganguly Malini Basu Mrinal K.Ghosh | 2023 | Genes & Diseases2023，10，4： | 1 |
| 11 | Experimental Evidence for Agency Models of Salesforce Compensation显示文摘 | Mrinal Ghosh George John | 2000 | Marketing Science2000，19，4： | 1 |
| 12 | Partially observable semi-Markov games with discounted payoff 显示文摘 | Ghosh Mrinal K Goswami | 2006 | Stoehastic Analysis and Ap- plications2006，24，5： | 1 |
| 13 | Nanocomposites: An ideal coating material to reduce the sensitivity of hydrazinium nitro- formate (HNF)显示文摘 | Athar Javaid Ghosh Mrinal Dendage Pundalik S | 2010 | Propellants Explosives Pyro-technics2010，35，2： | 1 |
| 14 | Vitamin C prevents cigarette smoke induced oxidative damage of proteins and increased proteolysis显示文摘 | Koustubh Panda Ranajoy Chattopadhyay Mrinal K Ghosh | | 0，，9： | 1 |
| 15 | Nanocompos- ites: An Ideal Coating Material to Reduce the Sensitivity of Hydrazinium Nitroformate (HNF) 显示文摘 | Javaid Athar Mrinal Ghosh Pundalik S | 2010 | Propellants Ex- plosive Pyrotechnics2010，35，2： | 1 |
| 16 | Governance Value Analysisand Marketing Strategy 显示文摘 | Mrinal Ghosh George John | 1999 | Journal of Marketing1999，，： | 1 |
| 17 | Experimental Evidence for Agency Models of Salesforce Compensation显示文摘 | Mrinal Ghosh George John | 2000 | Market-ing Science2000，19，4： | 1 |
| 18 | COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease COVID-19.Clinicians are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only hope.Globally,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical trials.Here in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early 2020.At last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines. | Sunny Kumar Malini Basu Pratyasha Ghosh Uttam Pal Mrinal K.Ghosh | 2023 | Genes & Diseases2023，10，4： | 0 |
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