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| 1 | Role of probiotics,prebiotics and synbiotics in chemoprevention for colorectal cancer显示文摘Colorectal cancer is the third most common form of cancer.Current treatments are all associated with a high risk of complications and a low success rate.Recently,synbiotics have been proposed as a new preventive and therapeutic option.There is no direct experimental evidence for cancer suppression in humans as a result of the consumption of pro-,pre-or synbiotics.However,there is a wealth of evidence emerging from laboratory studies.The mechanisms by which pro-,pre-and synbiotics may inhibit colon cancer are now beginning to be understood and will be addressed in the present review. | Constantine Iosif Fotiadis Christos Nikolaou Stoidis Basileios Georgiou Spyropoulos Eleftherios Dimitriou Zografos | 2008 | World Journal of Gastroenterology2008，14，42： | 16 |
| 2 | Effects of phosphodiesterase 5 inhibitors on sperm parameters and fertilizing capacity显示文摘这评论研究的目的是阐明效果那磷酸二酯酶 5 (PDE5 ) 禁止者在精子上施加活动性, capacitation 过程并且在他们使肥沃的能力上卵母细胞。第二个送信人系统象 cAMP/adenylate cyclase (交流) 那样系统和 cGMP/guanylate cyclase (GC ) 系统看起来调整精子功能。intracytosolic 营地的增加的层次导致精子活动性和生存能力的改进。由氮的氧化物的低剂量的 GC 的刺激(没有) 导致精子活动性的改进或维护,而更高的集中在精子参数上有不利效果。几在活体内和在试管内研究被执行了以便检验 PDE5 禁止者是否断然或否定地影响精子参数和精子使肥沃能力。这些研究的结果是争论的。一些这些研究不在从与 PDE5 禁止者被对待的人收集的精子的活动性,生存能力,和形态学上表明 PDE5 禁止者的重要效果。在另一方面,几研究在精子活动性上表明 PDE5 禁止者的积极效果在活体内和在试管内。sildenafil 柠檬酸盐的在试管内研究随在除 PDE5 以外的 PDE 对碘氧基苯甲醚上建议 sildenafil 柠檬酸盐的一个禁止的行动的细胞内部的营地的增加在精子活动性上表明 stimulatory 效果。在另一方面, tadalafil 的行动看起来在 PDE11 上与这混合物的禁止的效果被联系。在在一个每日的基础与 vardenafil 对待的人的在活体内研究每精液,量的精子活动性,和质的精子活动性表明了精子的一个显著地更大的全部的数字;vardenafil 管理提高前列腺的能分泌的功能并且随后增加精子的质、量的活动性,这被建议了。PDE5 禁止者在精子参数上施加的效果可以导致帮助繁殖技术(艺术) 的结果的改进程序。在未来 PDE5,禁止者可能为男不孕的缓和用作附属物 therapeutical 代理人。 | F. Dimitriadis D. Giannakis N. Pardalidis K. Zikopoulos E. Paraskevaidis N. Giotitsas V. Kalaboki P.Tsounapi D. Baltogiannis Georgiou M.Saito T.Watanabe I. Miyagawa N.Sofildtis | 2008 | Asian Journal of Andrology2008，10，1： | 11 |
| 3 | Genetic and epigenetic risks of intracytoplasmic sperm injection method显示文摘怀孕由帮助繁殖技术完成了,特别地由胞质内精子注射(ICSI ) 过程,产生对与 ICSI 对待的男人口固有的基因风险和对这个创新过程固有的另外的风险。记录,以及理论,风险在现在的评论学习被讨论。这些风险主要表示位于男性下面的基因畸形的后果代替生育力(或不孕) 并且可能在不孕的治疗为新奇途径和应用的发展成为激发器。另外,冒的风险,当先天的异例和另外的理论或随机的风险被讨论,一个复合基因背景出现在出生。最近的数据建议那种帮助繁殖技术可能也影响雄配子,雌配子,或力量的渐成说特征影响早胚胎开始。它可能也为印畸形的 genomic 与增加的风险被联系。 | Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis Konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis Motoaki Saito Ikuo Miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios Giannakis Michael Fatouros Nikolaos Sofikitis | 2006 | Asian Journal of Andrology2006，8，6： | 9 |
| 4 | Wireless capsule endoscopy in the investigation of patients with chronic renal failure and obscure gastrointestinal bleeding (preliminary data)显示文摘瞄准:在小肠(SB ) 的察觉调查无线的囊内视镜检查法(WCE ) 的角色在有长期的肾衰竭(CRF ) 并且阴暗流血的病人的病理。方法:有阴暗流血的连续 CRF 病人有希望地被学习。有正常肾的功能并且阴暗流血的病人,与 WCE 在一样的时期期间调查了,被用于结果的解释。结果:十七个 CRF 病人(11 公开, 6 玄术流血) 并且 51 个病人(33 公开, 18 玄术流血) 与正常,肾的功能在这研究被注册。积极 SB 调查结果在 70.6% CRF 病人被检测(P <
0.05 ) 。SB angiodysplasia 在 47% CRF 病人被识别。Univariate 逻辑回归为 angiodysplasia 作为一个重要预兆的因素揭示了 CRF (P <
0.05 ) 。治疗学的措施与积极调查结果在 66% 病人被承担。结论:根据我们的初步的结果, SB angiodysplasia 与阴暗流血在 CRF 病人之中在增加的流行被发现。WCE 在胃肠的病理的诊断并且在计划适当治疗学的干预是有用的并且因此,应该在这组病人的病情的检查被包括。 | Stephanos Karagiannis Spyros Goulas Georgios Kosmadakis Petros Galanis Dimitrios Arvanitis John Boletis Evangelos Georgiou Christos Mavrogiannis | 2006 | World Journal of Gastroenterology2006，12，32： | 8 |
| 5 | Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats显示文摘AIM: To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats.METHODS: Ninety male Wistar rats were randomly divided into five groups: Ⅰ (n = 10): controls, Ⅱ (n =20): sham operated, Ⅲ (n = 20): partial hepatectomy 70% (PHx), Ⅳ (n = 20): PHx+BBS (30 μg/kg/d), Ⅴ (n= 20): PHx+NT (300 μg/kg/d). Groups Ⅳ and Ⅴ were treated for 8 days before PHx and 48 h post surgery.At the end of the experiment, on day 10, intestinal barrier function was assessed by measuring endotoxin concentrations in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and villus density, mucosal thickness, mitotic activity and apoptosis in crypts were assessed. In addition, ileal mucosa was analyzed for DNA and protein content and microbiological analysis was performed in cecal contents.To estimate intestinal oxidative stress, lipid peroxidation was determined on tissue homogenates from terminal ileum.RESULTS: BBS or NT administration significantly reduced portal and systemic endotoxemia observed 48 h after partial hepatectomy. In hepatectomized rats (group Ⅲ), a trend towards induction of mucosal atrophy was observed, demonstrated by the reduction of villus density, mucosal thickness, protein content and significant reduction of DNA, while these alterations were reversed by regulatory peptides administration.This trophic effect of BBS and NT was accompanied by induction of mitoses above control levels and a significant reduction of apoptosis in intestinal crypts.Intestinal lipid peroxidation was found significantly lower in PHx group and regulatory peptides exerted an antioxidant action, further decreasing this parameter of oxidative stress. The bacterial population of E. coli and aerobic Gram (+) cocci was increased in cecal content of hepatectomized rats, while this parameter was not affected by the administration of BBS or NT.CONCLUSION: Gut regulatory peptides BBS and NT improve intestinal barrier function and reduce endotoxemia in experimental partial hepatectomy. This effect is, at least in part, mediated by their trophic,antiapoptotic, mitogenic, and antioxidant effect on the intestinal epithelium. This observation might be of potential value in patients undergoing liver resection. | Stelios F Assimakopoulos Ilias H Alexandris Chrisoula D Scopa Panagiotis G Mylonas Konstantinos C Thomopoulos Christos D Georgiou Vassiliki N Nikolopoulou Constantine E Vagianos | 2005 | World Journal of Gastroenterology2005，11，43： | 8 |
| 6 | 蠕墨铸铁的高速加工显示文摘通过对灰铸铁、球墨铸铁、蠕墨铸铁(CGI)切屑形成之显微结构的研究,对这些材料的加工状况有了进一步了解。结合切削刀具、机床和工件结构,讨论了切屑形成过程中所产生的物理和化学作用。介绍了兰姆公司利用二次开发的回转刀具高速加工CGI材料的工艺。最后还对这种提高了一个数量级的加工工艺的经济性作了评价。 | George Georgiou | 2005 | 世界制造技术与装备市场2005，，6： | 8 |
| 7 | 与 transarterial chemoembolization 对待的 Hepatocellular 癌: 有参量的提高对比的 ultrasonography 的评估显示文摘 AIM:To evaluate the response of hepatocellular carcinoma(HCC) to transarterial chemoembolization(TACE) using a simplified protocol of parametric contrastenhanced ultrasound(pCEUS).METHODS:Eighteen patients with HCC(18 target tumors,diameter:2.8-12 cm) were evaluated before,and 20 d after TACE.The distribution and morphology of TACE-induced necrosis in these tumors precluded accurate evaluation by visual assessment or by simple measurements.For pCEUS,a 4.8 mL bolus of SonoVue(Bracco,Milan,Italy) was intravenously administered and analysis of tumor perfusion during the initial phase of enhancement(0-30 s post injection) was performed with dedicated software(Qontrast,Bracco,Milan,Italy).Time-intensity curves were plotted and three parameters were calculated:peak intensity(PI,in percentage %),time to peak(TTP in seconds,s) and area under the curve during wash-in(AUC-WI,in arbitrary units,a.u).Magnetic resonance imaging was the standard imaging modality for post-treatment evaluation.Changes in tumor size were recorded and response was assessed according to response evaluation criteria in solid tumors criteria.RESULTS:A statistically significant decrease in PI and AUC-WI was observed in the treated tumors post TACE;PIpre:21.5% ± 8.7%(mean ± SD),PIpost:12.7% ± 6.7%,P < 0.001,AUC-WI pre:17493 ± 9563 a.u,AUCWI post:9585 ± 5494 a.u,P < 0.001.A slight increase in TTP was noted post TACE,but this was not statistically significant;TTP pre:13.1 ± 4.3 s,TTP post:13.6 ± 4.2 s,P = 0.058).The changes in the aforementioned parameters were not accompanied by significant tumor shrinkage.CONCLUSION:pCEUS,even when limited to the study of the arterial phase of tumoral enhancement,can detect and quantify early perfusional changes in HCC post TACE. | Hippocrates Moschouris Katerina Malagari Athanasios Marinis Ioannis Kornezos Konstantinos Stamatiou Georgios Nikas Marina Georgiou Papadaki Panagiotis Gkoutzios | 2012 | World Journal of Radiology2012，4，8： | 3 |
| 8 | The tumour biology of synchronous and metachronous colorectal liver metastases: a systematic review显示文摘 | A. A. P. Slesser P. Georgiou G. Brown S. Mudan R. Goldin P. Tekkis | 2013 | Clinical & Experimental Metastasis2013，，4： | 2 |
| 9 | Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats显示文摘AIM:To investigate the effect of the neuropeptides bombesin(BBS)and neurotensin(NT)on oval cell proliferation in partially hepatectomized rats not pretreated with a known hepatocyte inhibitor.METHODS:Seventy male Wistar rats were randomly divided into five groups:Ⅰ=controls,Ⅱ=sham operated,Ⅲ=partial hepatectomy 70%(PHx),Ⅳ=PHx+ BBS(30μg/kg per day),Ⅴ=PHx+NT(300μg/kg per day).Forty eight hours after liver resection,portal en-dotoxin levels and hepatic glutathione redox state were determined.α-fetoprotein(AFP)mRNA(in situ hybridisation),cytokeratin-19 and Ki67 antigen expression (immunohistochemistry)and apoptosis(TUNEL)were evaluated on liver tissue samples.Cells with morphological features of oval cells that were cytokeratin-19 (+)and AFP mRNA(+)were scored in morphometric analysis and their proliferation was recorded.In addition,the proliferation and apoptotic rates of hepatocytes were determined.RESULTS:In the control and sham operated groups,oval cells were significantly less compared to groups Ⅲ,ⅣandⅤ(P<0.001).The neuropeptides BBS and NT significantly increased the proliferation of oval cells compared to groupⅢ(P<0.001).In addition,BBS and NT induced a significant increase of hepatocyte proliferation(P<0.001),whereas it decreased their apoptotic activity(P<0.001)compared to groupⅢ.BBS and NT significantly decreased portal endotoxemia (P<0.001)and increased the hepatic GSH:GSSG ratio (P<0.05 and P<0.001,respectively)compared to groupⅢ.CONCLUSION:BBS and NT stimulated oval cell proliferation in a model of liver regeneration,without use of concomitant suppression of hepatocyte proliferation as oval cell activation stimuli,and improved the hepatocyte regenerative response.This peptides-induced combined stimulation of oval cell and hepatocyte proliferation might serve as a possible treatment modality for several liver diseases. | Stelios F Assimakopoulos Athanassios C Tsamandas Ilias H Alexandris Christos Georgiou Constantine E Vagianos Chrisoula D Scopa | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 2 |
| 10 | Ventral colporectopexy for overt rectal prolapse and obstructed defaecation syndrome: a systematic review显示文摘 | N. Gouvas P. A. Georgiou C. Agalianos E. Tan P. Tekkis C. Dervenis E. Xynos | 2015 | Colorectal Dis2015，，2： | 2 |
| 11 | Infected Completely Isolated Enteric Duplication Cyst Management with Percutaneous Drainage and Surgical Excision after Retreat of Infection: A Case Report显示文摘 | Neofytou Kyriakos Chysochos Andreas Sammouti Elena Andreou Charalampos Georgiou Chrisanthos C. Barnett F. Marchal B. Tokar | 2013 | Case Reports in Surgery2013，，： | 2 |
| 12 | 直肠癌根治术中扩大淋巴结清扫与常规淋巴结清扫比较的荟萃分析显示文摘背景:骨盆侧方淋巴结转移发生于10%-25%的直肠癌患者,并与局部复发率增高和生存率降低有关。但长期以来,对于是否常规进行侧方淋巴结清扫及其疗效存在诸多争议。本研究采用荟萃分析的方法,对扩大侧方淋巴结清扫术在直肠癌手术治疗中的价值进行评估。 | Georgiou P 张恩勇(摘译) 王颢(校) | 2010 | 中华胃肠外科杂志2010，13，1： | 2 |
| 13 | The association of aromatase (CYP19) gene variants wil sperm concentration and motility显示文摘 | Leandros Lazaros Nectaria Xita Apostolos Kaponis Elissavet Hatzi Nicolaos Plachouras Nicolaos Sofikitis Konstantinos Zikopoulos Ioannis Georgiou | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 14 | The adiponectin-to- leptin ratio in women with polycystic ovary syndrome : relation to insulin resistance and proinflammatory markers 显示文摘 | Xita N Papassotiriou I Georgiou I | 2007 | Metabolism2007，56，： | 1 |
| 15 | Sulphuric acid pressure leaching of limonitic laterite:chemistry and kinetics显示文摘 | Georgiou D Papangelakis V G | 1998 | Hydrometallurgy1998，49，12： | 1 |
| 16 | Mammographic masses char-acterization based on localized texture and dataset frae tal analysis using linear, neural and support vector ma- chine classifiers 显示文摘 | MAVROFORAKIS M E GEORGIOU H V DIM- ITROPOULOS N | 2006 | Artificial Intelligence in Medi- cine2006，37，2： | 1 |
| 17 | Post traumatic brain perfusion SPECT analysis using reconstructed ROI maps of radioactive microsphere derived cerebral blood flow and statistical parametric mapping 显示文摘 | McGoron A J Capille M Georgiou MF | 2008 | BMC Med Imaging2008，29，8： | 1 |
| 18 | Ryanodine re- ceptors : structure, expression, molecular details, and function in calcium release 显示文摘 | LANNER JT GEORGIOU DK JOSHI AD | 2010 | Cold Spring Harb Perspect Biol2010，2，11： | 1 |
| 19 | A Goal Programming Model for Partner Selection Decisions in International Joint Ventures 显示文摘 | HAJIDIMITRIOU Y A GEORGIOU A C | 2002 | European Journal of Operational Research2002，138，3： | 1 |
| 20 | Proleomic analysis of human plasma: failure of centrifugal ultrafiltration to remove albumin and other high molecular weight proteins显示文摘 | Georgiou HM Rice GE Baker MS | 2001 | Proteomics2001，1，12： | 1 |
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